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The map label for this gene is guaB [C]

Identifier: 33863397

GI number: 33863397

Start: 1219748

End: 1220911

Strand: Direct

Name: guaB [C]

Synonym: PMT1126

Alternate gene names: 33863397

Gene position: 1219748-1220911 (Clockwise)

Preceding gene: 33863396

Following gene: 33863398

Centisome position: 50.59

GC content: 56.79

Gene sequence:

>1164_bases
GTGAACATTCAGCTCGGACGCACCAAGGTCGTTCGCCGGGCCTATGGCATCGACGAAACCGCCCTTGTTCCGGGTGGACG
AACCGTAGACCCGGAGATCACTGACACCTGCTGGAACCTCGCAGGCATCGAACGTGAGATACCAATCATTGCGAGCGCTA
TGGATAGCGTTGTCAATGTCGATATGGCTGTTGCCCTATCTCGCCTTGGAGCCCTCGGCGTAATGAATCTGGAAGGAGTC
CAAACCCGCTACAAAGACCCCAACCCAGTACTGGATCGGATCTCCTCAATCGGAAATGATGCCTTCGTGCCACTGATGCA
GGAGATCTACAGCAAACCTGTGCAAGAAGCCCTGATCTATCAACGCATTAAAGAGATCAAAAATCAGGGGGGCATTGCTG
CTGTGAGTGGCACACCCGTGGCAGCAATGCGCTTTAGCAAAACCATTGCAGAAGCGGGTGCTGACCTCTTTTTTGTGCAG
GCGACAGTGGTATCAACCGAACACATTGGTCCTGAAGGTCAACAAACTCTCGACCTCGAAGCCCTTTGTCAAGGCATGGG
GGTCCCTGTGGTGATGGGTAATTGCGTCACCTACGAGGTCGCTCTGAAACTCATGCGTGCAGGTGCCGCAGGAGTGATGG
TTGGCATCGGCCCTGGTGCTGCTTGCACCTCTCGTGGGGTTCTTGGCGTGGGCATCCCCCAAGCCACCGCCGTAGCGGAC
TGCGCTGCCGCCCGTGAGGACTACGAGCGAGAGAGTGGTCGATACGTTCCGATCGTTGCAGATGGCGGCATCATTACAGG
AGGGGACGTATGTAAGTGCATTGCCTGCGGAGCCGATGCGGTCATGATCGGCTCTCCGATCGCCCGAGCATTGGAGGCGC
CTGGTCGTGGCTTCCACTGGGGCATGGCCACTCCCAGTCCAGTACTGCCAAGGGGCACAAGAATCAAGGTGGGCAGCACA
GGCAGCCTGGAACGCATCCTTAGAGGGCCTGCTCTGCTAGACGATGGCACCCATAACCTTCTAGGAGCTCTCAAAACGTC
CATGGGCACTCTTGGGGCCCGTACGATCAAAGAGATGCAACAGGTTGAGGTCGTCATCGCCCCATCTCTGCTGACCGAAG
GGAAGGTTTATCAGAAAGCCCAGCAGCTAGGCATGGGCAAGTAA

Upstream 100 bases:

>100_bases
GGAACAACTGACAACAAGCCCTAGCTAAAGCTCTTTTTTCCTCAAGGCAAAATTTGAATCACCCCAGTTGGTAACTTGGC
GTGACTTTATTTGGTCTGTG

Downstream 100 bases:

>100_bases
ACATTCCGATCGCAGACGAAAACCAATTGGATCCGAGAGAGGCCATGGCTAGTATGAATTCGTGAGGGCTACGGCCCACA
CACTCCTCACACACACCGGC

Product: inosine 5-monophosphate dehydrogenase

Products: xanthosine 5'-phosphate; NADH; H+

Alternate protein names: NA

Number of amino acids: Translated: 387; Mature: 387

Protein sequence:

>387_residues
MNIQLGRTKVVRRAYGIDETALVPGGRTVDPEITDTCWNLAGIEREIPIIASAMDSVVNVDMAVALSRLGALGVMNLEGV
QTRYKDPNPVLDRISSIGNDAFVPLMQEIYSKPVQEALIYQRIKEIKNQGGIAAVSGTPVAAMRFSKTIAEAGADLFFVQ
ATVVSTEHIGPEGQQTLDLEALCQGMGVPVVMGNCVTYEVALKLMRAGAAGVMVGIGPGAACTSRGVLGVGIPQATAVAD
CAAAREDYERESGRYVPIVADGGIITGGDVCKCIACGADAVMIGSPIARALEAPGRGFHWGMATPSPVLPRGTRIKVGST
GSLERILRGPALLDDGTHNLLGALKTSMGTLGARTIKEMQQVEVVIAPSLLTEGKVYQKAQQLGMGK

Sequences:

>Translated_387_residues
MNIQLGRTKVVRRAYGIDETALVPGGRTVDPEITDTCWNLAGIEREIPIIASAMDSVVNVDMAVALSRLGALGVMNLEGV
QTRYKDPNPVLDRISSIGNDAFVPLMQEIYSKPVQEALIYQRIKEIKNQGGIAAVSGTPVAAMRFSKTIAEAGADLFFVQ
ATVVSTEHIGPEGQQTLDLEALCQGMGVPVVMGNCVTYEVALKLMRAGAAGVMVGIGPGAACTSRGVLGVGIPQATAVAD
CAAAREDYERESGRYVPIVADGGIITGGDVCKCIACGADAVMIGSPIARALEAPGRGFHWGMATPSPVLPRGTRIKVGST
GSLERILRGPALLDDGTHNLLGALKTSMGTLGARTIKEMQQVEVVIAPSLLTEGKVYQKAQQLGMGK
>Mature_387_residues
MNIQLGRTKVVRRAYGIDETALVPGGRTVDPEITDTCWNLAGIEREIPIIASAMDSVVNVDMAVALSRLGALGVMNLEGV
QTRYKDPNPVLDRISSIGNDAFVPLMQEIYSKPVQEALIYQRIKEIKNQGGIAAVSGTPVAAMRFSKTIAEAGADLFFVQ
ATVVSTEHIGPEGQQTLDLEALCQGMGVPVVMGNCVTYEVALKLMRAGAAGVMVGIGPGAACTSRGVLGVGIPQATAVAD
CAAAREDYERESGRYVPIVADGGIITGGDVCKCIACGADAVMIGSPIARALEAPGRGFHWGMATPSPVLPRGTRIKVGST
GSLERILRGPALLDDGTHNLLGALKTSMGTLGARTIKEMQQVEVVIAPSLLTEGKVYQKAQQLGMGK

Specific function: Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. [C

COG id: COG0516

COG function: function code F; IMP dehydrogenase/GMP reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the IMPDH/GMPR family [H]

Homologues:

Organism=Homo sapiens, GI217035150, Length=111, Percent_Identity=45.945945945946, Blast_Score=81, Evalue=2e-15,
Organism=Homo sapiens, GI217035148, Length=111, Percent_Identity=45.945945945946, Blast_Score=81, Evalue=2e-15,
Organism=Homo sapiens, GI217035146, Length=111, Percent_Identity=45.945945945946, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI34328930, Length=109, Percent_Identity=46.7889908256881, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI217035152, Length=109, Percent_Identity=46.7889908256881, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI34328928, Length=109, Percent_Identity=46.7889908256881, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI156616279, Length=109, Percent_Identity=46.7889908256881, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI66933016, Length=112, Percent_Identity=42.8571428571429, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI50541954, Length=197, Percent_Identity=29.9492385786802, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI50541952, Length=197, Percent_Identity=29.9492385786802, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI50541948, Length=197, Percent_Identity=29.9492385786802, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI50541956, Length=197, Percent_Identity=29.9492385786802, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI156104880, Length=197, Percent_Identity=29.9492385786802, Blast_Score=77, Evalue=4e-14,
Organism=Escherichia coli, GI1786293, Length=339, Percent_Identity=28.6135693215339, Blast_Score=89, Evalue=7e-19,
Organism=Escherichia coli, GI1788855, Length=236, Percent_Identity=33.0508474576271, Blast_Score=80, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI71994385, Length=184, Percent_Identity=35.3260869565217, Blast_Score=82, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI71994389, Length=184, Percent_Identity=35.3260869565217, Blast_Score=82, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI17560440, Length=192, Percent_Identity=32.8125, Blast_Score=77, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6322012, Length=113, Percent_Identity=38.0530973451327, Blast_Score=76, Evalue=8e-15,
Organism=Saccharomyces cerevisiae, GI6323464, Length=112, Percent_Identity=34.8214285714286, Blast_Score=72, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6323585, Length=112, Percent_Identity=35.7142857142857, Blast_Score=71, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24641071, Length=170, Percent_Identity=38.2352941176471, Blast_Score=89, Evalue=4e-18,
Organism=Drosophila melanogaster, GI24641073, Length=170, Percent_Identity=38.2352941176471, Blast_Score=89, Evalue=4e-18,
Organism=Drosophila melanogaster, GI28571163, Length=170, Percent_Identity=38.2352941176471, Blast_Score=89, Evalue=5e-18,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR001093
- InterPro:   IPR005992 [H]

