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The map label for this gene is nadC [H]

Identifier: 34497043

GI number: 34497043

Start: 1712685

End: 1713524

Strand: Reverse

Name: nadC [H]

Synonym: CV_1588

Alternate gene names: 34497043

Gene position: 1713524-1712685 (Counterclockwise)

Preceding gene: 34497046

Following gene: 34497042

Centisome position: 36.07

GC content: 70.0

Gene sequence:

>840_bases
ATGCCCCTGCCTGCCCCCCACCTGATCGCCCAGCAAGTCGCCCTGGCCCTGGCCGAAGACATCGGCCCCTGCGACCGCAC
CGCCCAACTGATAGCCGCCGACAAGGCGGGCTCCGCCCGCGTGATCGCGCGCGAAGACGCCGTGATCTGCGGCCAGGCCT
GGTTCGATGAGTGCTTCCGCCAGGTGGACGCGCGCTGCCGGGTGGAATGGCTGGCCGCGGAAGGCGAGAAAGTGGCCGCG
GGCCGCGAACTGTGCCGGATCAGCGGTCCGGCCCGCGCGCTGCTCACCGCCGAGCGCAGCGCGCTCAACTTCCTGCAGCT
CTTATCGGGCGTGGCCAGCGAAACCCGCCGCTACGTCGACGCGGTCGCCGGTCACCGCGCCCGCATCCTGGACACCCGCA
AAACCCTGCCCGGCCTGCGCCTGGCGCAGAAATACGCGGTCACCGCCGGCGGCGGCGACAACCAGCGCATCGGCCTGTTC
GACGGCATCCTGATCAAGGAAAACCACATCATGGCGGCCGGCGGCGTCGCCCAGGCGATGGAGCAGGCGCTGGCCGACTT
GCCGCCGGGCGTCACGCTGCAGATCGAGGTGGAAAACCTAGCGCAGCTGGAGGAAGCGCTGAACCACGGCGCCCGGCTGG
TGCTGCTGGACAATATGTCGCTGGACGACATGCGCCGCGCGGTGGAAATCTGCGCCGGCCGCGCCGAGCTGGAAGCCTCC
GGCGGCGTCGATCTGGACAGCGTGCGCGCCATCGCCGCCACCGGCGTGGACCGCATCTCCGTAGGCAAGCTGACCAAGGA
TGTTCGCGCGCTGGATCTGTCCATGCGCTTCACCCTGTAA

Upstream 100 bases:

>100_bases
CCAGCATAGCAGATGACATCCCATCCCTCGCATTTTCGGCGCAGACCGCGCGCCAACTTCACCGCCTGCCGTTACAATAC
GTTTTTGGATGGAGACCCGT

Downstream 100 bases:

>100_bases
CTTGCTACGCAGCCGCGGAGAGAGCTGTCATACTGAAGGCATGCCTACTATAAGAAAAGCATAGCCCTCACCATCCATGG
ACATGACTCCGCGCAGATTC

Product: nicotinate-nucleotide pyrophosphorylase

Products: NA

Alternate protein names: Quinolinate phosphoribosyltransferase [decarboxylating]; QAPRTase [H]

Number of amino acids: Translated: 279; Mature: 278

Protein sequence:

>279_residues
MPLPAPHLIAQQVALALAEDIGPCDRTAQLIAADKAGSARVIAREDAVICGQAWFDECFRQVDARCRVEWLAAEGEKVAA
GRELCRISGPARALLTAERSALNFLQLLSGVASETRRYVDAVAGHRARILDTRKTLPGLRLAQKYAVTAGGGDNQRIGLF
DGILIKENHIMAAGGVAQAMEQALADLPPGVTLQIEVENLAQLEEALNHGARLVLLDNMSLDDMRRAVEICAGRAELEAS
GGVDLDSVRAIAATGVDRISVGKLTKDVRALDLSMRFTL

Sequences:

>Translated_279_residues
MPLPAPHLIAQQVALALAEDIGPCDRTAQLIAADKAGSARVIAREDAVICGQAWFDECFRQVDARCRVEWLAAEGEKVAA
GRELCRISGPARALLTAERSALNFLQLLSGVASETRRYVDAVAGHRARILDTRKTLPGLRLAQKYAVTAGGGDNQRIGLF
DGILIKENHIMAAGGVAQAMEQALADLPPGVTLQIEVENLAQLEEALNHGARLVLLDNMSLDDMRRAVEICAGRAELEAS
GGVDLDSVRAIAATGVDRISVGKLTKDVRALDLSMRFTL
>Mature_278_residues
PLPAPHLIAQQVALALAEDIGPCDRTAQLIAADKAGSARVIAREDAVICGQAWFDECFRQVDARCRVEWLAAEGEKVAAG
RELCRISGPARALLTAERSALNFLQLLSGVASETRRYVDAVAGHRARILDTRKTLPGLRLAQKYAVTAGGGDNQRIGLFD
GILIKENHIMAAGGVAQAMEQALADLPPGVTLQIEVENLAQLEEALNHGARLVLLDNMSLDDMRRAVEICAGRAELEASG
GVDLDSVRAIAATGVDRISVGKLTKDVRALDLSMRFTL

Specific function: Involved in the catabolism of quinolinic acid (QA) [H]

COG id: COG0157

COG function: function code H; Nicotinate-nucleotide pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nadC/modD family [H]

Homologues:

Organism=Homo sapiens, GI45269149, Length=277, Percent_Identity=33.9350180505415, Blast_Score=139, Evalue=2e-33,
Organism=Escherichia coli, GI1786299, Length=275, Percent_Identity=50.1818181818182, Blast_Score=231, Evalue=4e-62,
Organism=Saccharomyces cerevisiae, GI6321162, Length=291, Percent_Identity=30.5841924398625, Blast_Score=140, Evalue=2e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR004393
- InterPro:   IPR002638
- InterPro:   IPR022412 [H]

Pfam domain/function: PF01729 QRPTase_C; PF02749 QRPTase_N [H]

EC number: =2.4.2.19 [H]

Molecular weight: Translated: 29824; Mature: 29692

Theoretical pI: Translated: 5.44; Mature: 5.44

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPLPAPHLIAQQVALALAEDIGPCDRTAQLIAADKAGSARVIAREDAVICGQAWFDECFR
CCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHEECCCCCEEEEEECCCEEECHHHHHHHHH
QVDARCRVEWLAAEGEKVAAGRELCRISGPARALLTAERSALNFLQLLSGVASETRRYVD
HHHHHHEEEEEECCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AVAGHRARILDTRKTLPGLRLAQKYAVTAGGGDNQRIGLFDGILIKENHIMAAGGVAQAM
HHHCCHHHHHHHHHCCCCHHHHHHHEEEECCCCCCEEEEECCEEEECCCEEECCHHHHHH
EQALADLPPGVTLQIEVENLAQLEEALNHGARLVLLDNMSLDDMRRAVEICAGRAELEAS
HHHHHHCCCCCEEEEEHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHCCCHHCCCC
GGVDLDSVRAIAATGVDRISVGKLTKDVRALDLSMRFTL
CCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHEEEEEECC
>Mature Secondary Structure 
PLPAPHLIAQQVALALAEDIGPCDRTAQLIAADKAGSARVIAREDAVICGQAWFDECFR
CCCCHHHHHHHHHHHHHHHCCCCCHHHHHHEECCCCCEEEEEECCCEEECHHHHHHHHH
QVDARCRVEWLAAEGEKVAAGRELCRISGPARALLTAERSALNFLQLLSGVASETRRYVD
HHHHHHEEEEEECCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AVAGHRARILDTRKTLPGLRLAQKYAVTAGGGDNQRIGLFDGILIKENHIMAAGGVAQAM
HHHCCHHHHHHHHHCCCCHHHHHHHEEEECCCCCCEEEEECCEEEECCCEEECCHHHHHH
EQALADLPPGVTLQIEVENLAQLEEALNHGARLVLLDNMSLDDMRRAVEICAGRAELEAS
HHHHHHCCCCCEEEEEHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHCCCHHCCCC
GGVDLDSVRAIAATGVDRISVGKLTKDVRALDLSMRFTL
CCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10984043; 2430961; 8419294 [H]