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The map label for this gene is coaE

Identifier: 33864400

GI number: 33864400

Start: 2246543

End: 2247157

Strand: Direct

Name: coaE

Synonym: PMT2136

Alternate gene names: 33864400

Gene position: 2246543-2247157 (Clockwise)

Preceding gene: 33864397

Following gene: 33864401

Centisome position: 93.18

GC content: 54.31

Gene sequence:

>615_bases
GTGCCACAGGCACGCTGGCATGGGCCGCAACGACGCATCGGTGTTACCGGCGGCATCGCTAGTGGTAAAAGCAGTGTTGG
GCTCTACCTTTCAGAGCAACATGCCCTTCCTCTGCTAGATGCCGATATCTACGCCCGAGACGCTCTAGTCGCTGGTAGTG
CTGCCACAATGGCCGTACTGCAACGATATGGAAACGCTGTAGCTGAAGCAGGTCAACTCAATCCGATAAGCATTGATCGC
ATAGCCCTGGCCAGCATTATTTTTAGTGATGCGCAAGAGCGCCGGTGGTTAGAGCAGCTCATTCATCCCATCGTTGCAAA
GCGCTTTGATGTGGCCTTGGCTGATCTGTCAGCAGAGCCGGTGGTGGTGCTAATGATTCCGCTGTTATTTGAAGCGAAGC
TCAGCGGTCTTTGCAGTGATGTGTGGTTGGTGGACTGCAGCCCAGCCCAGCAATGCCAAAGGCTGATCGCTCGCGATGGC
CTAACGCTGAAACAAGCAGAGCAACGGATCAGCACTCAATGGCCCCTGGAGCAGAAACGGCCTTTAGCGGATTTAGTGAT
CGATAACAGTGGGGCACCTAGAGCATGGCGAGATCAGATCTCATCCATCTGCTAA

Upstream 100 bases:

>100_bases
GATGGGGCGCCAAAGGGAAGCAAGCGCAGAGCTCACGGCCTTAGGAGACAAACTAAACACATCCTCCACCAACGCCATGA
CCACCGAGCCCCCAACTACG

Downstream 100 bases:

>100_bases
CCAAACCACCTATCAAAAAACAAAGTTTTACTTGGCATATCAGTGTGATCAAGCTCACTGCCAAACTTGCATCATGGTCA
CAAGGAACTGGCAAGAATTC

Product: dephospho-CoA kinase

Products: NA

Alternate protein names: Dephosphocoenzyme A kinase

Number of amino acids: Translated: 204; Mature: 203

Protein sequence:

>204_residues
MPQARWHGPQRRIGVTGGIASGKSSVGLYLSEQHALPLLDADIYARDALVAGSAATMAVLQRYGNAVAEAGQLNPISIDR
IALASIIFSDAQERRWLEQLIHPIVAKRFDVALADLSAEPVVVLMIPLLFEAKLSGLCSDVWLVDCSPAQQCQRLIARDG
LTLKQAEQRISTQWPLEQKRPLADLVIDNSGAPRAWRDQISSIC

Sequences:

>Translated_204_residues
MPQARWHGPQRRIGVTGGIASGKSSVGLYLSEQHALPLLDADIYARDALVAGSAATMAVLQRYGNAVAEAGQLNPISIDR
IALASIIFSDAQERRWLEQLIHPIVAKRFDVALADLSAEPVVVLMIPLLFEAKLSGLCSDVWLVDCSPAQQCQRLIARDG
LTLKQAEQRISTQWPLEQKRPLADLVIDNSGAPRAWRDQISSIC
>Mature_203_residues
PQARWHGPQRRIGVTGGIASGKSSVGLYLSEQHALPLLDADIYARDALVAGSAATMAVLQRYGNAVAEAGQLNPISIDRI
ALASIIFSDAQERRWLEQLIHPIVAKRFDVALADLSAEPVVVLMIPLLFEAKLSGLCSDVWLVDCSPAQQCQRLIARDGL
TLKQAEQRISTQWPLEQKRPLADLVIDNSGAPRAWRDQISSIC

Specific function: Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A

COG id: COG0237

COG function: function code H; Dephospho-CoA kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 DPCK (dephospho-CoA kinase) domain

Homologues:

Organism=Homo sapiens, GI191252797, Length=183, Percent_Identity=36.0655737704918, Blast_Score=94, Evalue=1e-19,
Organism=Homo sapiens, GI191252795, Length=183, Percent_Identity=36.0655737704918, Blast_Score=94, Evalue=1e-19,
Organism=Escherichia coli, GI1786292, Length=184, Percent_Identity=35.3260869565217, Blast_Score=103, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI17554944, Length=196, Percent_Identity=28.5714285714286, Blast_Score=98, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI25143409, Length=187, Percent_Identity=31.5508021390374, Blast_Score=77, Evalue=5e-15,
Organism=Saccharomyces cerevisiae, GI6320402, Length=198, Percent_Identity=30.3030303030303, Blast_Score=91, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24644728, Length=183, Percent_Identity=32.2404371584699, Blast_Score=96, Evalue=1e-20,
Organism=Drosophila melanogaster, GI24658602, Length=186, Percent_Identity=30.1075268817204, Blast_Score=76, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): COAE_PROMM (Q7V435)

Other databases:

- EMBL:   BX548175
- RefSeq:   NP_895960.1
- ProteinModelPortal:   Q7V435
- SMR:   Q7V435
- STRING:   Q7V435
- GeneID:   1728186
- GenomeReviews:   BX548175_GR
- KEGG:   pmt:PMT2136
- NMPDR:   fig|74547.1.peg.2127
- eggNOG:   COG0237
- HOGENOM:   HBG650290
- OMA:   IIAREVV
- ProtClustDB:   PRK14730
- BioCyc:   PMAR74547:PMT2136-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00376
- InterPro:   IPR001977
- TIGRFAMs:   TIGR00152

Pfam domain/function: PF01121 CoaE

EC number: =2.7.1.24

Molecular weight: Translated: 22273; Mature: 22142

Theoretical pI: Translated: 6.77; Mature: 6.77

Prosite motif: PS51219 DPCK

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPQARWHGPQRRIGVTGGIASGKSSVGLYLSEQHALPLLDADIYARDALVAGSAATMAVL
CCCCCCCCCCCCEEECCCCCCCCCCCEEEEECCCCCCEECCHHHHHHHHHCCCHHHHHHH
QRYGNAVAEAGQLNPISIDRIALASIIFSDAQERRWLEQLIHPIVAKRFDVALADLSAEP
HHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
VVVLMIPLLFEAKLSGLCSDVWLVDCSPAQQCQRLIARDGLTLKQAEQRISTQWPLEQKR
HHHHHHHHHHHHHHHHHHCCEEEEECCHHHHHHHHHHHCCCCHHHHHHHHHCCCCCHHCC
PLADLVIDNSGAPRAWRDQISSIC
CHHHEEECCCCCCHHHHHHHHHCC
>Mature Secondary Structure 
PQARWHGPQRRIGVTGGIASGKSSVGLYLSEQHALPLLDADIYARDALVAGSAATMAVL
CCCCCCCCCCCEEECCCCCCCCCCCEEEEECCCCCCEECCHHHHHHHHHCCCHHHHHHH
QRYGNAVAEAGQLNPISIDRIALASIIFSDAQERRWLEQLIHPIVAKRFDVALADLSAEP
HHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
VVVLMIPLLFEAKLSGLCSDVWLVDCSPAQQCQRLIARDGLTLKQAEQRISTQWPLEQKR
HHHHHHHHHHHHHHHHHHCCEEEEECCHHHHHHHHHHHCCCCHHHHHHHHHCCCCCHHCC
PLADLVIDNSGAPRAWRDQISSIC
CHHHEEECCCCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12917642