| Definition | Prochlorococcus marinus str. MIT 9313 chromosome, complete genome. |
|---|---|
| Accession | NC_005071 |
| Length | 2,410,873 |
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The map label for this gene is purH [H]
Identifier: 33864124
GI number: 33864124
Start: 1964499
End: 1966052
Strand: Reverse
Name: purH [H]
Synonym: PMT1857
Alternate gene names: 33864124
Gene position: 1966052-1964499 (Counterclockwise)
Preceding gene: 33864126
Following gene: 33864118
Centisome position: 81.55
GC content: 56.76
Gene sequence:
>1554_bases ATGGCTCCCATCGCCTTGTTGAGCGTTTCAAACAAACATGGGATTGTGCCTCTAGCGGAATCCTTGCATCGCATGCATGG GTTTCAGCTGCTTTCCAGCGGTGGCACAGCCAAAGTGCTGGAGGATGCCGGTCTGCCCGTGACGCGGGTTGCTGAGCACA CAGGTGCAGCGGAAATTCTTGGAGGAAGGGTGAAGACTCTGCATCCTCGTGTCCATGGAGGCATCTTGGCGATGCGGGGC GACCCTGATCATGAGGTCGATCTGGAGCAGCATCAGATCCCTCCCATTGATGTGGTGGTGGTGAATCTTTACCCGTTTCG GGAAACAGTGGCCAATCCGCAGGTGAGTTGGGAAACTGCAATTGAGAATATTGATATCGGTGGCCCCGCCATGGTGCGAG CGGCGGCAAAGAACCATGCGCATGTGGCTGTGCTCACGAGGCCGGATCAGTACGACAGATTCCTAGTGGCTTTAAGTGAT GGTGTGGATGACCAGCTCCGTCGTGAGCTTGCCCTTGAAGCCTTTGAGCACACCGCTGCCTATGACGTGGCCATCAGCCA TTGGATGGGCGAGCGGCTGACTGAGCAAGCTTCCCAATGGCTTGAGGCTATTCCCCTTAGGCAGAGGCTGCGCTATGGCG AGAATCCCCATCAGCATGCGGCTTGGTACAGCGCTCCGCAGCAGGGTTGGGGAGGTGCCATTCAGTTGCAGGGCAAGGAG CTCAGTACCAACAATTTGCTTGATTTGGAAGCTGCCCTGGCCACTGTTCGGGAGTTTGGATATGGCACGGAAGGCGCTCA ACAAGCTGTTCAAGATGCTGCCGTGGTGGTTAAGCACACCAACCCTTGTGGCGTCGCGATTGGCACTGGCGTGGCGTCGG CCTTAAGCCGTGCCTTGGATGCGGATCGGGTGAGTGCATTTGGAGGGATCGTGGCTCTGAATGGATTGGTGGATGCCACG ACTGCTCGGGAGCTCACCAGTTTGTTCTTGGAGTGTGTTGTGGCACCAGGCTTTGAACCAGAAGCTCGGGAAATCCTTGC CACCAAGGCCAACTTACGTTTGTTGGAACTGGCACCAGGTGCCATTGATGCGGCTGGTCGTGATCACATTCGCACCATCC TCGGCGGGGTGTTGGTGCAGGACCAAGACGATCAATCGATTGATCCCACCAGTTGGACTGTGGCCAGCAAACGCTCGCCT AATGCTGAAGAAAACGCGGATCTCACCTTTGCATGGCGCCTGGTGAGACATGTGCGCTCTAACGCCATCGTGGTGGCTCG TGCTGGCCAGAGTCTCGGAGTTGGAGCGGGCCAGATGAACCGAGTCGGCTCGGCGCGACTAGCCCTTGAGGCAGCTGGCG ATCAAGCCAGGGGAGCTGTTTTGGCTAGTGATGGCTTCTTCCCCTTTGATGACACGGTGCGTTTGGCGGCTAACCATGGC ATCTGTGCCGTAATCCAGCCTGGTGGGAGCAAGCGTGATGCAGATTCAATCGCTGTTTGCGATGATTTTGGTCTGGCAAT GGTGTTGACGGGAAAGCGCCACTTCTTGCATTAA
Upstream 100 bases:
>100_bases AAGCACCTTTGGGAATGTCGCGGAGAAGGTTGTCGCTCACGGCAGGTGTTGTATCGCTGCTGCGTAGGTTGGCCCACGGA ATGCTTTCGTCTCTGCTGCC
Downstream 100 bases:
>100_bases GTTAGTAATAATCAAAGTTAATATCGAGCCAATTTGTTTGCCTATATTTTGACTTTGTTGATTTCCTTGATGAGTTTCAT TCTGACTGAATTTGCTTTGG
Product: bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase
Products: NA
Alternate protein names: Phosphoribosylaminoimidazolecarboxamide formyltransferase; AICAR transformylase; IMP cyclohydrolase; ATIC; IMP synthase; Inosinicase [H]
Number of amino acids: Translated: 517; Mature: 516
Protein sequence:
>517_residues MAPIALLSVSNKHGIVPLAESLHRMHGFQLLSSGGTAKVLEDAGLPVTRVAEHTGAAEILGGRVKTLHPRVHGGILAMRG DPDHEVDLEQHQIPPIDVVVVNLYPFRETVANPQVSWETAIENIDIGGPAMVRAAAKNHAHVAVLTRPDQYDRFLVALSD GVDDQLRRELALEAFEHTAAYDVAISHWMGERLTEQASQWLEAIPLRQRLRYGENPHQHAAWYSAPQQGWGGAIQLQGKE LSTNNLLDLEAALATVREFGYGTEGAQQAVQDAAVVVKHTNPCGVAIGTGVASALSRALDADRVSAFGGIVALNGLVDAT TARELTSLFLECVVAPGFEPEAREILATKANLRLLELAPGAIDAAGRDHIRTILGGVLVQDQDDQSIDPTSWTVASKRSP NAEENADLTFAWRLVRHVRSNAIVVARAGQSLGVGAGQMNRVGSARLALEAAGDQARGAVLASDGFFPFDDTVRLAANHG ICAVIQPGGSKRDADSIAVCDDFGLAMVLTGKRHFLH
Sequences:
>Translated_517_residues MAPIALLSVSNKHGIVPLAESLHRMHGFQLLSSGGTAKVLEDAGLPVTRVAEHTGAAEILGGRVKTLHPRVHGGILAMRG DPDHEVDLEQHQIPPIDVVVVNLYPFRETVANPQVSWETAIENIDIGGPAMVRAAAKNHAHVAVLTRPDQYDRFLVALSD GVDDQLRRELALEAFEHTAAYDVAISHWMGERLTEQASQWLEAIPLRQRLRYGENPHQHAAWYSAPQQGWGGAIQLQGKE LSTNNLLDLEAALATVREFGYGTEGAQQAVQDAAVVVKHTNPCGVAIGTGVASALSRALDADRVSAFGGIVALNGLVDAT TARELTSLFLECVVAPGFEPEAREILATKANLRLLELAPGAIDAAGRDHIRTILGGVLVQDQDDQSIDPTSWTVASKRSP NAEENADLTFAWRLVRHVRSNAIVVARAGQSLGVGAGQMNRVGSARLALEAAGDQARGAVLASDGFFPFDDTVRLAANHG ICAVIQPGGSKRDADSIAVCDDFGLAMVLTGKRHFLH >Mature_516_residues APIALLSVSNKHGIVPLAESLHRMHGFQLLSSGGTAKVLEDAGLPVTRVAEHTGAAEILGGRVKTLHPRVHGGILAMRGD PDHEVDLEQHQIPPIDVVVVNLYPFRETVANPQVSWETAIENIDIGGPAMVRAAAKNHAHVAVLTRPDQYDRFLVALSDG VDDQLRRELALEAFEHTAAYDVAISHWMGERLTEQASQWLEAIPLRQRLRYGENPHQHAAWYSAPQQGWGGAIQLQGKEL STNNLLDLEAALATVREFGYGTEGAQQAVQDAAVVVKHTNPCGVAIGTGVASALSRALDADRVSAFGGIVALNGLVDATT ARELTSLFLECVVAPGFEPEAREILATKANLRLLELAPGAIDAAGRDHIRTILGGVLVQDQDDQSIDPTSWTVASKRSPN AEENADLTFAWRLVRHVRSNAIVVARAGQSLGVGAGQMNRVGSARLALEAAGDQARGAVLASDGFFPFDDTVRLAANHGI CAVIQPGGSKRDADSIAVCDDFGLAMVLTGKRHFLH
Specific function: De novo purine biosynthesis; ninth step. De novo purine biosynthesis; tenth step. [C]
COG id: COG0138
COG function: function code F; AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful)
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the purH family [H]
Homologues:
Organism=Homo sapiens, GI20127454, Length=485, Percent_Identity=38.5567010309278, Blast_Score=265, Evalue=9e-71, Organism=Escherichia coli, GI1790439, Length=534, Percent_Identity=45.6928838951311, Blast_Score=430, Evalue=1e-121, Organism=Caenorhabditis elegans, GI71985564, Length=482, Percent_Identity=37.551867219917, Blast_Score=251, Evalue=6e-67, Organism=Caenorhabditis elegans, GI71985574, Length=327, Percent_Identity=29.6636085626911, Blast_Score=99, Evalue=5e-21, Organism=Saccharomyces cerevisiae, GI6323768, Length=481, Percent_Identity=39.0852390852391, Blast_Score=276, Evalue=6e-75, Organism=Saccharomyces cerevisiae, GI6323056, Length=475, Percent_Identity=38.7368421052632, Blast_Score=273, Evalue=4e-74, Organism=Drosophila melanogaster, GI24649832, Length=482, Percent_Identity=40.6639004149378, Blast_Score=273, Evalue=2e-73,
Paralogues:
None
Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 640 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR002695 - InterPro: IPR013982 - InterPro: IPR016193 - InterPro: IPR011607 [H]
Pfam domain/function: PF01808 AICARFT_IMPCHas; PF02142 MGS [H]
EC number: =2.1.2.3; =3.5.4.10 [H]
Molecular weight: Translated: 55197; Mature: 55066
Theoretical pI: Translated: 5.87; Mature: 5.87
Prosite motif: NA
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.8 %Cys (Translated Protein) 1.4 %Met (Translated Protein) 2.1 %Cys+Met (Translated Protein) 0.8 %Cys (Mature Protein) 1.2 %Met (Mature Protein) 1.9 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MAPIALLSVSNKHGIVPLAESLHRMHGFQLLSSGGTAKVLEDAGLPVTRVAEHTGAAEIL CCCEEEEEECCCCCCCHHHHHHHHHHHHHEECCCCCEEEHHHCCCCHHHHHHHCCHHHHH GGRVKTLHPRVHGGILAMRGDPDHEVDLEQHQIPPIDVVVVNLYPFRETVANPQVSWETA CCCCEEECCCCCCCEEEECCCCCCCCCCHHCCCCCEEEEEEEEECHHHHHCCCCCCHHHH IENIDIGGPAMVRAAAKNHAHVAVLTRPDQYDRFLVALSDGVDDQLRRELALEAFEHTAA HCCCCCCCHHHHHHHHCCCCEEEEEECCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHH YDVAISHWMGERLTEQASQWLEAIPLRQRLRYGENPHQHAAWYSAPQQGWGGAIQLQGKE HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHCCCCCCCCCCEEEEECCC LSTNNLLDLEAALATVREFGYGTEGAQQAVQDAAVVVKHTNPCGVAIGTGVASALSRALD CCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHCEEEEEECCCCCEEEHHHHHHHHHHHHC ADRVSAFGGIVALNGLVDATTARELTSLFLECVVAPGFEPEAREILATKANLRLLELAPG HHHHHHHCCEEEECCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCEEEEEECCC AIDAAGRDHIRTILGGVLVQDQDDQSIDPTSWTVASKRSPNAEENADLTFAWRLVRHVRS CCCCCCHHHHHHHHCCEEEECCCCCCCCCCCEEEECCCCCCCCCCCCHHHHHHHHHHHCC NAIVVARAGQSLGVGAGQMNRVGSARLALEAAGDQARGAVLASDGFFPFDDTVRLAANHG CEEEEEECCCCCCCCCCHHHCCCCCEEEEEECCCCCCCEEEECCCCCCCCCCEEEEECCC ICAVIQPGGSKRDADSIAVCDDFGLAMVLTGKRHFLH EEEEECCCCCCCCCCCEEEECCCCEEEEEECCHHCCC >Mature Secondary Structure APIALLSVSNKHGIVPLAESLHRMHGFQLLSSGGTAKVLEDAGLPVTRVAEHTGAAEIL CCEEEEEECCCCCCCHHHHHHHHHHHHHEECCCCCEEEHHHCCCCHHHHHHHCCHHHHH GGRVKTLHPRVHGGILAMRGDPDHEVDLEQHQIPPIDVVVVNLYPFRETVANPQVSWETA CCCCEEECCCCCCCEEEECCCCCCCCCCHHCCCCCEEEEEEEEECHHHHHCCCCCCHHHH IENIDIGGPAMVRAAAKNHAHVAVLTRPDQYDRFLVALSDGVDDQLRRELALEAFEHTAA HCCCCCCCHHHHHHHHCCCCEEEEEECCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHH YDVAISHWMGERLTEQASQWLEAIPLRQRLRYGENPHQHAAWYSAPQQGWGGAIQLQGKE HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHCCCCCCCCCCEEEEECCC LSTNNLLDLEAALATVREFGYGTEGAQQAVQDAAVVVKHTNPCGVAIGTGVASALSRALD CCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHCEEEEEECCCCCEEEHHHHHHHHHHHHC ADRVSAFGGIVALNGLVDATTARELTSLFLECVVAPGFEPEAREILATKANLRLLELAPG HHHHHHHCCEEEECCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCEEEEEECCC AIDAAGRDHIRTILGGVLVQDQDDQSIDPTSWTVASKRSPNAEENADLTFAWRLVRHVRS CCCCCCHHHHHHHHCCEEEECCCCCCCCCCCEEEECCCCCCCCCCCCHHHHHHHHHHHCC NAIVVARAGQSLGVGAGQMNRVGSARLALEAAGDQARGAVLASDGFFPFDDTVRLAANHG CEEEEEECCCCCCCCCCHHHCCCCCEEEEEECCCCCCCEEEECCCCCCCCCCEEEEECCC ICAVIQPGGSKRDADSIAVCDDFGLAMVLTGKRHFLH EEEEECCCCCCCCCCCEEEECCCCEEEEEECCHHCCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: NA