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The map label for this gene is hhoA [C]

Identifier: 33863779

GI number: 33863779

Start: 1600242

End: 1601399

Strand: Reverse

Name: hhoA [C]

Synonym: PMT1512

Alternate gene names: 33863779

Gene position: 1601399-1600242 (Counterclockwise)

Preceding gene: 33863780

Following gene: 33863778

Centisome position: 66.42

GC content: 53.97

Gene sequence:

>1158_bases
ATGATCTCTTTCAGATTGTTGCTGCAACAGGGTTGCATTGTTTTGAAGCGCTTTTGGGGATTGTTTTTGATGTCCGTGCT
GTTCCCTCTTGCTGCAGGGGGTCAGCCTGTTTGGGCTTTGTCTGGTTTAGATGGCACGACTAGCCATAACTTCGTTGCTG
ATGCGGTAAGTCAGGTGGCGCCTGCAGTGGTTCGCATTGATACCGAACGCACTGTGCAACGTCAGCCTTTTGATCCCACC
TTGATTGATCCCTTGCTCAGAGATCTCTTGGGCGAGCCAGGAATTGGGCCAGAGCGTGAGCGCGGTCAGGGTTCGGGTGT
CGTGATCGATGACCAGGGGTTGGTGCTGACCAATGCCCACGTGGTTGAACGGGTGGATGCGGTCAGCGTCACCCTTGCCG
ATGGAGATCAACACGATGGTTCGGTTGTCGGGACGGATCCTGTTACTGATCTTGCTCTTGTGAGACTGGATGGGGGCACA
CGTCCTGAGGCCGCCCCTCTCGGAGATTCTGATGCCCTTGAGGTAGGCGATTGGGCGATCGCTCTTGGTACCCCCTATGG
CCTTGAACGCACCGTCACCCTTGGCATTGTTAGCAGCCTGCATCGCAATATCAGCAGCCTTGGCTTCTCTGATAAACGTT
TGGATTTGATTCAGACCGATGCCGCGATTAACCCTGGCAATTCCGGTGGTCCACTCGTGAATGGTCGTGGTGAGGTGATC
GGTATCAACACACTGGTTCGTTCTGGTCCAGGCGCTGGTTTGGGATTTGCTATCCCGATCAATTTGGCTCGGCATGTTTC
TGAGCAGCTTTTGACCAGTGGGGAGGTGGTTCATCCTTATTTGGGTGTCCAATTGGTGCCGCTGACAGCTCGTATTGCCA
GGGAGCACAATCGTGATCCGAATTCGCTGGTGGAATTACCCGAACGCTTTGGGGCGCTTGTGCAGAGTGTTTTGCCGGAT
AGCCCGGCGGAACGCGCTGGTTTGCGGCGTGGTGATCTTGTGATTGCGGCAGCTGAAACATCAGTCTCTGATCCACAAAC
TCTGCTTAAACAGGTTGATCAGGCTGAGATCGGTGTCCCCTTGTCATTAAGGATCATGCGCAATGGTCAAGAGATGAGCC
TTTCGGTTAATCCAGCCGCATTACCTGGCCTTAGTTGA

Upstream 100 bases:

>100_bases
GCCACCTCATAGGCACGCAAAGTATTGATTTCAGCATTCTTCTGGCAGATCGGTTGCGCAGCTTTGCCTTGCTCCTCTGT
TTCGGCTTAGCCTCGCGTTC

Downstream 100 bases:

>100_bases
AACCCTTGCCCTTGCTACCGTCGCGCCGATGATTCAGAAACGATGGCGGACCTTCAAACTCAGATGAAGCAAGCGGTGGC
GGCAGCCGCTGTGGAGCAGA

Product: serine protease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 385; Mature: 385

Protein sequence:

>385_residues
MISFRLLLQQGCIVLKRFWGLFLMSVLFPLAAGGQPVWALSGLDGTTSHNFVADAVSQVAPAVVRIDTERTVQRQPFDPT
LIDPLLRDLLGEPGIGPERERGQGSGVVIDDQGLVLTNAHVVERVDAVSVTLADGDQHDGSVVGTDPVTDLALVRLDGGT
RPEAAPLGDSDALEVGDWAIALGTPYGLERTVTLGIVSSLHRNISSLGFSDKRLDLIQTDAAINPGNSGGPLVNGRGEVI
GINTLVRSGPGAGLGFAIPINLARHVSEQLLTSGEVVHPYLGVQLVPLTARIAREHNRDPNSLVELPERFGALVQSVLPD
SPAERAGLRRGDLVIAAAETSVSDPQTLLKQVDQAEIGVPLSLRIMRNGQEMSLSVNPAALPGLS

Sequences:

>Translated_385_residues
MISFRLLLQQGCIVLKRFWGLFLMSVLFPLAAGGQPVWALSGLDGTTSHNFVADAVSQVAPAVVRIDTERTVQRQPFDPT
LIDPLLRDLLGEPGIGPERERGQGSGVVIDDQGLVLTNAHVVERVDAVSVTLADGDQHDGSVVGTDPVTDLALVRLDGGT
RPEAAPLGDSDALEVGDWAIALGTPYGLERTVTLGIVSSLHRNISSLGFSDKRLDLIQTDAAINPGNSGGPLVNGRGEVI
GINTLVRSGPGAGLGFAIPINLARHVSEQLLTSGEVVHPYLGVQLVPLTARIAREHNRDPNSLVELPERFGALVQSVLPD
SPAERAGLRRGDLVIAAAETSVSDPQTLLKQVDQAEIGVPLSLRIMRNGQEMSLSVNPAALPGLS
>Mature_385_residues
MISFRLLLQQGCIVLKRFWGLFLMSVLFPLAAGGQPVWALSGLDGTTSHNFVADAVSQVAPAVVRIDTERTVQRQPFDPT
LIDPLLRDLLGEPGIGPERERGQGSGVVIDDQGLVLTNAHVVERVDAVSVTLADGDQHDGSVVGTDPVTDLALVRLDGGT
RPEAAPLGDSDALEVGDWAIALGTPYGLERTVTLGIVSSLHRNISSLGFSDKRLDLIQTDAAINPGNSGGPLVNGRGEVI
GINTLVRSGPGAGLGFAIPINLARHVSEQLLTSGEVVHPYLGVQLVPLTARIAREHNRDPNSLVELPERFGALVQSVLPD
SPAERAGLRRGDLVIAAAETSVSDPQTLLKQVDQAEIGVPLSLRIMRNGQEMSLSVNPAALPGLS

Specific function: Serine Protease That Is Required At High Temperature. Involved In The Degradation Of Damaged Proteins. It Can Degrade Icia, Ada, Casein And Globin. Shared Specificity With Degq. [C]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PDZ (DHR) domain [H]

Homologues:

Organism=Homo sapiens, GI4506141, Length=342, Percent_Identity=33.3333333333333, Blast_Score=171, Evalue=1e-42,
Organism=Homo sapiens, GI7019477, Length=338, Percent_Identity=36.6863905325444, Blast_Score=170, Evalue=2e-42,
Organism=Homo sapiens, GI22129776, Length=338, Percent_Identity=33.7278106508876, Blast_Score=160, Evalue=2e-39,
Organism=Homo sapiens, GI24308541, Length=356, Percent_Identity=30.6179775280899, Blast_Score=149, Evalue=6e-36,
Organism=Escherichia coli, GI1786356, Length=276, Percent_Identity=40.5797101449275, Blast_Score=192, Evalue=3e-50,
Organism=Escherichia coli, GI1789629, Length=329, Percent_Identity=36.4741641337386, Blast_Score=186, Evalue=3e-48,
Organism=Escherichia coli, GI1789630, Length=291, Percent_Identity=33.6769759450172, Blast_Score=150, Evalue=9e-38,
Organism=Drosophila melanogaster, GI24646839, Length=356, Percent_Identity=32.8651685393258, Blast_Score=152, Evalue=5e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.- [C]

Molecular weight: Translated: 40593; Mature: 40593

Theoretical pI: Translated: 4.64; Mature: 4.64

Prosite motif: PS50106 PDZ

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MISFRLLLQQGCIVLKRFWGLFLMSVLFPLAAGGQPVWALSGLDGTTSHNFVADAVSQVA
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCHHHHHHHHHHC
PAVVRIDTERTVQRQPFDPTLIDPLLRDLLGEPGIGPERERGQGSGVVIDDQGLVLTNAH
CEEEEECCHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCEEECCCCEEEECHH
VVERVDAVSVTLADGDQHDGSVVGTDPVTDLALVRLDGGTRPEAAPLGDSDALEVGDWAI
HHHHHCEEEEEEECCCCCCCCEECCCCCCCEEEEEECCCCCCCCCCCCCCCCEEECCEEE
ALGTPYGLERTVTLGIVSSLHRNISSLGFSDKRLDLIQTDAAINPGNSGGPLVNGRGEVI
EECCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCCCEECCCCCEE
GINTLVRSGPGAGLGFAIPINLARHVSEQLLTSGEVVHPYLGVQLVPLTARIAREHNRDP
EEHHHHHCCCCCCCEEEEHHHHHHHHHHHHHHCCCEECCCCCEEEEHHHHHHHHHHCCCH
NSLVELPERFGALVQSVLPDSPAERAGLRRGDLVIAAAETSVSDPQTLLKQVDQAEIGVP
HHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCCEEEEECCCCCCCHHHHHHHHHHHHCCCC
LSLRIMRNGQEMSLSVNPAALPGLS
EEEEEEECCCEEEEEECCCCCCCCC
>Mature Secondary Structure
MISFRLLLQQGCIVLKRFWGLFLMSVLFPLAAGGQPVWALSGLDGTTSHNFVADAVSQVA
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCHHHHHHHHHHC
PAVVRIDTERTVQRQPFDPTLIDPLLRDLLGEPGIGPERERGQGSGVVIDDQGLVLTNAH
CEEEEECCHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCEEECCCCEEEECHH
VVERVDAVSVTLADGDQHDGSVVGTDPVTDLALVRLDGGTRPEAAPLGDSDALEVGDWAI
HHHHHCEEEEEEECCCCCCCCEECCCCCCCEEEEEECCCCCCCCCCCCCCCCEEECCEEE
ALGTPYGLERTVTLGIVSSLHRNISSLGFSDKRLDLIQTDAAINPGNSGGPLVNGRGEVI
EECCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCCCEECCCCCEE
GINTLVRSGPGAGLGFAIPINLARHVSEQLLTSGEVVHPYLGVQLVPLTARIAREHNRDP
EEHHHHHCCCCCCCEEEEHHHHHHHHHHHHHHCCCEECCCCCEEEEHHHHHHHHHHCCCH
NSLVELPERFGALVQSVLPDSPAERAGLRRGDLVIAAAETSVSDPQTLLKQVDQAEIGVP
HHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCCEEEEECCCCCCCHHHHHHHHHHHHCCCC
LSLRIMRNGQEMSLSVNPAALPGLS
EEEEEEECCCEEEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: Serine endopeptidases [C]

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA