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The map label for this gene is argJ

Identifier: 33864399

GI number: 33864399

Start: 2245237

End: 2246520

Strand: Reverse

Name: argJ

Synonym: PMT2135

Alternate gene names: 33864399

Gene position: 2246520-2245237 (Counterclockwise)

Preceding gene: 33864403

Following gene: 33864398

Centisome position: 93.18

GC content: 53.35

Gene sequence:

>1284_bases
ATGGCGTTGGTGGAGGATGTGTTTAGTTTGTCTCCTAAGGCCGTGAGCTCTGCGCTTGCTTCCCTTTGGCGCCCCATCCA
AGGTGGTGTATCGGCACCTTTGGGTTTTCAGGCTGCAGGGATAACGGCTGGATTGAAGGACTCTGGTAAGCCGGATCTGG
CGTTGCTGCTAGCTCCAGAAGGTGCTGTTTGTGCAGGGATGTTCACCACGTCATTGGTGCGTGCAGCTTGTGTTGATCTT
TGTGTGGATCATTTGCAGGCTTGTGGTGGTAAGGCACGGGCTGTGTTGATTAATTCTGGCCAGGCGAATGCTTGCACCGG
TGAACGCGGTTGGCTCGATAGTCTTCGAGCAAGCCAGGCATTAGCCGGTCGACTTGAGCTACCAGTTGAGCAGGTTTTGA
TTTGTTCAACCGGTGTGATTGGTGTACCTATCCCCATGGATACCTTGCTTGCAGGGTTGGATCCCCTTGTGGAAGCACTC
AGCGATGAGGGTGGTGCTGAGGCGGCCGGCGCAATTCTGACGACCGATTTAGTCGAGAAGCAGTTTGCGCTCGAAGCTGA
ATTAGGTGGTCGTTCTGTTCGCATCGGCGGCATGGCCAAGGGATCTGGGATGATCCATCCTGATATGGCAACGATGCTGG
GCTATTTAAGTTGTGATGTCGGTGTTGAAGTAGACGCATGGCAAGCGATGCTGAAGCGGGTTGTTGATTGCTCCTTTAAT
GCGATGACTGTGGATGGTGATACCAGCACCAATGACTCTTGTCTGGCTTTTGCTGCTGGGGAACTTCTAGAGCAAGAACA
TCTGCAGGCTTTAGAGGCTGGCCTTTTAGTGGCTGCCCAGCAGCTCGCCAAGGCCATCGCTCGTGATGGTGAAGGTGCAA
CCTGTTTACTTGAGGTTCAGGTAGAGGGTGTTGTTGGCGATGTTGAGGCTCGCCGTATTGCACGTACTGTTTGCGGCTCC
TCTTTAGTGAAAACGGCCGTCCATGGTCGTGATCCCAACTGGGGGCGAATCGTTGCAGCTGCAGGGTGTGCTGGTGTGCC
TTTTGATCCTGCAGCAGTAGCCCTTTGGTTGGGCCCTCATCAGTTAATGGAATTCGGCGAACCCTTGCCTTTTGATCGGC
TAGCTGCATCTCGCTATATGCAAGAGCGGGTTGATGGGAGTTATTTATGTGATGACACAGTTCAGATTCGTTTGGTTGTG
GGTGATGGATCGGGCGATGGCATGGCTTGGGGCTGCGACCTCTCAGATCAATACGTGCGCATCAATGCCGATTACACTAC
GTAG

Upstream 100 bases:

>100_bases
AACACTGCTTTTACCACTAGCGATGCCGCCGGTAACACCGATGCGTCGTTGCGGCCCATGCCAGCGTGCCTGTGGCACCG
TAGTTGGGGGCTCGGTGGTC

Downstream 100 bases:

>100_bases
TATAAAAAGCTAGTGCTAGCAGTAGATTGCAGCGATCACTTTCTTCTGTTAGCGCAATGTTAGCACTTGTAAAAGACGTA
GTGCTCATTGGTTCCTTTGC

Product: bifunctional ornithine acetyltransferase/N-acetylglutamate synthase protein

Products: NA

Alternate protein names: Glutamate N-acetyltransferase; Ornithine acetyltransferase; OATase; Ornithine transacetylase; Amino-acid acetyltransferase; N-acetylglutamate synthase; AGS

Number of amino acids: Translated: 427; Mature: 426

Protein sequence:

>427_residues
MALVEDVFSLSPKAVSSALASLWRPIQGGVSAPLGFQAAGITAGLKDSGKPDLALLLAPEGAVCAGMFTTSLVRAACVDL
CVDHLQACGGKARAVLINSGQANACTGERGWLDSLRASQALAGRLELPVEQVLICSTGVIGVPIPMDTLLAGLDPLVEAL
SDEGGAEAAGAILTTDLVEKQFALEAELGGRSVRIGGMAKGSGMIHPDMATMLGYLSCDVGVEVDAWQAMLKRVVDCSFN
AMTVDGDTSTNDSCLAFAAGELLEQEHLQALEAGLLVAAQQLAKAIARDGEGATCLLEVQVEGVVGDVEARRIARTVCGS
SLVKTAVHGRDPNWGRIVAAAGCAGVPFDPAAVALWLGPHQLMEFGEPLPFDRLAASRYMQERVDGSYLCDDTVQIRLVV
GDGSGDGMAWGCDLSDQYVRINADYTT

Sequences:

>Translated_427_residues
MALVEDVFSLSPKAVSSALASLWRPIQGGVSAPLGFQAAGITAGLKDSGKPDLALLLAPEGAVCAGMFTTSLVRAACVDL
CVDHLQACGGKARAVLINSGQANACTGERGWLDSLRASQALAGRLELPVEQVLICSTGVIGVPIPMDTLLAGLDPLVEAL
SDEGGAEAAGAILTTDLVEKQFALEAELGGRSVRIGGMAKGSGMIHPDMATMLGYLSCDVGVEVDAWQAMLKRVVDCSFN
AMTVDGDTSTNDSCLAFAAGELLEQEHLQALEAGLLVAAQQLAKAIARDGEGATCLLEVQVEGVVGDVEARRIARTVCGS
SLVKTAVHGRDPNWGRIVAAAGCAGVPFDPAAVALWLGPHQLMEFGEPLPFDRLAASRYMQERVDGSYLCDDTVQIRLVV
GDGSGDGMAWGCDLSDQYVRINADYTT
>Mature_426_residues
ALVEDVFSLSPKAVSSALASLWRPIQGGVSAPLGFQAAGITAGLKDSGKPDLALLLAPEGAVCAGMFTTSLVRAACVDLC
VDHLQACGGKARAVLINSGQANACTGERGWLDSLRASQALAGRLELPVEQVLICSTGVIGVPIPMDTLLAGLDPLVEALS
DEGGAEAAGAILTTDLVEKQFALEAELGGRSVRIGGMAKGSGMIHPDMATMLGYLSCDVGVEVDAWQAMLKRVVDCSFNA
MTVDGDTSTNDSCLAFAAGELLEQEHLQALEAGLLVAAQQLAKAIARDGEGATCLLEVQVEGVVGDVEARRIARTVCGSS
LVKTAVHGRDPNWGRIVAAAGCAGVPFDPAAVALWLGPHQLMEFGEPLPFDRLAASRYMQERVDGSYLCDDTVQIRLVVG
DGSGDGMAWGCDLSDQYVRINADYTT

Specific function: Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis:the synthesis of acetylglutamate from glutamate and acetyl-CoA, and of ornithine by transacetylation between acetylornithine and glutamate

COG id: COG1364

COG function: function code E; N-acetylglutamate synthase (N-acetylornithine aminotransferase)

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ArgJ family

Homologues:

Organism=Saccharomyces cerevisiae, GI6323707, Length=439, Percent_Identity=33.2574031890661, Blast_Score=191, Evalue=3e-49,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ARGJ_PROMM (Q7V436)

Other databases:

- EMBL:   BX548175
- RefSeq:   NP_895959.1
- ProteinModelPortal:   Q7V436
- SMR:   Q7V436
- STRING:   Q7V436
- MEROPS:   T05.001
- GeneID:   1727636
- GenomeReviews:   BX548175_GR
- KEGG:   pmt:PMT2135
- NMPDR:   fig|74547.1.peg.2126
- eggNOG:   COG1364
- HOGENOM:   HBG284202
- OMA:   QNRFCAA
- ProtClustDB:   PRK05388
- BioCyc:   PMAR74547:PMT2135-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01106
- InterPro:   IPR002813
- InterPro:   IPR016117
- PANTHER:   PTHR23100
- TIGRFAMs:   TIGR00120

Pfam domain/function: PF01960 ArgJ; SSF56266 Pept_S58_DmpA/Arg_biosyn_ArgJ

EC number: =2.3.1.35; =2.3.1.1

Molecular weight: Translated: 44318; Mature: 44187

Theoretical pI: Translated: 4.25; Mature: 4.25

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.3 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
6.1 %Cys+Met (Translated Protein)
3.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALVEDVFSLSPKAVSSALASLWRPIQGGVSAPLGFQAAGITAGLKDSGKPDLALLLAPE
CCHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCEECCCEECCCCCCCCCEEEEECCC
GAVCAGMFTTSLVRAACVDLCVDHLQACGGKARAVLINSGQANACTGERGWLDSLRASQA
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCHHHHHHHHHH
LAGRLELPVEQVLICSTGVIGVPIPMDTLLAGLDPLVEALSDEGGAEAAGAILTTDLVEK
HHCCCCCCHHHHHEECCCCEECCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
QFALEAELGGRSVRIGGMAKGSGMIHPDMATMLGYLSCDVGVEVDAWQAMLKRVVDCSFN
HHHHHHHCCCCEEEECCEECCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCC
AMTVDGDTSTNDSCLAFAAGELLEQEHLQALEAGLLVAAQQLAKAIARDGEGATCLLEVQ
EEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEE
VEGVVGDVEARRIARTVCGSSLVKTAVHGRDPNWGRIVAAAGCAGVPFDPAAVALWLGPH
ECCEECHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCHHHEEEEECHH
QLMEFGEPLPFDRLAASRYMQERVDGSYLCDDTVQIRLVVGDGSGDGMAWGCDLSDQYVR
HHHHCCCCCCHHHHHHHHHHHHHCCCCEEECCCEEEEEEEECCCCCCCEEECCCCCCEEE
INADYTT
EEECCCC
>Mature Secondary Structure 
ALVEDVFSLSPKAVSSALASLWRPIQGGVSAPLGFQAAGITAGLKDSGKPDLALLLAPE
CHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCEECCCEECCCCCCCCCEEEEECCC
GAVCAGMFTTSLVRAACVDLCVDHLQACGGKARAVLINSGQANACTGERGWLDSLRASQA
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCHHHHHHHHHH
LAGRLELPVEQVLICSTGVIGVPIPMDTLLAGLDPLVEALSDEGGAEAAGAILTTDLVEK
HHCCCCCCHHHHHEECCCCEECCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
QFALEAELGGRSVRIGGMAKGSGMIHPDMATMLGYLSCDVGVEVDAWQAMLKRVVDCSFN
HHHHHHHCCCCEEEECCEECCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCC
AMTVDGDTSTNDSCLAFAAGELLEQEHLQALEAGLLVAAQQLAKAIARDGEGATCLLEVQ
EEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEE
VEGVVGDVEARRIARTVCGSSLVKTAVHGRDPNWGRIVAAAGCAGVPFDPAAVALWLGPH
ECCEECHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCHHHEEEEECHH
QLMEFGEPLPFDRLAASRYMQERVDGSYLCDDTVQIRLVVGDGSGDGMAWGCDLSDQYVR
HHHHCCCCCCHHHHHHHHHHHHHCCCCEEECCCEEEEEEEECCCCCCCEEECCCCCCEEE
INADYTT
EEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12917642