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The map label for this gene is accC [H]

Identifier: 33863855

GI number: 33863855

Start: 1690029

End: 1691375

Strand: Direct

Name: accC [H]

Synonym: PMT1588

Alternate gene names: 33863855

Gene position: 1690029-1691375 (Clockwise)

Preceding gene: 33863852

Following gene: 33863857

Centisome position: 70.1

GC content: 55.61

Gene sequence:

>1347_bases
ATGACCATCGGCAAAGTGCTGATCGCCAACCGCGGCGAAATTGCCCTCAGAATTCTGCGTAGCTGCAGAGAGCTGAATAT
CCCCACAGTGGCTGTTTACAGCACCGTGGATCGCAATGCGCTGCATGTTCAACTTGCTGATGAAGCCGTCTGCGTTGGCG
AGGCCCCTAGCAGCAAGAGCTATCTCAATGTCCCCAATATCCTCGCGGCTGCAACCTCCCGCGGGGTCGATGCAATTCAT
CCTGGCTATGGATTTCTAGCCGAAAACGATCGATTCGCCGAAATCTGTCGTGACCATGGCATCACCTTTGTCGGTCCTTC
ACCCCATGCAATCCGCTCCATGGGAGACAAGTCGACCGCTAAGGCGACCATGCAACAAGTCGGTGTTCCGACTGTGCCAG
GTAGCGAGGGCTTGCTCGCCAGTCCAGAAGCAGCAGCTGAGCTGGCGAAGGGAATGGGCTACCCAGTGATGATCAAAGCC
ACCGCAGGTGGGGGTGGCCGCGGCATGCGCCTGGTCACCACGCCAGACCAACTGGAAAACCTCTTCAAGGCCGCCCAAGG
AGAGGCCGAAGCGGCCTTCGGCAATCCTGGGCTCTACATGGAGAAATTCATTGACCGGCCCCGACACGTCGAAGTGCAGA
TCCTCTCGGATCGACACGGCAACGTCATCCACCTCGGCGAGCGTGACTGCTCCATTCAGCGACGTCATCAAAAACTGTTG
GAAGAATCCCCCAGCCCAGCCCTCACCCCCGAATTACGCCTGCGAATGGGTGAGGCTGCGGTGGCCGCCGCAAGGAGCAT
CAACTACGAAGGCGCTGGAACCGTGGAATTCCTCCTTGATCGCAAGGGTGACTTTTACTTCATGGAAATGAACACCCGTA
TTCAGGTTGAGCATCCCGTCACAGAAATGGTGACAGGCATCGATTTGATCGCAGAACAACTGCACATCGCCGGAGGCGAT
CCCATCAGCATCAAACAAGAGGACATCCAACTAAGAGGCCATGCCATCGAGTGTCGAATCAATGCTGAAGACTCCACCCA
CAACTTCCGCCCCTCACCAGGGCAAATCACAGGCTGGTTACCACCAGGAGGACCAGGGGTACGCATCGACAGCCACGTCT
ATACCGGCTACGACATACCGCCTTTCTATGATTCATTGATTGGCAAGGTGATCGCCTGGGGGCATAACCGAGACGCGGCA
CTTAAACGCATGAAAAGAGCACTCAATGAATGTGCTGTCACAGGCATCCCCACCACAGTTGAATTCCATCTCGAACTGCT
CAATCGGGAAGAATTTCTGAGAGGAGATGTTCACACCAAATTTGTCGAACAGGACATGCTCGACTGA

Upstream 100 bases:

>100_bases
TTCGTCGATCGAGGATCATACCGGCCAATGGTCCAACGTTTTGCAAAGTGGCCTGGCAAGGAGCGCTGATACGATCCGCC
CAAAGCCTGATTACTGCGGG

Downstream 100 bases:

>100_bases
AATTCCTTCGTTCAATCTCAAGCAATGGCCTGGCTCTTAAGCAGCATCTGAGAGAGCAGTCCTTGCTGGCCAACCAACAA
CTCCCTCAACAAACTGATCA

Product: acetyl-CoA carboxylase biotin carboxylase subunit

Products: NA

Alternate protein names: Acetyl-CoA carboxylase subunit A; ACC [H]

Number of amino acids: Translated: 448; Mature: 447

Protein sequence:

>448_residues
MTIGKVLIANRGEIALRILRSCRELNIPTVAVYSTVDRNALHVQLADEAVCVGEAPSSKSYLNVPNILAAATSRGVDAIH
PGYGFLAENDRFAEICRDHGITFVGPSPHAIRSMGDKSTAKATMQQVGVPTVPGSEGLLASPEAAAELAKGMGYPVMIKA
TAGGGGRGMRLVTTPDQLENLFKAAQGEAEAAFGNPGLYMEKFIDRPRHVEVQILSDRHGNVIHLGERDCSIQRRHQKLL
EESPSPALTPELRLRMGEAAVAAARSINYEGAGTVEFLLDRKGDFYFMEMNTRIQVEHPVTEMVTGIDLIAEQLHIAGGD
PISIKQEDIQLRGHAIECRINAEDSTHNFRPSPGQITGWLPPGGPGVRIDSHVYTGYDIPPFYDSLIGKVIAWGHNRDAA
LKRMKRALNECAVTGIPTTVEFHLELLNREEFLRGDVHTKFVEQDMLD

Sequences:

>Translated_448_residues
MTIGKVLIANRGEIALRILRSCRELNIPTVAVYSTVDRNALHVQLADEAVCVGEAPSSKSYLNVPNILAAATSRGVDAIH
PGYGFLAENDRFAEICRDHGITFVGPSPHAIRSMGDKSTAKATMQQVGVPTVPGSEGLLASPEAAAELAKGMGYPVMIKA
TAGGGGRGMRLVTTPDQLENLFKAAQGEAEAAFGNPGLYMEKFIDRPRHVEVQILSDRHGNVIHLGERDCSIQRRHQKLL
EESPSPALTPELRLRMGEAAVAAARSINYEGAGTVEFLLDRKGDFYFMEMNTRIQVEHPVTEMVTGIDLIAEQLHIAGGD
PISIKQEDIQLRGHAIECRINAEDSTHNFRPSPGQITGWLPPGGPGVRIDSHVYTGYDIPPFYDSLIGKVIAWGHNRDAA
LKRMKRALNECAVTGIPTTVEFHLELLNREEFLRGDVHTKFVEQDMLD
>Mature_447_residues
TIGKVLIANRGEIALRILRSCRELNIPTVAVYSTVDRNALHVQLADEAVCVGEAPSSKSYLNVPNILAAATSRGVDAIHP
GYGFLAENDRFAEICRDHGITFVGPSPHAIRSMGDKSTAKATMQQVGVPTVPGSEGLLASPEAAAELAKGMGYPVMIKAT
AGGGGRGMRLVTTPDQLENLFKAAQGEAEAAFGNPGLYMEKFIDRPRHVEVQILSDRHGNVIHLGERDCSIQRRHQKLLE
ESPSPALTPELRLRMGEAAVAAARSINYEGAGTVEFLLDRKGDFYFMEMNTRIQVEHPVTEMVTGIDLIAEQLHIAGGDP
ISIKQEDIQLRGHAIECRINAEDSTHNFRPSPGQITGWLPPGGPGVRIDSHVYTGYDIPPFYDSLIGKVIAWGHNRDAAL
KRMKRALNECAVTGIPTTVEFHLELLNREEFLRGDVHTKFVEQDMLD

Specific function: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA [H]

COG id: COG0439

COG function: function code I; Biotin carboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotin carboxylation domain [H]

Homologues:

Organism=Homo sapiens, GI116805327, Length=443, Percent_Identity=50.1128668171558, Blast_Score=471, Evalue=1e-133,
Organism=Homo sapiens, GI189095269, Length=443, Percent_Identity=48.7584650112867, Blast_Score=444, Evalue=1e-125,
Organism=Homo sapiens, GI65506442, Length=443, Percent_Identity=48.7584650112867, Blast_Score=444, Evalue=1e-125,
Organism=Homo sapiens, GI295821183, Length=443, Percent_Identity=48.7584650112867, Blast_Score=444, Evalue=1e-125,
Organism=Homo sapiens, GI106049528, Length=448, Percent_Identity=47.3214285714286, Blast_Score=421, Evalue=1e-118,
Organism=Homo sapiens, GI106049295, Length=448, Percent_Identity=47.3214285714286, Blast_Score=421, Evalue=1e-118,
Organism=Homo sapiens, GI106049292, Length=448, Percent_Identity=47.3214285714286, Blast_Score=421, Evalue=1e-118,
Organism=Homo sapiens, GI38679960, Length=510, Percent_Identity=34.5098039215686, Blast_Score=280, Evalue=2e-75,
Organism=Homo sapiens, GI38679977, Length=510, Percent_Identity=34.5098039215686, Blast_Score=280, Evalue=2e-75,
Organism=Homo sapiens, GI38679967, Length=510, Percent_Identity=34.5098039215686, Blast_Score=280, Evalue=2e-75,
Organism=Homo sapiens, GI38679974, Length=510, Percent_Identity=34.5098039215686, Blast_Score=280, Evalue=3e-75,
Organism=Homo sapiens, GI38679971, Length=510, Percent_Identity=34.5098039215686, Blast_Score=280, Evalue=3e-75,
Organism=Homo sapiens, GI134142062, Length=510, Percent_Identity=32.9411764705882, Blast_Score=261, Evalue=9e-70,
Organism=Escherichia coli, GI1789654, Length=445, Percent_Identity=56.4044943820225, Blast_Score=500, Evalue=1e-143,
Organism=Caenorhabditis elegans, GI17567343, Length=440, Percent_Identity=46.5909090909091, Blast_Score=417, Evalue=1e-117,
Organism=Caenorhabditis elegans, GI71987519, Length=441, Percent_Identity=46.2585034013605, Blast_Score=412, Evalue=1e-115,
Organism=Caenorhabditis elegans, GI17562816, Length=447, Percent_Identity=45.6375838926174, Blast_Score=397, Evalue=1e-111,
Organism=Caenorhabditis elegans, GI71997168, Length=507, Percent_Identity=31.5581854043393, Blast_Score=238, Evalue=6e-63,
Organism=Caenorhabditis elegans, GI71997163, Length=507, Percent_Identity=31.5581854043393, Blast_Score=237, Evalue=9e-63,
Organism=Caenorhabditis elegans, GI133931226, Length=491, Percent_Identity=32.1792260692464, Blast_Score=232, Evalue=3e-61,
Organism=Saccharomyces cerevisiae, GI6319685, Length=438, Percent_Identity=43.37899543379, Blast_Score=373, Evalue=1e-104,
Organism=Saccharomyces cerevisiae, GI6319695, Length=446, Percent_Identity=43.9461883408072, Blast_Score=361, Evalue=1e-100,
Organism=Saccharomyces cerevisiae, GI6321376, Length=446, Percent_Identity=45.067264573991, Blast_Score=355, Evalue=7e-99,
Organism=Saccharomyces cerevisiae, GI6324343, Length=516, Percent_Identity=34.1085271317829, Blast_Score=256, Evalue=7e-69,
Organism=Saccharomyces cerevisiae, GI6323863, Length=464, Percent_Identity=34.698275862069, Blast_Score=255, Evalue=8e-69,
Organism=Drosophila melanogaster, GI24651757, Length=446, Percent_Identity=47.085201793722, Blast_Score=431, Evalue=1e-121,
Organism=Drosophila melanogaster, GI24652212, Length=447, Percent_Identity=47.427293064877, Blast_Score=410, Evalue=1e-115,
Organism=Drosophila melanogaster, GI24652210, Length=447, Percent_Identity=47.427293064877, Blast_Score=410, Evalue=1e-115,
Organism=Drosophila melanogaster, GI24652214, Length=447, Percent_Identity=47.427293064877, Blast_Score=410, Evalue=1e-115,
Organism=Drosophila melanogaster, GI19921944, Length=447, Percent_Identity=47.427293064877, Blast_Score=410, Evalue=1e-115,
Organism=Drosophila melanogaster, GI24652216, Length=447, Percent_Identity=47.427293064877, Blast_Score=410, Evalue=1e-115,
Organism=Drosophila melanogaster, GI281363050, Length=447, Percent_Identity=47.427293064877, Blast_Score=410, Evalue=1e-115,
Organism=Drosophila melanogaster, GI24652224, Length=447, Percent_Identity=47.427293064877, Blast_Score=410, Evalue=1e-115,
Organism=Drosophila melanogaster, GI24652222, Length=447, Percent_Identity=47.427293064877, Blast_Score=410, Evalue=1e-115,
Organism=Drosophila melanogaster, GI24652220, Length=447, Percent_Identity=47.427293064877, Blast_Score=410, Evalue=1e-115,
Organism=Drosophila melanogaster, GI24652218, Length=447, Percent_Identity=47.427293064877, Blast_Score=410, Evalue=1e-115,
Organism=Drosophila melanogaster, GI24651759, Length=408, Percent_Identity=46.5686274509804, Blast_Score=390, Evalue=1e-108,
Organism=Drosophila melanogaster, GI161076409, Length=498, Percent_Identity=33.9357429718875, Blast_Score=262, Evalue=4e-70,
Organism=Drosophila melanogaster, GI161076407, Length=498, Percent_Identity=33.9357429718875, Blast_Score=261, Evalue=5e-70,
Organism=Drosophila melanogaster, GI24586460, Length=498, Percent_Identity=33.9357429718875, Blast_Score=261, Evalue=5e-70,
Organism=Drosophila melanogaster, GI24586458, Length=498, Percent_Identity=33.9357429718875, Blast_Score=261, Evalue=5e-70,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004549
- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR011764
- InterPro:   IPR005482
- InterPro:   IPR005479
- InterPro:   IPR005481
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02785 Biotin_carb_C; PF00289 CPSase_L_chain; PF02786 CPSase_L_D2 [H]

EC number: =6.3.4.14; =6.4.1.2 [H]

Molecular weight: Translated: 48894; Mature: 48763

Theoretical pI: Translated: 6.20; Mature: 6.20

Prosite motif: PS50975 ATP_GRASP ; PS00866 CPSASE_1 ; PS00867 CPSASE_2 ; PS50979 BC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTIGKVLIANRGEIALRILRSCRELNIPTVAVYSTVDRNALHVQLADEAVCVGEAPSSKS
CCCCEEEEECCCHHHHHHHHHHHHCCCCEEEEEECCCCCEEEEEECCCEEEECCCCCCCC
YLNVPNILAAATSRGVDAIHPGYGFLAENDRFAEICRDHGITFVGPSPHAIRSMGDKSTA
EECCCHHHHHHHHCCCCCCCCCCCEEECCCHHHHHHHHCCCEEECCCCHHHHHCCCHHHH
KATMQQVGVPTVPGSEGLLASPEAAAELAKGMGYPVMIKATAGGGGRGMRLVTTPDQLEN
HHHHHHCCCCCCCCCCCCCCCCHHHHHHHHCCCCCEEEEEECCCCCCCEEEEECHHHHHH
LFKAAQGEAEAAFGNPGLYMEKFIDRPRHVEVQILSDRHGNVIHLGERDCSIQRRHQKLL
HHHHHCCCCCCCCCCCCHHHHHHHCCCCEEEEEEEECCCCCEEEECCCCCHHHHHHHHHH
EESPSPALTPELRLRMGEAAVAAARSINYEGAGTVEFLLDRKGDFYFMEMNTRIQVEHPV
HCCCCCCCCHHHHHHHCHHHHHHHHHCCCCCCCEEEEEEECCCCEEEEEECCEEEEECCH
TEMVTGIDLIAEQLHIAGGDPISIKQEDIQLRGHAIECRINAEDSTHNFRPSPGQITGWL
HHHHHHHHHHHHHHHHCCCCCCEEECCCEEECCEEEEEEEECCCCCCCCCCCCCCEEEEC
PPGGPGVRIDSHVYTGYDIPPFYDSLIGKVIAWGHNRDAALKRMKRALNECAVTGIPTTV
CCCCCCCEECCEEEECCCCCHHHHHHHHHHEECCCCCHHHHHHHHHHHHHHCCCCCCCHH
EFHLELLNREEFLRGDVHTKFVEQDMLD
HHHHHHHCHHHHHHCCHHHHHHHHHCCC
>Mature Secondary Structure 
TIGKVLIANRGEIALRILRSCRELNIPTVAVYSTVDRNALHVQLADEAVCVGEAPSSKS
CCCEEEEECCCHHHHHHHHHHHHCCCCEEEEEECCCCCEEEEEECCCEEEECCCCCCCC
YLNVPNILAAATSRGVDAIHPGYGFLAENDRFAEICRDHGITFVGPSPHAIRSMGDKSTA
EECCCHHHHHHHHCCCCCCCCCCCEEECCCHHHHHHHHCCCEEECCCCHHHHHCCCHHHH
KATMQQVGVPTVPGSEGLLASPEAAAELAKGMGYPVMIKATAGGGGRGMRLVTTPDQLEN
HHHHHHCCCCCCCCCCCCCCCCHHHHHHHHCCCCCEEEEEECCCCCCCEEEEECHHHHHH
LFKAAQGEAEAAFGNPGLYMEKFIDRPRHVEVQILSDRHGNVIHLGERDCSIQRRHQKLL
HHHHHCCCCCCCCCCCCHHHHHHHCCCCEEEEEEEECCCCCEEEECCCCCHHHHHHHHHH
EESPSPALTPELRLRMGEAAVAAARSINYEGAGTVEFLLDRKGDFYFMEMNTRIQVEHPV
HCCCCCCCCHHHHHHHCHHHHHHHHHCCCCCCCEEEEEEECCCCEEEEEECCEEEEECCH
TEMVTGIDLIAEQLHIAGGDPISIKQEDIQLRGHAIECRINAEDSTHNFRPSPGQITGWL
HHHHHHHHHHHHHHHHCCCCCCEEECCCEEECCEEEEEEEECCCCCCCCCCCCCCEEEEC
PPGGPGVRIDSHVYTGYDIPPFYDSLIGKVIAWGHNRDAALKRMKRALNECAVTGIPTTV
CCCCCCCEECCEEEECCCCCHHHHHHHHHHEECCCCCHHHHHHHHHHHHHHCCCCCCCHH
EFHLELLNREEFLRGDVHTKFVEQDMLD
HHHHHHHCHHHHHHCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8102363; 11759840 [H]