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The map label for this gene is lon2 [H]

Identifier: 33864051

GI number: 33864051

Start: 1883282

End: 1883944

Strand: Direct

Name: lon2 [H]

Synonym: PMT1784

Alternate gene names: 33864051

Gene position: 1883282-1883944 (Clockwise)

Preceding gene: 33864050

Following gene: 33864052

Centisome position: 78.12

GC content: 53.09

Gene sequence:

>663_bases
GTGACCGACCTGTCCGTCAGGGAGTTGCCTCTCTTCCCTCTGCCGGATGTCGTCTTATTCCCCCAAGAAGTGCTTCCACT
GCACATTTTTGAGTCTCGTTACCGAATGATGCTTCAGAGTGTGCTTGAAAGTGATCGGCGTTTTGGTGTGCTGCGCTGGG
ATCCTCAAACAAAAACAATGGCGAATGTGGGATGTTGCGCAGAGATCCTGCAACACCAAACATCCAAAGACGGACGCAGC
AATATCGTCACCCTTGGACAGCAGCGCTTCCGAGTGCTCGATGTGATTAGAGACGCCCCTTTCCGCACTGCCATGGTGAG
CTGGATCGAGGATGACCAAATGGATAACCACAGCCAGCTAGAGGAGCTATCAATCAGCGTTGCAAAAGCCCTACACGATG
TGGTGATGCTTACAGGCAAGCTCACAGATTCAGACATCACCATGCCGGATGACCTGCCTGATCTTCCTAGGGAACTCTCT
TTCTGGATCGGAGCCCATCTCGGGGGACCTGTGGCTGAAGAGCAACAGGCACTACTGGAGCTCACAAGAACCAGCCATCG
CCTGCAGCGTGAATACGAGATGCTTGACCACACCCGCCGTCAGCTTGCAGCAAGGACTGCACTCAAAGAAAGCCTCACCA
ACGTCGATCAAGCCAACAATTAA

Upstream 100 bases:

>100_bases
CTCGACCTCCCAAGTGGTGTTGACATTGAAGTGAAACTCTGAAGGTCTTCCAAGAAGTGTGCAGGCTAACTAGGCTTTTA
ATCTCTCTAGGGCATTATCT

Downstream 100 bases:

>100_bases
TGGACCTTTGGGTGTGGATATTGATCCTGGCAGGGACAACCCTGACTTCTGCTGTAGTGATCTGGACCCAACGGGATCGA
CGATACAAATCAAGCGCCAG

Product: ATP-dependent protease La

Products: NA

Alternate protein names: ATP-dependent protease La 2 [H]

Number of amino acids: Translated: 220; Mature: 219

Protein sequence:

>220_residues
MTDLSVRELPLFPLPDVVLFPQEVLPLHIFESRYRMMLQSVLESDRRFGVLRWDPQTKTMANVGCCAEILQHQTSKDGRS
NIVTLGQQRFRVLDVIRDAPFRTAMVSWIEDDQMDNHSQLEELSISVAKALHDVVMLTGKLTDSDITMPDDLPDLPRELS
FWIGAHLGGPVAEEQQALLELTRTSHRLQREYEMLDHTRRQLAARTALKESLTNVDQANN

Sequences:

>Translated_220_residues
MTDLSVRELPLFPLPDVVLFPQEVLPLHIFESRYRMMLQSVLESDRRFGVLRWDPQTKTMANVGCCAEILQHQTSKDGRS
NIVTLGQQRFRVLDVIRDAPFRTAMVSWIEDDQMDNHSQLEELSISVAKALHDVVMLTGKLTDSDITMPDDLPDLPRELS
FWIGAHLGGPVAEEQQALLELTRTSHRLQREYEMLDHTRRQLAARTALKESLTNVDQANN
>Mature_219_residues
TDLSVRELPLFPLPDVVLFPQEVLPLHIFESRYRMMLQSVLESDRRFGVLRWDPQTKTMANVGCCAEILQHQTSKDGRSN
IVTLGQQRFRVLDVIRDAPFRTAMVSWIEDDQMDNHSQLEELSISVAKALHDVVMLTGKLTDSDITMPDDLPDLPRELSF
WIGAHLGGPVAEEQQALLELTRTSHRLQREYEMLDHTRRQLAARTALKESLTNVDQANN

Specific function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced

COG id: COG2802

COG function: function code R; Uncharacterized protein, similar to the N-terminal domain of Lon protease

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Lon domain [H]

Homologues:

Organism=Homo sapiens, GI73747840, Length=136, Percent_Identity=33.0882352941176, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI37622896, Length=136, Percent_Identity=33.0882352941176, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI148528975, Length=243, Percent_Identity=29.6296296296296, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI87080813, Length=131, Percent_Identity=32.0610687022901, Blast_Score=70, Evalue=1e-12,
Organism=Escherichia coli, GI1786643, Length=195, Percent_Identity=24.6153846153846, Blast_Score=62, Evalue=2e-11,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008269
- InterPro:   IPR004815
- InterPro:   IPR003111
- InterPro:   IPR008268
- InterPro:   IPR001984
- InterPro:   IPR015947
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00004 AAA; PF02190 LON; PF05362 Lon_C [H]

EC number: =3.4.21.53 [H]

Molecular weight: Translated: 25189; Mature: 25058

Theoretical pI: Translated: 4.97; Mature: 4.97

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDLSVRELPLFPLPDVVLFPQEVLPLHIFESRYRMMLQSVLESDRRFGVLRWDPQTKTM
CCCCCCCCCCCCCCCCHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCHHHH
ANVGCCAEILQHQTSKDGRSNIVTLGQQRFRVLDVIRDAPFRTAMVSWIEDDQMDNHSQL
HHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCHHHH
EELSISVAKALHDVVMLTGKLTDSDITMPDDLPDLPRELSFWIGAHLGGPVAEEQQALLE
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHH
LTRTSHRLQREYEMLDHTRRQLAARTALKESLTNVDQANN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TDLSVRELPLFPLPDVVLFPQEVLPLHIFESRYRMMLQSVLESDRRFGVLRWDPQTKTM
CCCCCCCCCCCCCCCHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCHHHH
ANVGCCAEILQHQTSKDGRSNIVTLGQQRFRVLDVIRDAPFRTAMVSWIEDDQMDNHSQL
HHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCHHHH
EELSISVAKALHDVVMLTGKLTDSDITMPDDLPDLPRELSFWIGAHLGGPVAEEQQALLE
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHH
LTRTSHRLQREYEMLDHTRRQLAARTALKESLTNVDQANN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8331083; 8331082 [H]