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The map label for this gene is macA [H]

Identifier: 33863426

GI number: 33863426

Start: 1245052

End: 1246182

Strand: Direct

Name: macA [H]

Synonym: PMT1156

Alternate gene names: 33863426

Gene position: 1245052-1246182 (Clockwise)

Preceding gene: 33863420

Following gene: 33863427

Centisome position: 51.64

GC content: 55.7

Gene sequence:

>1131_bases
TTGGTCCATCTCACACAACTCAAAGGTGCTTTAGGGCAACGCAAACGCTTGATCAGCCTCAGTGCAGCTGTGGTGCTAAT
CACTGCAGGGGGGATGGCATGGAGGTTCAGCCCCCAGCAGCGCTTGGGTCGCGATCTCAGCAATTACACCGTAGAAACCG
AGAGGGGCACCCTTCCTGGGATCGTGAGCGCCAACGGCGAATTGCAGGCGAAGCGGAGCGTGAATGTCAGTCCCAAAAAA
GCAGGTTTGCTGAAAGAGCTCTATGTCGATCAAGGCGACGAGGTCAAAAAGGGAGAGGTGCTCGCTCGCATGGATAGTGG
CGACTACAACGACCGCTTAGATGAAGCGAAGGCCCTTGAAAGAAAAGAGCAAGCTGAATACGAAACGAGAAAAGCAGACC
ATGAGCGGCGCGACAACCTCTACCAACAAGGAGCCATCTCAGCCGACGACGCGAGCAAATATCGCCGCCTCTACCTAACC
AGCCGCGCCAACCTTGCCGCCGCACAAGAGCGTGTTCAACAACGCATTACTGAAGGGAGCGAACTGCTGATCAGAGCACC
CTTCAGTGGTGTGATCACAGCCCGTTATGCGGAGCCAGGAGCCTTTGTGACCCCAACAACAGCAGCCTCTGCAACTGCCG
GCGCCAGCAGCTCCTCCCTGGTTGAACTCTCAGAAGGAATGGAGGTGAACGCCAAAGTGCCCGAAAGCGACATCGGCCGC
ATCCGCATCGGCCAAAATGCCAGCGTGCGTGTTGACGCCTTCCCAGAACAACGTTTTATGGCCCGCGTCAGCGAGATCGC
CCCGAGGGCAGCAAAAACTGAGAATGTCATCTCTTTCGCAGTCAAGCTCAACCTGATCAAGCCTTCGCCCCAACTGCTAA
TAGGCATGTCCGCAGACGTGGATTTTCAAACGGGCAAGACTGCACCCACCACGTTGGTTCCCACCGTGGCGATTGTGACT
GAAAAGGGCAAACCTGGAGTGCTTCTTGTGGGCCAAAAAAATCAACCACGCTTTCAAGCGGTGGAACTAGGCACCAGTAG
TGGCAGCAAAACAGCCATCCTGAGCGGGCTAAAGCCCGGCACGCGAATTTTTATCGATCTGCCCCCATGGGCCAAAACAA
AACGCGACTGA

Upstream 100 bases:

>100_bases
CTGCAGTCAGGCTCGCTGACCAGCGAGACTGCTTGACATCGTTGGTGGGTTGATGGCCAGTACAAAGGCCTCGCCCATAT
CGGCACATCAGGAGCAGGGA

Downstream 100 bases:

>100_bases
TGCCAACCCCCATCAATCCGTCCCATGCCTGAGGCTGCTAACAAGCCACTGTTGCTGCTGGTGGATGGCCACTCGCTGGC
CTTCCGCAGCTTTTATGCCT

Product: membrane fusion protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 376; Mature: 376

Protein sequence:

>376_residues
MVHLTQLKGALGQRKRLISLSAAVVLITAGGMAWRFSPQQRLGRDLSNYTVETERGTLPGIVSANGELQAKRSVNVSPKK
AGLLKELYVDQGDEVKKGEVLARMDSGDYNDRLDEAKALERKEQAEYETRKADHERRDNLYQQGAISADDASKYRRLYLT
SRANLAAAQERVQQRITEGSELLIRAPFSGVITARYAEPGAFVTPTTAASATAGASSSSLVELSEGMEVNAKVPESDIGR
IRIGQNASVRVDAFPEQRFMARVSEIAPRAAKTENVISFAVKLNLIKPSPQLLIGMSADVDFQTGKTAPTTLVPTVAIVT
EKGKPGVLLVGQKNQPRFQAVELGTSSGSKTAILSGLKPGTRIFIDLPPWAKTKRD

Sequences:

>Translated_376_residues
MVHLTQLKGALGQRKRLISLSAAVVLITAGGMAWRFSPQQRLGRDLSNYTVETERGTLPGIVSANGELQAKRSVNVSPKK
AGLLKELYVDQGDEVKKGEVLARMDSGDYNDRLDEAKALERKEQAEYETRKADHERRDNLYQQGAISADDASKYRRLYLT
SRANLAAAQERVQQRITEGSELLIRAPFSGVITARYAEPGAFVTPTTAASATAGASSSSLVELSEGMEVNAKVPESDIGR
IRIGQNASVRVDAFPEQRFMARVSEIAPRAAKTENVISFAVKLNLIKPSPQLLIGMSADVDFQTGKTAPTTLVPTVAIVT
EKGKPGVLLVGQKNQPRFQAVELGTSSGSKTAILSGLKPGTRIFIDLPPWAKTKRD
>Mature_376_residues
MVHLTQLKGALGQRKRLISLSAAVVLITAGGMAWRFSPQQRLGRDLSNYTVETERGTLPGIVSANGELQAKRSVNVSPKK
AGLLKELYVDQGDEVKKGEVLARMDSGDYNDRLDEAKALERKEQAEYETRKADHERRDNLYQQGAISADDASKYRRLYLT
SRANLAAAQERVQQRITEGSELLIRAPFSGVITARYAEPGAFVTPTTAASATAGASSSSLVELSEGMEVNAKVPESDIGR
IRIGQNASVRVDAFPEQRFMARVSEIAPRAAKTENVISFAVKLNLIKPSPQLLIGMSADVDFQTGKTAPTTLVPTVAIVT
EKGKPGVLLVGQKNQPRFQAVELGTSSGSKTAILSGLKPGTRIFIDLPPWAKTKRD

Specific function: Efflux transporter for macrolide antibiotics [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI87081796, Length=362, Percent_Identity=24.585635359116, Blast_Score=76, Evalue=4e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 40746; Mature: 40746

Theoretical pI: Translated: 10.24; Mature: 10.24

Prosite motif: PS00012 PHOSPHOPANTETHEINE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVHLTQLKGALGQRKRLISLSAAVVLITAGGMAWRFSPQQRLGRDLSNYTVETERGTLPG
CEEHHHHHHHHHHHHHHHHHEEEEEEEEECCEEEEECHHHHHCCCHHHCEEEECCCCCCE
IVSANGELQAKRSVNVSPKKAGLLKELYVDQGDEVKKGEVLARMDSGDYNDRLDEAKALE
EEECCCCEEEECCCCCCHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCHHHHHHHHHH
RKEQAEYETRKADHERRDNLYQQGAISADDASKYRRLYLTSRANLAAAQERVQQRITEGS
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHEEEEEECCCHHHHHHHHHHHHHCCCC
ELLIRAPFSGVITARYAEPGAFVTPTTAASATAGASSSSLVELSEGMEVNAKVPESDIGR
EEEEECCCCCEEEEEECCCCCEECCCCCCCCCCCCCCCCEEECCCCCEEECCCCCCCCCE
IRIGQNASVRVDAFPEQRFMARVSEIAPRAAKTENVISFAVKLNLIKPSPQLLIGMSADV
EEECCCCEEEEECCCHHHHHHHHHHHCCCCCCHHHHEEEEEEEEEECCCCCEEEEECCCC
DFQTGKTAPTTLVPTVAIVTEKGKPGVLLVGQKNQPRFQAVELGTSSGSKTAILSGLKPG
CCCCCCCCCCEECCEEEEEEECCCCCEEEEECCCCCCEEEEEECCCCCCCEEEEECCCCC
TRIFIDLPPWAKTKRD
CEEEEECCCCCCCCCC
>Mature Secondary Structure
MVHLTQLKGALGQRKRLISLSAAVVLITAGGMAWRFSPQQRLGRDLSNYTVETERGTLPG
CEEHHHHHHHHHHHHHHHHHEEEEEEEEECCEEEEECHHHHHCCCHHHCEEEECCCCCCE
IVSANGELQAKRSVNVSPKKAGLLKELYVDQGDEVKKGEVLARMDSGDYNDRLDEAKALE
EEECCCCEEEECCCCCCHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCHHHHHHHHHH
RKEQAEYETRKADHERRDNLYQQGAISADDASKYRRLYLTSRANLAAAQERVQQRITEGS
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHEEEEEECCCHHHHHHHHHHHHHCCCC
ELLIRAPFSGVITARYAEPGAFVTPTTAASATAGASSSSLVELSEGMEVNAKVPESDIGR
EEEEECCCCCEEEEEECCCCCEECCCCCCCCCCCCCCCCEEECCCCCEEECCCCCCCCCE
IRIGQNASVRVDAFPEQRFMARVSEIAPRAAKTENVISFAVKLNLIKPSPQLLIGMSADV
EEECCCCEEEEECCCHHHHHHHHHHHCCCCCCHHHHEEEEEEEEEECCCCCEEEEECCCC
DFQTGKTAPTTLVPTVAIVTEKGKPGVLLVGQKNQPRFQAVELGTSSGSKTAILSGLKPG
CCCCCCCCCCEECCEEEEEEECCCCCEEEEECCCCCCEEEEEECCCCCCCEEEEECCCCC
TRIFIDLPPWAKTKRD
CEEEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430 [H]