Click here to switch to the map view.

The map label for this gene is ndhH [H]

Identifier: 33864314

GI number: 33864314

Start: 2160727

End: 2161911

Strand: Direct

Name: ndhH [H]

Synonym: PMT2049

Alternate gene names: 33864314

Gene position: 2160727-2161911 (Clockwise)

Preceding gene: 33864311

Following gene: 33864315

Centisome position: 89.62

GC content: 54.6

Gene sequence:

>1185_bases
ATGTCGCAGCTGGAAACGCGTACGGAGCCAATGGTCGTCAACTTCGGCCCCCATCATCCCTCGATGCATGGAGTGCTGAG
GCTGGTGGTCACCCTCGACGGTGAAGACGTGGTGGACTGCGAACCGGTGATCGGTTATCTCCATCGGGGCATGGAAAAAA
TTGCCGAAAACCGCACGAGTGTGATGTTCGTGCCCTACGTGAGCCGCATGGACTATGCAGCCGGAATGTTCTACGAGGCA
ATCGTCGTGAACGCTCCGGAGCGCTTGGCCAACATCTCTGTGCCGAAGCGAGCCAGCTACATCCGCGTGCTGATGCTCGA
GCTCAATCGCATTGCCAACCACCTGCTCTGGCTTGGCCCCTTCCTGGCTGATGTGGGTGCCCAAACACCCTTTTTCTATA
TCTTCCGAGAAAGAGAAATGATCTACGACCTGTGGGAAGCAGCCACAGGGCAACGATTGATCAACAACAACTATTTCCGC
ATCGGTGGCGTCGCCTGTGATTTGCCCTGGGGCTGGCTAGAGAAATGCCAAGACTTCTGCGACTGGTTTGGTCCCAAAAT
CGATGAGTACGAAAAACTAATCACCAACAACCCAATCTTCCGTCGCCGCATCGAAGGTTTGGGCGCCATTGGGCGAGATG
AGGCAATCAACTGGAGCCTTTCGGGGCCAATGCTGCGGGCATCAGGAGTGCCATGGGATCTACGCAAAGTGGATCACTAC
GAGTGCTATGACGACTTCGATTGGGATGTCGCCTGGGAGAAAGAAGGCGATTGCTATGCGCGCTATCGCGTTCGGATCGA
AGAAATGCGCCAATCACTGAAGATCCTGCGCCAGGCCTGCGACATGATCCCAGGCGGCCCAACAGAAAACCTCGAAGCTC
AGCGGATGGCGGAGGGTAAGACAAGCCCCTTTATGGGATTTGACTATCAATACGTCGCCAAGAAAGTTGCACCCACCTTC
AAGATCCCTAATGGCGAGCTTTACACCAGGCTTGAGTCAGGCAAGGGAGAAATCGGCGTTTTCCTACAGGGCAACAATGA
CGTCACACCATGGCGTTTCAAAATCCGCGCTGCTGATCTCAATAACCTGCAAATCCTGCCTCATATCCTCAAGGGAGCGA
AAGTCGCAGACATCATGGCGATCCTTGGCTCCATCGACGTGATCATGGGGTCTGTGGATCGCTAA

Upstream 100 bases:

>100_bases
CATTACGGACAGATGCTTGAAACCTGAATCCGAATTAATGGACGAATCGGGCATGGGTTCCTTCCTAAGATCCCGCTAAC
GCTCTGCAACTCAAGGCCCC

Downstream 100 bases:

>100_bases
GGCACAAGGCACTGAACCGTTTTCTGCGACGGCTGCAACGGGCTGGTTATCTCCTGCCGGCAACACTCACTGGCTGCCTA
TGGATCAAGGGTCTGCATCC

Product: NAD(P)H-quinone oxidoreductase subunit H

Products: NAD+; ubiquinol

Alternate protein names: NAD(P)H dehydrogenase subunit H; NADH-plastoquinone oxidoreductase subunit H; NDH-1 subunit H; NDH-H [H]

Number of amino acids: Translated: 394; Mature: 393

Protein sequence:

>394_residues
MSQLETRTEPMVVNFGPHHPSMHGVLRLVVTLDGEDVVDCEPVIGYLHRGMEKIAENRTSVMFVPYVSRMDYAAGMFYEA
IVVNAPERLANISVPKRASYIRVLMLELNRIANHLLWLGPFLADVGAQTPFFYIFREREMIYDLWEAATGQRLINNNYFR
IGGVACDLPWGWLEKCQDFCDWFGPKIDEYEKLITNNPIFRRRIEGLGAIGRDEAINWSLSGPMLRASGVPWDLRKVDHY
ECYDDFDWDVAWEKEGDCYARYRVRIEEMRQSLKILRQACDMIPGGPTENLEAQRMAEGKTSPFMGFDYQYVAKKVAPTF
KIPNGELYTRLESGKGEIGVFLQGNNDVTPWRFKIRAADLNNLQILPHILKGAKVADIMAILGSIDVIMGSVDR

Sequences:

>Translated_394_residues
MSQLETRTEPMVVNFGPHHPSMHGVLRLVVTLDGEDVVDCEPVIGYLHRGMEKIAENRTSVMFVPYVSRMDYAAGMFYEA
IVVNAPERLANISVPKRASYIRVLMLELNRIANHLLWLGPFLADVGAQTPFFYIFREREMIYDLWEAATGQRLINNNYFR
IGGVACDLPWGWLEKCQDFCDWFGPKIDEYEKLITNNPIFRRRIEGLGAIGRDEAINWSLSGPMLRASGVPWDLRKVDHY
ECYDDFDWDVAWEKEGDCYARYRVRIEEMRQSLKILRQACDMIPGGPTENLEAQRMAEGKTSPFMGFDYQYVAKKVAPTF
KIPNGELYTRLESGKGEIGVFLQGNNDVTPWRFKIRAADLNNLQILPHILKGAKVADIMAILGSIDVIMGSVDR
>Mature_393_residues
SQLETRTEPMVVNFGPHHPSMHGVLRLVVTLDGEDVVDCEPVIGYLHRGMEKIAENRTSVMFVPYVSRMDYAAGMFYEAI
VVNAPERLANISVPKRASYIRVLMLELNRIANHLLWLGPFLADVGAQTPFFYIFREREMIYDLWEAATGQRLINNNYFRI
GGVACDLPWGWLEKCQDFCDWFGPKIDEYEKLITNNPIFRRRIEGLGAIGRDEAINWSLSGPMLRASGVPWDLRKVDHYE
CYDDFDWDVAWEKEGDCYARYRVRIEEMRQSLKILRQACDMIPGGPTENLEAQRMAEGKTSPFMGFDYQYVAKKVAPTFK
IPNGELYTRLESGKGEIGVFLQGNNDVTPWRFKIRAADLNNLQILPHILKGAKVADIMAILGSIDVIMGSVDR

Specific function: NDH-1 shuttles electrons from an unknown electron donor, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory and/or the photosynthetic chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone

COG id: COG0649

COG function: function code C; NADH:ubiquinone oxidoreductase 49 kD subunit 7

Gene ontology:

Cell location: Cellular thylakoid membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I 49 kDa subunit family [H]

Homologues:

Organism=Homo sapiens, GI4758786, Length=394, Percent_Identity=41.6243654822335, Blast_Score=296, Evalue=3e-80,
Organism=Homo sapiens, GI260898743, Length=388, Percent_Identity=40.979381443299, Blast_Score=285, Evalue=5e-77,
Organism=Escherichia coli, GI145693162, Length=391, Percent_Identity=39.1304347826087, Blast_Score=293, Evalue=2e-80,
Organism=Escherichia coli, GI1789076, Length=387, Percent_Identity=29.9741602067183, Blast_Score=142, Evalue=4e-35,
Organism=Escherichia coli, GI1788832, Length=393, Percent_Identity=27.9898218829517, Blast_Score=117, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI17568379, Length=403, Percent_Identity=39.7022332506204, Blast_Score=300, Evalue=1e-81,
Organism=Caenorhabditis elegans, GI17555284, Length=397, Percent_Identity=39.5465994962217, Blast_Score=299, Evalue=2e-81,
Organism=Drosophila melanogaster, GI24638644, Length=398, Percent_Identity=40.9547738693467, Blast_Score=315, Evalue=2e-86,
Organism=Drosophila melanogaster, GI221459469, Length=390, Percent_Identity=41.025641025641, Blast_Score=315, Evalue=3e-86,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001135
- InterPro:   IPR014029
- InterPro:   IPR022885 [H]

Pfam domain/function: PF00346 Complex1_49kDa [H]

EC number: 1.6.5.3

Molecular weight: Translated: 45091; Mature: 44960

Theoretical pI: Translated: 5.51; Mature: 5.51

Prosite motif: PS00535 COMPLEX1_49K

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQLETRTEPMVVNFGPHHPSMHGVLRLVVTLDGEDVVDCEPVIGYLHRGMEKIAENRTS
CCCCCCCCCCEEEEECCCCCCHHEEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCE
VMFVPYVSRMDYAAGMFYEAIVVNAPERLANISVPKRASYIRVLMLELNRIANHLLWLGP
EEEEECHHHHHHHHHHHHHHHEECCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
FLADVGAQTPFFYIFREREMIYDLWEAATGQRLINNNYFRIGGVACDLPWGWLEKCQDFC
HHHHHCCCCCEEEEEEHHHHHHHHHHHHCCCHHHCCCCEEECCEEEECCHHHHHHHHHHH
DWFGPKIDEYEKLITNNPIFRRRIEGLGAIGRDEAINWSLSGPMLRASGVPWDLRKVDHY
HHHCCCHHHHHHHHCCCHHHHHHHHHCCCCCCCCCEEEECCCCEEECCCCCCHHHCCCCC
ECYDDFDWDVAWEKEGDCYARYRVRIEEMRQSLKILRQACDMIPGGPTENLEAQRMAEGK
CCCCCCCCCEEECCCCCEEHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHCCC
TSPFMGFDYQYVAKKVAPTFKIPNGELYTRLESGKGEIGVFLQGNNDVTPWRFKIRAADL
CCCCCCCCHHHHHHHHCCCEECCCCCEEEEEECCCCCEEEEEECCCCCCCEEEEEEECCC
NNLQILPHILKGAKVADIMAILGSIDVIMGSVDR
CCCHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
SQLETRTEPMVVNFGPHHPSMHGVLRLVVTLDGEDVVDCEPVIGYLHRGMEKIAENRTS
CCCCCCCCCEEEEECCCCCCHHEEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCE
VMFVPYVSRMDYAAGMFYEAIVVNAPERLANISVPKRASYIRVLMLELNRIANHLLWLGP
EEEEECHHHHHHHHHHHHHHHEECCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
FLADVGAQTPFFYIFREREMIYDLWEAATGQRLINNNYFRIGGVACDLPWGWLEKCQDFC
HHHHHCCCCCEEEEEEHHHHHHHHHHHHCCCHHHCCCCEEECCEEEECCHHHHHHHHHHH
DWFGPKIDEYEKLITNNPIFRRRIEGLGAIGRDEAINWSLSGPMLRASGVPWDLRKVDHY
HHHCCCHHHHHHHHCCCHHHHHHHHHCCCCCCCCCEEEECCCCEEECCCCCCHHHCCCCC
ECYDDFDWDVAWEKEGDCYARYRVRIEEMRQSLKILRQACDMIPGGPTENLEAQRMAEGK
CCCCCCCCCEEECCCCCEEHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHCCC
TSPFMGFDYQYVAKKVAPTFKIPNGELYTRLESGKGEIGVFLQGNNDVTPWRFKIRAADL
CCCCCCCCHHHHHHHHCCCEECCCCCEEEEEECCCCCEEEEEECCCCCCCEEEEEEECCC
NNLQILPHILKGAKVADIMAILGSIDVIMGSVDR
CCCHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NADH; H+; ubiquinone

Specific reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA