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The map label for this gene is ggt [H]

Identifier: 34496870

GI number: 34496870

Start: 1492314

End: 1493978

Strand: Direct

Name: ggt [H]

Synonym: CV_1415

Alternate gene names: 34496870

Gene position: 1492314-1493978 (Clockwise)

Preceding gene: 34496869

Following gene: 34496871

Centisome position: 31.41

GC content: 67.39

Gene sequence:

>1665_bases
ATGAATTGGGTTTCCATGTCCCGCAAGGCCTTGGCCGGCGGCGGCCTGTTGCTGATCGCGCTGCCGGCGCTGGCGGGGCA
GGGCGCGGTGGCTGCGCCGGACCAGTACGGCGCCGAAGTCGCCGCCCGTATCCTGAAGTCGGGCGGCAACGCGGTGGACG
CCGCGGTGGCCACCGCCTTCGCCCTGGCCGTCACGTATCCCGAGGCCGGCAATATCGGCGGCGGCGGCTTCATGACCATC
TACCAGGGCGGCAAACCGTATTTTCTCGACTACCGCGAAGTGGCGCCCAAGGCGGCCAGCCGCGACATGTACCTGGACAA
GGACGGCAAGGTGGTGCCGGACATGAGCCTGGTCGGCGCGCGCGCCGCCGGCGTGCCGGGCACGGTGATGGGCTTGTGGC
AGGCGCACCAGCGCTTCGGCAAGCTGCAATGGAAGCAGCTGCTGGATCCGGCGATAGGCTACGCCGAGCAGGGCTTCACC
GTGGCCGCCCGCCAATACCAGTACCGCGACGAGGCGGTGAAGCTGTTCGACGGCAAGACCAATTTCGCCCAGTACTTCGG
CAAGATGAAGGGCGGCGAAACCTTCCGCCAGCCCGAACTGGCCGCCACGCTGAAACGCATCGCCCGCTACGGCGCGGCCG
AGTTCTACCAGGGCGAGACCGCCAAGCTTCTGGTGGCGCAGATGAAGCGCGACAAGGGCCTGATCACCGCCGACGACCTC
AACGACTACCGCGCCAAGTGGCGGGAGCCGGTCCGGATCAGCTGGCATGACCGTACGGTCTACACCGCGCCGCCGCCCAG
CTCCGGCGGCGTCGCGCTGGCCCAGCTGCTGACCATCAAGCAGGAGCGGGCGTCGGACTTCACCGGCGTGGCGCTGAATT
CCGCCCGCTACATCCATTTGCTCGCGGAAATCGAGAAGCGGGTGTTCGCCGACCGCGCCGACTATCTGGGCGATCCCGAC
TTCGTCAAGACGCCGGTGGCGCAGCTGATCGATCCGGACTACCTGGCGCGGCGCGCGGCCGAGATCAACCCGACGGCCAT
CTCGCCGACGCCGGACATCAAGCCCGGCCTGGATCCGCGCCAGACCACCCACTTCTCCATCGTCGACCAGTGGGGCAACG
CGGTGGCCAATACTTACACCCTGAATTTCGACTTCGGCAGCGGCGTGGTGGTCAAGGGCGCCGGCTTCCTGCTCAACGAC
GAGATGGACGATTTCAGCGCCAAACCCGGCGTGGCCAACGCCTTCGGCGTGGTGGGCAAGGACGCCAACGCCATCGCCCC
GGGCAAGCGCATGCTGTCGTCGATGTCGCCCACCATCGTCACCCGCGACGGCAAGGTGGAGCTGGTGATCGGCACGCCCG
GCGGCTCGCGCATCTTCACCTCCATCTTCCAGGTGCTGAACAATCTGTACGACTACAAGCTGCCGCTGAAGGAGGCGGTG
GCGGCGCAGCGCGTGCATCACCAGCTGCTGCCCAAGGACACCATTTTCTACGACCAGTACGCGCCGCTGGCCGGCCAGGC
CGCCCAGGAATTGAAAGCGATGGGCTACACGCTGAAGGACCAGGGCTGGCGCATGGGCGACATCCAGGCGGTGAGGGTGG
TCGGCGGCAAGACTGAAACCGCGTCCGATCCGCGCGGCCGCGGCGTCGGCATCGTCGTCGAATGA

Upstream 100 bases:

>100_bases
GCATGAAATGTTCCGCAGTCTGAATTTACGTTAAATATGTGGCGCACTTTCTTAATAAATGGCATAAGCATCATGTGTCT
GCTTACAAAGGAGGTGCGTT

Downstream 100 bases:

>100_bases
ACGGTTTTCCCAACCACGATAAAACGAGAAAACATGCAGTACAGAACCGTGTTGAGCGATGCGGCGGAGGCCGACACCCG
GGCGGCCATCGCCGCCCCCC

Product: g-glutamyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 554; Mature: 554

Protein sequence:

>554_residues
MNWVSMSRKALAGGGLLLIALPALAGQGAVAAPDQYGAEVAARILKSGGNAVDAAVATAFALAVTYPEAGNIGGGGFMTI
YQGGKPYFLDYREVAPKAASRDMYLDKDGKVVPDMSLVGARAAGVPGTVMGLWQAHQRFGKLQWKQLLDPAIGYAEQGFT
VAARQYQYRDEAVKLFDGKTNFAQYFGKMKGGETFRQPELAATLKRIARYGAAEFYQGETAKLLVAQMKRDKGLITADDL
NDYRAKWREPVRISWHDRTVYTAPPPSSGGVALAQLLTIKQERASDFTGVALNSARYIHLLAEIEKRVFADRADYLGDPD
FVKTPVAQLIDPDYLARRAAEINPTAISPTPDIKPGLDPRQTTHFSIVDQWGNAVANTYTLNFDFGSGVVVKGAGFLLND
EMDDFSAKPGVANAFGVVGKDANAIAPGKRMLSSMSPTIVTRDGKVELVIGTPGGSRIFTSIFQVLNNLYDYKLPLKEAV
AAQRVHHQLLPKDTIFYDQYAPLAGQAAQELKAMGYTLKDQGWRMGDIQAVRVVGGKTETASDPRGRGVGIVVE

Sequences:

>Translated_554_residues
MNWVSMSRKALAGGGLLLIALPALAGQGAVAAPDQYGAEVAARILKSGGNAVDAAVATAFALAVTYPEAGNIGGGGFMTI
YQGGKPYFLDYREVAPKAASRDMYLDKDGKVVPDMSLVGARAAGVPGTVMGLWQAHQRFGKLQWKQLLDPAIGYAEQGFT
VAARQYQYRDEAVKLFDGKTNFAQYFGKMKGGETFRQPELAATLKRIARYGAAEFYQGETAKLLVAQMKRDKGLITADDL
NDYRAKWREPVRISWHDRTVYTAPPPSSGGVALAQLLTIKQERASDFTGVALNSARYIHLLAEIEKRVFADRADYLGDPD
FVKTPVAQLIDPDYLARRAAEINPTAISPTPDIKPGLDPRQTTHFSIVDQWGNAVANTYTLNFDFGSGVVVKGAGFLLND
EMDDFSAKPGVANAFGVVGKDANAIAPGKRMLSSMSPTIVTRDGKVELVIGTPGGSRIFTSIFQVLNNLYDYKLPLKEAV
AAQRVHHQLLPKDTIFYDQYAPLAGQAAQELKAMGYTLKDQGWRMGDIQAVRVVGGKTETASDPRGRGVGIVVE
>Mature_554_residues
MNWVSMSRKALAGGGLLLIALPALAGQGAVAAPDQYGAEVAARILKSGGNAVDAAVATAFALAVTYPEAGNIGGGGFMTI
YQGGKPYFLDYREVAPKAASRDMYLDKDGKVVPDMSLVGARAAGVPGTVMGLWQAHQRFGKLQWKQLLDPAIGYAEQGFT
VAARQYQYRDEAVKLFDGKTNFAQYFGKMKGGETFRQPELAATLKRIARYGAAEFYQGETAKLLVAQMKRDKGLITADDL
NDYRAKWREPVRISWHDRTVYTAPPPSSGGVALAQLLTIKQERASDFTGVALNSARYIHLLAEIEKRVFADRADYLGDPD
FVKTPVAQLIDPDYLARRAAEINPTAISPTPDIKPGLDPRQTTHFSIVDQWGNAVANTYTLNFDFGSGVVVKGAGFLLND
EMDDFSAKPGVANAFGVVGKDANAIAPGKRMLSSMSPTIVTRDGKVELVIGTPGGSRIFTSIFQVLNNLYDYKLPLKEAV
AAQRVHHQLLPKDTIFYDQYAPLAGQAAQELKAMGYTLKDQGWRMGDIQAVRVVGGKTETASDPRGRGVGIVVE

Specific function: GGT PLAYS A KEY ROLE IN THE GAMMA-GLUTAMYL CYCLE, A PATHWAY FOR THE SYNTHESIS AND DEGRADATION OF GLUTATHIONE. [C]

COG id: COG0405

COG function: function code E; Gamma-glutamyltransferase

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI73915092, Length=543, Percent_Identity=33.7016574585635, Blast_Score=234, Evalue=2e-61,
Organism=Homo sapiens, GI73915090, Length=543, Percent_Identity=33.7016574585635, Blast_Score=234, Evalue=2e-61,
Organism=Homo sapiens, GI73915096, Length=543, Percent_Identity=33.7016574585635, Blast_Score=234, Evalue=2e-61,
Organism=Homo sapiens, GI73915094, Length=543, Percent_Identity=33.7016574585635, Blast_Score=234, Evalue=2e-61,
Organism=Homo sapiens, GI113429324, Length=543, Percent_Identity=31.6758747697974, Blast_Score=204, Evalue=1e-52,
Organism=Homo sapiens, GI113429326, Length=549, Percent_Identity=31.511839708561, Blast_Score=198, Evalue=1e-50,
Organism=Homo sapiens, GI153266885, Length=547, Percent_Identity=26.8738574040219, Blast_Score=151, Evalue=2e-36,
Organism=Homo sapiens, GI153266901, Length=548, Percent_Identity=27.007299270073, Blast_Score=151, Evalue=2e-36,
Organism=Homo sapiens, GI109148539, Length=505, Percent_Identity=29.9009900990099, Blast_Score=139, Evalue=9e-33,
Organism=Homo sapiens, GI153266907, Length=545, Percent_Identity=25.5045871559633, Blast_Score=133, Evalue=5e-31,
Organism=Homo sapiens, GI30581157, Length=223, Percent_Identity=36.322869955157, Blast_Score=106, Evalue=7e-23,
Organism=Homo sapiens, GI30581155, Length=223, Percent_Identity=36.322869955157, Blast_Score=106, Evalue=7e-23,
Organism=Homo sapiens, GI218505805, Length=192, Percent_Identity=36.9791666666667, Blast_Score=89, Evalue=9e-18,
Organism=Homo sapiens, GI310124095, Length=192, Percent_Identity=33.3333333333333, Blast_Score=69, Evalue=9e-12,
Organism=Escherichia coli, GI1789856, Length=535, Percent_Identity=43.7383177570093, Blast_Score=403, Evalue=1e-113,
Organism=Caenorhabditis elegans, GI212646519, Length=544, Percent_Identity=32.7205882352941, Blast_Score=241, Evalue=6e-64,
Organism=Caenorhabditis elegans, GI72000294, Length=544, Percent_Identity=32.7205882352941, Blast_Score=241, Evalue=8e-64,
Organism=Caenorhabditis elegans, GI17542894, Length=502, Percent_Identity=33.6653386454183, Blast_Score=213, Evalue=3e-55,
Organism=Caenorhabditis elegans, GI17506189, Length=535, Percent_Identity=33.2710280373832, Blast_Score=206, Evalue=3e-53,
Organism=Caenorhabditis elegans, GI193208247, Length=502, Percent_Identity=30.6772908366534, Blast_Score=205, Evalue=4e-53,
Organism=Caenorhabditis elegans, GI193208245, Length=502, Percent_Identity=30.6772908366534, Blast_Score=204, Evalue=7e-53,
Organism=Caenorhabditis elegans, GI17564448, Length=429, Percent_Identity=26.8065268065268, Blast_Score=117, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI72001495, Length=228, Percent_Identity=28.5087719298246, Blast_Score=99, Evalue=4e-21,
Organism=Caenorhabditis elegans, GI72001497, Length=228, Percent_Identity=28.5087719298246, Blast_Score=99, Evalue=6e-21,
Organism=Saccharomyces cerevisiae, GI6323330, Length=546, Percent_Identity=31.3186813186813, Blast_Score=183, Evalue=6e-47,
Organism=Drosophila melanogaster, GI18859893, Length=525, Percent_Identity=34.4761904761905, Blast_Score=245, Evalue=7e-65,
Organism=Drosophila melanogaster, GI45551474, Length=522, Percent_Identity=31.8007662835249, Blast_Score=229, Evalue=4e-60,
Organism=Drosophila melanogaster, GI161077880, Length=522, Percent_Identity=31.8007662835249, Blast_Score=229, Evalue=4e-60,
Organism=Drosophila melanogaster, GI161077878, Length=522, Percent_Identity=31.8007662835249, Blast_Score=229, Evalue=5e-60,
Organism=Drosophila melanogaster, GI24642670, Length=522, Percent_Identity=31.8007662835249, Blast_Score=228, Evalue=6e-60,
Organism=Drosophila melanogaster, GI24642666, Length=522, Percent_Identity=31.8007662835249, Blast_Score=228, Evalue=6e-60,
Organism=Drosophila melanogaster, GI161077496, Length=557, Percent_Identity=31.4183123877917, Blast_Score=219, Evalue=4e-57,
Organism=Drosophila melanogaster, GI18859741, Length=491, Percent_Identity=29.7352342158859, Blast_Score=188, Evalue=1e-47,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000101 [H]

Pfam domain/function: PF01019 G_glu_transpept [H]

EC number: =2.3.2.2 [H]

Molecular weight: Translated: 59883; Mature: 59883

Theoretical pI: Translated: 9.41; Mature: 9.41

Prosite motif: PS00462 G_GLU_TRANSPEPTIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNWVSMSRKALAGGGLLLIALPALAGQGAVAAPDQYGAEVAARILKSGGNAVDAAVATAF
CCCHHHCHHHHCCCCEEEEEEHHHCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHH
ALAVTYPEAGNIGGGGFMTIYQGGKPYFLDYREVAPKAASRDMYLDKDGKVVPDMSLVGA
HHEEECCCCCCCCCCCEEEEEECCCCEEEEHHHHCCCCCCCCEEECCCCCCCCCHHHHCC
RAAGVPGTVMGLWQAHQRFGKLQWKQLLDPAIGYAEQGFTVAARQYQYRDEAVKLFDGKT
CCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHCHHHCCCEEHHHHHHHHHHHEEEECCCC
NFAQYFGKMKGGETFRQPELAATLKRIARYGAAEFYQGETAKLLVAQMKRDKGLITADDL
HHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCHHHHCCCHHHHHHHHHHHCCCCEEECCC
NDYRAKWREPVRISWHDRTVYTAPPPSSGGVALAQLLTIKQERASDFTGVALNSARYIHL
HHHHHHCCCCCEEEEECCEEEECCCCCCCCHHHHHHHHHHHHHCCCCCCEEECCHHHHHH
LAEIEKRVFADRADYLGDPDFVKTPVAQLIDPDYLARRAAEINPTAISPTPDIKPGLDPR
HHHHHHHHHHHHHHHCCCCCHHHCCHHHHCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCC
QTTHFSIVDQWGNAVANTYTLNFDFGSGVVVKGAGFLLNDEMDDFSAKPGVANAFGVVGK
CCCEEEHHHHHCCCEEEEEEEEEECCCCEEEECCCEEECCCCCCCCCCCCCCCHHHCCCC
DANAIAPGKRMLSSMSPTIVTRDGKVELVIGTPGGSRIFTSIFQVLNNLYDYKLPLKEAV
CCCCCCCHHHHHHHCCCEEEECCCEEEEEEECCCCHHHHHHHHHHHHHHHHCCCCHHHHH
AAQRVHHQLLPKDTIFYDQYAPLAGQAAQELKAMGYTLKDQGWRMGDIQAVRVVGGKTET
HHHHHHHHHCCCCCEEECCCCCCHHHHHHHHHHHCCEECCCCCEECCEEEEEEECCCCCC
ASDPRGRGVGIVVE
CCCCCCCCEEEEEC
>Mature Secondary Structure
MNWVSMSRKALAGGGLLLIALPALAGQGAVAAPDQYGAEVAARILKSGGNAVDAAVATAF
CCCHHHCHHHHCCCCEEEEEEHHHCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHH
ALAVTYPEAGNIGGGGFMTIYQGGKPYFLDYREVAPKAASRDMYLDKDGKVVPDMSLVGA
HHEEECCCCCCCCCCCEEEEEECCCCEEEEHHHHCCCCCCCCEEECCCCCCCCCHHHHCC
RAAGVPGTVMGLWQAHQRFGKLQWKQLLDPAIGYAEQGFTVAARQYQYRDEAVKLFDGKT
CCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHCHHHCCCEEHHHHHHHHHHHEEEECCCC
NFAQYFGKMKGGETFRQPELAATLKRIARYGAAEFYQGETAKLLVAQMKRDKGLITADDL
HHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCHHHHCCCHHHHHHHHHHHCCCCEEECCC
NDYRAKWREPVRISWHDRTVYTAPPPSSGGVALAQLLTIKQERASDFTGVALNSARYIHL
HHHHHHCCCCCEEEEECCEEEECCCCCCCCHHHHHHHHHHHHHCCCCCCEEECCHHHHHH
LAEIEKRVFADRADYLGDPDFVKTPVAQLIDPDYLARRAAEINPTAISPTPDIKPGLDPR
HHHHHHHHHHHHHHHCCCCCHHHCCHHHHCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCC
QTTHFSIVDQWGNAVANTYTLNFDFGSGVVVKGAGFLLNDEMDDFSAKPGVANAFGVVGK
CCCEEEHHHHHCCCEEEEEEEEEECCCCEEEECCCEEECCCCCCCCCCCCCCCHHHCCCC
DANAIAPGKRMLSSMSPTIVTRDGKVELVIGTPGGSRIFTSIFQVLNNLYDYKLPLKEAV
CCCCCCCHHHHHHHCCCEEEECCCEEEEEEECCCCHHHHHHHHHHHHHHHHCCCCHHHHH
AAQRVHHQLLPKDTIFYDQYAPLAGQAAQELKAMGYTLKDQGWRMGDIQAVRVVGGKTET
HHHHHHHHHCCCCCEEECCCCCCHHHHHHHHHHHCCEECCCCCEECCEEEEEEECCCCCC
ASDPRGRGVGIVVE
CCCCCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]