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The map label for this gene is accC [H]

Identifier: 34496440

GI number: 34496440

Start: 1021678

End: 1023033

Strand: Reverse

Name: accC [H]

Synonym: CV_0985

Alternate gene names: 34496440

Gene position: 1023033-1021678 (Counterclockwise)

Preceding gene: 34496441

Following gene: 34496439

Centisome position: 21.53

GC content: 65.04

Gene sequence:

>1356_bases
ATGTTCGAAAAAATTCTGATCGCCAACCGTGGTGAAATCGCGCTGCGCATTCAACGCGCCTGCCGTGAAATGGGCATCAA
GACCGTGGTCGTGCACTCCGAAGCCGACCGCGAAGCCAAATACGTGAAGCTGGCCGACGAATCGGTCTGCATCGGCCCCG
CGCCGTCGGCCAAGAGCTACCTCAACGTGCCGGCGCTGATCGCCGCCGCCGAGGTCACCGACGCCCAGGCCATCCACCCC
GGCTACGGCTTCCTGTCGGAAAACGCCGACTTCGCCGAGCGCGTCGAGCAGTCCGGCTTCGTGTTCATCGGCCCGCGCCC
CGACACCATCCGCATGATGGGCGACAAGGTGTCGGCCAAGCACGCGATGATCGAGGCCGGCGTGCCCTGCGTGCCTGGCT
CCGACGGCGCGCTGCCGGACGACCCGGCCGAAATCGTCAAGATCGCCAAGAAGATCGGCTTCCCGGTCATCATCAAGGCG
GCTGGCGGCGGCGGCGGCCGCGGCATGCGCGTGGTCCACACCGAGGGCGCGCTGATCAACTCGGTGCAGATGACCCGCAC
CGAAGCCGGCGCCGCGTTCGGCAATCCCACCGTGTACATGGAAAAATTCCTGGAGTTGCCGCGCCACATCGAAATCCAGA
TCCTGGCCGACGAATACGGCAACGCCATCTACCTGGGCGAGCGCGACTGCTCGATGCAGCGCCGCCACCAGAAGATCATC
GAGGAGGCGCCGGCGCCCGGCATCACCGACAAGCAACGCCAGAAGATCGGCGAAGCCTGCGCCGAAGCCTGCCGCCGCAT
CGGCTACCGCGGCGCCGGCACCTTCGAATTCCTGTACGAGAACGGCGAGTTCTACTTCATCGAAATGAACACCCGCGTGC
AGGTGGAGCACCCGGTGACCGAAATGATCACCGGCGTGGACATCGTGCAGGAGCAGATCCGCATCGCTGCGGGCGAGAAA
CTGCGCTATAAGCAAAAGGACATCGTGCTCGCCGGCCACGCGATGGAATGCCGCATCAATGCCGAGGACCCGTTCACCTT
CGTGCCGTCCCCGGGCAAGATCGAGAGCTACCACCCGGCCGGCGGCCCCGGCATCCGCATCGATTCGCACATCTACCAGG
GCTACACCGTGCCCTCGCACTACGATTCGATGGTGGGCAAGCTGATCGCCTACGGCGACACCCGCGACCAGGCGATGGCG
CGGATGCGCGTGGCGCTGTCGGAGATGGCGATCTCCGGCATCAAGACCAACATCCCGCTGCACCAGGAGCTGTTCCTGGA
TGCGGCCTTCCAGCGCGGCGGCACCAGCATCCATTACCTGGAGCACCGGCTGCAGCAGAAGAAAGGGGAAGCCTGA

Upstream 100 bases:

>100_bases
TCAGGGCACGGCCAAGGTCTGTGCCCTTGTCGTTTGACGTGACAGCAAGGGCCCCGGCCCGGCCAGGCGCCCTGACCGGA
CCAGCCCGCGGAGAGATTCC

Downstream 100 bases:

>100_bases
TGGCATGGTTGCAAGCCACCATTGACTCCGACTCCGCTGTCGCCGAGCGTCTGGCCGACGCGCTGATGGACGCCGGCGCC
CTGTCCACCGCGATCGAGGA

Product: acetyl-CoA carboxylase biotin carboxylase subunit

Products: NA

Alternate protein names: Acetyl-CoA carboxylase subunit A; ACC [H]

Number of amino acids: Translated: 451; Mature: 451

Protein sequence:

>451_residues
MFEKILIANRGEIALRIQRACREMGIKTVVVHSEADREAKYVKLADESVCIGPAPSAKSYLNVPALIAAAEVTDAQAIHP
GYGFLSENADFAERVEQSGFVFIGPRPDTIRMMGDKVSAKHAMIEAGVPCVPGSDGALPDDPAEIVKIAKKIGFPVIIKA
AGGGGGRGMRVVHTEGALINSVQMTRTEAGAAFGNPTVYMEKFLELPRHIEIQILADEYGNAIYLGERDCSMQRRHQKII
EEAPAPGITDKQRQKIGEACAEACRRIGYRGAGTFEFLYENGEFYFIEMNTRVQVEHPVTEMITGVDIVQEQIRIAAGEK
LRYKQKDIVLAGHAMECRINAEDPFTFVPSPGKIESYHPAGGPGIRIDSHIYQGYTVPSHYDSMVGKLIAYGDTRDQAMA
RMRVALSEMAISGIKTNIPLHQELFLDAAFQRGGTSIHYLEHRLQQKKGEA

Sequences:

>Translated_451_residues
MFEKILIANRGEIALRIQRACREMGIKTVVVHSEADREAKYVKLADESVCIGPAPSAKSYLNVPALIAAAEVTDAQAIHP
GYGFLSENADFAERVEQSGFVFIGPRPDTIRMMGDKVSAKHAMIEAGVPCVPGSDGALPDDPAEIVKIAKKIGFPVIIKA
AGGGGGRGMRVVHTEGALINSVQMTRTEAGAAFGNPTVYMEKFLELPRHIEIQILADEYGNAIYLGERDCSMQRRHQKII
EEAPAPGITDKQRQKIGEACAEACRRIGYRGAGTFEFLYENGEFYFIEMNTRVQVEHPVTEMITGVDIVQEQIRIAAGEK
LRYKQKDIVLAGHAMECRINAEDPFTFVPSPGKIESYHPAGGPGIRIDSHIYQGYTVPSHYDSMVGKLIAYGDTRDQAMA
RMRVALSEMAISGIKTNIPLHQELFLDAAFQRGGTSIHYLEHRLQQKKGEA
>Mature_451_residues
MFEKILIANRGEIALRIQRACREMGIKTVVVHSEADREAKYVKLADESVCIGPAPSAKSYLNVPALIAAAEVTDAQAIHP
GYGFLSENADFAERVEQSGFVFIGPRPDTIRMMGDKVSAKHAMIEAGVPCVPGSDGALPDDPAEIVKIAKKIGFPVIIKA
AGGGGGRGMRVVHTEGALINSVQMTRTEAGAAFGNPTVYMEKFLELPRHIEIQILADEYGNAIYLGERDCSMQRRHQKII
EEAPAPGITDKQRQKIGEACAEACRRIGYRGAGTFEFLYENGEFYFIEMNTRVQVEHPVTEMITGVDIVQEQIRIAAGEK
LRYKQKDIVLAGHAMECRINAEDPFTFVPSPGKIESYHPAGGPGIRIDSHIYQGYTVPSHYDSMVGKLIAYGDTRDQAMA
RMRVALSEMAISGIKTNIPLHQELFLDAAFQRGGTSIHYLEHRLQQKKGEA

Specific function: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA [H]

COG id: COG0439

COG function: function code I; Biotin carboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotin carboxylation domain [H]

Homologues:

Organism=Homo sapiens, GI189095269, Length=443, Percent_Identity=48.7584650112867, Blast_Score=431, Evalue=1e-120,
Organism=Homo sapiens, GI65506442, Length=443, Percent_Identity=48.7584650112867, Blast_Score=430, Evalue=1e-120,
Organism=Homo sapiens, GI295821183, Length=443, Percent_Identity=48.7584650112867, Blast_Score=429, Evalue=1e-120,
Organism=Homo sapiens, GI116805327, Length=446, Percent_Identity=47.9820627802691, Blast_Score=424, Evalue=1e-119,
Organism=Homo sapiens, GI106049528, Length=447, Percent_Identity=45.1901565995526, Blast_Score=371, Evalue=1e-103,
Organism=Homo sapiens, GI106049295, Length=447, Percent_Identity=45.1901565995526, Blast_Score=371, Evalue=1e-103,
Organism=Homo sapiens, GI106049292, Length=447, Percent_Identity=45.1901565995526, Blast_Score=371, Evalue=1e-103,
Organism=Homo sapiens, GI38679960, Length=515, Percent_Identity=31.8446601941748, Blast_Score=248, Evalue=6e-66,
Organism=Homo sapiens, GI38679977, Length=515, Percent_Identity=31.8446601941748, Blast_Score=248, Evalue=6e-66,
Organism=Homo sapiens, GI38679967, Length=515, Percent_Identity=31.8446601941748, Blast_Score=248, Evalue=6e-66,
Organism=Homo sapiens, GI38679974, Length=515, Percent_Identity=31.8446601941748, Blast_Score=248, Evalue=7e-66,
Organism=Homo sapiens, GI38679971, Length=515, Percent_Identity=31.8446601941748, Blast_Score=248, Evalue=7e-66,
Organism=Homo sapiens, GI134142062, Length=517, Percent_Identity=31.7214700193424, Blast_Score=235, Evalue=7e-62,
Organism=Escherichia coli, GI1789654, Length=444, Percent_Identity=70.2702702702703, Blast_Score=626, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17567343, Length=443, Percent_Identity=46.7268623024831, Blast_Score=409, Evalue=1e-114,
Organism=Caenorhabditis elegans, GI71987519, Length=442, Percent_Identity=47.737556561086, Blast_Score=392, Evalue=1e-109,
Organism=Caenorhabditis elegans, GI17562816, Length=440, Percent_Identity=46.3636363636364, Blast_Score=359, Evalue=1e-99,
Organism=Caenorhabditis elegans, GI133931226, Length=497, Percent_Identity=29.3762575452716, Blast_Score=209, Evalue=2e-54,
Organism=Caenorhabditis elegans, GI71997168, Length=511, Percent_Identity=28.9628180039139, Blast_Score=196, Evalue=2e-50,
Organism=Caenorhabditis elegans, GI71997163, Length=511, Percent_Identity=28.9628180039139, Blast_Score=196, Evalue=2e-50,
Organism=Saccharomyces cerevisiae, GI6319685, Length=445, Percent_Identity=40.4494382022472, Blast_Score=350, Evalue=3e-97,
Organism=Saccharomyces cerevisiae, GI6319695, Length=452, Percent_Identity=43.8053097345133, Blast_Score=336, Evalue=5e-93,
Organism=Saccharomyces cerevisiae, GI6321376, Length=452, Percent_Identity=44.0265486725664, Blast_Score=325, Evalue=1e-89,
Organism=Saccharomyces cerevisiae, GI6324343, Length=522, Percent_Identity=31.992337164751, Blast_Score=243, Evalue=6e-65,
Organism=Saccharomyces cerevisiae, GI6323863, Length=474, Percent_Identity=34.3881856540084, Blast_Score=237, Evalue=3e-63,
Organism=Drosophila melanogaster, GI24651757, Length=447, Percent_Identity=45.6375838926174, Blast_Score=402, Evalue=1e-112,
Organism=Drosophila melanogaster, GI24652212, Length=448, Percent_Identity=47.9910714285714, Blast_Score=387, Evalue=1e-107,
Organism=Drosophila melanogaster, GI24652210, Length=448, Percent_Identity=47.9910714285714, Blast_Score=387, Evalue=1e-107,
Organism=Drosophila melanogaster, GI24652214, Length=448, Percent_Identity=47.9910714285714, Blast_Score=387, Evalue=1e-107,
Organism=Drosophila melanogaster, GI19921944, Length=448, Percent_Identity=47.9910714285714, Blast_Score=387, Evalue=1e-107,
Organism=Drosophila melanogaster, GI24652216, Length=448, Percent_Identity=47.9910714285714, Blast_Score=387, Evalue=1e-107,
Organism=Drosophila melanogaster, GI281363050, Length=448, Percent_Identity=47.9910714285714, Blast_Score=387, Evalue=1e-107,
Organism=Drosophila melanogaster, GI24652224, Length=448, Percent_Identity=47.9910714285714, Blast_Score=387, Evalue=1e-107,
Organism=Drosophila melanogaster, GI24652222, Length=448, Percent_Identity=47.9910714285714, Blast_Score=387, Evalue=1e-107,
Organism=Drosophila melanogaster, GI24652220, Length=448, Percent_Identity=47.9910714285714, Blast_Score=387, Evalue=1e-107,
Organism=Drosophila melanogaster, GI24652218, Length=448, Percent_Identity=47.9910714285714, Blast_Score=387, Evalue=1e-107,
Organism=Drosophila melanogaster, GI24651759, Length=410, Percent_Identity=45.1219512195122, Blast_Score=362, Evalue=1e-100,
Organism=Drosophila melanogaster, GI161076409, Length=475, Percent_Identity=32.8421052631579, Blast_Score=230, Evalue=2e-60,
Organism=Drosophila melanogaster, GI24586458, Length=475, Percent_Identity=32.8421052631579, Blast_Score=229, Evalue=2e-60,
Organism=Drosophila melanogaster, GI161076407, Length=475, Percent_Identity=32.8421052631579, Blast_Score=229, Evalue=2e-60,
Organism=Drosophila melanogaster, GI24586460, Length=475, Percent_Identity=32.8421052631579, Blast_Score=229, Evalue=2e-60,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004549
- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR011764
- InterPro:   IPR005482
- InterPro:   IPR005479
- InterPro:   IPR005481
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02785 Biotin_carb_C; PF00289 CPSase_L_chain; PF02786 CPSase_L_D2 [H]

EC number: =6.3.4.14; =6.4.1.2 [H]

Molecular weight: Translated: 49531; Mature: 49531

Theoretical pI: Translated: 6.63; Mature: 6.63

Prosite motif: PS50975 ATP_GRASP ; PS00866 CPSASE_1 ; PS00867 CPSASE_2 ; PS50979 BC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFEKILIANRGEIALRIQRACREMGIKTVVVHSEADREAKYVKLADESVCIGPAPSAKSY
CCCEEEEECCCCEEHHHHHHHHHCCCEEEEEECCCCCCCEEEEECCCCEEECCCCCCHHH
LNVPALIAAAEVTDAQAIHPGYGFLSENADFAERVEQSGFVFIGPRPDTIRMMGDKVSAK
CCCCHHEEEHHCCCCCEECCCCCCCCCCCHHHHHHHHCCEEEECCCCCEEEECCCCHHHH
HAMIEAGVPCVPGSDGALPDDPAEIVKIAKKIGFPVIIKAAGGGGGRGMRVVHTEGALIN
HHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCEEEEEECCCEEE
SVQMTRTEAGAAFGNPTVYMEKFLELPRHIEIQILADEYGNAIYLGERDCSMQRRHQKII
CEEEHHHHCCCCCCCCHHHHHHHHCCCCCEEEEEEEECCCCEEEECCCCHHHHHHHHHHH
EEAPAPGITDKQRQKIGEACAEACRRIGYRGAGTFEFLYENGEFYFIEMNTRVQVEHPVT
HHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCEEEEEECCEEEECCCHH
EMITGVDIVQEQIRIAAGEKLRYKQKDIVLAGHAMECRINAEDPFTFVPSPGKIESYHPA
HHHHHHHHHHHHHHHHCCCCCEECCCCEEEECCEEEEEECCCCCEEECCCCCCCCCCCCC
GGPGIRIDSHIYQGYTVPSHYDSMVGKLIAYGDTRDQAMARMRVALSEMAISGIKTNIPL
CCCCCEECCEEECCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCC
HQELFLDAAFQRGGTSIHYLEHRLQQKKGEA
HHHHHHHHHHHCCCCCHHHHHHHHHHHCCCC
>Mature Secondary Structure
MFEKILIANRGEIALRIQRACREMGIKTVVVHSEADREAKYVKLADESVCIGPAPSAKSY
CCCEEEEECCCCEEHHHHHHHHHCCCEEEEEECCCCCCCEEEEECCCCEEECCCCCCHHH
LNVPALIAAAEVTDAQAIHPGYGFLSENADFAERVEQSGFVFIGPRPDTIRMMGDKVSAK
CCCCHHEEEHHCCCCCEECCCCCCCCCCCHHHHHHHHCCEEEECCCCCEEEECCCCHHHH
HAMIEAGVPCVPGSDGALPDDPAEIVKIAKKIGFPVIIKAAGGGGGRGMRVVHTEGALIN
HHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCEEEEEECCCEEE
SVQMTRTEAGAAFGNPTVYMEKFLELPRHIEIQILADEYGNAIYLGERDCSMQRRHQKII
CEEEHHHHCCCCCCCCHHHHHHHHCCCCCEEEEEEEECCCCEEEECCCCHHHHHHHHHHH
EEAPAPGITDKQRQKIGEACAEACRRIGYRGAGTFEFLYENGEFYFIEMNTRVQVEHPVT
HHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCEEEEEECCEEEECCCHH
EMITGVDIVQEQIRIAAGEKLRYKQKDIVLAGHAMECRINAEDPFTFVPSPGKIESYHPA
HHHHHHHHHHHHHHHHCCCCCEECCCCEEEECCEEEEEECCCCCEEECCCCCCCCCCCCC
GGPGIRIDSHIYQGYTVPSHYDSMVGKLIAYGDTRDQAMARMRVALSEMAISGIKTNIPL
CCCCCEECCEEECCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCC
HQELFLDAAFQRGGTSIHYLEHRLQQKKGEA
HHHHHHHHHHHCCCCCHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9560425 [H]