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The map label for this gene is qor [C]

Identifier: 34497085

GI number: 34497085

Start: 1768055

End: 1769068

Strand: Reverse

Name: qor [C]

Synonym: CV_1630

Alternate gene names: 34497085

Gene position: 1769068-1768055 (Counterclockwise)

Preceding gene: 34497093

Following gene: 34497084

Centisome position: 37.24

GC content: 68.15

Gene sequence:

>1014_bases
ATGAAAGCCGTCGCTTATTACCAGAATCTGCCCATCTCCCATCCGGAAGCGCTGCAGGACGTGCAACTGCCCGAGCCCGT
CATCGGCGAGCGCGATCTGCTGGTGGAGGTGCAAGCCATTTCCGTCAACCCGGTAGACGTGAAGGTGCGCGCCAATATGG
CGCCGGAAGCCGGCCAGCCCAAGGTGCTGGGCTGGGATGTGGCCGGCGTGGTGCGCGCCGTCGGCGCCAAGACCACGCTG
TTCCAGCCGGGCGACCGCGTCTGGTACGCCGGCGCGCTGCAGCGCCCCGGCGCCAACAGCGAGCTGCACGCGGTGGACGA
GCGCATCGTCGGCCGCATGCCGGACAGCCTGGACTTCGAGACCGCGGCCGCGCTGCCGCTGACCGCCATCACCGCCTGGG
AGCTGCTGTTCGACCGCCTGCAGGTGTTGGCCAACGGCCAGCCGGCCGGCCGCAAGCTGATGATCGTCGGCGCCGCCGGC
GGCGTCGGCTCCATCATGATCCAGCTAGCGCGCCAGCTGACCGGCCTCACCGTGATCGCCACCGCGTCGCGGCCGGAAAC
CCAGGCCTGGGTCAGAGAGCTGGGCGCCCATCACGTGATCGACCACAGCCAGCCGCTGAGCCGGGAGCTGAAACGCATCG
GCATCGAGAGCGTCGACTACGTCGCCAGCCTGAACCAGACCGACGCCCACTTCGGCGAGATCGTCGAATCGCTGGCGCCG
CAGGGCAAGCTCGCGCTGATCGACGACCCGGCAGCGCTGGACGCGCGCCCGTTGAAAGTGAAAAGCATCTCGCTGCACTG
GGAGTTCATGTACACCCGCTCGATGTTCGCCACCGACGACCAGATCGAGCAGCACAAGCTGCTGACCGAGCTGGCGCGGC
TGGTGGACGCCGGCATCGTCAAGAGCACCGTCGCCGAGCGTTTCGGCGCGATCAACGCCGCCAACCTCAAGCGCGCCCAC
GCCTTGCTGGAAAGCAACGCCGCCCGCGGCAAGATCGTGCTCAGCGGTTTCTGA

Upstream 100 bases:

>100_bases
TCGTATATTAGCCGGATTTTCTTCAAATCAAACAGCAATACCATGCGAGGCATCACGAAGGCGGCCCCGCCGCCGGGATT
GCGTAACCAGAGGAAACCCC

Downstream 100 bases:

>100_bases
CCCAGCCGCGCCGTGGCGGCCGGCACCGCACAGGCCGCCACGGGCCCTTCTTTCCCTCCCCGGCCGCGCAACGCGGCCTT
TCCGGTCCGACGACATGAAT

Product: oxidoreductase

Products: NADP(+); Semiquinone. [C]

Alternate protein names: NA

Number of amino acids: Translated: 337; Mature: 337

Protein sequence:

>337_residues
MKAVAYYQNLPISHPEALQDVQLPEPVIGERDLLVEVQAISVNPVDVKVRANMAPEAGQPKVLGWDVAGVVRAVGAKTTL
FQPGDRVWYAGALQRPGANSELHAVDERIVGRMPDSLDFETAAALPLTAITAWELLFDRLQVLANGQPAGRKLMIVGAAG
GVGSIMIQLARQLTGLTVIATASRPETQAWVRELGAHHVIDHSQPLSRELKRIGIESVDYVASLNQTDAHFGEIVESLAP
QGKLALIDDPAALDARPLKVKSISLHWEFMYTRSMFATDDQIEQHKLLTELARLVDAGIVKSTVAERFGAINAANLKRAH
ALLESNAARGKIVLSGF

Sequences:

>Translated_337_residues
MKAVAYYQNLPISHPEALQDVQLPEPVIGERDLLVEVQAISVNPVDVKVRANMAPEAGQPKVLGWDVAGVVRAVGAKTTL
FQPGDRVWYAGALQRPGANSELHAVDERIVGRMPDSLDFETAAALPLTAITAWELLFDRLQVLANGQPAGRKLMIVGAAG
GVGSIMIQLARQLTGLTVIATASRPETQAWVRELGAHHVIDHSQPLSRELKRIGIESVDYVASLNQTDAHFGEIVESLAP
QGKLALIDDPAALDARPLKVKSISLHWEFMYTRSMFATDDQIEQHKLLTELARLVDAGIVKSTVAERFGAINAANLKRAH
ALLESNAARGKIVLSGF
>Mature_337_residues
MKAVAYYQNLPISHPEALQDVQLPEPVIGERDLLVEVQAISVNPVDVKVRANMAPEAGQPKVLGWDVAGVVRAVGAKTTL
FQPGDRVWYAGALQRPGANSELHAVDERIVGRMPDSLDFETAAALPLTAITAWELLFDRLQVLANGQPAGRKLMIVGAAG
GVGSIMIQLARQLTGLTVIATASRPETQAWVRELGAHHVIDHSQPLSRELKRIGIESVDYVASLNQTDAHFGEIVESLAP
QGKLALIDDPAALDARPLKVKSISLHWEFMYTRSMFATDDQIEQHKLLTELARLVDAGIVKSTVAERFGAINAANLKRAH
ALLESNAARGKIVLSGF

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily [H]

Homologues:

Organism=Homo sapiens, GI47519420, Length=340, Percent_Identity=28.2352941176471, Blast_Score=104, Evalue=9e-23,
Organism=Homo sapiens, GI194239674, Length=263, Percent_Identity=28.1368821292776, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI13236495, Length=263, Percent_Identity=28.1368821292776, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI194239676, Length=208, Percent_Identity=32.6923076923077, Blast_Score=99, Evalue=7e-21,
Organism=Homo sapiens, GI24308257, Length=299, Percent_Identity=28.0936454849498, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI18379349, Length=215, Percent_Identity=34.4186046511628, Blast_Score=80, Evalue=4e-15,
Organism=Homo sapiens, GI28557745, Length=228, Percent_Identity=29.3859649122807, Blast_Score=67, Evalue=2e-11,
Organism=Escherichia coli, GI1790485, Length=326, Percent_Identity=28.8343558282209, Blast_Score=88, Evalue=7e-19,
Organism=Caenorhabditis elegans, GI17507255, Length=314, Percent_Identity=27.7070063694268, Blast_Score=90, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI71987554, Length=179, Percent_Identity=30.1675977653631, Blast_Score=78, Evalue=5e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR014182
- InterPro:   IPR011032
- InterPro:   IPR016040
- InterPro:   IPR002364 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: 1.6.5.5 [C]

Molecular weight: Translated: 36453; Mature: 36453

Theoretical pI: Translated: 6.43; Mature: 6.43

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAVAYYQNLPISHPEALQDVQLPEPVIGERDLLVEVQAISVNPVDVKVRANMAPEAGQP
CCCEEEECCCCCCCHHHHHHCCCCCCCCCCCCEEEEEEEEEECCEEEEEEECCCCCCCCC
KVLGWDVAGVVRAVGAKTTLFQPGDRVWYAGALQRPGANSELHAVDERIVGRMPDSLDFE
CEEEECHHHHHHHHCCCCEEECCCCCEEEECCCCCCCCCCHHHHHHHHHHHCCCCCCCCC
TAAALPLTAITAWELLFDRLQVLANGQPAGRKLMIVGAAGGVGSIMIQLARQLTGLTVIA
HHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCHHHHHHHHHHHHCCEEEEE
TASRPETQAWVRELGAHHVIDHSQPLSRELKRIGIESVDYVASLNQTDAHFGEIVESLAP
ECCCCHHHHHHHHHCCHHCCCCCCHHHHHHHHCCCCHHHHHHHCCCCHHHHHHHHHHHCC
QGKLALIDDPAALDARPLKVKSISLHWEFMYTRSMFATDDQIEQHKLLTELARLVDAGIV
CCCEEEEECCCCCCCCCEEEEEEEEEEEEEEEHHHHCCCHHHHHHHHHHHHHHHHHHHHH
KSTVAERFGAINAANLKRAHALLESNAARGKIVLSGF
HHHHHHHHCCCCHHHHHHHHHHHHCCCCCCEEEEECC
>Mature Secondary Structure
MKAVAYYQNLPISHPEALQDVQLPEPVIGERDLLVEVQAISVNPVDVKVRANMAPEAGQP
CCCEEEECCCCCCCHHHHHHCCCCCCCCCCCCEEEEEEEEEECCEEEEEEECCCCCCCCC
KVLGWDVAGVVRAVGAKTTLFQPGDRVWYAGALQRPGANSELHAVDERIVGRMPDSLDFE
CEEEECHHHHHHHHCCCCEEECCCCCEEEECCCCCCCCCCHHHHHHHHHHHCCCCCCCCC
TAAALPLTAITAWELLFDRLQVLANGQPAGRKLMIVGAAGGVGSIMIQLARQLTGLTVIA
HHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCHHHHHHHHHHHHCCEEEEE
TASRPETQAWVRELGAHHVIDHSQPLSRELKRIGIESVDYVASLNQTDAHFGEIVESLAP
ECCCCHHHHHHHHHCCHHCCCCCCHHHHHHHHCCCCHHHHHHHCCCCHHHHHHHHHHHCC
QGKLALIDDPAALDARPLKVKSISLHWEFMYTRSMFATDDQIEQHKLLTELARLVDAGIV
CCCEEEEECCCCCCCCCEEEEEEEEEEEEEEEHHHHCCCHHHHHHHHHHHHHHHHHHHHH
KSTVAERFGAINAANLKRAHALLESNAARGKIVLSGF
HHHHHHHHCCCCHHHHHHHHHHHHCCCCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 0.017 {9,10-phenanthrenequinone}} 0.0153 {2,6-dichlorophenolindophenol}} 0.013 {2,6-dichlorophenolindophenol}} 0.065 {1,4-benzoquinone}} 0.007 {NADPH}} 0.0069 {NADPH}} 0.26 {1,4-naphthoquinone}} 0.0024 {1,2-naphthoquinone}} [C]

Substrates: NADPH; Quinone [C]

Specific reaction: NADPH + Quinone = NADP(+) + Semiquinone. [C]

General reaction: Oxidation; Reduction [C]

Inhibitor: 2, 3-Dimercaptopropanol; 2, 5-Dichloro-3, 6-dihydroxy -1, 4-benzoquinone; 4-Hydroxy coumarin; 5, 5'-Dithiobis (2-nitrobenzoate); ADP; Cibacronblue3GA; Coumarin; Cu2+; Dicoumarol warfarin, coumarin; Dithiothreitol preincubation with 9, 10-phenanthrenequino

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11418146 [H]