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The map label for this gene is mraY

Identifier: 33864528

GI number: 33864528

Start: 2394717

End: 2395838

Strand: Direct

Name: mraY

Synonym: PMT2264

Alternate gene names: 33864528

Gene position: 2394717-2395838 (Clockwise)

Preceding gene: 33864527

Following gene: 33864529

Centisome position: 99.33

GC content: 55.08

Gene sequence:

>1122_bases
GTGAGCAACTCTCCGAAGCCATTGGCTGATACGGATACACAAAGCTGGTGGACTAAAGGGTCAACGTCCGCAAGCTTGCT
CGGGATCGTTATCTTTGCTGCAAGCTTCACATCGGACCGCTTCATAGCCAACAGTCTGCTCAGCTTGCCGTTGATGATTT
CAACACTGATTTCAGTGCTGATCGCGAGCTGGGGCATCCCAAAGTTAAGGGCCCTAAAAATGGGGCAAGTGATTCGAGAA
GACGGACCACAGACTCATCAGCGCAAATCTGGCACACCAACCATGGGTGGGCTGCTAGTCGTGCCAGTGGGGCTCATCAT
CGGAAGTTTCGTCAGTGTGAATGGCGAAAGCAGCGAGCAACTACTAGCTCTGTCATGGATCACCCTGGCTTACATGTTGA
TCGGTGGCTTCGACGACTGGCGCAGTCTCACGCGCGGAACCAACACTGGTCTTACCCCTCGGGGAAAACTTCTACTTCAA
ACCGCAGCCAGCCTGATCTTTCTCGCTTGGGCGGGCTGGCAACACTGGATCGACTCCAGCATCGCCCTGCCCCTTGGCAT
CTCCATCCAGATGGGATTCATGATCTGGCCACTAGCACTGTTCGTGTTCCTAGCGGAAAGCAACGCCACCAATCTCACCG
ACGGACTCGATGGGCTAGCCAGTGGCTGCGGGGCGCTTGTCTTCACTGGACTAGCGGTGCAACTGATGCTCAGAGGTAAT
GATGGCAATCCTGTACTTGCAGGCTTCTGCATGGCAATGGCAGGGGCCTGGCTCGGTTTCCTGATGCACAACCGCAACCC
AGCCCAGGTGTTCATGGGCGACACAGGCTCACTAGCAATGGGGGCCGCCTTGAGTGGAGTTGCAATCCTCTCCAACAGCC
TCTGGCCGCTATTGGTCATGGGTGGTGTGTTCTTGGCTGAATCCCTTTCTGTGATTATTCAGGTATGGGTTTTCAAAGCC
ACCAAAGGACCTGACGGAGTTGGACGACGCGTGTTCCGCATGGCCCCGCTTCACCACCACTATGAAATCGGAGGTACCGA
CGAGCAAATGGTGGTGCGAAGATTTTGGTTAAGCACTGGAGGCTTAGTGCTGCTGGGTCTGCTATTACGCCCCACTGCAT
AA

Upstream 100 bases:

>100_bases
GCCGACGACGAGCAAACAGAAGAAAACTGGGAAGAATAGCCATTTTCTCAAACCGAAGAAGCCTGCTCACTTCATTACGC
ACCGCCAATCAAGCCCTGAC

Downstream 100 bases:

>100_bases
GTGCTGGCATGAGTTACTTCTATAAGAAATAAAGATGCACTTTTAAACTCACTTCTTGCAAGCAACTCGTATCAGTTCCA
GAATATCAATACCGAAATGA

Product: phospho-N-acetylmuramoyl-pentapeptide- transferase

Products: NA

Alternate protein names: UDP-MurNAc-pentapeptide phosphotransferase

Number of amino acids: Translated: 373; Mature: 372

Protein sequence:

>373_residues
MSNSPKPLADTDTQSWWTKGSTSASLLGIVIFAASFTSDRFIANSLLSLPLMISTLISVLIASWGIPKLRALKMGQVIRE
DGPQTHQRKSGTPTMGGLLVVPVGLIIGSFVSVNGESSEQLLALSWITLAYMLIGGFDDWRSLTRGTNTGLTPRGKLLLQ
TAASLIFLAWAGWQHWIDSSIALPLGISIQMGFMIWPLALFVFLAESNATNLTDGLDGLASGCGALVFTGLAVQLMLRGN
DGNPVLAGFCMAMAGAWLGFLMHNRNPAQVFMGDTGSLAMGAALSGVAILSNSLWPLLVMGGVFLAESLSVIIQVWVFKA
TKGPDGVGRRVFRMAPLHHHYEIGGTDEQMVVRRFWLSTGGLVLLGLLLRPTA

Sequences:

>Translated_373_residues
MSNSPKPLADTDTQSWWTKGSTSASLLGIVIFAASFTSDRFIANSLLSLPLMISTLISVLIASWGIPKLRALKMGQVIRE
DGPQTHQRKSGTPTMGGLLVVPVGLIIGSFVSVNGESSEQLLALSWITLAYMLIGGFDDWRSLTRGTNTGLTPRGKLLLQ
TAASLIFLAWAGWQHWIDSSIALPLGISIQMGFMIWPLALFVFLAESNATNLTDGLDGLASGCGALVFTGLAVQLMLRGN
DGNPVLAGFCMAMAGAWLGFLMHNRNPAQVFMGDTGSLAMGAALSGVAILSNSLWPLLVMGGVFLAESLSVIIQVWVFKA
TKGPDGVGRRVFRMAPLHHHYEIGGTDEQMVVRRFWLSTGGLVLLGLLLRPTA
>Mature_372_residues
SNSPKPLADTDTQSWWTKGSTSASLLGIVIFAASFTSDRFIANSLLSLPLMISTLISVLIASWGIPKLRALKMGQVIRED
GPQTHQRKSGTPTMGGLLVVPVGLIIGSFVSVNGESSEQLLALSWITLAYMLIGGFDDWRSLTRGTNTGLTPRGKLLLQT
AASLIFLAWAGWQHWIDSSIALPLGISIQMGFMIWPLALFVFLAESNATNLTDGLDGLASGCGALVFTGLAVQLMLRGND
GNPVLAGFCMAMAGAWLGFLMHNRNPAQVFMGDTGSLAMGAALSGVAILSNSLWPLLVMGGVFLAESLSVIIQVWVFKAT
KGPDGVGRRVFRMAPLHHHYEIGGTDEQMVVRRFWLSTGGLVLLGLLLRPTA

Specific function: First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan

COG id: COG0472

COG function: function code M; UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N-acetylglucosamine-1-phosphate transferase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glycosyltransferase 4 family. MraY subfamily

Homologues:

Organism=Escherichia coli, GI1786275, Length=349, Percent_Identity=37.8223495702006, Blast_Score=187, Evalue=8e-49,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MRAY_PROMM (Q7V3S7)

Other databases:

- EMBL:   BX548175
- RefSeq:   NP_896088.1
- STRING:   Q7V3S7
- GeneID:   1728725
- GenomeReviews:   BX548175_GR
- KEGG:   pmt:PMT2264
- NMPDR:   fig|74547.1.peg.2255
- eggNOG:   COG0472
- HOGENOM:   HBG708263
- OMA:   TFWQFRN
- ProtClustDB:   PRK00108
- BioCyc:   PMAR74547:PMT2264-MONOMER
- HAMAP:   MF_00038
- InterPro:   IPR000715
- InterPro:   IPR003524
- InterPro:   IPR018480
- PANTHER:   PTHR22926
- PANTHER:   PTHR22926:SF3
- TIGRFAMs:   TIGR00445

Pfam domain/function: PF00953 Glycos_transf_4; PF10555 MraY_sig1

EC number: =2.7.8.13

Molecular weight: Translated: 39827; Mature: 39696

Theoretical pI: Translated: 9.26; Mature: 9.26

Prosite motif: PS01347 MRAY_1; PS01348 MRAY_2; PS00012 PHOSPHOPANTETHEINE

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0xe8e693c)-; HASH(0xfbdbd44)-; HASH(0x10805f20)-; HASH(0x10803c6c)-; HASH(0x10805e48)-; HASH(0x100020c8)-; HASH(0x10257980)-; HASH(0x10801098)-; HASH(0x107ee180)-; HASH(0x107dc4d4)-; HASH(0xf60a0fc)-;

Cys/Met content:

0.5 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNSPKPLADTDTQSWWTKGSTSASLLGIVIFAASFTSDRFIANSLLSLPLMISTLISVL
CCCCCCCCCCCCCHHHHCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHH
IASWGIPKLRALKMGQVIREDGPQTHQRKSGTPTMGGLLVVPVGLIIGSFVSVNGESSEQ
HHHCCCCHHHHHHHHHHHHHCCCHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCHH
LLALSWITLAYMLIGGFDDWRSLTRGTNTGLTPRGKLLLQTAASLIFLAWAGWQHWIDSS
HHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCC
IALPLGISIQMGFMIWPLALFVFLAESNATNLTDGLDGLASGCGALVFTGLAVQLMLRGN
CCCCCCCEEEHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHEEEEECC
DGNPVLAGFCMAMAGAWLGFLMHNRNPAQVFMGDTGSLAMGAALSGVAILSNSLWPLLVM
CCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCHHHHHHHHHHHHHHCCCHHHHHH
GGVFLAESLSVIIQVWVFKATKGPDGVGRRVFRMAPLHHHYEIGGTDEQMVVRRFWLSTG
HHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCHHCEECCCCHHHHHHHHHHHCCC
GLVLLGLLLRPTA
HHHHHHHHHCCCH
>Mature Secondary Structure 
SNSPKPLADTDTQSWWTKGSTSASLLGIVIFAASFTSDRFIANSLLSLPLMISTLISVL
CCCCCCCCCCCCHHHHCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHH
IASWGIPKLRALKMGQVIREDGPQTHQRKSGTPTMGGLLVVPVGLIIGSFVSVNGESSEQ
HHHCCCCHHHHHHHHHHHHHCCCHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCHH
LLALSWITLAYMLIGGFDDWRSLTRGTNTGLTPRGKLLLQTAASLIFLAWAGWQHWIDSS
HHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCC
IALPLGISIQMGFMIWPLALFVFLAESNATNLTDGLDGLASGCGALVFTGLAVQLMLRGN
CCCCCCCEEEHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHEEEEECC
DGNPVLAGFCMAMAGAWLGFLMHNRNPAQVFMGDTGSLAMGAALSGVAILSNSLWPLLVM
CCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCHHHHHHHHHHHHHHCCCHHHHHH
GGVFLAESLSVIIQVWVFKATKGPDGVGRRVFRMAPLHHHYEIGGTDEQMVVRRFWLSTG
HHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCHHCEECCCCHHHHHHHHHHHCCC
GLVLLGLLLRPTA
HHHHHHHHHCCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 12917642