Pfam domain/function: PF00478 IMPDH [H]

EC number: 1.1.1.205

Molecular weight: Translated: 40500; Mature: 40500

Theoretical pI: Translated: 6.29; Mature: 6.29

Prosite motif: PS00912 DHODEHASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIQLGRTKVVRRAYGIDETALVPGGRTVDPEITDTCWNLAGIEREIPIIASAMDSVVNV
CCCCCCHHHHHHHHHCCCCCEECCCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHH
DMAVALSRLGALGVMNLEGVQTRYKDPNPVLDRISSIGNDAFVPLMQEIYSKPVQEALIY
HHHHHHHHHCCCCCCCCCCHHHHCCCCCHHHHHHHHCCCCHHHHHHHHHHHCHHHHHHHH
QRIKEIKNQGGIAAVSGTPVAAMRFSKTIAEAGADLFFVQATVVSTEHIGPEGQQTLDLE
HHHHHHHCCCCEEEECCCCHHHHHHHHHHHHCCCCEEEEEEEEEEHHCCCCCCCCEECHH
ALCQGMGVPVVMGNCVTYEVALKLMRAGAAGVMVGIGPGAACTSRGVLGVGIPQATAVAD
HHHCCCCCCEEECCHHHHHHHHHHHHCCCCEEEEECCCCCHHHCCCEEEECCCCHHHHHH
CAAAREDYERESGRYVPIVADGGIITGGDVCKCIACGADAVMIGSPIARALEAPGRGFHW
HHHHHHHHHHCCCCEEEEEECCCEEECCHHHHHHHCCCCEEEECCHHHHHHHCCCCCEEC
GMATPSPVLPRGTRIKVGSTGSLERILRGPALLDDGTHNLLGALKTSMGTLGARTIKEMQ
CCCCCCCCCCCCCEEEECCCCCHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
QVEVVIAPSLLTEGKVYQKAQQLGMGK
HHEEEEECHHHHCCHHHHHHHHHCCCC
>Mature Secondary Structure
MNIQLGRTKVVRRAYGIDETALVPGGRTVDPEITDTCWNLAGIEREIPIIASAMDSVVNV
CCCCCCHHHHHHHHHCCCCCEECCCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHH
DMAVALSRLGALGVMNLEGVQTRYKDPNPVLDRISSIGNDAFVPLMQEIYSKPVQEALIY
HHHHHHHHHCCCCCCCCCCHHHHCCCCCHHHHHHHHCCCCHHHHHHHHHHHCHHHHHHHH
QRIKEIKNQGGIAAVSGTPVAAMRFSKTIAEAGADLFFVQATVVSTEHIGPEGQQTLDLE
HHHHHHHCCCCEEEECCCCHHHHHHHHHHHHCCCCEEEEEEEEEEHHCCCCCCCCEECHH
ALCQGMGVPVVMGNCVTYEVALKLMRAGAAGVMVGIGPGAACTSRGVLGVGIPQATAVAD
HHHCCCCCCEEECCHHHHHHHHHHHHCCCCEEEEECCCCCHHHCCCEEEECCCCHHHHHH
CAAAREDYERESGRYVPIVADGGIITGGDVCKCIACGADAVMIGSPIARALEAPGRGFHW
HHHHHHHHHHCCCCEEEEEECCCEEECCHHHHHHHCCCCEEEECCHHHHHHHCCCCCEEC
GMATPSPVLPRGTRIKVGSTGSLERILRGPALLDDGTHNLLGALKTSMGTLGARTIKEMQ
CCCCCCCCCCCCCEEEECCCCCHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
QVEVVIAPSLLTEGKVYQKAQQLGMGK
HHEEEEECHHHHCCHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: inosine 5'-phosphate; NAD+; H2O

Specific reaction: inosine 5'-phosphate + NAD+ + H2O = xanthosine 5'-phosphate + NADH + H+

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA