Click here to switch to the map view.

The map label for this gene is lpxC [H]

Identifier: 33863679

GI number: 33863679

Start: 1497885

End: 1498742

Strand: Reverse

Name: lpxC [H]

Synonym: PMT1412

Alternate gene names: 33863679

Gene position: 1498742-1497885 (Counterclockwise)

Preceding gene: 33863680

Following gene: 33863678

Centisome position: 62.17

GC content: 56.18

Gene sequence:

>858_bases
GTGGCTTTTTGGCCTACGAGTTATGACCGTGCTTGGACCCTAGGCGGAGCTGTCTCAAGACAAGGGATTGGGCTTCATGG
TGGGGAGGTCGCCGAGGTGCGTTTACAGCCTTCTGCTCAAGTTGGCTTCCATGTCTCCTGGCTGGACAACAGCGACTCAC
CAGTCACTTTGGGGCCGCATCAGGTTCGCGATAGTCAGCTTTGCACCACTTTGGAACTGGGCGACCGCCATTTAGGCACG
GTGGAACATCTACTGGCGGCCTTAGCGGGCTGTGGCTTGACCCATGTGGAGATCCAGGTTGGTGGTGAGGAAATACCGCT
TCTTGATGGTTCAGCTCTGGGCTGGGTGGAGGCGATAGCAGAGGTGGGCCTTACTCCTGCTGCAACCCCTCGTGCCGATC
CGCTCGTGCTTGAGCATGCTTTGGTGTGTCATCGCGGTAGCAGTGTGATCACAGCGACACCCGCCGAGCGCTTCAATGTT
GTTGGTGTGATTGATTTCCCCCAAGCTGCTATTGGTCATCAGATGCTGGCGATTGAGCTCACTCCAGAGGGGTTTACTGA
ACAGATTGCTCCGGCGAGAACATTTGGGTTTCGCGAACAGGTGGATCAGCTCTTGGCGGCGGGCCTCATCCAGGGGGGTG
CCCTCGACAATGCCTTGGTTTGTGATGGTGATCACTGGTTGAATCCTCCACTGCGATTTGCTGATGAACCAGTGCGCCAT
AAGCTCTTGGACTTGATCGGAGACCTTGCACTTGTGGGATTCCCTCAGGCTCAGGTTCTTGTCTATCGGGGGTCCCATGG
ACTCCATAACGATCTGGCCAATGCTCTCCTTGCCGTCTGTCCTGTCACTGTCTCTTGA

Upstream 100 bases:

>100_bases
TGATTGTTACCACTCCAGTAGGGCCATTGCGCCTTGAGGTTGCAACACAGGATTTCACCGATGAGTGGCGCTTTAATCTC
GGGGTTGGCTGGAAGTTCTA

Downstream 100 bases:

>100_bases
CCGATCCCTCTCCTAATCCTGTTGTGTTGACAAGTGAGCAGATCATGGGGCTGCTGCCTCATCGTTATCCGTTTGCTCTG
GTTGATCGTGTTGTGCTCCA

Product: UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase

Products: NA

Alternate protein names: UDP-3-O-acyl-GlcNAc deacetylase [H]

Number of amino acids: Translated: 285; Mature: 284

Protein sequence:

>285_residues
MAFWPTSYDRAWTLGGAVSRQGIGLHGGEVAEVRLQPSAQVGFHVSWLDNSDSPVTLGPHQVRDSQLCTTLELGDRHLGT
VEHLLAALAGCGLTHVEIQVGGEEIPLLDGSALGWVEAIAEVGLTPAATPRADPLVLEHALVCHRGSSVITATPAERFNV
VGVIDFPQAAIGHQMLAIELTPEGFTEQIAPARTFGFREQVDQLLAAGLIQGGALDNALVCDGDHWLNPPLRFADEPVRH
KLLDLIGDLALVGFPQAQVLVYRGSHGLHNDLANALLAVCPVTVS

Sequences:

>Translated_285_residues
MAFWPTSYDRAWTLGGAVSRQGIGLHGGEVAEVRLQPSAQVGFHVSWLDNSDSPVTLGPHQVRDSQLCTTLELGDRHLGT
VEHLLAALAGCGLTHVEIQVGGEEIPLLDGSALGWVEAIAEVGLTPAATPRADPLVLEHALVCHRGSSVITATPAERFNV
VGVIDFPQAAIGHQMLAIELTPEGFTEQIAPARTFGFREQVDQLLAAGLIQGGALDNALVCDGDHWLNPPLRFADEPVRH
KLLDLIGDLALVGFPQAQVLVYRGSHGLHNDLANALLAVCPVTVS
>Mature_284_residues
AFWPTSYDRAWTLGGAVSRQGIGLHGGEVAEVRLQPSAQVGFHVSWLDNSDSPVTLGPHQVRDSQLCTTLELGDRHLGTV
EHLLAALAGCGLTHVEIQVGGEEIPLLDGSALGWVEAIAEVGLTPAATPRADPLVLEHALVCHRGSSVITATPAERFNVV
GVIDFPQAAIGHQMLAIELTPEGFTEQIAPARTFGFREQVDQLLAAGLIQGGALDNALVCDGDHWLNPPLRFADEPVRHK
LLDLIGDLALVGFPQAQVLVYRGSHGLHNDLANALLAVCPVTVS

Specific function: Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell [H]

COG id: COG0774

COG function: function code M; UDP-3-O-acyl-N-acetylglucosamine deacetylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxC family [H]

Homologues:

Organism=Escherichia coli, GI1786285, Length=276, Percent_Identity=35.5072463768116, Blast_Score=141, Evalue=5e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020568
- InterPro:   IPR004463
- InterPro:   IPR011334
- InterPro:   IPR015870 [H]

Pfam domain/function: PF03331 LpxC [H]

EC number: 3.5.1.-

Molecular weight: Translated: 30239; Mature: 30108

Theoretical pI: Translated: 4.73; Mature: 4.73

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
0.4 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAFWPTSYDRAWTLGGAVSRQGIGLHGGEVAEVRLQPSAQVGFHVSWLDNSDSPVTLGPH
CCCCCCCCCCEEEECCCCCCCCCCCCCCCEEEEEECCCCCCCEEEEEECCCCCCEEECHH
QVRDSQLCTTLELGDRHLGTVEHLLAALAGCGLTHVEIQVGGEEIPLLDGSALGWVEAIA
HCCCCHHEEEEECCCCCCCHHHHHHHHHHCCCCEEEEEEECCCCCCEECCCHHHHHHHHH
EVGLTPAATPRADPLVLEHALVCHRGSSVITATPAERFNVVGVIDFPQAAIGHQMLAIEL
HCCCCCCCCCCCCHHHHHHHHHHCCCCCEEEECCHHHEEEEEEEECCCHHHCCEEEEEEE
TPEGFTEQIAPARTFGFREQVDQLLAAGLIQGGALDNALVCDGDHWLNPPLRFADEPVRH
CCCCCHHHHCHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEECCCCCCCCCHHCCCCHHHH
KLLDLIGDLALVGFPQAQVLVYRGSHGLHNDLANALLAVCPVTVS
HHHHHHHHHHHCCCCCEEEEEEECCCCCHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
AFWPTSYDRAWTLGGAVSRQGIGLHGGEVAEVRLQPSAQVGFHVSWLDNSDSPVTLGPH
CCCCCCCCCEEEECCCCCCCCCCCCCCCEEEEEECCCCCCCEEEEEECCCCCCEEECHH
QVRDSQLCTTLELGDRHLGTVEHLLAALAGCGLTHVEIQVGGEEIPLLDGSALGWVEAIA
HCCCCHHEEEEECCCCCCCHHHHHHHHHHCCCCEEEEEEECCCCCCEECCCHHHHHHHHH
EVGLTPAATPRADPLVLEHALVCHRGSSVITATPAERFNVVGVIDFPQAAIGHQMLAIEL
HCCCCCCCCCCCCHHHHHHHHHHCCCCCEEEECCHHHEEEEEEEECCCHHHCCEEEEEEE
TPEGFTEQIAPARTFGFREQVDQLLAAGLIQGGALDNALVCDGDHWLNPPLRFADEPVRH
CCCCCHHHHCHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEECCCCCCCCCHHCCCCHHHH
KLLDLIGDLALVGFPQAQVLVYRGSHGLHNDLANALLAVCPVTVS
HHHHHHHHHHHCCCCCEEEEEEECCCCCHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on carbon-nitrogen bonds, other than peptide bonds; In linear amides [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12240834 [H]