Click here to switch to the map view.

The map label for this gene is yitJ [H]

Identifier: 33864278

GI number: 33864278

Start: 2128180

End: 2129073

Strand: Reverse

Name: yitJ [H]

Synonym: PMT2013

Alternate gene names: 33864278

Gene position: 2129073-2128180 (Counterclockwise)

Preceding gene: 33864280

Following gene: 33864272

Centisome position: 88.31

GC content: 53.24

Gene sequence:

>894_bases
TTGAGTTCAGCCTTGCAGCGCTCCATCGAGGCCGGAGCAGTGACGATCACTGCTGAGGTCATGCCTCCTCGTGGTGCAGA
TCCTGTTCATTCCTTGACGATGGCTCAAGGTTTGAAAGGTTTTGTTCATGCCATCAATGTGACTGATGGCAGCCGTGCAG
TGATGCGGATGAGCAGCCTTGCTCTCTGTCGCTTGCTGTTAGATGAGGGGCTTGAACCGATTTTGCAGCTCGCTTGCCGT
GATCGCAATCGGATCGCCCTTCAATCAGATTTACTTGGAGCTCATGCTCTGGGTATTCGCAACTTGCTCTGCCTTACAGG
TGATCCGGTTCGGGTTGGTGATCAACCTGAGGCGAGACCTGTTCATGACTACGAGTCGGTGAAATTGCTGCATCAGGTCT
CTGCCTTCAACCGTGCTGAGGACCCTGTTTCGGGATTACTCCCTGATGGAGCGACTGCTTTTTTTGCTGGGGCCGCTGCT
GATCCCAATTGCCAGAGCTTGAGTGGTTTGCGTCGTCGCCTCGAACGAAAGAAGGAAGCCGGCGCTCGCTTTCTTCAGAC
TCAGATGGTGATGAAACCCGCTGTGCTTGAACACTTTTGCAATGAGGTGGCCAATCCCCTTGGGTTGCCTGTGCTTGCTG
GGGTGTTTTTGCTGAAATCAGCTCGTAATGCAAGCTTCATTAATAGGGTTGTGCCTGGAGCATGCATTCCTGAATCACTT
GTGGTTCGGCTGGAGCAAGCATCTGATCCAATGGCTGAGGGAATCGCTATTGCTGCTGAGCAGGTCAGGAGTTACTTGTC
TCTTACCCAGGGCGTCCATCTGATGGCCGTGAAAGCAGAAGAGCGCATCCCCGAGATTCTTGATCAGGCTGGAATCAGCT
TGGTGCCGGTGTGA

Upstream 100 bases:

>100_bases
CTGTGGCCATTTCCTCCCCATTGATTATCTCCGGTCATCTTACGCAGACTTTGGGCTAGCGATCCCTCATAGTTGGTGAG
TGAGTGAAGGACATCGTGAT

Downstream 100 bases:

>100_bases
GGTCTGTGCCAAGGAGTTCGGCCATGGCCTTCTGCTGAGGAGATGGTTCAACCAGGTCTTGGCGCCTTGCATCGGTGATC
AGCCAATCAAGGGCTGCTTC

Product: methylenetetrahydrofolate reductase

Products: NA

Alternate protein names: Homocysteine S-methyltransferase; S-methylmethionine:homocysteine methyltransferase; 5,10-methylenetetrahydrofolate reductase [H]

Number of amino acids: Translated: 297; Mature: 296

Protein sequence:

>297_residues
MSSALQRSIEAGAVTITAEVMPPRGADPVHSLTMAQGLKGFVHAINVTDGSRAVMRMSSLALCRLLLDEGLEPILQLACR
DRNRIALQSDLLGAHALGIRNLLCLTGDPVRVGDQPEARPVHDYESVKLLHQVSAFNRAEDPVSGLLPDGATAFFAGAAA
DPNCQSLSGLRRRLERKKEAGARFLQTQMVMKPAVLEHFCNEVANPLGLPVLAGVFLLKSARNASFINRVVPGACIPESL
VVRLEQASDPMAEGIAIAAEQVRSYLSLTQGVHLMAVKAEERIPEILDQAGISLVPV

Sequences:

>Translated_297_residues
MSSALQRSIEAGAVTITAEVMPPRGADPVHSLTMAQGLKGFVHAINVTDGSRAVMRMSSLALCRLLLDEGLEPILQLACR
DRNRIALQSDLLGAHALGIRNLLCLTGDPVRVGDQPEARPVHDYESVKLLHQVSAFNRAEDPVSGLLPDGATAFFAGAAA
DPNCQSLSGLRRRLERKKEAGARFLQTQMVMKPAVLEHFCNEVANPLGLPVLAGVFLLKSARNASFINRVVPGACIPESL
VVRLEQASDPMAEGIAIAAEQVRSYLSLTQGVHLMAVKAEERIPEILDQAGISLVPV
>Mature_296_residues
SSALQRSIEAGAVTITAEVMPPRGADPVHSLTMAQGLKGFVHAINVTDGSRAVMRMSSLALCRLLLDEGLEPILQLACRD
RNRIALQSDLLGAHALGIRNLLCLTGDPVRVGDQPEARPVHDYESVKLLHQVSAFNRAEDPVSGLLPDGATAFFAGAAAD
PNCQSLSGLRRRLERKKEAGARFLQTQMVMKPAVLEHFCNEVANPLGLPVLAGVFLLKSARNASFINRVVPGACIPESLV
VRLEQASDPMAEGIAIAAEQVRSYLSLTQGVHLMAVKAEERIPEILDQAGISLVPV

Specific function: Unknown

COG id: COG0685

COG function: function code E; 5,10-methylenetetrahydrofolate reductase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Hcy-binding domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003171
- InterPro:   IPR003726 [H]

Pfam domain/function: PF02219 MTHFR; PF02574 S-methyl_trans [H]

EC number: =2.1.1.10; =1.5.1.20 [H]

Molecular weight: Translated: 31787; Mature: 31656

Theoretical pI: Translated: 6.86; Mature: 6.86

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSALQRSIEAGAVTITAEVMPPRGADPVHSLTMAQGLKGFVHAINVTDGSRAVMRMSSL
CCHHHHHHHHCCEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHEEECCCCHHHHHHHHHH
ALCRLLLDEGLEPILQLACRDRNRIALQSDLLGAHALGIRNLLCLTGDPVRVGDQPEARP
HHHHHHHHHCHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHEECCCCCCCCCCCCCCC
VHDYESVKLLHQVSAFNRAEDPVSGLLPDGATAFFAGAAADPNCQSLSGLRRRLERKKEA
CCHHHHHHHHHHHHHHHCCCCCHHCCCCCCCHHHHCCCCCCCCHHHHHHHHHHHHHHHHH
GARFLQTQMVMKPAVLEHFCNEVANPLGLPVLAGVFLLKSARNASFINRVVPGACIPESL
HHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCHHHHHHHCCCCCCCHHH
VVRLEQASDPMAEGIAIAAEQVRSYLSLTQGVHLMAVKAEERIPEILDQAGISLVPV
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEECHHHHHHHHHHHCCCEECCC
>Mature Secondary Structure 
SSALQRSIEAGAVTITAEVMPPRGADPVHSLTMAQGLKGFVHAINVTDGSRAVMRMSSL
CHHHHHHHHCCEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHEEECCCCHHHHHHHHHH
ALCRLLLDEGLEPILQLACRDRNRIALQSDLLGAHALGIRNLLCLTGDPVRVGDQPEARP
HHHHHHHHHCHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHEECCCCCCCCCCCCCCC
VHDYESVKLLHQVSAFNRAEDPVSGLLPDGATAFFAGAAADPNCQSLSGLRRRLERKKEA
CCHHHHHHHHHHHHHHHCCCCCHHCCCCCCCHHHHCCCCCCCCHHHHHHHHHHHHHHHHH
GARFLQTQMVMKPAVLEHFCNEVANPLGLPVLAGVFLLKSARNASFINRVVPGACIPESL
HHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCHHHHHHHCCCCCCCHHH
VVRLEQASDPMAEGIAIAAEQVRSYLSLTQGVHLMAVKAEERIPEILDQAGISLVPV
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEECHHHHHHHHHHHCCCEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9353932; 9384377 [H]