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The map label for this gene is gluQ [H]

Identifier: 33863661

GI number: 33863661

Start: 1480254

End: 1481174

Strand: Reverse

Name: gluQ [H]

Synonym: PMT1394

Alternate gene names: 33863661

Gene position: 1481174-1480254 (Counterclockwise)

Preceding gene: 33863662

Following gene: 33863660

Centisome position: 61.44

GC content: 57.0

Gene sequence:

>921_bases
ATGGCCAAGTCCTCTGCACTGCCTGATCATCTGTATGAGCAGATGGAAGTGGGGCAGCGCCTTAGGAATCAGGGCTATCG
GGGCCGGTTTGCCCCGTCTCCGACCGGACCATTACACCTGGGCAATCTGTGCACTGCTCTGGTGTCTTGGTTGCAAGCGC
GCTTGGCTAATGGGGCTTGGCTGTTGCGGGTGGATGACCTGGATCAGCCTCGCAATCGTGTGGGAGCGGTTGAGAGCCTC
CAGCAGGATTTGCACTGGCTAGGCCTTGAGTGGGATGGCCCCGTGGTGTTTCAGAGCCGCCGCCGTGGGATTTACAACTC
TTTCCTCTCGGCTCTGCGGCGTCAGGGGAAGTTGTATGCCTGTCGATGTAGCCGGCGAATGTTGGCTGACATCTCAGCAC
CAGCTGGGCGGCACTTGGTTTACCCAGGCACGTGTCGAGATCTGGAGCTGTTTTGGGGGTGGCATGAGGGCAGGCTGCCC
AGTTGGCGTTTAAGGGTGAGCAAAGAGTTCTCCCATACCAGTGGGGATGTGATTTTGCGGCGCGCTGATGGTTTTATCGC
TTATCACTTGGCGACGGTTGTTGATGAACTGACTCTCGGGATTAGCGAGGTGGTACGCGGTGAAGACTTGCTTGACGCCA
TGAATGCACAGCTCGCTTTGATCAATGCGATTTCAGAGCGGCCTGTGATCTATCGCCACGTGCCGTTGTTGTGTGATGAC
CAAGGCCGCAAGTTGGCCAAGCGCGAGGGACATGCTGGTTTGGACAGCCTGCGTTCCGAGGGACTGGGGCCTTCTCATGT
GGTGGGCTGGCTGGCTGCTAGCCAGAGCCTTGTTCCTTTTGGTGCTGAACTCACGGCAGGGGAGTTATTGAGTGAGTTGA
AGAAGAAGGAGGGGGTTTTGAAAAGCGTGCTGAAACCTTAA

Upstream 100 bases:

>100_bases
GTTCAGGGCTGATTTTTTAGCCTTTGTTTGCAGACGGGCGGTCGTCACGGCCGCCTTTTATTTGTGGGCCTACTGAGCCA
GGGCTCCTTCCATTGATTCA

Downstream 100 bases:

>100_bases
AGGAGCAACGGCTCTAATTCTTAACGAAGCCTTCGGGATCACAAGCGCAAAAATGTATGAAAATAAAAAGCCACATAATG
CACACAATCAATGTCGATCT

Product: glutamyl/glutaminyl-tRNA synthetase

Products: NA

Alternate protein names: Glu-Q-RSs [H]

Number of amino acids: Translated: 306; Mature: 305

Protein sequence:

>306_residues
MAKSSALPDHLYEQMEVGQRLRNQGYRGRFAPSPTGPLHLGNLCTALVSWLQARLANGAWLLRVDDLDQPRNRVGAVESL
QQDLHWLGLEWDGPVVFQSRRRGIYNSFLSALRRQGKLYACRCSRRMLADISAPAGRHLVYPGTCRDLELFWGWHEGRLP
SWRLRVSKEFSHTSGDVILRRADGFIAYHLATVVDELTLGISEVVRGEDLLDAMNAQLALINAISERPVIYRHVPLLCDD
QGRKLAKREGHAGLDSLRSEGLGPSHVVGWLAASQSLVPFGAELTAGELLSELKKKEGVLKSVLKP

Sequences:

