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The map label for this gene is cobT

Identifier: 34495948

GI number: 34495948

Start: 521304

End: 522338

Strand: Reverse

Name: cobT

Synonym: CV_0493

Alternate gene names: 34495948

Gene position: 522338-521304 (Counterclockwise)

Preceding gene: 34495956

Following gene: 34495947

Centisome position: 10.99

GC content: 73.04

Gene sequence:

>1035_bases
ATGAACAGCAGCAAACCCCTGGATCTTTCCGCCCGCAACGCCGCCCGCGCCCGTCAGGCCGTCCTGACCAAGCCGCCCGG
CAGCCTGGGCCAGCTGGAGGAACTGGCCTGCCGCTTCGCCGCATGGCAGGGCCGCGCCCAGCCGGAAGACCTGCGGCCGG
CGATCACCGTGTTCGCCGCCGATCACGGCGTCACCGTGGAGGGCGTGTCCGCCTTCCCGTCGGCGGTCACCACCGAGATG
GTGCGCAATTTCGCCAATGGCGGCGCCGCCATCTGCGTGCTGGCGCGCGCGCTGGACGCCCGCCTGGAGGTGGTGGACGT
GGGCGTGGCCGGCGACGTGTCGGCGCTGCCCATCGTCCACGCCAAGGTCCGTCCCGGCAGCCACAACCTGGCCAGGCAGG
CGGCGATGAGCGCCGAGGAAACCGAGGCCGCGCTGGAGGCCGGCCGCGCCGCCGCCCGCCGCGCGGTGGAAGCCGGCGCC
AACCTGCTGGTCGCCGGCGACATGGGCATCGGCAACACCACCGCGTCGGCGGCGCTGATCTGCCGACTCACCGGCGCGGC
GCCGGAACTGGTGGTGGGCCGCGGCACCGGCGTCGATGACGCCGGTCTCGCCAACAAGCGCCGCGCGGTGAAAACCGCGC
TGGCCCGCGTGGCCTGGGAAAACCTCAGCGGACTCGACACCCTGTCCGAGCTGGGCGGCCTGGAAATCGCGGCGATCGCC
GGCTTTTACCTGGAAGGCGCCCGCCTGGGCGTGCCGTCGCTGGTGGACGGCTTCATCGCCAGCGCCGCCGCGCTGTGCGC
CAAGACCATCGATCCCTCGCTGCACGACTGGCTGCTGGCCAGCCACCGCTCGGCGGAGTCCGGCCACGAGCTGGCGCTGA
CGGCGCTGCAGCTGCATCCGCTGGTCGACCTGGGCATGCGGCTGGGCGAAGGCTCCGGCGCCGCCGTCTGCGTGCCGCTG
CTGCAGCTGGCGGTCAAGCTGCACAACGGCATGGCCACCTTCGACGAAGCCGGCGTCAGCGGCAAGTCGGCATGA

Upstream 100 bases:

>100_bases
GGCATCGCCCAAGCAGTAATATGCTTAGAGTCCAACCGACGCCCCGCGCCGGACCCACTCAACCGCCGGACCCCGTCCGC
TCCCGCAGCAGGCCCATACC

Downstream 100 bases:

>100_bases
ACCCCTATACCCTCACCCTGCTGCGCCACGGCGACATCGATCACGACGGCCGCCTGATCGGCCTGACCGACCTGCCGCTG
ACCGAGCTCGGACAGCAGCA

Product: nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase

Products: NA

Alternate protein names: NN:DBI PRT; N(1)-alpha-phosphoribosyltransferase

Number of amino acids: Translated: 344; Mature: 344

Protein sequence:

>344_residues
MNSSKPLDLSARNAARARQAVLTKPPGSLGQLEELACRFAAWQGRAQPEDLRPAITVFAADHGVTVEGVSAFPSAVTTEM
VRNFANGGAAICVLARALDARLEVVDVGVAGDVSALPIVHAKVRPGSHNLARQAAMSAEETEAALEAGRAAARRAVEAGA
NLLVAGDMGIGNTTASAALICRLTGAAPELVVGRGTGVDDAGLANKRRAVKTALARVAWENLSGLDTLSELGGLEIAAIA
GFYLEGARLGVPSLVDGFIASAAALCAKTIDPSLHDWLLASHRSAESGHELALTALQLHPLVDLGMRLGEGSGAAVCVPL
LQLAVKLHNGMATFDEAGVSGKSA

Sequences:

>Translated_344_residues
MNSSKPLDLSARNAARARQAVLTKPPGSLGQLEELACRFAAWQGRAQPEDLRPAITVFAADHGVTVEGVSAFPSAVTTEM
VRNFANGGAAICVLARALDARLEVVDVGVAGDVSALPIVHAKVRPGSHNLARQAAMSAEETEAALEAGRAAARRAVEAGA
NLLVAGDMGIGNTTASAALICRLTGAAPELVVGRGTGVDDAGLANKRRAVKTALARVAWENLSGLDTLSELGGLEIAAIA
GFYLEGARLGVPSLVDGFIASAAALCAKTIDPSLHDWLLASHRSAESGHELALTALQLHPLVDLGMRLGEGSGAAVCVPL
LQLAVKLHNGMATFDEAGVSGKSA
>Mature_344_residues
MNSSKPLDLSARNAARARQAVLTKPPGSLGQLEELACRFAAWQGRAQPEDLRPAITVFAADHGVTVEGVSAFPSAVTTEM
VRNFANGGAAICVLARALDARLEVVDVGVAGDVSALPIVHAKVRPGSHNLARQAAMSAEETEAALEAGRAAARRAVEAGA
NLLVAGDMGIGNTTASAALICRLTGAAPELVVGRGTGVDDAGLANKRRAVKTALARVAWENLSGLDTLSELGGLEIAAIA
GFYLEGARLGVPSLVDGFIASAAALCAKTIDPSLHDWLLASHRSAESGHELALTALQLHPLVDLGMRLGEGSGAAVCVPL
LQLAVKLHNGMATFDEAGVSGKSA

Specific function: Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB)

COG id: COG2038

COG function: function code H; NaMN:DMB phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CobT family

Homologues:

Organism=Escherichia coli, GI1788300, Length=335, Percent_Identity=37.6119402985075, Blast_Score=198, Evalue=4e-52,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): COBT_CHRVO (Q7P0S3)

Other databases:

- EMBL:   AE016825
- RefSeq:   NP_900163.1
- ProteinModelPortal:   Q7P0S3
- SMR:   Q7P0S3
- GeneID:   2548148
- GenomeReviews:   AE016825_GR
- KEGG:   cvi:CV_0493
- NMPDR:   fig|243365.1.peg.493
- HOGENOM:   HBG634399
- OMA:   RSGERGH
- PhylomeDB:   Q7P0S3
- ProtClustDB:   CLSK2485280
- BioCyc:   CVIO243365:CV_0493-MONOMER
- BRENDA:   2.4.2.21
- HAMAP:   MF_00230
- InterPro:   IPR003200
- InterPro:   IPR023195
- InterPro:   IPR017846
- Gene3D:   G3DSA:1.10.1610.10
- TIGRFAMs:   TIGR03160

Pfam domain/function: PF02277 DBI_PRT; SSF52733 NN:DBI_PRT

EC number: =2.4.2.21

Molecular weight: Translated: 35104; Mature: 35104

Theoretical pI: Translated: 6.31; Mature: 6.31

Prosite motif: NA

Important sites: ACT_SITE 310-310

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNSSKPLDLSARNAARARQAVLTKPPGSLGQLEELACRFAAWQGRAQPEDLRPAITVFAA
CCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEC
DHGVTVEGVSAFPSAVTTEMVRNFANGGAAICVLARALDARLEVVDVGVAGDVSALPIVH
CCCCEEECHHHCHHHHHHHHHHHHCCCCHHHHHHHHHHHCCEEEEEECCCCCCCCCCEEE
AKVRPGSHNLARQAAMSAEETEAALEAGRAAARRAVEAGANLLVAGDMGIGNTTASAALI
EEECCCCHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHEEE
CRLTGAAPELVVGRGTGVDDAGLANKRRAVKTALARVAWENLSGLDTLSELGGLEIAAIA
EEECCCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCEEEHHH
GFYLEGARLGVPSLVDGFIASAAALCAKTIDPSLHDWLLASHRSAESGHELALTALQLHP
HHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHH
LVDLGMRLGEGSGAAVCVPLLQLAVKLHNGMATFDEAGVSGKSA
HHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCHHHHHCCCCCCCC
>Mature Secondary Structure
MNSSKPLDLSARNAARARQAVLTKPPGSLGQLEELACRFAAWQGRAQPEDLRPAITVFAA
CCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEC
DHGVTVEGVSAFPSAVTTEMVRNFANGGAAICVLARALDARLEVVDVGVAGDVSALPIVH
CCCCEEECHHHCHHHHHHHHHHHHCCCCHHHHHHHHHHHCCEEEEEECCCCCCCCCCEEE
AKVRPGSHNLARQAAMSAEETEAALEAGRAAARRAVEAGANLLVAGDMGIGNTTASAALI
EEECCCCHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHEEE
CRLTGAAPELVVGRGTGVDDAGLANKRRAVKTALARVAWENLSGLDTLSELGGLEIAAIA
EEECCCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCEEEHHH
GFYLEGARLGVPSLVDGFIASAAALCAKTIDPSLHDWLLASHRSAESGHELALTALQLHP
HHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHH
LVDLGMRLGEGSGAAVCVPLLQLAVKLHNGMATFDEAGVSGKSA
HHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 14500782