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The map label for this gene is galM [H]

Identifier: 34496850

GI number: 34496850

Start: 1470116

End: 1471123

Strand: Reverse

Name: galM [H]

Synonym: CV_1395

Alternate gene names: 34496850

Gene position: 1471123-1470116 (Counterclockwise)

Preceding gene: 34496851

Following gene: 34496849

Centisome position: 30.96

GC content: 69.35

Gene sequence:

>1008_bases
CTGAGCAACGGCGTCAGCGCCGCCATCCTGGCCTGGGGTGCCACCTTGCAGTCGCTGCGCAGCCCCGACCGCCACGGCCA
CTTCGACTCGGTGGTGCTGGGCTACACCCGGCTGGACGACTACCGCCAGGCCGGCGGCCGCCTGGGCGCCACCATGGGCC
GCTACGCCAACCGGATAGAAAACGGCCGCTTCCAGCTGGACGGCCGCTGGCACCAGGTGGACCTGAACGAGGGCAGCCAC
GCCATACACGGCGGGCCGGAAGGCTTCGACCGCCGGCTGTGGCAGGTGGCCGCCGTGGCCGATGCGCCCGACCATCCAGA
AGTGCTGTTGCGGCTGGAAAGCCCGGATGGCGACCAGGGCTTCCCCGGGCGGCTGACCCTGACCGTCAGCTACGCGCTGA
AGCCGCCCGGCGACCTGGTGATCAGCTGCGAGGCCAGCTGCGACCGCCCCACCGTGTTCAACACCACCAACCACGCCTAT
TTCAACCTGGCGGGAGAAGGCAGCGGCAGCGCGCTGGACCACAGGCTGGCCATTTTGGCCGACCACTTCCTGCCGGTGAC
GGAAGCGCTGATCCCCACCGGCGAAATCCGCAGCGTGCAGGGTACGGTATTCGATTTCCGCGAACCCAAGCCGCTGGGCC
GGGACATACGGGCCGACGACCCGCAAATCCGGCTGGGACGCGGCTACGACCATTGCTACGCGTTATCGCGCGACGGCGCC
GAGCCCTACCCGCGGCTGGCCGCGCGCGTGGTGGAAGATAGCCGCGGTCGCCTGCTGGACGTGCTCACCACCGAACCCGG
CCTCCAGCTGCACAGCGGCAACGTGCTCACCGGTCGCTACAACGGCGCGTCCGGACGCGCCTACCGGCAATCCGATGGCT
TCTGCCTGGAAGCCCAGCACTTTCCCAACGCGCCCAACGTCCCCCACTTCCCCAGCTCGGTATTGCGGCCAGAGCAGCCT
TACCGCAGCACCACCATCTACCGCTTGGGCATCGCCCCGCCCCGCTGA

Upstream 100 bases:

>100_bases
GCGCCGCGCGCGCGCCCAAACCGGAGAAAACCCCATGATCACCCGTTCCGCATTCGGCACCCTGCCAGGCGGCGAAACCG
TCGAGAAAGTGGAGCTGACG

Downstream 100 bases:

>100_bases
GCGCAAACCGCCGGGCGGCTTGCCCGGCGGCGGCAAGCCGCCTACCATGGGCGCGAAACCCGAACACAACTCTCCGCCAT
GCCCCAAGCCGATTTCACCC

Product: aldose 1-epimerase

Products: NA

Alternate protein names: Galactose mutarotase; Type-1 mutarotase [H]

Number of amino acids: Translated: 335; Mature: 334

Protein sequence:

>335_residues
MSNGVSAAILAWGATLQSLRSPDRHGHFDSVVLGYTRLDDYRQAGGRLGATMGRYANRIENGRFQLDGRWHQVDLNEGSH
AIHGGPEGFDRRLWQVAAVADAPDHPEVLLRLESPDGDQGFPGRLTLTVSYALKPPGDLVISCEASCDRPTVFNTTNHAY
FNLAGEGSGSALDHRLAILADHFLPVTEALIPTGEIRSVQGTVFDFREPKPLGRDIRADDPQIRLGRGYDHCYALSRDGA
EPYPRLAARVVEDSRGRLLDVLTTEPGLQLHSGNVLTGRYNGASGRAYRQSDGFCLEAQHFPNAPNVPHFPSSVLRPEQP
YRSTTIYRLGIAPPR

Sequences:

>Translated_335_residues
MSNGVSAAILAWGATLQSLRSPDRHGHFDSVVLGYTRLDDYRQAGGRLGATMGRYANRIENGRFQLDGRWHQVDLNEGSH
AIHGGPEGFDRRLWQVAAVADAPDHPEVLLRLESPDGDQGFPGRLTLTVSYALKPPGDLVISCEASCDRPTVFNTTNHAY
FNLAGEGSGSALDHRLAILADHFLPVTEALIPTGEIRSVQGTVFDFREPKPLGRDIRADDPQIRLGRGYDHCYALSRDGA
EPYPRLAARVVEDSRGRLLDVLTTEPGLQLHSGNVLTGRYNGASGRAYRQSDGFCLEAQHFPNAPNVPHFPSSVLRPEQP
YRSTTIYRLGIAPPR
>Mature_334_residues
SNGVSAAILAWGATLQSLRSPDRHGHFDSVVLGYTRLDDYRQAGGRLGATMGRYANRIENGRFQLDGRWHQVDLNEGSHA
IHGGPEGFDRRLWQVAAVADAPDHPEVLLRLESPDGDQGFPGRLTLTVSYALKPPGDLVISCEASCDRPTVFNTTNHAYF
NLAGEGSGSALDHRLAILADHFLPVTEALIPTGEIRSVQGTVFDFREPKPLGRDIRADDPQIRLGRGYDHCYALSRDGAE
PYPRLAARVVEDSRGRLLDVLTTEPGLQLHSGNVLTGRYNGASGRAYRQSDGFCLEAQHFPNAPNVPHFPSSVLRPEQPY
RSTTIYRLGIAPPR

Specific function: Mutarotase converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose [H]

COG id: COG2017

COG function: function code G; Galactose mutarotase and related enzymes

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aldose epimerase family [H]

Homologues:

Organism=Homo sapiens, GI20270355, Length=324, Percent_Identity=40.1234567901235, Blast_Score=251, Evalue=5e-67,
Organism=Escherichia coli, GI1786971, Length=328, Percent_Identity=40.8536585365854, Blast_Score=227, Evalue=8e-61,
Organism=Caenorhabditis elegans, GI17557428, Length=326, Percent_Identity=33.1288343558282, Blast_Score=187, Evalue=8e-48,
Organism=Caenorhabditis elegans, GI115533334, Length=326, Percent_Identity=33.1288343558282, Blast_Score=187, Evalue=8e-48,
Organism=Saccharomyces cerevisiae, GI6319493, Length=314, Percent_Identity=26.7515923566879, Blast_Score=104, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6324399, Length=293, Percent_Identity=31.0580204778157, Blast_Score=103, Evalue=4e-23,
Organism=Saccharomyces cerevisiae, GI6322004, Length=346, Percent_Identity=29.1907514450867, Blast_Score=95, Evalue=1e-20,
Organism=Drosophila melanogaster, GI24659048, Length=340, Percent_Identity=37.0588235294118, Blast_Score=213, Evalue=2e-55,
Organism=Drosophila melanogaster, GI24668278, Length=334, Percent_Identity=35.0299401197605, Blast_Score=204, Evalue=5e-53,
Organism=Drosophila melanogaster, GI24583720, Length=335, Percent_Identity=34.3283582089552, Blast_Score=191, Evalue=5e-49,
Organism=Drosophila melanogaster, GI24668282, Length=346, Percent_Identity=37.2832369942197, Blast_Score=191, Evalue=8e-49,
Organism=Drosophila melanogaster, GI24641876, Length=341, Percent_Identity=31.0850439882698, Blast_Score=169, Evalue=2e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018052
- InterPro:   IPR008183
- InterPro:   IPR015443
- InterPro:   IPR011013
- InterPro:   IPR014718 [H]

Pfam domain/function: PF01263 Aldose_epim [H]

EC number: =5.1.3.3 [H]

Molecular weight: Translated: 36753; Mature: 36622

Theoretical pI: Translated: 6.84; Mature: 6.84

Prosite motif: PS00545 ALDOSE_1_EPIMERASE ; PS00213 LIPOCALIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
0.3 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNGVSAAILAWGATLQSLRSPDRHGHFDSVVLGYTRLDDYRQAGGRLGATMGRYANRIE
CCCCCEEEEHHHHHHHHHHCCCCCCCCCCCEEEEHHHHHHHHHCCCCCCHHHHHHHHHHC
NGRFQLDGRWHQVDLNEGSHAIHGGPEGFDRRLWQVAAVADAPDHPEVLLRLESPDGDQG
CCEEEECCEEEEEECCCCCEEECCCCCHHHHHHHEEEECCCCCCCCEEEEEEECCCCCCC
FPGRLTLTVSYALKPPGDLVISCEASCDRPTVFNTTNHAYFNLAGEGSGSALDHRLAILA
CCCEEEEEEEEEECCCCCEEEEECCCCCCCEEECCCCCEEEEEECCCCCCHHHHHHHHHH
DHFLPVTEALIPTGEIRSVQGTVFDFREPKPLGRDIRADDPQIRLGRGYDHCYALSRDGA
HHHHHHHHHHCCCCCCEECCCEEEECCCCCCCCCCCCCCCCCEEECCCCCCEEEECCCCC
EPYPRLAARVVEDSRGRLLDVLTTEPGLQLHSGNVLTGRYNGASGRAYRQSDGFCLEAQH
CCHHHHHHHHHHCCCCCEEEEEECCCCCEEECCCEEEEEECCCCCCEEECCCCCEEECCC
FPNAPNVPHFPSSVLRPEQPYRSTTIYRLGIAPPR
CCCCCCCCCCCHHHCCCCCCCCCEEEEEEECCCCC
>Mature Secondary Structure 
SNGVSAAILAWGATLQSLRSPDRHGHFDSVVLGYTRLDDYRQAGGRLGATMGRYANRIE
CCCCEEEEHHHHHHHHHHCCCCCCCCCCCEEEEHHHHHHHHHCCCCCCHHHHHHHHHHC
NGRFQLDGRWHQVDLNEGSHAIHGGPEGFDRRLWQVAAVADAPDHPEVLLRLESPDGDQG
CCEEEECCEEEEEECCCCCEEECCCCCHHHHHHHEEEECCCCCCCCEEEEEEECCCCCCC
FPGRLTLTVSYALKPPGDLVISCEASCDRPTVFNTTNHAYFNLAGEGSGSALDHRLAILA
CCCEEEEEEEEEECCCCCEEEEECCCCCCCEEECCCCCEEEEEECCCCCCHHHHHHHHHH
DHFLPVTEALIPTGEIRSVQGTVFDFREPKPLGRDIRADDPQIRLGRGYDHCYALSRDGA
HHHHHHHHHHCCCCCCEECCCEEEECCCCCCCCCCCCCCCCCEEECCCCCCEEEECCCCC
EPYPRLAARVVEDSRGRLLDVLTTEPGLQLHSGNVLTGRYNGASGRAYRQSDGFCLEAQH
CCHHHHHHHHHHCCCCCEEEEEECCCCCEEECCCEEEEEECCCCCCEEECCCCCEEECCC
FPNAPNVPHFPSSVLRPEQPYRSTTIYRLGIAPPR
CCCCCCCCCCCHHHCCCCCCCCCEEEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3012466; 3531172 [H]