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The map label for this gene is purE [H]

Identifier: 33864303

GI number: 33864303

Start: 2151623

End: 2152114

Strand: Reverse

Name: purE [H]

Synonym: PMT2038

Alternate gene names: 33864303

Gene position: 2152114-2151623 (Counterclockwise)

Preceding gene: 33864306

Following gene: 33864302

Centisome position: 89.27

GC content: 57.72

Gene sequence:

>492_bases
ATGGGTAGTGATTCTGATTTGCCAACCCTGCAACCGGCCGTCACCGTCTTAGAGGAGTTCGGTGTGAAGGTGGAGGTGCG
TGTGCTTTCTGCGCACCGTACGCCCCTTGAGATGGTGGCCTTTGCAAAGGAAGCTCATCAGAGAGGTTTGAAGGTGATCG
TGGCAGGTGCCGGCGGTGCTGCTCATTTGCCGGGCATGGTGGCGTCACTCACCACGCTGCCAGTGATTGGAGTACCTGTG
CAGAGCAGGGCTCTTTCCGGGGTGGATTCCTTGCATTCGATTGTGCAGATGCCTGGGGGAATCCCTGTGGCAACAGTGGC
GATTGGTGGAGGGCTTAATGCTGGCTTGCTGGCGGCTCAGATCCTGGCGATCTGTGATCCACAGCTTGCAGAGCGGTTGA
GGGCCTACCGCCAGGATCTTCACGATGCTGTGGTAGCCAAGGATGCTCGCTTGTTGGAGCTTGGCAGTGAGGCTTATTTG
GGGCAGATGTGA

Upstream 100 bases:

>100_bases
GTGCGGGACCATGGCATTGTCGTCATTATTCATCGTGACCTCTGCTTCTCTGCCTGTGCCTTTGGCAGCTGCTGAATCGC
CGCCGCAGGTGGCTGTGGTG

Downstream 100 bases:

>100_bases
AGGTCTTGTTGGAACCTCGCAACTCCACTCAAGCCACAGGTAAGGTCCCGGCTTGATGCTTGTCTATGAGTTTTGATGCT
GCGTAATCCTTTCACCCGCC

Product: phosphoribosylaminoimidazole carboxylase

Products: NA

Alternate protein names: N5-CAIR mutase; 5-(carboxyamino)imidazole ribonucleotide mutase [H]

Number of amino acids: Translated: 163; Mature: 162

Protein sequence:

>163_residues
MGSDSDLPTLQPAVTVLEEFGVKVEVRVLSAHRTPLEMVAFAKEAHQRGLKVIVAGAGGAAHLPGMVASLTTLPVIGVPV
QSRALSGVDSLHSIVQMPGGIPVATVAIGGGLNAGLLAAQILAICDPQLAERLRAYRQDLHDAVVAKDARLLELGSEAYL
GQM

Sequences:

>Translated_163_residues
MGSDSDLPTLQPAVTVLEEFGVKVEVRVLSAHRTPLEMVAFAKEAHQRGLKVIVAGAGGAAHLPGMVASLTTLPVIGVPV
QSRALSGVDSLHSIVQMPGGIPVATVAIGGGLNAGLLAAQILAICDPQLAERLRAYRQDLHDAVVAKDARLLELGSEAYL
GQM
>Mature_162_residues
GSDSDLPTLQPAVTVLEEFGVKVEVRVLSAHRTPLEMVAFAKEAHQRGLKVIVAGAGGAAHLPGMVASLTTLPVIGVPVQ
SRALSGVDSLHSIVQMPGGIPVATVAIGGGLNAGLLAAQILAICDPQLAERLRAYRQDLHDAVVAKDARLLELGSEAYLG
QM

Specific function: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) [H]

COG id: COG0041

COG function: function code F; Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR carboxylase family [H]

Homologues:

Organism=Escherichia coli, GI1786734, Length=147, Percent_Identity=51.7006802721088, Blast_Score=131, Evalue=2e-32,
Organism=Saccharomyces cerevisiae, GI6324702, Length=160, Percent_Identity=55.625, Blast_Score=176, Evalue=2e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000031 [H]

Pfam domain/function: PF00731 AIRC [H]

EC number: =5.4.99.18 [H]

Molecular weight: Translated: 16858; Mature: 16727

Theoretical pI: Translated: 6.34; Mature: 6.34

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGSDSDLPTLQPAVTVLEEFGVKVEVRVLSAHRTPLEMVAFAKEAHQRGLKVIVAGAGGA
CCCCCCCCCHHHHHHHHHHHCCEEEEEEECCCCCHHHHHHHHHHHHHCCCEEEEECCCCC
AHLPGMVASLTTLPVIGVPVQSRALSGVDSLHSIVQMPGGIPVATVAIGGGLNAGLLAAQ
HHHHHHHHHHHHCCEECCCCHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHH
ILAICDPQLAERLRAYRQDLHDAVVAKDARLLELGSEAYLGQM
HHHHCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCHHHCCCC
>Mature Secondary Structure 
GSDSDLPTLQPAVTVLEEFGVKVEVRVLSAHRTPLEMVAFAKEAHQRGLKVIVAGAGGA
CCCCCCCCHHHHHHHHHHHCCEEEEEEECCCCCHHHHHHHHHHHHHCCCEEEEECCCCC
AHLPGMVASLTTLPVIGVPVQSRALSGVDSLHSIVQMPGGIPVATVAIGGGLNAGLLAAQ
HHHHHHHHHHHHCCEECCCCHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHH
ILAICDPQLAERLRAYRQDLHDAVVAKDARLLELGSEAYLGQM
HHHHCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9679194 [H]