>Translated_306_residues
MAKSSALPDHLYEQMEVGQRLRNQGYRGRFAPSPTGPLHLGNLCTALVSWLQARLANGAWLLRVDDLDQPRNRVGAVESL
QQDLHWLGLEWDGPVVFQSRRRGIYNSFLSALRRQGKLYACRCSRRMLADISAPAGRHLVYPGTCRDLELFWGWHEGRLP
SWRLRVSKEFSHTSGDVILRRADGFIAYHLATVVDELTLGISEVVRGEDLLDAMNAQLALINAISERPVIYRHVPLLCDD
QGRKLAKREGHAGLDSLRSEGLGPSHVVGWLAASQSLVPFGAELTAGELLSELKKKEGVLKSVLKP
>Mature_305_residues
AKSSALPDHLYEQMEVGQRLRNQGYRGRFAPSPTGPLHLGNLCTALVSWLQARLANGAWLLRVDDLDQPRNRVGAVESLQ
QDLHWLGLEWDGPVVFQSRRRGIYNSFLSALRRQGKLYACRCSRRMLADISAPAGRHLVYPGTCRDLELFWGWHEGRLPS
WRLRVSKEFSHTSGDVILRRADGFIAYHLATVVDELTLGISEVVRGEDLLDAMNAQLALINAISERPVIYRHVPLLCDDQ
GRKLAKREGHAGLDSLRSEGLGPSHVVGWLAASQSLVPFGAELTAGELLSELKKKEGVLKSVLKP

Specific function: Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble positi

COG id: COG0008

COG function: function code J; Glutamyl- and glutaminyl-tRNA synthetases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I aminoacyl-tRNA synthetase family. GluQ subfamily [H]

Homologues:

Organism=Homo sapiens, GI134288884, Length=312, Percent_Identity=33.0128205128205, Blast_Score=138, Evalue=6e-33,
Organism=Escherichia coli, GI226510925, Length=260, Percent_Identity=36.5384615384615, Blast_Score=150, Evalue=7e-38,
Organism=Escherichia coli, GI1788743, Length=261, Percent_Identity=33.3333333333333, Blast_Score=149, Evalue=2e-37,
Organism=Saccharomyces cerevisiae, GI6324540, Length=274, Percent_Identity=34.3065693430657, Blast_Score=144, Evalue=2e-35,
Organism=Drosophila melanogaster, GI24665321, Length=278, Percent_Identity=35.9712230215827, Blast_Score=143, Evalue=2e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001412
- InterPro:   IPR022380
- InterPro:   IPR000924
- InterPro:   IPR020058
- InterPro:   IPR014729 [H]

Pfam domain/function: PF00749 tRNA-synt_1c [H]

EC number: NA

Molecular weight: Translated: 34098; Mature: 33966

Theoretical pI: Translated: 9.20; Mature: 9.20

Prosite motif: PS00178 AA_TRNA_LIGASE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKSSALPDHLYEQMEVGQRLRNQGYRGRFAPSPTGPLHLGNLCTALVSWLQARLANGAW
CCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCEE
LLRVDDLDQPRNRVGAVESLQQDLHWLGLEWDGPVVFQSRRRGIYNSFLSALRRQGKLYA
EEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCHHHHHHHHHHHHCCCEEE
CRCSRRMLADISAPAGRHLVYPGTCRDLELFWGWHEGRLPSWRLRVSKEFSHTSGDVILR
EHHHHHHHHHCCCCCCCEEECCCCCCCCCEEEEECCCCCCCCEEEEEHHCCCCCCCEEEE
RADGFIAYHLATVVDELTLGISEVVRGEDLLDAMNAQLALINAISERPVIYRHVPLLCDD
ECCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCEEEEECCEEECC
QGRKLAKREGHAGLDSLRSEGLGPSHVVGWLAASQSLVPFGAELTAGELLSELKKKEGVL
CCHHHHHHCCCCCHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHH
KSVLKP
HHHCCC
>Mature Secondary Structure 
AKSSALPDHLYEQMEVGQRLRNQGYRGRFAPSPTGPLHLGNLCTALVSWLQARLANGAW
CCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCEE
LLRVDDLDQPRNRVGAVESLQQDLHWLGLEWDGPVVFQSRRRGIYNSFLSALRRQGKLYA
EEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCHHHHHHHHHHHHCCCEEE
CRCSRRMLADISAPAGRHLVYPGTCRDLELFWGWHEGRLPSWRLRVSKEFSHTSGDVILR
EHHHHHHHHHCCCCCCCEEECCCCCCCCCEEEEECCCCCCCCEEEEEHHCCCCCCCEEEE
RADGFIAYHLATVVDELTLGISEVVRGEDLLDAMNAQLALINAISERPVIYRHVPLLCDD
ECCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCEEEEECCEEECC
QGRKLAKREGHAGLDSLRSEGLGPSHVVGWLAASQSLVPFGAELTAGELLSELKKKEGVL
CCHHHHHHCCCCCHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHH
KSVLKP
HHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA