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The map label for this gene is icd [H]

Identifier: 33864200

GI number: 33864200

Start: 2043745

End: 2045169

Strand: Direct

Name: icd [H]

Synonym: PMT1935

Alternate gene names: 33864200

Gene position: 2043745-2045169 (Clockwise)

Preceding gene: 33864198

Following gene: 33864201

Centisome position: 84.77

GC content: 57.05

Gene sequence:

>1425_bases
ATGGCTCAGTTCGAGAAACTCTCCCCACCAAGCCAGGGCACGGCCATCCGCTTCGTGAACGGTCAGCCAGTCATACCCAA
CGAGCCAATCATTCCCTTCATCCGCGGTGATGGCACAGGTGTGGACATCTGGCCGGCGACCCAACGAGTGCTGGATGCAG
CTGTAACAAAGGCCTATCAAGGCGTGCGTCGTATCGAATGGTTCAAGGTCTATGCAGGCGACGAGGCCTGCGATCTCTAC
GGCACCTACCAGTACCTACCAGAGGACACCCTTGAAGCGATCCGAACCTATGGGGTCGCCATCAAAGGTCCCCTCACGAC
TCCAATTGGTGGGGGCATCCGTTCCCTCAATGTGGCCCTACGTCAAATCTTCGATTTGTATTCCTGCGTCCGCCCATGTC
GCTACTACAAGGGCACACCCAGTCCCCACAAACGGCCTCAGGATCTTGATGTCATCGTCTACCGAGAAAACACGGAAGAT
ATCTACATGGGGGTGGAATGGGAAGCCGATGATCCAGTCGGCAAGACATTGCGCGAACATCTCAACACTGTCGTCATTCC
CGCCAACGGCAAGCTCGGCAAACGCCAGATTCCTGAAGGCTCAGGCATCGGCATCAAGCCGGTAAGCAAGCACGGCAGCC
AGCGTCATATCCGCAAAGCGATTCAACATGCTCTTCGGCTAAAGGGCGACAAGCGCCACGTCACCTTGGTGCACAAAGGC
AACATCATGAAGTTCACTGAAGGAGCCTTCCGTGACTGGGGCTATGAACTCGCCACAAGTGAGTTCCGCGACGTGTGCAT
CACCGAAAGGGAGAGCTGGATTCTCGGCAATCTTGAAAACGATCCACAACTAAGCATCCAAGCCAATGCCCGCATGATCG
AGCCTGGCTACGACAGCCTCACGCCTGAGAGAAAGGCCAGCATCGATGCCGAAGTGCACGGCGTGCTGGATGCCATCGGC
ACCAGTCATGGCAACGGCCAATGGAAAGCGATGGTGCTTGTCGATGACCGCATCGCCGACAGCATCTTCCAACAGATCCA
AACACGGCCGCAGGAATACTCAATCCTGGCAACACTCAACCTCAATGGCGACTACATCTCCGACGCAGCCGCGGCGATGG
TGGGCGGATTAGGCATGGCCCCGGGAGCCAACATCGGCGAGAACGCTGCCATCTTCGAGGCGACCCACGGAACAGCACCC
AAGCATGCCGGCCTTGATCGCATCAACCCTGGATCGGTGATCCTCAGCGGCGTGATGATGCTGGAGTTTCTGGGCTGGCA
AGAAGCCGCAGACTTGATCACAAAAGGGCTCAGTGCTGCGATTGCCAATCAACAGGTCACCTATGACCTGGCTCGCCTCA
TGGACCCACCCGTAGACCCTGTGAGCTGCAGTGGCTTCTCTGAGGCCGTCATCAGCCACTTCTAA

Upstream 100 bases:

>100_bases
AATTTGGCAAGCTCAAGCTAAGTCGCTTAAGTCTGGTCGTCAGGGCCACCACCAAGACATAGGCTCGCCTGAGCACGCGT
CACCGTCGCGAACGTTTCCC

Downstream 100 bases:

>100_bases
GGCTAACGCCCTAAAAATTTCCAGCTGTAATCAATGATTATTAGCCATAGTGAAAGGTTCATTTTTATCGGCAAACGCAA
GACTAGATCGACTGCAATAG

Product: isocitrate dehydrogenase

Products: NA

Alternate protein names: IDH; IDP; NADP(+)-specific ICDH; Oxalosuccinate decarboxylase [H]

Number of amino acids: Translated: 474; Mature: 473

Protein sequence:

>474_residues
MAQFEKLSPPSQGTAIRFVNGQPVIPNEPIIPFIRGDGTGVDIWPATQRVLDAAVTKAYQGVRRIEWFKVYAGDEACDLY
GTYQYLPEDTLEAIRTYGVAIKGPLTTPIGGGIRSLNVALRQIFDLYSCVRPCRYYKGTPSPHKRPQDLDVIVYRENTED
IYMGVEWEADDPVGKTLREHLNTVVIPANGKLGKRQIPEGSGIGIKPVSKHGSQRHIRKAIQHALRLKGDKRHVTLVHKG
NIMKFTEGAFRDWGYELATSEFRDVCITERESWILGNLENDPQLSIQANARMIEPGYDSLTPERKASIDAEVHGVLDAIG
TSHGNGQWKAMVLVDDRIADSIFQQIQTRPQEYSILATLNLNGDYISDAAAAMVGGLGMAPGANIGENAAIFEATHGTAP
KHAGLDRINPGSVILSGVMMLEFLGWQEAADLITKGLSAAIANQQVTYDLARLMDPPVDPVSCSGFSEAVISHF

Sequences:

>Translated_474_residues
MAQFEKLSPPSQGTAIRFVNGQPVIPNEPIIPFIRGDGTGVDIWPATQRVLDAAVTKAYQGVRRIEWFKVYAGDEACDLY
GTYQYLPEDTLEAIRTYGVAIKGPLTTPIGGGIRSLNVALRQIFDLYSCVRPCRYYKGTPSPHKRPQDLDVIVYRENTED
IYMGVEWEADDPVGKTLREHLNTVVIPANGKLGKRQIPEGSGIGIKPVSKHGSQRHIRKAIQHALRLKGDKRHVTLVHKG
NIMKFTEGAFRDWGYELATSEFRDVCITERESWILGNLENDPQLSIQANARMIEPGYDSLTPERKASIDAEVHGVLDAIG
TSHGNGQWKAMVLVDDRIADSIFQQIQTRPQEYSILATLNLNGDYISDAAAAMVGGLGMAPGANIGENAAIFEATHGTAP
KHAGLDRINPGSVILSGVMMLEFLGWQEAADLITKGLSAAIANQQVTYDLARLMDPPVDPVSCSGFSEAVISHF
>Mature_473_residues
AQFEKLSPPSQGTAIRFVNGQPVIPNEPIIPFIRGDGTGVDIWPATQRVLDAAVTKAYQGVRRIEWFKVYAGDEACDLYG
TYQYLPEDTLEAIRTYGVAIKGPLTTPIGGGIRSLNVALRQIFDLYSCVRPCRYYKGTPSPHKRPQDLDVIVYRENTEDI
YMGVEWEADDPVGKTLREHLNTVVIPANGKLGKRQIPEGSGIGIKPVSKHGSQRHIRKAIQHALRLKGDKRHVTLVHKGN
IMKFTEGAFRDWGYELATSEFRDVCITERESWILGNLENDPQLSIQANARMIEPGYDSLTPERKASIDAEVHGVLDAIGT
SHGNGQWKAMVLVDDRIADSIFQQIQTRPQEYSILATLNLNGDYISDAAAAMVGGLGMAPGANIGENAAIFEATHGTAPK
HAGLDRINPGSVILSGVMMLEFLGWQEAADLITKGLSAAIANQQVTYDLARLMDPPVDPVSCSGFSEAVISHF

Specific function: Unknown

COG id: COG0538

COG function: function code C; Isocitrate dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the isocitrate and isopropylmalate dehydrogenases family [H]

Homologues:

Organism=Homo sapiens, GI5031777, Length=254, Percent_Identity=29.1338582677165, Blast_Score=91, Evalue=3e-18,
Organism=Homo sapiens, GI28178838, Length=133, Percent_Identity=32.3308270676692, Blast_Score=76, Evalue=5e-14,
Organism=Homo sapiens, GI4758582, Length=116, Percent_Identity=31.8965517241379, Blast_Score=71, Evalue=2e-12,
Organism=Escherichia coli, GI1787381, Length=473, Percent_Identity=48.8372093023256, Blast_Score=442, Evalue=1e-125,
Organism=Escherichia coli, GI1788101, Length=124, Percent_Identity=32.258064516129, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI87081683, Length=115, Percent_Identity=33.9130434782609, Blast_Score=62, Evalue=1e-10,
Organism=Caenorhabditis elegans, GI71986051, Length=104, Percent_Identity=44.2307692307692, Blast_Score=96, Evalue=4e-20,
Organism=Caenorhabditis elegans, GI25144293, Length=152, Percent_Identity=32.8947368421053, Blast_Score=85, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17505779, Length=110, Percent_Identity=35.4545454545455, Blast_Score=74, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6324709, Length=241, Percent_Identity=30.7053941908714, Blast_Score=100, Evalue=6e-22,
Organism=Saccharomyces cerevisiae, GI6322097, Length=153, Percent_Identity=35.2941176470588, Blast_Score=90, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6324291, Length=158, Percent_Identity=31.6455696202532, Blast_Score=69, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24643270, Length=252, Percent_Identity=31.3492063492063, Blast_Score=109, Evalue=4e-24,
Organism=Drosophila melanogaster, GI24643268, Length=253, Percent_Identity=31.2252964426877, Blast_Score=108, Evalue=6e-24,
Organism=Drosophila melanogaster, GI24661184, Length=147, Percent_Identity=37.4149659863946, Blast_Score=103, Evalue=2e-22,

