Click here to switch to the map view.

The map label for this gene is fumC

Identifier: 33863752

GI number: 33863752

Start: 1567708

End: 1569108

Strand: Direct

Name: fumC

Synonym: PMT1485

Alternate gene names: 33863752

Gene position: 1567708-1569108 (Clockwise)

Preceding gene: 33863751

Following gene: 33863753

Centisome position: 65.03

GC content: 54.68

Gene sequence:

>1401_bases
TTGATGGCTGACCTGATGCGTATCGAACACGACAGCATGGGCACTATTGAGGTGCCCGCTGGGGTTCTCTGGGGTGCACA
AACCCAGCGATCGCTCCTTAACTTCGCCATCAGCACAGACCGCATGCCAGTCGAACTGATCCATGCCTTGGCATTGATCA
AACAGGCTGCCGCCAGCGTGAACTGTCGCCTGGGTGTGCTCGATGAAGTCCAGCGGGATCAAATTATCAAGGCTGCCTCT
GCTGTTGCATCCGGTCTTCACGACGATCAGTTTCCACTGAGGGTGTGGCAAACCGGTAGCGGTACCCACACAAACATGAA
TGTCAACGAGGTGATTAGCAACCTGGCGTCTCAGGCAAACGACGAACCCCTAGGTAGCCATAGGCCGGTGCATCCAAACG
ATCATGTCAATCGATCCCAGTCCACCAATGACGCCTTCCCTACAGCTATACATATCGCCGCAGTCCAGGGGATCACCAAC
AACTTGCTGCCTGAACTGGAGCAATTGATCGCAGCCTTTGCCCGAAAAAGCGATGCCTGGAGTGACATCATCAAAATCGG
TCGCACTCATCTACAGGATGCCGTACCTCTCACCCTTGGTCAGGAGGCCTCTGCGTGGCGGGATCAAATTGCCTCAGCCC
ATAGTCGTATTCAGTCAAGCCTGATAGAGCTCTACCCCCTGCCGCTTGGAGGCACCGCCGTGGGAACAGGCCTCAACGCC
CCAGCTCGCTTCGGTCAAGAAACAGCTGCGCAACTTGCCAGCATCACAGGCCTGCCATTCAGCTCAGCGAAAAACAAGTT
CGCCGTGATGGCGAGCCATGACGGGTTAGTGAATGCAATGGCTCAGTTGCGCATGTTGGCGGTTGCCCTTTTCAAGATCT
CCAATGATCTGCGCCTACTGGCCTGTGGCCCAAGGGCCGGCCTGGCAGAGCTGCATCTACCTGAGAATGAGCCGGGAAGC
TCGATCATGCCTGGGAAAGTCAACCCCTCTCAATGCGAGGCCATGGCCATGGTCTGTTTACAGGTCATCGGGCTTGATTC
AGCCGTGACCATGGCAGGTGGGAGTGGTCATCTCCAAATGAACGTCTACAAACCCCTGATTGGCTTCAACCTGCTTCACA
GCATTGAATTGCTACATGACGCCTGCCGCAAGTACCGGCTGGCAATGGTGCAAGGGATTGAACCAAACCGAATCAAGATC
CAGCATGATCTAGAGCAATCGCTGATGCTAGTGACTGCTTTAGCCCCAGAAATCGGTTACGACAAAGCCAGTGAGATTGC
CCACCTCGCCCATGAGAAGGGATTCAGCCTGCGTGAAGCAGCACTAAAACTCGGCTATGTGAGCAAAGAAGACTTCGATC
GCATTGTTAATCCGGCATTGATGACATCTGCTCGGCTGTGA

Upstream 100 bases:

>100_bases
GCCAGACTTTTTACCATCATTGAATGGGTTCTAACGCGCTCTCAAACCCCACAAAACCAGTGAAGGTCAATTTGATCTGC
TTCTACCCCTTGCCGACAAC

Downstream 100 bases:

>100_bases
CCCCCCGATGACATCAAATTCTGGCGAATCAAGAAGCATCCAGAGTCAGAGTTCCGCACAGCAACGAATCAGCAATCTTC
ATGGTCAAGCCCAGCACGCC

Product: fumarate hydratase

Products: NA

Alternate protein names: Fumarase C

Number of amino acids: Translated: 466; Mature: 466

Protein sequence:

>466_residues
MMADLMRIEHDSMGTIEVPAGVLWGAQTQRSLLNFAISTDRMPVELIHALALIKQAAASVNCRLGVLDEVQRDQIIKAAS
AVASGLHDDQFPLRVWQTGSGTHTNMNVNEVISNLASQANDEPLGSHRPVHPNDHVNRSQSTNDAFPTAIHIAAVQGITN
NLLPELEQLIAAFARKSDAWSDIIKIGRTHLQDAVPLTLGQEASAWRDQIASAHSRIQSSLIELYPLPLGGTAVGTGLNA
PARFGQETAAQLASITGLPFSSAKNKFAVMASHDGLVNAMAQLRMLAVALFKISNDLRLLACGPRAGLAELHLPENEPGS
SIMPGKVNPSQCEAMAMVCLQVIGLDSAVTMAGGSGHLQMNVYKPLIGFNLLHSIELLHDACRKYRLAMVQGIEPNRIKI
QHDLEQSLMLVTALAPEIGYDKASEIAHLAHEKGFSLREAALKLGYVSKEDFDRIVNPALMTSARL

Sequences:

>Translated_466_residues
MMADLMRIEHDSMGTIEVPAGVLWGAQTQRSLLNFAISTDRMPVELIHALALIKQAAASVNCRLGVLDEVQRDQIIKAAS
AVASGLHDDQFPLRVWQTGSGTHTNMNVNEVISNLASQANDEPLGSHRPVHPNDHVNRSQSTNDAFPTAIHIAAVQGITN
NLLPELEQLIAAFARKSDAWSDIIKIGRTHLQDAVPLTLGQEASAWRDQIASAHSRIQSSLIELYPLPLGGTAVGTGLNA
PARFGQETAAQLASITGLPFSSAKNKFAVMASHDGLVNAMAQLRMLAVALFKISNDLRLLACGPRAGLAELHLPENEPGS
SIMPGKVNPSQCEAMAMVCLQVIGLDSAVTMAGGSGHLQMNVYKPLIGFNLLHSIELLHDACRKYRLAMVQGIEPNRIKI
QHDLEQSLMLVTALAPEIGYDKASEIAHLAHEKGFSLREAALKLGYVSKEDFDRIVNPALMTSARL
>Mature_466_residues
MMADLMRIEHDSMGTIEVPAGVLWGAQTQRSLLNFAISTDRMPVELIHALALIKQAAASVNCRLGVLDEVQRDQIIKAAS
AVASGLHDDQFPLRVWQTGSGTHTNMNVNEVISNLASQANDEPLGSHRPVHPNDHVNRSQSTNDAFPTAIHIAAVQGITN
NLLPELEQLIAAFARKSDAWSDIIKIGRTHLQDAVPLTLGQEASAWRDQIASAHSRIQSSLIELYPLPLGGTAVGTGLNA
PARFGQETAAQLASITGLPFSSAKNKFAVMASHDGLVNAMAQLRMLAVALFKISNDLRLLACGPRAGLAELHLPENEPGS
SIMPGKVNPSQCEAMAMVCLQVIGLDSAVTMAGGSGHLQMNVYKPLIGFNLLHSIELLHDACRKYRLAMVQGIEPNRIKI
QHDLEQSLMLVTALAPEIGYDKASEIAHLAHEKGFSLREAALKLGYVSKEDFDRIVNPALMTSARL

Specific function: Tricarboxylic acid cycle [C]

COG id: COG0114

COG function: function code C; Fumarase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily

Homologues:

Organism=Homo sapiens, GI19743875, Length=458, Percent_Identity=53.7117903930131, Blast_Score=468, Evalue=1e-132,
Organism=Homo sapiens, GI266458395, Length=62, Percent_Identity=54.8387096774194, Blast_Score=77, Evalue=3e-14,
Organism=Escherichia coli, GI1787896, Length=461, Percent_Identity=53.5791757049892, Blast_Score=482, Evalue=1e-137,
Organism=Escherichia coli, GI87082375, Length=457, Percent_Identity=39.6061269146608, Blast_Score=319, Evalue=2e-88,
Organism=Escherichia coli, GI1790398, Length=307, Percent_Identity=26.7100977198697, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17553882, Length=458, Percent_Identity=52.4017467248908, Blast_Score=471, Evalue=1e-133,
Organism=Caenorhabditis elegans, GI32565146, Length=323, Percent_Identity=52.0123839009288, Blast_Score=336, Evalue=2e-92,
Organism=Saccharomyces cerevisiae, GI6324993, Length=462, Percent_Identity=51.9480519480519, Blast_Score=459, Evalue=1e-130,
Organism=Drosophila melanogaster, GI24640179, Length=464, Percent_Identity=52.801724137931, Blast_Score=484, Evalue=1e-137,
Organism=Drosophila melanogaster, GI24640177, Length=459, Percent_Identity=53.1590413943355, Blast_Score=483, Evalue=1e-136,
Organism=Drosophila melanogaster, GI78710009, Length=460, Percent_Identity=51.5217391304348, Blast_Score=459, Evalue=1e-129,
Organism=Drosophila melanogaster, GI24662684, Length=459, Percent_Identity=50.7625272331155, Blast_Score=456, Evalue=1e-128,
Organism=Drosophila melanogaster, GI24583245, Length=459, Percent_Identity=47.276688453159, Blast_Score=434, Evalue=1e-122,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FUMC_PROMM (Q7V5R2)

Other databases:

- EMBL:   BX548175
- RefSeq:   NP_895312.1
- ProteinModelPortal:   Q7V5R2
- SMR:   Q7V5R2
- STRING:   Q7V5R2
- GeneID:   1728513
- GenomeReviews:   BX548175_GR
- KEGG:   pmt:PMT1485
- NMPDR:   fig|74547.1.peg.1479
- eggNOG:   COG0114
- HOGENOM:   HBG284369
- OMA:   RIEKDTM
- ProtClustDB:   PRK00485
- BioCyc:   PMAR74547:PMT1485-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00743
- InterPro:   IPR005677
- InterPro:   IPR018951
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761
- PRINTS:   PR00149

Pfam domain/function: PF10415 FumaraseC_C; PF00206 Lyase_1; SSF48557 L-Aspartase-like

EC number: =4.2.1.2

Molecular weight: Translated: 50233; Mature: 50233

Theoretical pI: Translated: 6.60; Mature: 6.60

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: BINDING 102-102

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMADLMRIEHDSMGTIEVPAGVLWGAQTQRSLLNFAISTDRMPVELIHALALIKQAAASV
CCCHHHHHCCCCCCCEECCCHHHCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCC
NCRLGVLDEVQRDQIIKAASAVASGLHDDQFPLRVWQTGSGTHTNMNVNEVISNLASQAN
CCEECCHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHCC
DEPLGSHRPVHPNDHVNRSQSTNDAFPTAIHIAAVQGITNNLLPELEQLIAAFARKSDAW
CCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHH
SDIIKIGRTHLQDAVPLTLGQEASAWRDQIASAHSRIQSSLIELYPLPLGGTAVGTGLNA
HHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHCCCCCC
PARFGQETAAQLASITGLPFSSAKNKFAVMASHDGLVNAMAQLRMLAVALFKISNDLRLL
CHHCCHHHHHHHHHHCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCEEE
ACGPRAGLAELHLPENEPGSSIMPGKVNPSQCEAMAMVCLQVIGLDSAVTMAGGSGHLQM
EECCCCCCCEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEECCCCCEEEE
NVYKPLIGFNLLHSIELLHDACRKYRLAMVQGIEPNRIKIQHDLEQSLMLVTALAPEIGY
EEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEHHHHHHHHHHHHHHCCCCCC
DKASEIAHLAHEKGFSLREAALKLGYVSKEDFDRIVNPALMTSARL
CHHHHHHHHHHHCCCHHHHHHHHHCCCCHHHHHHHCCHHHHHHCCC
>Mature Secondary Structure
MMADLMRIEHDSMGTIEVPAGVLWGAQTQRSLLNFAISTDRMPVELIHALALIKQAAASV
CCCHHHHHCCCCCCCEECCCHHHCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCC
NCRLGVLDEVQRDQIIKAASAVASGLHDDQFPLRVWQTGSGTHTNMNVNEVISNLASQAN
CCEECCHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHCC
DEPLGSHRPVHPNDHVNRSQSTNDAFPTAIHIAAVQGITNNLLPELEQLIAAFARKSDAW
CCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHH
SDIIKIGRTHLQDAVPLTLGQEASAWRDQIASAHSRIQSSLIELYPLPLGGTAVGTGLNA
HHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHCCCCCC
PARFGQETAAQLASITGLPFSSAKNKFAVMASHDGLVNAMAQLRMLAVALFKISNDLRLL
CHHCCHHHHHHHHHHCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCEEE
ACGPRAGLAELHLPENEPGSSIMPGKVNPSQCEAMAMVCLQVIGLDSAVTMAGGSGHLQM
EECCCCCCCEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEECCCCCEEEE
NVYKPLIGFNLLHSIELLHDACRKYRLAMVQGIEPNRIKIQHDLEQSLMLVTALAPEIGY
EEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEHHHHHHHHHHHHHHCCCCCC
DKASEIAHLAHEKGFSLREAALKLGYVSKEDFDRIVNPALMTSARL
CHHHHHHHHHHHCCCHHHHHHHHHCCCCHHHHHHHCCHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12917642