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The map label for this gene is cobC [H]

Identifier: 33863376

GI number: 33863376

Start: 1197849

End: 1198439

Strand: Direct

Name: cobC [H]

Synonym: PMT1105

Alternate gene names: 33863376

Gene position: 1197849-1198439 (Clockwise)

Preceding gene: 33863375

Following gene: 33863377

Centisome position: 49.69

GC content: 55.67

Gene sequence:

>591_bases
ATGACATCTCGTCAACTTTGGATCATCCGCCATGGGGCTACCGAATGGGCACTCCAAGGCCGTCATACCGGCAGCACCGA
CCTCCCCTTGCTACCCCAGGGGGAAGAAGAGGCGAAGGCTCTTGCTCCTGTGCTCAAAGGCGTGACATTTGCCGCTGTGT
TGTCATCTCCCCTGCAACGAGCCATACGCACCTGTGCGCTGGCTGAGCTTGAAATACCTGCTGAAATCATGCCGGAGCTG
ATCGAATGGAACTACGGAAACTATGAAGGCATCACCACAGCAGAGATCCGTCAAACCGTTCCTGCGTGGACCATTTGGGA
CCAAGGTTGTCCTGGTGGCGAGCACGCTACTGCCGTGCAAGAGCGTTGTGAACGAATTATTGAACATGCCCTCGGCATCT
CAAACAACGGTGACATCGTTCTCTTCGCCCATGGACATATCTTGCGAGCCCTGACTGGCACCTGGCTAGGTCTCGGTGCC
GCAGCAGGCCGACTGTTCAGACTAGATACCGGCAGCATTTGCATTCTTGGTTTCGAAAGAGAGCAGCGCGTGATCACACG
CTGGAATGCCCTCTGCACTGGCACGTTCTAA

Upstream 100 bases:

>100_bases
GCAATCAATCCCAGCAACAAGTGATTTCTGAACAGCACAAACCCAGGAAGACATCATTTGAAGATGCTCGTCAAAATTCA
GCCAGCAGCAACCGTCCTGC

Downstream 100 bases:

>100_bases
ATCGAACAACGAAAGGTTCTTGCGCCAAGATTGACCATTGATCATGAGCGAATATTGACAAGCTCACCTGATCGCCTCAA
TGGCTGACACCACCCTATGG

Product: phosphoglycerate mutase family protein

Products: NA

Alternate protein names: Alpha-ribazole-5'-phosphate phosphatase [H]

Number of amino acids: Translated: 196; Mature: 195

Protein sequence:

>196_residues
MTSRQLWIIRHGATEWALQGRHTGSTDLPLLPQGEEEAKALAPVLKGVTFAAVLSSPLQRAIRTCALAELEIPAEIMPEL
IEWNYGNYEGITTAEIRQTVPAWTIWDQGCPGGEHATAVQERCERIIEHALGISNNGDIVLFAHGHILRALTGTWLGLGA
AAGRLFRLDTGSICILGFEREQRVITRWNALCTGTF

Sequences:

>Translated_196_residues
MTSRQLWIIRHGATEWALQGRHTGSTDLPLLPQGEEEAKALAPVLKGVTFAAVLSSPLQRAIRTCALAELEIPAEIMPEL
IEWNYGNYEGITTAEIRQTVPAWTIWDQGCPGGEHATAVQERCERIIEHALGISNNGDIVLFAHGHILRALTGTWLGLGA
AAGRLFRLDTGSICILGFEREQRVITRWNALCTGTF
>Mature_195_residues
TSRQLWIIRHGATEWALQGRHTGSTDLPLLPQGEEEAKALAPVLKGVTFAAVLSSPLQRAIRTCALAELEIPAEIMPELI
EWNYGNYEGITTAEIRQTVPAWTIWDQGCPGGEHATAVQERCERIIEHALGISNNGDIVLFAHGHILRALTGTWLGLGAA
AGRLFRLDTGSICILGFEREQRVITRWNALCTGTF

Specific function: Converts N1-(5-phospho-alpha-D-ribosyl)-5,6- dimethylbenzimidazole into N1-alpha-D-ribosyl-5,6- dimethylbenzimidazole; involved in the assembly of the nucleotide loop of cobalamin [H]

COG id: COG0406

COG function: function code G; Fructose-2,6-bisphosphatase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the phosphoglycerate mutase family [H]

Homologues:

Organism=Escherichia coli, GI1786857, Length=175, Percent_Identity=33.1428571428571, Blast_Score=89, Evalue=1e-19,
Organism=Escherichia coli, GI1790856, Length=183, Percent_Identity=27.8688524590164, Blast_Score=66, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6322896, Length=183, Percent_Identity=33.3333333333333, Blast_Score=93, Evalue=2e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013078
- InterPro:   IPR001345
- InterPro:   IPR017578 [H]

Pfam domain/function: PF00300 PGAM [H]

EC number: =3.1.3.73 [H]

Molecular weight: Translated: 21509; Mature: 21378

Theoretical pI: Translated: 5.93; Mature: 5.93

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSRQLWIIRHGATEWALQGRHTGSTDLPLLPQGEEEAKALAPVLKGVTFAAVLSSPLQR
CCCCEEEEEEECCCHHEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
AIRTCALAELEIPAEIMPELIEWNYGNYEGITTAEIRQTVPAWTIWDQGCPGGEHATAVQ
HHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCCHHHHHHCCCCEEEECCCCCCCCHHHHHH
ERCERIIEHALGISNNGDIVLFAHGHILRALTGTWLGLGAAAGRLFRLDTGSICILGFER
HHHHHHHHHHCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHCCEEEEECCCCEEEEECCC
EQRVITRWNALCTGTF
HHHHHHHHHCEEECCC
>Mature Secondary Structure 
TSRQLWIIRHGATEWALQGRHTGSTDLPLLPQGEEEAKALAPVLKGVTFAAVLSSPLQR
CCCEEEEEEECCCHHEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
AIRTCALAELEIPAEIMPELIEWNYGNYEGITTAEIRQTVPAWTIWDQGCPGGEHATAVQ
HHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCCHHHHHHCCCCEEEECCCCCCCCHHHHHH
ERCERIIEHALGISNNGDIVLFAHGHILRALTGTWLGLGAAAGRLFRLDTGSICILGFER
HHHHHHHHHHCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHCCEEEEECCCCEEEEECCC
EQRVITRWNALCTGTF
HHHHHHHHHCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905232; 9278503 [H]