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The map label for this gene is purC [H]

Identifier: 33863681

GI number: 33863681

Start: 1501100

End: 1501828

Strand: Reverse

Name: purC [H]

Synonym: PMT1414

Alternate gene names: 33863681

Gene position: 1501828-1501100 (Counterclockwise)

Preceding gene: 33863682

Following gene: 33863680

Centisome position: 62.29

GC content: 54.6

Gene sequence:

>729_bases
ATGACGCCAGATCACGGCCCTCTGCTCTATGAGGGCAAGGCCAAAAGGGTCTTCGCTGCGGATCAGCCCGATCGTGTGTT
GGTGGAGTTCAAGAATGACGCCACGGCGTTTAATGCACTCAAAAGGGCTGAACTCGAGGGCAAGGGGCGACTGAATTGTC
AGATCTCGGCACGACTGTTCGAGATGCTTGAGCGCGAGGGTGTGCCCACCCACTACCTCGACCTGGTTTCCGAAACCTGG
ATGCTTGTTCAGCATGTTGATGTGATTCCCCTGGAGGTTGTGATTCGCAACGTGGCGACTGGATCGCTTTGTCAACAAAC
GCCTATTGCGGCCGGTACTGAGCTTTCGCCCGCTTTGTTGGACCTCTACTACAAGGACGACAATTTGGGAGATCCCCTGC
TGAGCGAATCAAGGCTGCAGCTGCTTGGATTAATCAGTTCGCAGCAGCGTTTAGAGATCGAACAGTTGGCCCGTCGGGTG
AATCAGCTGTTGCTGTCATTTTTTGAGAGCTTGGACCTGTTGTTGGTGGACTTCAAGCTCGAACTTGGACTCAACAGTGC
AGGCACTCTGCTGGTGGCGGATGAAATCAGTCCTGATACCTGCAGGCTTTGGGACCATCGAAATAGCGATCCCCAGGCCC
GCATCCTGGATAAGGATCGCTTCCGCCAGGACCTTGGTGGAGTGATTGAAGCCTACGGGGAGATCCTCAAACGGGTCCAA
GGGGTATGA

Upstream 100 bases:

>100_bases
TGCTAGAGCAAGAGCTGCGCTCGCCGCGTCAGCCTGGCGGCCATGCTGCTGTTGAAGCGCATCAAAGTGCGCCTCCTGTT
TCAGTTCCATCAGAATTCAA

Downstream 100 bases:

>100_bases
GCTAATTCCTACAACTGCAGGTAATGTCAGCGCACATTTGGCGGCTCTGTAGCCGGATTCCTATCACCCATGGCCAGCTT
CCTATCTAGCGGACCCTCGG

Product: phosphoribosylaminoimidazole-succinocarboxamide synthase

Products: NA

Alternate protein names: SAICAR synthetase [H]

Number of amino acids: Translated: 242; Mature: 241

Protein sequence:

>242_residues
MTPDHGPLLYEGKAKRVFAADQPDRVLVEFKNDATAFNALKRAELEGKGRLNCQISARLFEMLEREGVPTHYLDLVSETW
MLVQHVDVIPLEVVIRNVATGSLCQQTPIAAGTELSPALLDLYYKDDNLGDPLLSESRLQLLGLISSQQRLEIEQLARRV
NQLLLSFFESLDLLLVDFKLELGLNSAGTLLVADEISPDTCRLWDHRNSDPQARILDKDRFRQDLGGVIEAYGEILKRVQ
GV

Sequences:

>Translated_242_residues
MTPDHGPLLYEGKAKRVFAADQPDRVLVEFKNDATAFNALKRAELEGKGRLNCQISARLFEMLEREGVPTHYLDLVSETW
MLVQHVDVIPLEVVIRNVATGSLCQQTPIAAGTELSPALLDLYYKDDNLGDPLLSESRLQLLGLISSQQRLEIEQLARRV
NQLLLSFFESLDLLLVDFKLELGLNSAGTLLVADEISPDTCRLWDHRNSDPQARILDKDRFRQDLGGVIEAYGEILKRVQ
GV
>Mature_241_residues
TPDHGPLLYEGKAKRVFAADQPDRVLVEFKNDATAFNALKRAELEGKGRLNCQISARLFEMLEREGVPTHYLDLVSETWM
LVQHVDVIPLEVVIRNVATGSLCQQTPIAAGTELSPALLDLYYKDDNLGDPLLSESRLQLLGLISSQQRLEIEQLARRVN
QLLLSFFESLDLLLVDFKLELGLNSAGTLLVADEISPDTCRLWDHRNSDPQARILDKDRFRQDLGGVIEAYGEILKRVQG
V

Specific function: De novo purine biosynthesis; seventh step. [C]

COG id: COG0152

COG function: function code F; Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SAICAR synthetase family [H]

Homologues:

Organism=Homo sapiens, GI119220557, Length=226, Percent_Identity=31.4159292035398, Blast_Score=114, Evalue=6e-26,
Organism=Homo sapiens, GI5453539, Length=226, Percent_Identity=31.4159292035398, Blast_Score=114, Evalue=6e-26,
Organism=Homo sapiens, GI119220559, Length=233, Percent_Identity=30.0429184549356, Blast_Score=104, Evalue=7e-23,
Organism=Escherichia coli, GI1788820, Length=231, Percent_Identity=39.3939393939394, Blast_Score=181, Evalue=4e-47,
Organism=Caenorhabditis elegans, GI17531275, Length=236, Percent_Identity=32.6271186440678, Blast_Score=123, Evalue=1e-28,
Organism=Drosophila melanogaster, GI24583917, Length=207, Percent_Identity=30.4347826086957, Blast_Score=99, Evalue=2e-21,
Organism=Drosophila melanogaster, GI18860083, Length=210, Percent_Identity=30, Blast_Score=96, Evalue=2e-20,

Paralogues:

None

Copy number: 1680 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 13,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013816
- InterPro:   IPR001636
- InterPro:   IPR018236 [H]

Pfam domain/function: PF01259 SAICAR_synt [H]

EC number: =6.3.2.6 [H]

Molecular weight: Translated: 27181; Mature: 27049

Theoretical pI: Translated: 4.64; Mature: 4.64

Prosite motif: PS01057 SAICAR_SYNTHETASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPDHGPLLYEGKAKRVFAADQPDRVLVEFKNDATAFNALKRAELEGKGRLNCQISARLF
CCCCCCCEEECCCCCEEEECCCCCEEEEEECCCHHHHHHHHHHHCCCCCCEEEEHHHHHH
EMLEREGVPTHYLDLVSETWMLVQHVDVIPLEVVIRNVATGSLCQQTPIAAGTELSPALL
HHHHHCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCHHHCCCCCCCCCCCHHHH
DLYYKDDNLGDPLLSESRLQLLGLISSQQRLEIEQLARRVNQLLLSFFESLDLLLVDFKL
EEEECCCCCCCCHHHHHHHHHHHHHCCHHCCCHHHHHHHHHHHHHHHHHHHCEEEEEEEE
ELGLNSAGTLLVADEISPDTCRLWDHRNSDPQARILDKDRFRQDLGGVIEAYGEILKRVQ
EECCCCCCCEEEEECCCCCCEECCCCCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHC
GV
CC
>Mature Secondary Structure 
TPDHGPLLYEGKAKRVFAADQPDRVLVEFKNDATAFNALKRAELEGKGRLNCQISARLF
CCCCCCEEECCCCCEEEECCCCCEEEEEECCCHHHHHHHHHHHCCCCCCEEEEHHHHHH
EMLEREGVPTHYLDLVSETWMLVQHVDVIPLEVVIRNVATGSLCQQTPIAAGTELSPALL
HHHHHCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCHHHCCCCCCCCCCCHHHH
DLYYKDDNLGDPLLSESRLQLLGLISSQQRLEIEQLARRVNQLLLSFFESLDLLLVDFKL
EEEECCCCCCCCHHHHHHHHHHHHHCCHHCCCHHHHHHHHHHHHHHHHHHHCEEEEEEEE
ELGLNSAGTLLVADEISPDTCRLWDHRNSDPQARILDKDRFRQDLGGVIEAYGEILKRVQ
EECCCCCCCEEEEECCCCCCEECCCCCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHC
GV
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA