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The map label for this gene is bioF [C]

Identifier: 33863755

GI number: 33863755

Start: 1573401

End: 1574543

Strand: Direct

Name: bioF [C]

Synonym: PMT1488

Alternate gene names: 33863755

Gene position: 1573401-1574543 (Clockwise)

Preceding gene: 33863753

Following gene: 33863756

Centisome position: 65.26

GC content: 58.62

Gene sequence:

>1143_bases
ATGCAAAGCCAGCCCACATCACGTCGCCGCCAGCTGCGCACCTGGCGGCCAGGGCCAGGGCCAGCTGAGTTCAAACCAGT
GTCACCTCAGGGGAAATCAAAACCTCTACTAGATCTGGCAAGCAACGATTACCTAGGCCTATGTCGGCATCCTGATCTGA
TCGAAGCCGCCGGAGCGGCCTTGCATTCAGAAGGTGTTGGAGCAGGTGGATCCAGGCTAGTCACTGGTAGCCGGCCAGTG
CATGTTGCACTGGAAGAAGCACTCGCCGACTGGCTAGGTCGCGAGCGGATCTTACTTTTCCCAAGCGGGTTCCAAGCAAA
CCTGGCCGCAGTGATCGCACTGGCCAACCGCAATACCCCAGTACTGGCTGATCGCCTAGCTCACCATTCTCTATTGATGG
GTGTCAAAGCAAGTGGCGCCAGGCTGCAGCGTTATGGCCACAATGACCTGGCAGACCTTGAGCGGCGCCTCAAGCTCTGC
CGGCATCATCAACCGCATCAACGGCCGCTTGTAGTCACCGAAAGCCTATTCAGCATGGAGGGGACCAGTCCACCGCTCTC
AACAATGGCCGAACTCTGCGAAGTGCATGGTGCCAGGCTGCTCGTGGATGAAGCCCATGCCCTGGGTGTCATCGGTCCTC
AAGGGCGAGGTCTTTGCCATGGGCTCTCTGCACCAGTTTCAATCATCAGCGGCACTTTCGGGAAAGCATTCGGTAGCGGT
GGTGCCTTCCTGGCTGGTGATTGCGCCATGGGCGATCACCTTCTGCAAACCAGTGGCGCCTTTCGTTACACCACAGCACT
AGCACCGCCTTTAGCAGCGGCAGCTCTCACTGCCCTAAACCTGATCCAATCTCACCCTCAATGGGGCAAGCAACTGCAAG
AGCGTGCCGAGCAATGGCGTGGTCAATTGACAGCTAGAGGATGGGCTCGCCCGCCTGGATATGGACCCATCCTCTCTCTG
GTGATCGGTTCCGACCAACAAGCTCTGAATCGCCAAAGTCAACTCGAGGAAGCCGGCCTCCTTAGCGTGGCCATCCGTCC
TCCCACTGTTCCAGAAGGCACGGCGCGCCTTCGGCTTGTGCTGCGCAGGGGGCTACCCGATGAGACATTGGAACGGCTGA
TGAGCGCCCTTGAAACTGGATGA

Upstream 100 bases:

>100_bases
TTCTGGCCATCGTTGGCATTGGCCCCAGCCAGCATGCCAACAAGGCAAAATCAAGCCAAAGAAGCCATCCTGAACTGCGC
AGGGCTTGCAGACTGGAGCC

Downstream 100 bases:

>100_bases
AAGAGGTAATCGCCATGCACGGATGGTGTGGCGATAGCAACACCTGGCAGCTCTGGGCCCGCCATTTTCAAGCCCATGGC
TGGTTGTGGCAAAGCCAAGA

Product: 8-amino-7-oxononanoate synthase

Products: NA

Alternate protein names: AONS/AKB ligase; 7-keto-8-amino-pelargonic acid synthase; 7-KAP synthase; KAPA synthase; 8-amino-7-ketopelargonate synthase; Alpha-oxoamine synthase; L-alanine--pimeloyl-CoA ligase [H]

Number of amino acids: Translated: 380; Mature: 380

Protein sequence:

>380_residues
MQSQPTSRRRQLRTWRPGPGPAEFKPVSPQGKSKPLLDLASNDYLGLCRHPDLIEAAGAALHSEGVGAGGSRLVTGSRPV
HVALEEALADWLGRERILLFPSGFQANLAAVIALANRNTPVLADRLAHHSLLMGVKASGARLQRYGHNDLADLERRLKLC
RHHQPHQRPLVVTESLFSMEGTSPPLSTMAELCEVHGARLLVDEAHALGVIGPQGRGLCHGLSAPVSIISGTFGKAFGSG
GAFLAGDCAMGDHLLQTSGAFRYTTALAPPLAAAALTALNLIQSHPQWGKQLQERAEQWRGQLTARGWARPPGYGPILSL
VIGSDQQALNRQSQLEEAGLLSVAIRPPTVPEGTARLRLVLRRGLPDETLERLMSALETG

Sequences:

>Translated_380_residues
MQSQPTSRRRQLRTWRPGPGPAEFKPVSPQGKSKPLLDLASNDYLGLCRHPDLIEAAGAALHSEGVGAGGSRLVTGSRPV
HVALEEALADWLGRERILLFPSGFQANLAAVIALANRNTPVLADRLAHHSLLMGVKASGARLQRYGHNDLADLERRLKLC
RHHQPHQRPLVVTESLFSMEGTSPPLSTMAELCEVHGARLLVDEAHALGVIGPQGRGLCHGLSAPVSIISGTFGKAFGSG
GAFLAGDCAMGDHLLQTSGAFRYTTALAPPLAAAALTALNLIQSHPQWGKQLQERAEQWRGQLTARGWARPPGYGPILSL
VIGSDQQALNRQSQLEEAGLLSVAIRPPTVPEGTARLRLVLRRGLPDETLERLMSALETG
>Mature_380_residues
MQSQPTSRRRQLRTWRPGPGPAEFKPVSPQGKSKPLLDLASNDYLGLCRHPDLIEAAGAALHSEGVGAGGSRLVTGSRPV
HVALEEALADWLGRERILLFPSGFQANLAAVIALANRNTPVLADRLAHHSLLMGVKASGARLQRYGHNDLADLERRLKLC
RHHQPHQRPLVVTESLFSMEGTSPPLSTMAELCEVHGARLLVDEAHALGVIGPQGRGLCHGLSAPVSIISGTFGKAFGSG
GAFLAGDCAMGDHLLQTSGAFRYTTALAPPLAAAALTALNLIQSHPQWGKQLQERAEQWRGQLTARGWARPPGYGPILSL
VIGSDQQALNRQSQLEEAGLLSVAIRPPTVPEGTARLRLVLRRGLPDETLERLMSALETG

Specific function: Catalyzes the decarboxylative condensation of pimeloyl- CoA and L-alanine to produce 8-amino-7-oxononanoate (AON), coenzyme A and/or converts 2-amino-3-ketobutyrate to glycine and acetyl-CoA [H]

COG id: COG0156

COG function: function code H; 7-keto-8-aminopelargonate synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI7657118, Length=375, Percent_Identity=30.4, Blast_Score=181, Evalue=1e-45,
Organism=Homo sapiens, GI284448556, Length=345, Percent_Identity=31.0144927536232, Blast_Score=178, Evalue=6e-45,
Organism=Homo sapiens, GI83977442, Length=338, Percent_Identity=33.7278106508876, Blast_Score=163, Evalue=3e-40,
Organism=Homo sapiens, GI83977444, Length=338, Percent_Identity=33.7278106508876, Blast_Score=162, Evalue=3e-40,
Organism=Homo sapiens, GI83977440, Length=338, Percent_Identity=33.7278106508876, Blast_Score=162, Evalue=4e-40,
Organism=Homo sapiens, GI4758668, Length=367, Percent_Identity=30.2452316076294, Blast_Score=150, Evalue=2e-36,
Organism=Homo sapiens, GI4502025, Length=329, Percent_Identity=31.9148936170213, Blast_Score=142, Evalue=5e-34,
Organism=Homo sapiens, GI40316939, Length=329, Percent_Identity=31.9148936170213, Blast_Score=142, Evalue=5e-34,
Organism=Homo sapiens, GI119220554, Length=365, Percent_Identity=28.4931506849315, Blast_Score=141, Evalue=8e-34,
Organism=Homo sapiens, GI5454084, Length=375, Percent_Identity=29.3333333333333, Blast_Score=132, Evalue=8e-31,
Organism=Escherichia coli, GI1786993, Length=350, Percent_Identity=38.5714285714286, Blast_Score=200, Evalue=1e-52,
Organism=Escherichia coli, GI1790046, Length=346, Percent_Identity=31.7919075144509, Blast_Score=186, Evalue=2e-48,
Organism=Caenorhabditis elegans, GI71994529, Length=357, Percent_Identity=29.9719887955182, Blast_Score=193, Evalue=1e-49,
Organism=Caenorhabditis elegans, GI32566772, Length=365, Percent_Identity=28.7671232876712, Blast_Score=169, Evalue=2e-42,
Organism=Caenorhabditis elegans, GI17560914, Length=367, Percent_Identity=25.0681198910082, Blast_Score=136, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI17560912, Length=367, Percent_Identity=25.0681198910082, Blast_Score=136, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI71982617, Length=283, Percent_Identity=27.5618374558304, Blast_Score=116, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI71982625, Length=283, Percent_Identity=27.5618374558304, Blast_Score=116, Evalue=2e-26,
Organism=Saccharomyces cerevisiae, GI6320438, Length=384, Percent_Identity=28.3854166666667, Blast_Score=149, Evalue=5e-37,
Organism=Saccharomyces cerevisiae, GI6320267, Length=361, Percent_Identity=27.1468144044321, Blast_Score=145, Evalue=1e-35,
Organism=Saccharomyces cerevisiae, GI6323954, Length=275, Percent_Identity=27.6363636363636, Blast_Score=108, Evalue=1e-24,
Organism=Drosophila melanogaster, GI24662918, Length=354, Percent_Identity=29.0960451977401, Blast_Score=186, Evalue=2e-47,
Organism=Drosophila melanogaster, GI17137420, Length=355, Percent_Identity=33.5211267605634, Blast_Score=161, Evalue=6e-40,
Organism=Drosophila melanogaster, GI17136286, Length=263, Percent_Identity=31.9391634980989, Blast_Score=131, Evalue=9e-31,
Organism=Drosophila melanogaster, GI24653280, Length=413, Percent_Identity=23.728813559322, Blast_Score=122, Evalue=3e-28,
Organism=Drosophila melanogaster, GI24653276, Length=413, Percent_Identity=23.728813559322, Blast_Score=122, Evalue=3e-28,
Organism=Drosophila melanogaster, GI24653278, Length=413, Percent_Identity=23.728813559322, Blast_Score=122, Evalue=3e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR004723
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.3.1.29; =2.3.1.47 [H]

Molecular weight: Translated: 40674; Mature: 40674

Theoretical pI: Translated: 9.61; Mature: 9.61

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQSQPTSRRRQLRTWRPGPGPAEFKPVSPQGKSKPLLDLASNDYLGLCRHPDLIEAAGAA
CCCCCCHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCEEECCCCCEEECCCCHHHHHHHHH
LHSEGVGAGGSRLVTGSRPVHVALEEALADWLGRERILLFPSGFQANLAAVIALANRNTP
HHCCCCCCCCCEEEECCCCHHHHHHHHHHHHHCCCEEEEECCCCCCCCEEEEEECCCCCC
VLADRLAHHSLLMGVKASGARLQRYGHNDLADLERRLKLCRHHQPHQRPLVVTESLFSME
HHHHHHHHHHHHHCCCCCCHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCEEEHHHHHHCC
GTSPPLSTMAELCEVHGARLLVDEAHALGVIGPQGRGLCHGLSAPVSIISGTFGKAFGSG
CCCCCHHHHHHHHHHCCCEEEEECHHHCEEECCCCCCCHHCCCCHHHHHHCCHHHHHCCC
GAFLAGDCAMGDHLLQTSGAFRYTTALAPPLAAAALTALNLIQSHPQWGKQLQERAEQWR
CCEEECCHHHCCHHHHCCCCEEEHHHHCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
GQLTARGWARPPGYGPILSLVIGSDQQALNRQSQLEEAGLLSVAIRPPTVPEGTARLRLV
CCCCCCCCCCCCCCCHHHHEEECCCHHHHHHHHHHHHCCEEEEEECCCCCCCHHHHHHHH
LRRGLPDETLERLMSALETG
HHCCCCHHHHHHHHHHHCCC
>Mature Secondary Structure
MQSQPTSRRRQLRTWRPGPGPAEFKPVSPQGKSKPLLDLASNDYLGLCRHPDLIEAAGAA
CCCCCCHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCEEECCCCCEEECCCCHHHHHHHHH
LHSEGVGAGGSRLVTGSRPVHVALEEALADWLGRERILLFPSGFQANLAAVIALANRNTP
HHCCCCCCCCCEEEECCCCHHHHHHHHHHHHHCCCEEEEECCCCCCCCEEEEEECCCCCC
VLADRLAHHSLLMGVKASGARLQRYGHNDLADLERRLKLCRHHQPHQRPLVVTESLFSME
HHHHHHHHHHHHHCCCCCCHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCEEEHHHHHHCC
GTSPPLSTMAELCEVHGARLLVDEAHALGVIGPQGRGLCHGLSAPVSIISGTFGKAFGSG
CCCCCHHHHHHHHHHCCCEEEEECHHHCEEECCCCCCCHHCCCCHHHHHHCCHHHHHCCC
GAFLAGDCAMGDHLLQTSGAFRYTTALAPPLAAAALTALNLIQSHPQWGKQLQERAEQWR
CCEEECCHHHCCHHHHCCCCEEEHHHHCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
GQLTARGWARPPGYGPILSLVIGSDQQALNRQSQLEEAGLLSVAIRPPTVPEGTARLRLV
CCCCCCCCCCCCCCCHHHHEEECCCHHHHHHHHHHHHCCEEEEEECCCCCCCHHHHHHHH
LRRGLPDETLERLMSALETG
HHCCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA