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The map label for this gene is hisB

Identifier: 33863722

GI number: 33863722

Start: 1541051

End: 1541836

Strand: Direct

Name: hisB

Synonym: PMT1455

Alternate gene names: NA

Gene position: 1541051-1541836 (Clockwise)

Preceding gene: 33863720

Following gene: 33863724

Centisome position: 63.92

GC content: 56.36

Gene sequence:

>786_bases
CTGAACCTGCAAGGCCTGCTGCTGTTTGACATCGACGGCGTGATCCGCGATGTAGCAGCCAGCTACCGCCGTGCCATCCA
GGAAACAGTGCACCATTACAGCGGCTGGCGGCCCAGCGTCGCTGAGATCGACGCACTCAAAACAGAAGGCATCTGGAATA
ACGACTGGGACGCCAGCCTGGAGCTCCTCAGACGTGATCAGAAAAGCCGTAACCAAGCCCTAGAGCTACCGAGCCGCGAG
CAGCTCATAGAGGTGTTTAGTCGTTTTTATTTTGGCGGTGATCCCAATGGCGACCCCAGCAATTGGCAGGGCTTTATCCG
CAATGAGCCACTGCTGGTGAATCACAGATTCTTTGAGGAGCTAAGTTCGCTCGGCTTCGCCTGGGGGTTTGTTAGCGGTG
CTGAGCCTCCTTCTGCCCGCTTTGTATTGGAACAACGCTTGGGGCTCAAGCATCCAACCTTGATCGCCATGGGCGAAGCA
CCTGATAAACCAGATCCCACTGGCCTGCTTCAACTAGCCAGCCAACTTGCTGGTAGGAGATTGGGTCAAGGCGTTCCAAC
AGTCGCCTACCTAGGCGACACGGTGGCCGATGTGCGCACAGTGATCAATGCCCGCCAGCAACAACCCGAGCAGCAATGGA
TGAGCTTGGCAGTCGCGCCACCCCATTTACATGGGATCGAGCAACAAGAAGCACGCAACGCCTATGAAGATCGACTGAAG
CAGGCCGGCGCCGATCACATTCTGAGCTGCACAACCGATGCGATCGAGACCCTCAAAAACTGGTAA

Upstream 100 bases:

>100_bases
TCTTGATCAGCGGCAGCGCCTTCGGAAACCGTCATGCTCTCTGCGCTCAAGGAATCTGAACAAACAACTAACCTAACAGT
CGCTCAACACTCTCTATCCA

Downstream 100 bases:

>100_bases
ACATGCTGCTCAGGGATTTGGTTGGAAGCATGGCTAATGCTTGAGAGCTGATGCCATCAGCCCATGGCTCGAGCCAAACG
CTTACTGCCGTCTGGCTGCA

Product: imidazoleglycerol-phosphate dehydratase

Products: 3-(imidazol-4-yl)-2-oxopropyl phosphate; H2O

Alternate protein names: HAD Family Hydrolase; HAD Superfamily Hydrolase; HAD Superfamily Phosphatase; HAD Superfamily Hydrolase TIGR

Number of amino acids: Translated: 261; Mature: 261

Protein sequence:

>261_residues
MNLQGLLLFDIDGVIRDVAASYRRAIQETVHHYSGWRPSVAEIDALKTEGIWNNDWDASLELLRRDQKSRNQALELPSRE
QLIEVFSRFYFGGDPNGDPSNWQGFIRNEPLLVNHRFFEELSSLGFAWGFVSGAEPPSARFVLEQRLGLKHPTLIAMGEA
PDKPDPTGLLQLASQLAGRRLGQGVPTVAYLGDTVADVRTVINARQQQPEQQWMSLAVAPPHLHGIEQQEARNAYEDRLK
QAGADHILSCTTDAIETLKNW

Sequences:

>Translated_261_residues
MNLQGLLLFDIDGVIRDVAASYRRAIQETVHHYSGWRPSVAEIDALKTEGIWNNDWDASLELLRRDQKSRNQALELPSRE
QLIEVFSRFYFGGDPNGDPSNWQGFIRNEPLLVNHRFFEELSSLGFAWGFVSGAEPPSARFVLEQRLGLKHPTLIAMGEA
PDKPDPTGLLQLASQLAGRRLGQGVPTVAYLGDTVADVRTVINARQQQPEQQWMSLAVAPPHLHGIEQQEARNAYEDRLK
QAGADHILSCTTDAIETLKNW
>Mature_261_residues
MNLQGLLLFDIDGVIRDVAASYRRAIQETVHHYSGWRPSVAEIDALKTEGIWNNDWDASLELLRRDQKSRNQALELPSRE
QLIEVFSRFYFGGDPNGDPSNWQGFIRNEPLLVNHRFFEELSSLGFAWGFVSGAEPPSARFVLEQRLGLKHPTLIAMGEA
PDKPDPTGLLQLASQLAGRRLGQGVPTVAYLGDTVADVRTVINARQQQPEQQWMSLAVAPPHLHGIEQQEARNAYEDRLK
QAGADHILSCTTDAIETLKNW

Specific function: Unknown

COG id: COG0546

COG function: function code R; Predicted phosphatases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: 4.2.1.19

Molecular weight: Translated: 29291; Mature: 29291

Theoretical pI: Translated: 5.16; Mature: 5.16

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLQGLLLFDIDGVIRDVAASYRRAIQETVHHYSGWRPSVAEIDALKTEGIWNNDWDASL
CCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCHHHHH
ELLRRDQKSRNQALELPSREQLIEVFSRFYFGGDPNGDPSNWQGFIRNEPLLVNHRFFEE
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCCCCHHHCCCCEEEHHHHHHH
LSSLGFAWGFVSGAEPPSARFVLEQRLGLKHPTLIAMGEAPDKPDPTGLLQLASQLAGRR
HHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHH
LGQGVPTVAYLGDTVADVRTVINARQQQPEQQWMSLAVAPPHLHGIEQQEARNAYEDRLK
HCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCHHHCCCCHHHHHHHHHHHHH
QAGADHILSCTTDAIETLKNW
HCCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNLQGLLLFDIDGVIRDVAASYRRAIQETVHHYSGWRPSVAEIDALKTEGIWNNDWDASL
CCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCHHHHH
ELLRRDQKSRNQALELPSREQLIEVFSRFYFGGDPNGDPSNWQGFIRNEPLLVNHRFFEE
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCCCCHHHCCCCEEEHHHHHHH
LSSLGFAWGFVSGAEPPSARFVLEQRLGLKHPTLIAMGEAPDKPDPTGLLQLASQLAGRR
HHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHH
LGQGVPTVAYLGDTVADVRTVINARQQQPEQQWMSLAVAPPHLHGIEQQEARNAYEDRLK
HCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCHHHCCCCHHHHHHHHHHHHH
QAGADHILSCTTDAIETLKNW
HCCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate

Specific reaction: D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + H2O

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA