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The map label for this gene is pth [H]

Identifier: 33864102

GI number: 33864102

Start: 1942219

End: 1942839

Strand: Reverse

Name: pth [H]

Synonym: PMT1835

Alternate gene names: 33864102

Gene position: 1942839-1942219 (Counterclockwise)

Preceding gene: 33864103

Following gene: 33864101

Centisome position: 80.59

GC content: 53.62

Gene sequence:

>621_bases
ATGAGGCCGGGTCGTTTACGTCTATTGGTAGGCCTAGGTAATCCAGGCTCAAAGTATGTCGGTACCCGTCACAACATCGG
CTTCATGGCCCTCGATAAGTTGGCTGCGCAGAAGTCAGTCAGTTTCAGGCCGCAAACAAAGTTCCATGGACTGATGGCGG
AAGTGGCGGTTGGCTCAGAGAGGGTTCGATTGCTGATGCCTCAAACTTATATGAATGAAAGCGGTCGGGCGATTCGTGCA
GCCATCGATTGGTTTGGCTTGGAGGTTGATCAGTTGCTGGTGCTTGTAGATGACATGGATTTGTCTTTGGGTCGACTGCG
GCTTCGCGCCCAGGGAAGTGCAGGAGGTCACAATGGTTTGCGCAGCGCGATTCAACATCTGGGGACTCAGGATTTTTGTC
GTCTGCGGATCGGGATCGGTGCTCCAGGTTGTACCTCTGAGGAACGAAGAGCTCGAACCGTCTCGCATGTGCTCGGGGTG
TTTAGTCGGCAGGAGAGCCTCCTAGTCGATCAAGTGCTTGATGAGGTGCTGATGGGTTTGGATCTGATTCAGTGCCTTGG
GTTGGAACGGGCAGGTAATCGTCTCAATGCTTTTCAACCGGAGGGTTGTTCTGCCTGCTGA

Upstream 100 bases:

>100_bases
ATCGAACAGGCTGCGACGGAAGAGTCCATGCAGCAAGACACCAATGCAATAGGTGAAACCCCTCAGGAGGCTAAAAACCC
TCCCGCTAGCTGAGAGTGGT

Downstream 100 bases:

>100_bases
TGAGTCATTTGCCTGTCACCACGGCTCGCCTCTGTGTACACCGCCAAAGCTTTGCCGACCAACGCTTGGATGGGGAGGTC
TCCGCTGGGGGGTTTCAGTG

Product: peptidyl-tRNA hydrolase

Products: NA

Alternate protein names: PTH [H]

Number of amino acids: Translated: 206; Mature: 206

Protein sequence:

>206_residues
MRPGRLRLLVGLGNPGSKYVGTRHNIGFMALDKLAAQKSVSFRPQTKFHGLMAEVAVGSERVRLLMPQTYMNESGRAIRA
AIDWFGLEVDQLLVLVDDMDLSLGRLRLRAQGSAGGHNGLRSAIQHLGTQDFCRLRIGIGAPGCTSEERRARTVSHVLGV
FSRQESLLVDQVLDEVLMGLDLIQCLGLERAGNRLNAFQPEGCSAC

Sequences:

>Translated_206_residues
MRPGRLRLLVGLGNPGSKYVGTRHNIGFMALDKLAAQKSVSFRPQTKFHGLMAEVAVGSERVRLLMPQTYMNESGRAIRA
AIDWFGLEVDQLLVLVDDMDLSLGRLRLRAQGSAGGHNGLRSAIQHLGTQDFCRLRIGIGAPGCTSEERRARTVSHVLGV
FSRQESLLVDQVLDEVLMGLDLIQCLGLERAGNRLNAFQPEGCSAC
>Mature_206_residues
MRPGRLRLLVGLGNPGSKYVGTRHNIGFMALDKLAAQKSVSFRPQTKFHGLMAEVAVGSERVRLLMPQTYMNESGRAIRA
AIDWFGLEVDQLLVLVDDMDLSLGRLRLRAQGSAGGHNGLRSAIQHLGTQDFCRLRIGIGAPGCTSEERRARTVSHVLGV
FSRQESLLVDQVLDEVLMGLDLIQCLGLERAGNRLNAFQPEGCSAC

Specific function: The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis [H]

COG id: COG0193

COG function: function code J; Peptidyl-tRNA hydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PTH family [H]

Homologues:

Organism=Homo sapiens, GI50897284, Length=181, Percent_Identity=37.5690607734807, Blast_Score=103, Evalue=1e-22,
Organism=Escherichia coli, GI1787455, Length=195, Percent_Identity=41.025641025641, Blast_Score=130, Evalue=5e-32,
Organism=Saccharomyces cerevisiae, GI6321983, Length=169, Percent_Identity=33.7278106508876, Blast_Score=67, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001328
- InterPro:   IPR018171 [H]

Pfam domain/function: PF01195 Pept_tRNA_hydro [H]

EC number: =3.1.1.29 [H]

Molecular weight: Translated: 22511; Mature: 22511

Theoretical pI: Translated: 9.10; Mature: 9.10

Prosite motif: PS01195 PEPT_TRNA_HYDROL_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRPGRLRLLVGLGNPGSKYVGTRHNIGFMALDKLAAQKSVSFRPQTKFHGLMAEVAVGSE
CCCCEEEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCC
RVRLLMPQTYMNESGRAIRAAIDWFGLEVDQLLVLVDDMDLSLGRLRLRAQGSAGGHNGL
CEEEECCHHHHCCCCCEEHHHHHHHCCCHHHEEEEECCCCCCCCCEEEEECCCCCCHHHH
RSAIQHLGTQDFCRLRIGIGAPGCTSEERRARTVSHVLGVFSRQESLLVDQVLDEVLMGL
HHHHHHCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DLIQCLGLERAGNRLNAFQPEGCSAC
HHHHHHCHHHCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MRPGRLRLLVGLGNPGSKYVGTRHNIGFMALDKLAAQKSVSFRPQTKFHGLMAEVAVGSE
CCCCEEEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCC
RVRLLMPQTYMNESGRAIRAAIDWFGLEVDQLLVLVDDMDLSLGRLRLRAQGSAGGHNGL
CEEEECCHHHHCCCCCEEHHHHHHHCCCHHHEEEEECCCCCCCCCEEEEECCCCCCHHHH
RSAIQHLGTQDFCRLRIGIGAPGCTSEERRARTVSHVLGVFSRQESLLVDQVLDEVLMGL
HHHHHHCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DLIQCLGLERAGNRLNAFQPEGCSAC
HHHHHHCHHHCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA