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The map label for this gene is nagB [H]

Identifier: 33863691

GI number: 33863691

Start: 1511948

End: 1512784

Strand: Reverse

Name: nagB [H]

Synonym: PMT1424

Alternate gene names: 33863691

Gene position: 1512784-1511948 (Counterclockwise)

Preceding gene: 33863692

Following gene: 33863686

Centisome position: 62.75

GC content: 56.03

Gene sequence:

>837_bases
TTGAACCTCTTGCGGCCTTCTGTGGCCTCTGAGCAAGGGTTCGCGAGCACGATCACGGTGCGAGAGAACCTACCAAGCCT
TGTGGAAGCGGTTGTTGATGCGCTGGAGGGGCATCTAAGGCAGCGGCTGGGGGAGCAGAGGCCGAAACCGCTTGGCTTGG
CCACTGGCCGCACGATGGTGCCGATCTATGGCGAATTGGTGGCCCGTTTACAGCGTTGGCCAGCTGATGAGCTCGAGCAT
CTGCGGCGCAGCTGGTGCAGTTTCAATCTTGATGAGTATGTGGGCTTGGGGGCAGCTGATCGGCGCAGCTTTGCGGCCTA
TATGGCGCGTCATTTAGGCAAGCCGTTGCAATTGAGCCCGCAGCAGTTGCATCTTCCCGATGGCGAGGCGACTGATCCAG
AGCAGCAGGCTGGCAGTTATGCCGCTCAGTTGCAGAGTTTTGGTGGTGTTGGCGTGCAATTGCTGGGCTTAGGCAGCAAT
GGCCATGTGGGTTTCAATGAGCCGCCTTGTGGCCCAGAGGCGGCTTGCCGGGTGGTGGCGTTATCGCAGTCCACCCGGCA
ACAGAATGCTGCTGCTTTTGGTGGTGATCCAAGCCAGGTGCCATCTCAAGCACTCACGCTTGGATTAAAAGAAATACTCG
CGGCTGATGAGATTCATCTGATCGTGACGGGTTCAGCCAAAGCAGAGATTCTCAAGGCGTTGTTTGATTCGCCATGCACG
GATCAGTTGCCGGCAAGTTGGTTGCGCAATCATGCTCGGGTTTCACTTTGGCTAGACCAATTAGCTGTTACTGGAGAGAT
CGTTACTGAAGCGAATGACAGTTCAAAGTTGATTTGA

Upstream 100 bases:

>100_bases
CGCAGAGATTGTTCCCTATCGGCAGCTGCAGAATTCATCTTTGGCCTTCCTGTGGCGCTCTCGCCAGCCTGGAGGAGTTG
AGAGCATGGGAGACGCCTAA

Downstream 100 bases:

>100_bases
GTTTTACCTTTTGGTTGCTTATAAGGAAGCAAATTATTGGTAAAAGCAGGTAATTTATTGCATCGCAATAGGGTGCTATT
GGTATAGCATTTTGCCTTGT

Product: hypothetical protein

Products: NA

Alternate protein names: GlcN6P deaminase; GNPDA; Glucosamine-6-phosphate isomerase [H]

Number of amino acids: Translated: 278; Mature: 278

Protein sequence:

>278_residues
MNLLRPSVASEQGFASTITVRENLPSLVEAVVDALEGHLRQRLGEQRPKPLGLATGRTMVPIYGELVARLQRWPADELEH
LRRSWCSFNLDEYVGLGAADRRSFAAYMARHLGKPLQLSPQQLHLPDGEATDPEQQAGSYAAQLQSFGGVGVQLLGLGSN
GHVGFNEPPCGPEAACRVVALSQSTRQQNAAAFGGDPSQVPSQALTLGLKEILAADEIHLIVTGSAKAEILKALFDSPCT
DQLPASWLRNHARVSLWLDQLAVTGEIVTEANDSSKLI

Sequences:

>Translated_278_residues
MNLLRPSVASEQGFASTITVRENLPSLVEAVVDALEGHLRQRLGEQRPKPLGLATGRTMVPIYGELVARLQRWPADELEH
LRRSWCSFNLDEYVGLGAADRRSFAAYMARHLGKPLQLSPQQLHLPDGEATDPEQQAGSYAAQLQSFGGVGVQLLGLGSN
GHVGFNEPPCGPEAACRVVALSQSTRQQNAAAFGGDPSQVPSQALTLGLKEILAADEIHLIVTGSAKAEILKALFDSPCT
DQLPASWLRNHARVSLWLDQLAVTGEIVTEANDSSKLI
>Mature_278_residues
MNLLRPSVASEQGFASTITVRENLPSLVEAVVDALEGHLRQRLGEQRPKPLGLATGRTMVPIYGELVARLQRWPADELEH
LRRSWCSFNLDEYVGLGAADRRSFAAYMARHLGKPLQLSPQQLHLPDGEATDPEQQAGSYAAQLQSFGGVGVQLLGLGSN
GHVGFNEPPCGPEAACRVVALSQSTRQQNAAAFGGDPSQVPSQALTLGLKEILAADEIHLIVTGSAKAEILKALFDSPCT
DQLPASWLRNHARVSLWLDQLAVTGEIVTEANDSSKLI

Specific function: Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion [H]

COG id: COG0363

COG function: function code G; 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. NagB subfamily [H]

Homologues:

Organism=Homo sapiens, GI19923881, Length=220, Percent_Identity=30.4545454545455, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI13027378, Length=230, Percent_Identity=28.2608695652174, Blast_Score=114, Evalue=1e-25,
Organism=Escherichia coli, GI1786893, Length=214, Percent_Identity=30.8411214953271, Blast_Score=117, Evalue=1e-27,
Organism=Escherichia coli, GI1789530, Length=210, Percent_Identity=31.4285714285714, Blast_Score=86, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17554876, Length=212, Percent_Identity=30.188679245283, Blast_Score=122, Evalue=1e-28,
Organism=Drosophila melanogaster, GI24581960, Length=230, Percent_Identity=29.5652173913043, Blast_Score=122, Evalue=2e-28,
Organism=Drosophila melanogaster, GI19920764, Length=230, Percent_Identity=29.5652173913043, Blast_Score=122, Evalue=2e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006148
- InterPro:   IPR004547
- InterPro:   IPR018321 [H]

Pfam domain/function: PF01182 Glucosamine_iso [H]

EC number: =3.5.99.6 [H]

Molecular weight: Translated: 29914; Mature: 29914

Theoretical pI: Translated: 5.60; Mature: 5.60

Prosite motif: PS01161 GLC_GALNAC_ISOMERASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLLRPSVASEQGFASTITVRENLPSLVEAVVDALEGHLRQRLGEQRPKPLGLATGRTMV
CCCCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEH
PIYGELVARLQRWPADELEHLRRSWCSFNLDEYVGLGAADRRSFAAYMARHLGKPLQLSP
HHHHHHHHHHHHCCHHHHHHHHHHHHCCCHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCC
QQLHLPDGEATDPEQQAGSYAAQLQSFGGVGVQLLGLGSNGHVGFNEPPCGPEAACRVVA
CEEECCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCHHHHHHHHH
LSQSTRQQNAAAFGGDPSQVPSQALTLGLKEILAADEIHLIVTGSAKAEILKALFDSPCT
HHHHHHHHCCHHCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHCCCCC
DQLPASWLRNHARVSLWLDQLAVTGEIVTEANDSSKLI
CCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MNLLRPSVASEQGFASTITVRENLPSLVEAVVDALEGHLRQRLGEQRPKPLGLATGRTMV
CCCCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEH
PIYGELVARLQRWPADELEHLRRSWCSFNLDEYVGLGAADRRSFAAYMARHLGKPLQLSP
HHHHHHHHHHHHCCHHHHHHHHHHHHCCCHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCC
QQLHLPDGEATDPEQQAGSYAAQLQSFGGVGVQLLGLGSNGHVGFNEPPCGPEAACRVVA
CEEECCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCHHHHHHHHH
LSQSTRQQNAAAFGGDPSQVPSQALTLGLKEILAADEIHLIVTGSAKAEILKALFDSPCT
HHHHHHHHCCHHCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHCCCCC
DQLPASWLRNHARVSLWLDQLAVTGEIVTEANDSSKLI
CCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12235376 [H]