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The map label for this gene is hisD

Identifier: 33863777

GI number: 33863777

Start: 1598149

End: 1599477

Strand: Direct

Name: hisD

Synonym: PMT1510

Alternate gene names: 33863777

Gene position: 1598149-1599477 (Clockwise)

Preceding gene: 33863763

Following gene: 33863782

Centisome position: 66.29

GC content: 57.71

Gene sequence:

>1329_bases
TTGACACAAAGCGGCCAGGCCGAGTCAGAGACTCCCTCAACCCTGATTCATTGTGTTCGGGATCGGCAACAAGCCAAGCG
TGAACTAGAGCGGCTGGCCAACCGCTCTACCGGCAATTCTCAAAAGCAAGCCATGGCGACGGTGGAGGACATCCTCGACA
CCGTTCGCAGCCAAGGGGACCAAGCCCTGATCACCTTGACCGAGCGCTTTGACGGTTTTCGTCCAGAGCCATTAACCGTA
GCTCCAGAAGAGTTGGAAGACGCCTGGCGAAAAACTCCCCAAAAACTTCAATCTGCTCTGGAACTGGCCTATCGCCGTAT
CCAGGATTTCCATCAGCATCAGCGACCGAATGACCTGATGGTGCAAGGCATCCATGGCGAACAATTGGGCCGCCGCTGGC
GCCCTGTACAAAAAGCCGGGATCTACATCCCAGGAGGCCGAGCTGCCTATCCGAGCACAGTGCTAATGAATGCAGTCCCA
GCCCAAGTAGCCGGTGTGGAGCAGCTGGTGATGACTTCACCCGCGGGAAGGGATGGTCAGATCAACAGAACCGTTCTAGC
CGCCGCACACCTAGCAGGCATTCGTGAGGTCTTGCGTCTCGGTGGTGCCCAAGCCATCGCAGCCCTGGCCTTTGGCACTG
AAACCGTGCCAAAGGTCGATGTGATCAGCGGACCCGGCAATCTCTACGTCACCCTTGCGAAAAAGGCCGTCTACGGGCAA
GTGGGCATTGATTCGCTCGCCGGCCCAAGTGAGGTTTTAGTCATCGCCGACCAGAGTGCTCGTGTTGAGCAGGTGGCCGC
CGACCTACTGGCCCAATCAGAACACGATCCACTTGCTGCTGCAGTACTACTCACCACCGAAGCAAGCCTCGCCGAACAGC
TCCCATCCCATTTGGAGGCTCAGCTTAAGGGGCACCCTCGCGAGCAGATCTGCCGAGCCTCTTTAAGCAACTGGGGGCTG
GTCGTGATCTGTGAAAGCCTGGAAAGATGCGCTCAACTCAGCGATCACTTCGCACCTGAGCACTTGGAGTTATTGGTCGA
GCACCCGCACGCCATTGCCGACTGCATCAAAAATGCCGGCGCCATCTTCATCGGCCCCTGGACCCCTGAAGCGGTAGGCG
ACTATCTAGCCGGACCAAACCACACACTACCGACATGCGGAACGGCCCGCTTCAGCGGCGCCCTGAGCGTGGAAACATTT
CTGCGGCACACCTCTCTAATCGAATTCAATCGATCTGCCCTTGAGGCCACTGCTAACGCCGTAAGGGAATTGGCCAGCAG
CGAAGGCTTGCACAGCCATGCTGAATCCGTGCGTATCCGCTTCGAATAA

Upstream 100 bases:

>100_bases
CATTAACCCAGCACCAATTTTTGAGATGCCATTACAAGCGCTTTAAGACAAGCCAGAAGAGCAAGCCCTAACTTGATTTC
AGATATTCAGGTTGCAGACT

Downstream 100 bases:

>100_bases
CCCCTCTACTCACGGCGCTGTAGACGACGCACTCCCGCAACACCATCACTAATCTGGCCAACCAAAACTTCATCGGTGAG
ATTGACGAACAAACCGTTCT

Product: histidinol dehydrogenase

Products: NA

Alternate protein names: HDH

Number of amino acids: Translated: 442; Mature: 441

Protein sequence:

>442_residues
MTQSGQAESETPSTLIHCVRDRQQAKRELERLANRSTGNSQKQAMATVEDILDTVRSQGDQALITLTERFDGFRPEPLTV
APEELEDAWRKTPQKLQSALELAYRRIQDFHQHQRPNDLMVQGIHGEQLGRRWRPVQKAGIYIPGGRAAYPSTVLMNAVP
AQVAGVEQLVMTSPAGRDGQINRTVLAAAHLAGIREVLRLGGAQAIAALAFGTETVPKVDVISGPGNLYVTLAKKAVYGQ
VGIDSLAGPSEVLVIADQSARVEQVAADLLAQSEHDPLAAAVLLTTEASLAEQLPSHLEAQLKGHPREQICRASLSNWGL
VVICESLERCAQLSDHFAPEHLELLVEHPHAIADCIKNAGAIFIGPWTPEAVGDYLAGPNHTLPTCGTARFSGALSVETF
LRHTSLIEFNRSALEATANAVRELASSEGLHSHAESVRIRFE

Sequences:

>Translated_442_residues
MTQSGQAESETPSTLIHCVRDRQQAKRELERLANRSTGNSQKQAMATVEDILDTVRSQGDQALITLTERFDGFRPEPLTV
APEELEDAWRKTPQKLQSALELAYRRIQDFHQHQRPNDLMVQGIHGEQLGRRWRPVQKAGIYIPGGRAAYPSTVLMNAVP
AQVAGVEQLVMTSPAGRDGQINRTVLAAAHLAGIREVLRLGGAQAIAALAFGTETVPKVDVISGPGNLYVTLAKKAVYGQ
VGIDSLAGPSEVLVIADQSARVEQVAADLLAQSEHDPLAAAVLLTTEASLAEQLPSHLEAQLKGHPREQICRASLSNWGL
VVICESLERCAQLSDHFAPEHLELLVEHPHAIADCIKNAGAIFIGPWTPEAVGDYLAGPNHTLPTCGTARFSGALSVETF
LRHTSLIEFNRSALEATANAVRELASSEGLHSHAESVRIRFE
>Mature_441_residues
TQSGQAESETPSTLIHCVRDRQQAKRELERLANRSTGNSQKQAMATVEDILDTVRSQGDQALITLTERFDGFRPEPLTVA
PEELEDAWRKTPQKLQSALELAYRRIQDFHQHQRPNDLMVQGIHGEQLGRRWRPVQKAGIYIPGGRAAYPSTVLMNAVPA
QVAGVEQLVMTSPAGRDGQINRTVLAAAHLAGIREVLRLGGAQAIAALAFGTETVPKVDVISGPGNLYVTLAKKAVYGQV
GIDSLAGPSEVLVIADQSARVEQVAADLLAQSEHDPLAAAVLLTTEASLAEQLPSHLEAQLKGHPREQICRASLSNWGLV
VICESLERCAQLSDHFAPEHLELLVEHPHAIADCIKNAGAIFIGPWTPEAVGDYLAGPNHTLPTCGTARFSGALSVETFL
RHTSLIEFNRSALEATANAVRELASSEGLHSHAESVRIRFE

Specific function: Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine

COG id: COG0141

COG function: function code E; Histidinol dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histidinol dehydrogenase family

Homologues:

Organism=Escherichia coli, GI1788331, Length=400, Percent_Identity=40.75, Blast_Score=292, Evalue=3e-80,
Organism=Saccharomyces cerevisiae, GI6319819, Length=450, Percent_Identity=37.5555555555556, Blast_Score=273, Evalue=4e-74,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HISX_PROMM (Q7V5N9)

Other databases:

- EMBL:   BX548175
- RefSeq:   NP_895337.1
- ProteinModelPortal:   Q7V5N9
- SMR:   Q7V5N9
- STRING:   Q7V5N9
- GeneID:   1728529
- GenomeReviews:   BX548175_GR
- KEGG:   pmt:PMT1510
- NMPDR:   fig|74547.1.peg.1504
- eggNOG:   COG0141
- HOGENOM:   HBG329596
- OMA:   IEAFHRQ
- ProtClustDB:   PRK00877
- BioCyc:   PMAR74547:PMT1510-MONOMER
- HAMAP:   MF_01024
- InterPro:   IPR016161
- InterPro:   IPR022695
- InterPro:   IPR001692
- InterPro:   IPR012131
- PANTHER:   PTHR21256:SF2
- PIRSF:   PIRSF000099
- PRINTS:   PR00083
- TIGRFAMs:   TIGR00069

Pfam domain/function: PF00815 Histidinol_dh; SSF53720 Aldehyde_DH/Histidinol_DH

EC number: =1.1.1.23

Molecular weight: Translated: 47870; Mature: 47739

Theoretical pI: Translated: 6.08; Mature: 6.08

Prosite motif: PS00611 HISOL_DEHYDROGENASE; PS00024 HEMOPEXIN

Important sites: ACT_SITE 340-340 ACT_SITE 341-341 BINDING 142-142 BINDING 204-204 BINDING 227-227 BINDING 250-250 BINDING 272-272 BINDING 275-275 BINDING 341-341 BINDING 374-374 BINDING 428-428 BINDING 433-433

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQSGQAESETPSTLIHCVRDRQQAKRELERLANRSTGNSQKQAMATVEDILDTVRSQGD
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCC
QALITLTERFDGFRPEPLTVAPEELEDAWRKTPQKLQSALELAYRRIQDFHQHQRPNDLM
CEEEEEHHHHCCCCCCCCCCCHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCCCCE
VQGIHGEQLGRRWRPVQKAGIYIPGGRAAYPSTVLMNAVPAQVAGVEQLVMTSPAGRDGQ
EECCCHHHHHHHCCCHHHCCEECCCCCCCCCHHHHHHCCHHHHHHHHHHHHCCCCCCCCC
INRTVLAAAHLAGIREVLRLGGAQAIAALAFGTETVPKVDVISGPGNLYVTLAKKAVYGQ
CHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCEEEEECCCCEEEEEEHHHHHCC
VGIDSLAGPSEVLVIADQSARVEQVAADLLAQSEHDPLAAAVLLTTEASLAEQLPSHLEA
CCCCCCCCCCCEEEEECCCHHHHHHHHHHHHCCCCCCHHHHHHHHCHHHHHHHHHHHHHH
QLKGHPREQICRASLSNWGLVVICESLERCAQLSDHFAPEHLELLVEHPHAIADCIKNAG
HHCCCCHHHHHHHHHCCCCEEEEHHHHHHHHHHHHCCCHHHHHHHHHCCHHHHHHHHCCC
AIFIGPWTPEAVGDYLAGPNHTLPTCGTARFSGALSVETFLRHTSLIEFNRSALEATANA
EEEECCCCHHHHHHHHCCCCCCCCCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
VRELASSEGLHSHAESVRIRFE
HHHHHHCCCHHHHHHCEEEECC
>Mature Secondary Structure 
TQSGQAESETPSTLIHCVRDRQQAKRELERLANRSTGNSQKQAMATVEDILDTVRSQGD
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCC
QALITLTERFDGFRPEPLTVAPEELEDAWRKTPQKLQSALELAYRRIQDFHQHQRPNDLM
CEEEEEHHHHCCCCCCCCCCCHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCCCCE
VQGIHGEQLGRRWRPVQKAGIYIPGGRAAYPSTVLMNAVPAQVAGVEQLVMTSPAGRDGQ
EECCCHHHHHHHCCCHHHCCEECCCCCCCCCHHHHHHCCHHHHHHHHHHHHCCCCCCCCC
INRTVLAAAHLAGIREVLRLGGAQAIAALAFGTETVPKVDVISGPGNLYVTLAKKAVYGQ
CHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCEEEEECCCCEEEEEEHHHHHCC
VGIDSLAGPSEVLVIADQSARVEQVAADLLAQSEHDPLAAAVLLTTEASLAEQLPSHLEA
CCCCCCCCCCCEEEEECCCHHHHHHHHHHHHCCCCCCHHHHHHHHCHHHHHHHHHHHHHH
QLKGHPREQICRASLSNWGLVVICESLERCAQLSDHFAPEHLELLVEHPHAIADCIKNAG
HHCCCCHHHHHHHHHCCCCEEEEHHHHHHHHHHHHCCCHHHHHHHHHCCHHHHHHHHCCC
AIFIGPWTPEAVGDYLAGPNHTLPTCGTARFSGALSVETFLRHTSLIEFNRSALEATANA
EEEECCCCHHHHHHHHCCCCCCCCCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
VRELASSEGLHSHAESVRIRFE
HHHHHHCCCHHHHHHCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12917642