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The map label for this gene is aaeR [H]

Identifier: 34496846

GI number: 34496846

Start: 1467340

End: 1468227

Strand: Reverse

Name: aaeR [H]

Synonym: CV_1391

Alternate gene names: 34496846

Gene position: 1468227-1467340 (Counterclockwise)

Preceding gene: 34496849

Following gene: 34496845

Centisome position: 30.9

GC content: 69.03

Gene sequence:

>888_bases
ATGATAGACGAACTACGCGCGTTGGCCGTATTCGCCAAGACCACCGAAACCGGCTCTTTCCGCGCCGCCGCCCGCGCGCT
GGGCCTGGCGCCATCGGTGGTCAGCCATCACGTCTCGCAGCTGGAAAGCCGGCTGGGGGTCGCCTTGCTGTACCGCTCCA
CCCGGCGGCTGTCGCTGACGCCGGATGGCCAGGCGCTTTACGGCCACGCCCAGGCGATGCTGCAAGCGGCCGAAACCGGA
CTCAACGAGCTGGCGGGACGCGCGGCCGAGCCCGCCGGCACGCTCAGGCTGAGCCTGCCCGCCTTCTTCGCCCGCGGCCC
GCTCACCACCAGCCTGGCGGCGTTCTCCCGATGCCATCCCAAGGTGGAGCTGGAATTGGATTACAGCGACGAGAAACGCG
ATCTGATCCGGGATGGCATCGACCTGGCCATCCGCATCGGCGAACTGCAGGACAGCGCGCTGAAATCGCGCCGCCTGTTC
GACATGCCGCGCCTGCTGGTGGCCGCGCCCAGCTTGCTGGACGCGCGCGGCGAGCCCGCCTCTCCCGCAGAACTGGCAGA
CTGGCCTTGGCTGGGCATACGGATGCGAGCCAAACGCAAAACCCTGATCGACGCCGCCGGCCGACGCCACGACTTCGCCA
TCCAGCCGCGCATCACCGCCAACAGCGTCGATGCCGCCTGCCAGCTAGCCATCGCGGGCTGTGGCCTGGCCACGCCGCCA
GCGTTCTTGGTGGAAAACGAATTGGCCGCGGGACAGCTGCGCGTCGTCCTCCCCGACTGCCAGGTGGAAGCGCTGGGCGT
CTACGCCGTCTGGCCCGCCAACGCCGCGCGGGAAAGCCTGACGCTGCGCCTGGTCCGTTTCCTGGCCGAGCTCCCGCCAC
ATCAATGA

Upstream 100 bases:

>100_bases
AATGGCTCCTGAACACGAAAAGAACCGGTCCACTATGCGCCGCCGCCAAATGATCCACAATTAAGTACAATTGAAATTCA
ATAATCGAAAAAACCGAACA

Downstream 100 bases:

>100_bases
TATTTATTGCAATGTCATAATTCAGCATTCAATGCCCTGGGAGGCAAACCATGCAGAATCCACGCGACCTCGACGCGGCG
ATCGCCGCCGGCATTCGCGC

Product: transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 295; Mature: 295

Protein sequence:

>295_residues
MIDELRALAVFAKTTETGSFRAAARALGLAPSVVSHHVSQLESRLGVALLYRSTRRLSLTPDGQALYGHAQAMLQAAETG
LNELAGRAAEPAGTLRLSLPAFFARGPLTTSLAAFSRCHPKVELELDYSDEKRDLIRDGIDLAIRIGELQDSALKSRRLF
DMPRLLVAAPSLLDARGEPASPAELADWPWLGIRMRAKRKTLIDAAGRRHDFAIQPRITANSVDAACQLAIAGCGLATPP
AFLVENELAAGQLRVVLPDCQVEALGVYAVWPANAARESLTLRLVRFLAELPPHQ

Sequences:

>Translated_295_residues
MIDELRALAVFAKTTETGSFRAAARALGLAPSVVSHHVSQLESRLGVALLYRSTRRLSLTPDGQALYGHAQAMLQAAETG
LNELAGRAAEPAGTLRLSLPAFFARGPLTTSLAAFSRCHPKVELELDYSDEKRDLIRDGIDLAIRIGELQDSALKSRRLF
DMPRLLVAAPSLLDARGEPASPAELADWPWLGIRMRAKRKTLIDAAGRRHDFAIQPRITANSVDAACQLAIAGCGLATPP
AFLVENELAAGQLRVVLPDCQVEALGVYAVWPANAARESLTLRLVRFLAELPPHQ
>Mature_295_residues
MIDELRALAVFAKTTETGSFRAAARALGLAPSVVSHHVSQLESRLGVALLYRSTRRLSLTPDGQALYGHAQAMLQAAETG
LNELAGRAAEPAGTLRLSLPAFFARGPLTTSLAAFSRCHPKVELELDYSDEKRDLIRDGIDLAIRIGELQDSALKSRRLF
DMPRLLVAAPSLLDARGEPASPAELADWPWLGIRMRAKRKTLIDAAGRRHDFAIQPRITANSVDAACQLAIAGCGLATPP
AFLVENELAAGQLRVVLPDCQVEALGVYAVWPANAARESLTLRLVRFLAELPPHQ

Specific function: Activates transcription of the aaeXAB operon [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789639, Length=271, Percent_Identity=36.5313653136531, Blast_Score=151, Evalue=5e-38,
Organism=Escherichia coli, GI1786401, Length=286, Percent_Identity=31.4685314685315, Blast_Score=129, Evalue=2e-31,
Organism=Escherichia coli, GI87081978, Length=296, Percent_Identity=30.7432432432432, Blast_Score=124, Evalue=9e-30,
Organism=Escherichia coli, GI145693193, Length=300, Percent_Identity=31.6666666666667, Blast_Score=124, Evalue=1e-29,
Organism=Escherichia coli, GI1789440, Length=287, Percent_Identity=28.2229965156794, Blast_Score=110, Evalue=1e-25,
Organism=Escherichia coli, GI1787128, Length=282, Percent_Identity=28.0141843971631, Blast_Score=105, Evalue=5e-24,
Organism=Escherichia coli, GI1787589, Length=275, Percent_Identity=27.2727272727273, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI1789173, Length=266, Percent_Identity=28.9473684210526, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI1789492, Length=279, Percent_Identity=31.1827956989247, Blast_Score=86, Evalue=2e-18,
Organism=Escherichia coli, GI1786448, Length=284, Percent_Identity=28.169014084507, Blast_Score=84, Evalue=8e-18,
Organism=Escherichia coli, GI1788706, Length=283, Percent_Identity=27.5618374558304, Blast_Score=80, Evalue=1e-16,
Organism=Escherichia coli, GI87082132, Length=255, Percent_Identity=26.6666666666667, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI1788481, Length=294, Percent_Identity=25.1700680272109, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1789506, Length=169, Percent_Identity=27.810650887574, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI157672245, Length=230, Percent_Identity=29.5652173913043, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI1787601, Length=199, Percent_Identity=24.1206030150754, Blast_Score=62, Evalue=4e-11,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 31879; Mature: 31879

Theoretical pI: Translated: 8.34; Mature: 8.34

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIDELRALAVFAKTTETGSFRAAARALGLAPSVVSHHVSQLESRLGVALLYRSTRRLSLT
CCCHHHHHHHHEECCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHCCCEEECCCCEEEEC
PDGQALYGHAQAMLQAAETGLNELAGRAAEPAGTLRLSLPAFFARGPLTTSLAAFSRCHP
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECHHHHHCCCCHHHHHHHHHCCC
KVELELDYSDEKRDLIRDGIDLAIRIGELQDSALKSRRLFDMPRLLVAAPSLLDARGEPA
CEEEEECCCCHHHHHHHCCCEEEEEECCHHHHHHHHHHHHCCHHHHHHCCHHHHCCCCCC
SPAELADWPWLGIRMRAKRKTLIDAAGRRHDFAIQPRITANSVDAACQLAIAGCGLATPP
CCCCCCCCCCCCEEEHHHHHHHHHHCCCCCCEEECCCCCCCCHHHHHHHHHHCCCCCCCC
AFLVENELAAGQLRVVLPDCQVEALGVYAVWPANAARESLTLRLVRFLAELPPHQ
HHEEECCCCCCEEEEEECCCCEEEEEEEEECCCCHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MIDELRALAVFAKTTETGSFRAAARALGLAPSVVSHHVSQLESRLGVALLYRSTRRLSLT
CCCHHHHHHHHEECCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHCCCEEECCCCEEEEC
PDGQALYGHAQAMLQAAETGLNELAGRAAEPAGTLRLSLPAFFARGPLTTSLAAFSRCHP
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECHHHHHCCCCHHHHHHHHHCCC
KVELELDYSDEKRDLIRDGIDLAIRIGELQDSALKSRRLFDMPRLLVAAPSLLDARGEPA
CEEEEECCCCHHHHHHHCCCEEEEEECCHHHHHHHHHHHHCCHHHHHHCCHHHHCCCCCC
SPAELADWPWLGIRMRAKRKTLIDAAGRRHDFAIQPRITANSVDAACQLAIAGCGLATPP
CCCCCCCCCCCCEEEHHHHHHHHHHCCCCCCEEECCCCCCCCHHHHHHHHHHCCCCCCCC
AFLVENELAAGQLRVVLPDCQVEALGVYAVWPANAARESLTLRLVRFLAELPPHQ
HHEEECCCCCCEEEEEECCCCEEEEEEEEECCCCHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]