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The map label for this gene is ctaB [H]

Identifier: 33863606

GI number: 33863606

Start: 1424461

End: 1425462

Strand: Reverse

Name: ctaB [H]

Synonym: PMT1339

Alternate gene names: 33863606

Gene position: 1425462-1424461 (Counterclockwise)

Preceding gene: 33863607

Following gene: 33863605

Centisome position: 59.13

GC content: 56.79

Gene sequence:

>1002_bases
ATGGTTAGTTCAACGCCAGAGATGCTCCAGGGGGGGGTGACCCGCGAGCAGATCGTGCCTTCTCGCAAGCGGATCAAGCT
GCCCGCTTGGTTGGAGATTGCCAAACCACGCTTAATTCCACTGCTTTTGGCCACAACCCTTGGTGGGATGGCGCTATCCG
AAGGTTGGCCCCTACCTTCTCTCAGGCTGGCCTGCACCCTAGGAGGAGGGGCTCTGGCTGCTGCGGCTGCTGGTGTTCTC
AACTGCATTTGGGAACAGGATCTTGATGGGCGCATGCAACGCACAAGTGGTAGGGCTTTGCCTTCAGGACGCTTGTCTCC
AACTGCGGCGTTCATTGGTGCCATCTCTTGCACCTTGGCGGCAGCGGCTCTGTTAGTGAGTGGTGTGAACTGTCTTGCGG
CTGGCCTGTCTTTGCTTGGTCTGTGCAGTTACGTGCTGCTTTACACGGCGATCTTGAAGCCCCGCACGCCCCAAAACATT
GTCATCGGAGGGGTTGCTGGAGCGATCCCCCCTCTCGTGGGTGCGGCTGCGGCCAGCGGGCATGTGGGCCTTAGTGGATG
GTGGTTGTTCTCGCTGGTCATGCTTTGGACCCCAGCGCATTTTTGGGCACTGGCCCTGTTGCTGCGGGACGACTACAGGG
CTGTTGGGATACCCATGCTTCCTGTTATTCAGGGCCCTGTTGTCACCGTCAGAGCTATTTCTCGTTATGGCTGGGCCACG
GTTCTACTCAGCGGTTTTGGTGTCTGGGCCTTGCCGGAGGGGGGCTTGCTCTACGGACTTTTGTTGATCCCTTTCAATGC
TCGTCTGCTGCAAATGGTTCATCAGTTAGGTGCTGCTCCGGAGAATGTTGATCGAGCCAAGGGGCTCTTCCGTTGGTCGA
TCTTCTATATGTTTGGTATCTGCCTTCTTCTGGTGGTTAGTCGTTTGCCCATGGCGGCTAATTTTGATCTTCAGGCCTGG
TCTTTGCTTCAGCAGATGGCTAGCAGCGGGCAGTTCATCTAA

Upstream 100 bases:

>100_bases
CTGCTTGTGGCCTTGCTTGCCGCCCTTACCTTTCGTAATCCGGAAGGATCACCTTTGCCGGTGTCTGCCGTTGATGATTC
ATCCTCGATAGACCATAGTC

Downstream 100 bases:

>100_bases
ACAGAAGTCACTAGAGACCCCCTGGAGGGTCTGGTAGCTCTATAGAGCTGCCTAGATTTTTAACACTTGTACTACGTTCC
CTCTTGATGCCGATGATTGA

Product: protoheme IX farnesyltransferase

Products: NA

Alternate protein names: Heme B farnesyltransferase; Heme O synthase [H]

Number of amino acids: Translated: 333; Mature: 333

Protein sequence:

>333_residues
MVSSTPEMLQGGVTREQIVPSRKRIKLPAWLEIAKPRLIPLLLATTLGGMALSEGWPLPSLRLACTLGGGALAAAAAGVL
NCIWEQDLDGRMQRTSGRALPSGRLSPTAAFIGAISCTLAAAALLVSGVNCLAAGLSLLGLCSYVLLYTAILKPRTPQNI
VIGGVAGAIPPLVGAAAASGHVGLSGWWLFSLVMLWTPAHFWALALLLRDDYRAVGIPMLPVIQGPVVTVRAISRYGWAT
VLLSGFGVWALPEGGLLYGLLLIPFNARLLQMVHQLGAAPENVDRAKGLFRWSIFYMFGICLLLVVSRLPMAANFDLQAW
SLLQQMASSGQFI

Sequences:

>Translated_333_residues
MVSSTPEMLQGGVTREQIVPSRKRIKLPAWLEIAKPRLIPLLLATTLGGMALSEGWPLPSLRLACTLGGGALAAAAAGVL
NCIWEQDLDGRMQRTSGRALPSGRLSPTAAFIGAISCTLAAAALLVSGVNCLAAGLSLLGLCSYVLLYTAILKPRTPQNI
VIGGVAGAIPPLVGAAAASGHVGLSGWWLFSLVMLWTPAHFWALALLLRDDYRAVGIPMLPVIQGPVVTVRAISRYGWAT
VLLSGFGVWALPEGGLLYGLLLIPFNARLLQMVHQLGAAPENVDRAKGLFRWSIFYMFGICLLLVVSRLPMAANFDLQAW
SLLQQMASSGQFI
>Mature_333_residues
MVSSTPEMLQGGVTREQIVPSRKRIKLPAWLEIAKPRLIPLLLATTLGGMALSEGWPLPSLRLACTLGGGALAAAAAGVL
NCIWEQDLDGRMQRTSGRALPSGRLSPTAAFIGAISCTLAAAALLVSGVNCLAAGLSLLGLCSYVLLYTAILKPRTPQNI
VIGGVAGAIPPLVGAAAASGHVGLSGWWLFSLVMLWTPAHFWALALLLRDDYRAVGIPMLPVIQGPVVTVRAISRYGWAT
VLLSGFGVWALPEGGLLYGLLLIPFNARLLQMVHQLGAAPENVDRAKGLFRWSIFYMFGICLLLVVSRLPMAANFDLQAW
SLLQQMASSGQFI

Specific function: Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group [H]

COG id: COG0109

COG function: function code O; Polyprenyltransferase (cytochrome oxidase assembly factor)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ubiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily [H]

Homologues:

Organism=Homo sapiens, GI17921982, Length=196, Percent_Identity=35.2040816326531, Blast_Score=96, Evalue=7e-20,
Organism=Escherichia coli, GI1786631, Length=207, Percent_Identity=31.8840579710145, Blast_Score=108, Evalue=5e-25,
Organism=Caenorhabditis elegans, GI71998235, Length=264, Percent_Identity=29.5454545454545, Blast_Score=84, Evalue=7e-17,
Organism=Saccharomyces cerevisiae, GI6325085, Length=216, Percent_Identity=30.5555555555556, Blast_Score=86, Evalue=6e-18,
Organism=Drosophila melanogaster, GI19921064, Length=282, Percent_Identity=30.8510638297872, Blast_Score=109, Evalue=2e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006369
- InterPro:   IPR000537 [H]

Pfam domain/function: PF01040 UbiA [H]

EC number: 2.5.1.-

Molecular weight: Translated: 35332; Mature: 35332

Theoretical pI: Translated: 9.97; Mature: 9.97

Prosite motif: PS00943 UBIA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVSSTPEMLQGGVTREQIVPSRKRIKLPAWLEIAKPRLIPLLLATTLGGMALSEGWPLPS
CCCCCHHHHHCCCCHHHHCCCHHHCCCCHHHHHHCCHHHHHHHHHHHCCHHHCCCCCCCC
LRLACTLGGGALAAAAAGVLNCIWEQDLDGRMQRTSGRALPSGRLSPTAAFIGAISCTLA
EEEEEEECCHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCCCCCCCHHHHHHHHHHHHHH
AAALLVSGVNCLAAGLSLLGLCSYVLLYTAILKPRTPQNIVIGGVAGAIPPLVGAAAASG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECHHHHHHHHHHHHHCCC
HVGLSGWWLFSLVMLWTPAHFWALALLLRDDYRAVGIPMLPVIQGPVVTVRAISRYGWAT
CCCCHHHHHHHHHHHHCHHHHHHHHHHHHCCCHHCCCCCHHHHCCCHHHHHHHHHHHHHH
VLLSGFGVWALPEGGLLYGLLLIPFNARLLQMVHQLGAAPENVDRAKGLFRWSIFYMFGI
HHHHCCCEEECCCCCHHHHHHHHCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
CLLLVVSRLPMAANFDLQAWSLLQQMASSGQFI
HHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MVSSTPEMLQGGVTREQIVPSRKRIKLPAWLEIAKPRLIPLLLATTLGGMALSEGWPLPS
CCCCCHHHHHCCCCHHHHCCCHHHCCCCHHHHHHCCHHHHHHHHHHHCCHHHCCCCCCCC
LRLACTLGGGALAAAAAGVLNCIWEQDLDGRMQRTSGRALPSGRLSPTAAFIGAISCTLA
EEEEEEECCHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCCCCCCCHHHHHHHHHHHHHH
AAALLVSGVNCLAAGLSLLGLCSYVLLYTAILKPRTPQNIVIGGVAGAIPPLVGAAAASG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECHHHHHHHHHHHHHCCC
HVGLSGWWLFSLVMLWTPAHFWALALLLRDDYRAVGIPMLPVIQGPVVTVRAISRYGWAT
CCCCHHHHHHHHHHHHCHHHHHHHHHHHHCCCHHCCCCCHHHHCCCHHHHHHHHHHHHHH
VLLSGFGVWALPEGGLLYGLLLIPFNARLLQMVHQLGAAPENVDRAKGLFRWSIFYMFGI
HHHHCCCEEECCCCCHHHHHHHHCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
CLLLVVSRLPMAANFDLQAWSLLQQMASSGQFI
HHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA