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The map label for this gene is pepA

Identifier: 33863674

GI number: 33863674

Start: 1492628

End: 1494100

Strand: Direct

Name: pepA

Synonym: PMT1407

Alternate gene names: 33863674

Gene position: 1492628-1494100 (Clockwise)

Preceding gene: 33863673

Following gene: 33863683

Centisome position: 61.91

GC content: 57.3

Gene sequence:

>1473_bases
ATGGAGATTTGCCTTTTTCCAGCAACCTTGCAGAGCTGGACTGGCGATGTGCTCATGGTGGGCATGTTTGAGGGAAAGAT
GGAGGAACGTTTAAACGAGCTGGAAACACTCTGCAAAGGCTCTCTGATGCAGAGCCTTGAGAAGCAGATGTTCAAAGGCA
AATCCGGAGAAATCGCCACCGTTCAACTGCTCCAAAACAAGCCAAACCTGCTGGTGCTCGTAGGGCTCGGAGAACCCCAG
GAGATGAGGCTTGACGACCTTCGCAAGGCGGCTGCCCTAGGAGCGAAAGCAAGCCTCGGATGTAGTGGAACCCTGGGGAT
GATGCTCCCCTGGGAGCCCTTAGATGCGGCATCTGCAGCAAGGGCCGTCGCAGAAGCCGTTCGCCTTTCCCTATATAAAG
ACCTCCGCTTTCGCAGTGCTCCTGAGCCCCGCTCTACGCCAACAAAACTGGAGCTCATTGGTCTGCCCGACTCAGCCGGC
AAAGATCTTCAAGCCGTTCACCCCACCTGTGCCGGAGTGGAGCTAGCAAGGCAGCTGGTTGCGGCTCCTGCCAACAGTCT
TACCCCTGCGGCCCTCGCCCAAACAGCGATTCAACTTGCCCACGAACACGGCCTCGAGTGCAGTGTGCTGGAGCGGTCTG
ACTGCGCCGAACGGGAAATGGGTGCCTACCTAGCAGTCTCTCAAGGTTCTGATCTGGAGCCAAAATTCATTCACCTCACC
TATCGCCCTCAAGGACCAGTTCAACGACGACTTGCCCTTGTCGGCAAGGGACTCACCTTCGATTCCGGTGGATACAACCT
CAAGGTTGGAGCTGCCCAGATCGATCTGATGAAATTCGACATGGGCGGCAGCGCAGCTGTACTTGGGGCCGCCCGAGCGA
TTGCAGAACTGCGACCCAAGGGAGTGGAAGTGCATGTGATCGTGGCAGCCTGCGAAAACATGGTGAATGGATCAGCTGTC
CATCCAGGAGACCTCGTGCGGGCCTCAAACGGCACCACCATCGAGATCAATAACACCGATGCCGAAGGCCGTCTGACCCT
TGCCGATGCACTGGTATACACCTGCGGACTCGAACCAGACGCAATCGTGGATTTAGCAACCCTTACAGGGGCTTGCGTTA
TCGCACTTGGCGAAGAGATCGCTGGCCTTTGGACAGGTCATGATCCCCTGGCTGAGGGCCTAACCGCTGCAGCCGAAGCG
GCCGGCGAAGGCCTGTGGCGCATGCCATTGCCAAGCTCCTATCGAGAGGGTCTCAAATCCAACCTCGCTGACCTCAAGAA
CACAGGACCCCGTCCAGGCGGATCCATTACCGCGGCCCTTTTCCTCAAAGAGTTTGTTGAGGCCTCCATCCCATGGGCCC
ACATCGACATCGCCGGAACGGTCTGGTCTGAAAAGGGCCGTGGCCTCAATCCATCTGGTGCCACCGGCTACGGGGTTCGC
ACTTTGGTGAATTGGATTTGTAGTCAGTCTTGA

Upstream 100 bases:

>100_bases
CACCGTTCAACAAAGAAACAAGAGCTCGCTGGAGCACCCCGTTCACAGCTGAATGCAGCTAAACGGCACGGCTAACATCG
CTCCACCTCATCAACATCCC

Downstream 100 bases:

>100_bases
GTCAAGAGGCATTGCATGCAACTCAGCGAAAAATGAGCTGAAGAAGGAATCACAACACGAGTACAACGTTGATCGCTAAA
GGTCGCGCAGGGTTGGCAAT

Product: leucyl aminopeptidase

Products: NA

Alternate protein names: Leucine aminopeptidase; LAP; Leucyl aminopeptidase

Number of amino acids: Translated: 490; Mature: 490

Protein sequence:

>490_residues
MEICLFPATLQSWTGDVLMVGMFEGKMEERLNELETLCKGSLMQSLEKQMFKGKSGEIATVQLLQNKPNLLVLVGLGEPQ
EMRLDDLRKAAALGAKASLGCSGTLGMMLPWEPLDAASAARAVAEAVRLSLYKDLRFRSAPEPRSTPTKLELIGLPDSAG
KDLQAVHPTCAGVELARQLVAAPANSLTPAALAQTAIQLAHEHGLECSVLERSDCAEREMGAYLAVSQGSDLEPKFIHLT
YRPQGPVQRRLALVGKGLTFDSGGYNLKVGAAQIDLMKFDMGGSAAVLGAARAIAELRPKGVEVHVIVAACENMVNGSAV
HPGDLVRASNGTTIEINNTDAEGRLTLADALVYTCGLEPDAIVDLATLTGACVIALGEEIAGLWTGHDPLAEGLTAAAEA
AGEGLWRMPLPSSYREGLKSNLADLKNTGPRPGGSITAALFLKEFVEASIPWAHIDIAGTVWSEKGRGLNPSGATGYGVR
TLVNWICSQS

Sequences:

>Translated_490_residues
MEICLFPATLQSWTGDVLMVGMFEGKMEERLNELETLCKGSLMQSLEKQMFKGKSGEIATVQLLQNKPNLLVLVGLGEPQ
EMRLDDLRKAAALGAKASLGCSGTLGMMLPWEPLDAASAARAVAEAVRLSLYKDLRFRSAPEPRSTPTKLELIGLPDSAG
KDLQAVHPTCAGVELARQLVAAPANSLTPAALAQTAIQLAHEHGLECSVLERSDCAEREMGAYLAVSQGSDLEPKFIHLT
YRPQGPVQRRLALVGKGLTFDSGGYNLKVGAAQIDLMKFDMGGSAAVLGAARAIAELRPKGVEVHVIVAACENMVNGSAV
HPGDLVRASNGTTIEINNTDAEGRLTLADALVYTCGLEPDAIVDLATLTGACVIALGEEIAGLWTGHDPLAEGLTAAAEA
AGEGLWRMPLPSSYREGLKSNLADLKNTGPRPGGSITAALFLKEFVEASIPWAHIDIAGTVWSEKGRGLNPSGATGYGVR
TLVNWICSQS
>Mature_490_residues
MEICLFPATLQSWTGDVLMVGMFEGKMEERLNELETLCKGSLMQSLEKQMFKGKSGEIATVQLLQNKPNLLVLVGLGEPQ
EMRLDDLRKAAALGAKASLGCSGTLGMMLPWEPLDAASAARAVAEAVRLSLYKDLRFRSAPEPRSTPTKLELIGLPDSAG
KDLQAVHPTCAGVELARQLVAAPANSLTPAALAQTAIQLAHEHGLECSVLERSDCAEREMGAYLAVSQGSDLEPKFIHLT
YRPQGPVQRRLALVGKGLTFDSGGYNLKVGAAQIDLMKFDMGGSAAVLGAARAIAELRPKGVEVHVIVAACENMVNGSAV
HPGDLVRASNGTTIEINNTDAEGRLTLADALVYTCGLEPDAIVDLATLTGACVIALGEEIAGLWTGHDPLAEGLTAAAEA
AGEGLWRMPLPSSYREGLKSNLADLKNTGPRPGGSITAALFLKEFVEASIPWAHIDIAGTVWSEKGRGLNPSGATGYGVR
TLVNWICSQS

Specific function: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides

COG id: COG0260

COG function: function code E; Leucyl aminopeptidase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M17 family

Homologues:

Organism=Homo sapiens, GI41393561, Length=487, Percent_Identity=34.2915811088296, Blast_Score=224, Evalue=1e-58,
Organism=Homo sapiens, GI47155554, Length=329, Percent_Identity=33.434650455927, Blast_Score=137, Evalue=3e-32,
Organism=Escherichia coli, GI1790710, Length=514, Percent_Identity=36.3813229571984, Blast_Score=254, Evalue=1e-68,
Organism=Escherichia coli, GI87082123, Length=353, Percent_Identity=37.6770538243626, Blast_Score=195, Evalue=6e-51,
Organism=Caenorhabditis elegans, GI17556903, Length=310, Percent_Identity=32.9032258064516, Blast_Score=128, Evalue=7e-30,
Organism=Caenorhabditis elegans, GI17565172, Length=360, Percent_Identity=26.3888888888889, Blast_Score=82, Evalue=4e-16,
Organism=Drosophila melanogaster, GI21355725, Length=368, Percent_Identity=33.4239130434783, Blast_Score=173, Evalue=2e-43,
Organism=Drosophila melanogaster, GI24661038, Length=368, Percent_Identity=33.1521739130435, Blast_Score=173, Evalue=2e-43,
Organism=Drosophila melanogaster, GI20129969, Length=492, Percent_Identity=28.6585365853659, Blast_Score=158, Evalue=7e-39,
Organism=Drosophila melanogaster, GI21355645, Length=483, Percent_Identity=28.3643892339545, Blast_Score=151, Evalue=1e-36,
Organism=Drosophila melanogaster, GI24662223, Length=483, Percent_Identity=28.3643892339545, Blast_Score=151, Evalue=1e-36,
Organism=Drosophila melanogaster, GI24662227, Length=411, Percent_Identity=28.2238442822384, Blast_Score=146, Evalue=3e-35,
Organism=Drosophila melanogaster, GI161077148, Length=321, Percent_Identity=31.7757009345794, Blast_Score=144, Evalue=9e-35,
Organism=Drosophila melanogaster, GI20130057, Length=321, Percent_Identity=31.7757009345794, Blast_Score=144, Evalue=9e-35,
Organism=Drosophila melanogaster, GI20129963, Length=447, Percent_Identity=29.082774049217, Blast_Score=142, Evalue=5e-34,
Organism=Drosophila melanogaster, GI19922386, Length=427, Percent_Identity=30.6791569086651, Blast_Score=132, Evalue=7e-31,
Organism=Drosophila melanogaster, GI221379063, Length=328, Percent_Identity=29.8780487804878, Blast_Score=126, Evalue=3e-29,
Organism=Drosophila melanogaster, GI221379062, Length=328, Percent_Identity=29.8780487804878, Blast_Score=126, Evalue=3e-29,
Organism=Drosophila melanogaster, GI21357381, Length=328, Percent_Identity=29.8780487804878, Blast_Score=126, Evalue=3e-29,
Organism=Drosophila melanogaster, GI24646701, Length=324, Percent_Identity=28.7037037037037, Blast_Score=99, Evalue=9e-21,
Organism=Drosophila melanogaster, GI24646703, Length=324, Percent_Identity=28.7037037037037, Blast_Score=99, Evalue=9e-21,
Organism=Drosophila melanogaster, GI21358201, Length=324, Percent_Identity=28.7037037037037, Blast_Score=99, Evalue=9e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): AMPA_PROMM (Q7V5X8)

Other databases:

- EMBL:   BX548175
- RefSeq:   NP_895234.1
- ProteinModelPortal:   Q7V5X8
- SMR:   Q7V5X8
- STRING:   Q7V5X8
- MEROPS:   M17.002
- GeneID:   1728152
- GenomeReviews:   BX548175_GR
- KEGG:   pmt:PMT1407
- NMPDR:   fig|74547.1.peg.1401
- eggNOG:   COG0260
- HOGENOM:   HBG742580
- OMA:   CKPTRII
- ProtClustDB:   PRK00913
- BioCyc:   PMAR74547:PMT1407-MONOMER
- GO:   GO:0005737
- GO:   GO:0006508
- HAMAP:   MF_00181
- InterPro:   IPR011356
- InterPro:   IPR000819
- InterPro:   IPR023042
- InterPro:   IPR008283
- PANTHER:   PTHR11963:SF3
- PRINTS:   PR00481

Pfam domain/function: PF00883 Peptidase_M17; PF02789 Peptidase_M17_N

EC number: =3.4.11.1; =3.4.11.10

Molecular weight: Translated: 51729; Mature: 51729

Theoretical pI: Translated: 5.02; Mature: 5.02

Prosite motif: PS00631 CYTOSOL_AP

Important sites: ACT_SITE 268-268 ACT_SITE 344-344

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEICLFPATLQSWTGDVLMVGMFEGKMEERLNELETLCKGSLMQSLEKQMFKGKSGEIAT
CEEEEECHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEE
VQLLQNKPNLLVLVGLGEPQEMRLDDLRKAAALGAKASLGCSGTLGMMLPWEPLDAASAA
EEEECCCCCEEEEEECCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHH
RAVAEAVRLSLYKDLRFRSAPEPRSTPTKLELIGLPDSAGKDLQAVHPTCAGVELARQLV
HHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCCCCCHHCCCCHHHHHHHHHHH
AAPANSLTPAALAQTAIQLAHEHGLECSVLERSDCAEREMGAYLAVSQGSDLEPKFIHLT
HCCCCCCCHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHCCCEEEECCCCCCCCEEEEEE
YRPQGPVQRRLALVGKGLTFDSGGYNLKVGAAQIDLMKFDMGGSAAVLGAARAIAELRPK
ECCCCHHHHHHHHHCCCCEECCCCCEEEECCEEEEEEEECCCCCHHHHHHHHHHHHHCCC
GVEVHVIVAACENMVNGSAVHPGDLVRASNGTTIEINNTDAEGRLTLADALVYTCGLEPD
CCEEEEEHHHHHHHCCCCCCCCCCEEECCCCCEEEEECCCCCCEEEHHHHHHHHCCCCCH
AIVDLATLTGACVIALGEEIAGLWTGHDPLAEGLTAAAEAAGEGLWRMPLPSSYREGLKS
HHHHHHHHHHHHHEEHHHHHHHEECCCCHHHHHHHHHHHHHCCCEEECCCCHHHHHHHHH
NLADLKNTGPRPGGSITAALFLKEFVEASIPWAHIDIAGTVWSEKGRGLNPSGATGYGVR
HHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEEEEEEECCCCCCCCCCCCCCHHHH
TLVNWICSQS
HHHHHHHCCC
>Mature Secondary Structure
MEICLFPATLQSWTGDVLMVGMFEGKMEERLNELETLCKGSLMQSLEKQMFKGKSGEIAT
CEEEEECHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEE
VQLLQNKPNLLVLVGLGEPQEMRLDDLRKAAALGAKASLGCSGTLGMMLPWEPLDAASAA
EEEECCCCCEEEEEECCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHH
RAVAEAVRLSLYKDLRFRSAPEPRSTPTKLELIGLPDSAGKDLQAVHPTCAGVELARQLV
HHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCCCCCHHCCCCHHHHHHHHHHH
AAPANSLTPAALAQTAIQLAHEHGLECSVLERSDCAEREMGAYLAVSQGSDLEPKFIHLT
HCCCCCCCHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHCCCEEEECCCCCCCCEEEEEE
YRPQGPVQRRLALVGKGLTFDSGGYNLKVGAAQIDLMKFDMGGSAAVLGAARAIAELRPK
ECCCCHHHHHHHHHCCCCEECCCCCEEEECCEEEEEEEECCCCCHHHHHHHHHHHHHCCC
GVEVHVIVAACENMVNGSAVHPGDLVRASNGTTIEINNTDAEGRLTLADALVYTCGLEPD
CCEEEEEHHHHHHHCCCCCCCCCCEEECCCCCEEEEECCCCCCEEEHHHHHHHHCCCCCH
AIVDLATLTGACVIALGEEIAGLWTGHDPLAEGLTAAAEAAGEGLWRMPLPSSYREGLKS
HHHHHHHHHHHHHEEHHHHHHHEECCCCHHHHHHHHHHHHHCCCEEECCCCHHHHHHHHH
NLADLKNTGPRPGGSITAALFLKEFVEASIPWAHIDIAGTVWSEKGRGLNPSGATGYGVR
HHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEEEEEEECCCCCCCCCCCCCCHHHH
TLVNWICSQS
HHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12917642