Paralogues:

None

Copy number: 8180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR019818
- InterPro:   IPR001804
- InterPro:   IPR004439 [H]

Pfam domain/function: PF00180 Iso_dh [H]

EC number: =1.1.1.42 [H]

Molecular weight: Translated: 51962; Mature: 51830

Theoretical pI: Translated: 6.10; Mature: 6.10

Prosite motif: PS00470 IDH_IMDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAQFEKLSPPSQGTAIRFVNGQPVIPNEPIIPFIRGDGTGVDIWPATQRVLDAAVTKAYQ
CCCCCCCCCCCCCCEEEEECCCCCCCCCCEEEEEECCCCCEEECHHHHHHHHHHHHHHHH
GVRRIEWFKVYAGDEACDLYGTYQYLPEDTLEAIRTYGVAIKGPLTTPIGGGIRSLNVAL
HHHHEEEEEEEECCCCEECCCHHHCCCHHHHHHHHHHCEEEECCCCCCCCCCHHHHHHHH
RQIFDLYSCVRPCRYYKGTPSPHKRPQDLDVIVYRENTEDIYMGVEWEADDPVGKTLREH
HHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEECCCCEEEEEEEECCCCCHHHHHHHH
LNTVVIPANGKLGKRQIPEGSGIGIKPVSKHGSQRHIRKAIQHALRLKGDKRHVTLVHKG
CCEEEEECCCCCCCCCCCCCCCCCCCCHHCCCCHHHHHHHHHHHHHCCCCCEEEEEEECC
NIMKFTEGAFRDWGYELATSEFRDVCITERESWILGNLENDPQLSIQANARMIEPGYDSL
CEEEECCCHHHHCCHHHHHHHHHHHHHCCCCCEEECCCCCCCCEEEEECCEEECCCCCCC
TPERKASIDAEVHGVLDAIGTSHGNGQWKAMVLVDDRIADSIFQQIQTRPQEYSILATLN
CCCHHCCCCHHHHHHHHHHCCCCCCCCEEEEEEECHHHHHHHHHHHHCCCCCEEEEEEEE
LNGDYISDAAAAMVGGLGMAPGANIGENAAIFEATHGTAPKHAGLDRINPGSVILSGVMM
CCCCHHHHHHHHHHCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCHHHHHHHHHH
LEFLGWQEAADLITKGLSAAIANQQVTYDLARLMDPPVDPVSCSGFSEAVISHF
HHHHCHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCCCCHHHHHHHCC
>Mature Secondary Structure 
AQFEKLSPPSQGTAIRFVNGQPVIPNEPIIPFIRGDGTGVDIWPATQRVLDAAVTKAYQ
CCCCCCCCCCCCCEEEEECCCCCCCCCCEEEEEECCCCCEEECHHHHHHHHHHHHHHHH
GVRRIEWFKVYAGDEACDLYGTYQYLPEDTLEAIRTYGVAIKGPLTTPIGGGIRSLNVAL
HHHHEEEEEEEECCCCEECCCHHHCCCHHHHHHHHHHCEEEECCCCCCCCCCHHHHHHHH
RQIFDLYSCVRPCRYYKGTPSPHKRPQDLDVIVYRENTEDIYMGVEWEADDPVGKTLREH
HHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEECCCCEEEEEEEECCCCCHHHHHHHH
LNTVVIPANGKLGKRQIPEGSGIGIKPVSKHGSQRHIRKAIQHALRLKGDKRHVTLVHKG
CCEEEEECCCCCCCCCCCCCCCCCCCCHHCCCCHHHHHHHHHHHHHCCCCCEEEEEEECC
NIMKFTEGAFRDWGYELATSEFRDVCITERESWILGNLENDPQLSIQANARMIEPGYDSL
CEEEECCCHHHHCCHHHHHHHHHHHHHCCCCCEEECCCCCCCCEEEEECCEEECCCCCCC
TPERKASIDAEVHGVLDAIGTSHGNGQWKAMVLVDDRIADSIFQQIQTRPQEYSILATLN
CCCHHCCCCHHHHHHHHHHCCCCCCCCEEEEEEECHHHHHHHHHHHHCCCCCEEEEEEEE
LNGDYISDAAAAMVGGLGMAPGANIGENAAIFEATHGTAPKHAGLDRINPGSVILSGVMM
CCCCHHHHHHHHHHCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCHHHHHHHHHH
LEFLGWQEAADLITKGLSAAIANQQVTYDLARLMDPPVDPVSCSGFSEAVISHF
HHHHCHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCCCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8169222; 11759840 [H]