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The map label for this gene is crtH [H]

Identifier: 33863322

GI number: 33863322

Start: 1131223

End: 1132785

Strand: Direct

Name: crtH [H]

Synonym: PMT1051

Alternate gene names: 33863322

Gene position: 1131223-1132785 (Clockwise)

Preceding gene: 33863321

Following gene: 33863323

Centisome position: 46.92

GC content: 55.28

Gene sequence:

>1563_bases
ATGGAACCTATCCGCATCGAAAAAGACGCAACACAGCCTTGGGATGCTGTGGTTATCGGTTCGGGCATCGGCGGCCTGGT
CACCGCTAGTCAGCTAGCTGTCAAAGGCGCCAAGGTTCTTGTTCTGGAGAGCTACACAATCCCAGGTGGTAGTAGCGGCT
CATTCCAACGAGAGGGCTACACCTTTGATGTAGGTGCCTCAATGATCTTCGGGTTCGGAGAAAAGGGATACACCAACCTG
CTCACCCGAGCCTTGGCCGATGTGGGGGAGCACTGTGACACCCTGCCTGACCCCGCCCAACTCGCCTACCACCTTCCTGG
AGGATTAGAGCTCGCAGTTGATCGGAAATACGAGCAGTTCATTGCTGATCTCACCGCACGCTTCCCCCACGAAGCGAAGG
GGATCCGTCACTTTTACGACATCTGTTGGCAAGTGTTCAACTGCCTGGATGCAATGCCACTGCTATCGATCGAGGATCCC
ACTTATCTGGCCAAAGTTTTTTTCAAGTCCCCCCTGGCCTGTCTCGGTCTTGCGCGCTGGTTGCCCGTCAACGTGGGTGA
TGTAGCCAGGCGTCACATCAAAGACCCAGAACTGTTGCGGTTCATCGACATTGAATGCTTCTGCTGGTCAGTGATGCCTG
CCGACCTCACACCGATGATCAATGCTGGCATGGTGTTTTCAGATCGCCATGCCGGTGGCATCAACTACCCCAGAGGAGGC
GTTGGTGTGATAGCCCAAAAGCTCGTCAAAGGCATGCAACGTCATGGTGGTGAGATCCGCTACAAGGCACGGGTCACACG
AGTGGTGCTGAAAGATAATCGTGCTGTTGGTGTACAGCTAGCAAATGGAGAAATCATCCACGCCCGCAGGGTGATATCCA
ACGCCACTCGCTGGGACACATTCAGCGGTGAGGGGTCCAAACAGGCCCTGGTGGATGCAGAACACACACCCGCAGCGGAG
CAGACCTGGCGACGCCGCTATGTGCCCTCGCCATCCTTCCTCTCTCTTCACCTTGGAGTCCGTAACGAGGCCATTCCAGC
CAACAGCCACTGCCACCATCTGCTCCTAGAAAGCTGGGATGAAATGGAGAGTGAACAGGGTGTCGCATTCGTCTCTATGC
CGACGCTCCTGGATCCATCACTGGCGCCAGAGGGACATCACATCGTCCACGCCTTCACACCATCCTCAATGCAGGCATGG
CAAGACCTAAGCCCTGCGACCTACAACAGCAAAAAGCAAGCTGATGCTGATCGTCTAATCAGGAAACTCGAAAAAATCCT
GCCTGGCCTAAGTCAAGCCATCGTTCACCGAGAGGTGGGCACTCCTCGTAGCCATCGACGTTTCCTAGGACGATTTCAGG
GTAGCTATGGGCCAATCCCCTCAAGTCGTTTACCAGGCCTTCTCACCATGCCCTTTAACCGCACTGGACTCAAAGGGCTT
TATTGCGTCGGCGACTCTTGTTTCCCTGGCCAAGGCCTAAATGCAGTTGCTTTTAGTGGCTTTGCCTGCTCCCATCTCAT
CGGTGCCGATTTAGGGATCAACCCCTGGGCCCTGCCCAATTGA

Upstream 100 bases:

>100_bases
CTTTAATCTCTCCAGCAAAGCTGCCGCAAACTTCACAGTCAGAGTTGACGGGTTCAGAGTTGCATGCAAGCCCTTAGCGT
CAAGGGATTGAGACCATGCC

Downstream 100 bases:

>100_bases
GCCATCTTCTAGATCTTCATAGAAGACAATCGCTACCCAAACGAACTTGAAGTACAAGGCAGCAGCAGAAATTGTTCCGC
GGTATCGCTAGCACATCTCA

Product: carotenoid isomerase

Products: NA

Alternate protein names: Phytoene desaturase [H]

Number of amino acids: Translated: 520; Mature: 520

Protein sequence:

>520_residues
MEPIRIEKDATQPWDAVVIGSGIGGLVTASQLAVKGAKVLVLESYTIPGGSSGSFQREGYTFDVGASMIFGFGEKGYTNL
LTRALADVGEHCDTLPDPAQLAYHLPGGLELAVDRKYEQFIADLTARFPHEAKGIRHFYDICWQVFNCLDAMPLLSIEDP
TYLAKVFFKSPLACLGLARWLPVNVGDVARRHIKDPELLRFIDIECFCWSVMPADLTPMINAGMVFSDRHAGGINYPRGG
VGVIAQKLVKGMQRHGGEIRYKARVTRVVLKDNRAVGVQLANGEIIHARRVISNATRWDTFSGEGSKQALVDAEHTPAAE
QTWRRRYVPSPSFLSLHLGVRNEAIPANSHCHHLLLESWDEMESEQGVAFVSMPTLLDPSLAPEGHHIVHAFTPSSMQAW
QDLSPATYNSKKQADADRLIRKLEKILPGLSQAIVHREVGTPRSHRRFLGRFQGSYGPIPSSRLPGLLTMPFNRTGLKGL
YCVGDSCFPGQGLNAVAFSGFACSHLIGADLGINPWALPN

Sequences:

>Translated_520_residues
MEPIRIEKDATQPWDAVVIGSGIGGLVTASQLAVKGAKVLVLESYTIPGGSSGSFQREGYTFDVGASMIFGFGEKGYTNL
LTRALADVGEHCDTLPDPAQLAYHLPGGLELAVDRKYEQFIADLTARFPHEAKGIRHFYDICWQVFNCLDAMPLLSIEDP
TYLAKVFFKSPLACLGLARWLPVNVGDVARRHIKDPELLRFIDIECFCWSVMPADLTPMINAGMVFSDRHAGGINYPRGG
VGVIAQKLVKGMQRHGGEIRYKARVTRVVLKDNRAVGVQLANGEIIHARRVISNATRWDTFSGEGSKQALVDAEHTPAAE
QTWRRRYVPSPSFLSLHLGVRNEAIPANSHCHHLLLESWDEMESEQGVAFVSMPTLLDPSLAPEGHHIVHAFTPSSMQAW
QDLSPATYNSKKQADADRLIRKLEKILPGLSQAIVHREVGTPRSHRRFLGRFQGSYGPIPSSRLPGLLTMPFNRTGLKGL
YCVGDSCFPGQGLNAVAFSGFACSHLIGADLGINPWALPN
>Mature_520_residues
MEPIRIEKDATQPWDAVVIGSGIGGLVTASQLAVKGAKVLVLESYTIPGGSSGSFQREGYTFDVGASMIFGFGEKGYTNL
LTRALADVGEHCDTLPDPAQLAYHLPGGLELAVDRKYEQFIADLTARFPHEAKGIRHFYDICWQVFNCLDAMPLLSIEDP
TYLAKVFFKSPLACLGLARWLPVNVGDVARRHIKDPELLRFIDIECFCWSVMPADLTPMINAGMVFSDRHAGGINYPRGG
VGVIAQKLVKGMQRHGGEIRYKARVTRVVLKDNRAVGVQLANGEIIHARRVISNATRWDTFSGEGSKQALVDAEHTPAAE
QTWRRRYVPSPSFLSLHLGVRNEAIPANSHCHHLLLESWDEMESEQGVAFVSMPTLLDPSLAPEGHHIVHAFTPSSMQAW
QDLSPATYNSKKQADADRLIRKLEKILPGLSQAIVHREVGTPRSHRRFLGRFQGSYGPIPSSRLPGLLTMPFNRTGLKGL
YCVGDSCFPGQGLNAVAFSGFACSHLIGADLGINPWALPN

Specific function: This enzyme converts phytoene into lycopene via the intermediaries of phytofluene, zeta-carotene and neurosporene by the introduction of four double bonds [H]

COG id: COG1233

COG function: function code Q; Phytoene dehydrogenase and related proteins

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the carotenoid/retinoid oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI229577391, Length=561, Percent_Identity=24.2424242424242, Blast_Score=82, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002937
- InterPro:   IPR008150
- InterPro:   IPR014105 [H]

Pfam domain/function: PF01593 Amino_oxidase [H]

EC number: NA

Molecular weight: Translated: 57056; Mature: 57056

Theoretical pI: Translated: 7.81; Mature: 7.81

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEPIRIEKDATQPWDAVVIGSGIGGLVTASQLAVKGAKVLVLESYTIPGGSSGSFQREGY
CCCCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHCCCEEEEEEEEECCCCCCCCCCCCCE
TFDVGASMIFGFGEKGYTNLLTRALADVGEHCDTLPDPAQLAYHLPGGLELAVDRKYEQF
EEECCCHHEECCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHEEECCCCEEEEECHHHHHH
IADLTARFPHEAKGIRHFYDICWQVFNCLDAMPLLSIEDPTYLAKVFFKSPLACLGLARW
HHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCEECCCHHHHHHHHHHCCHHHHHHHHH
LPVNVGDVARRHIKDPELLRFIDIECFCWSVMPADLTPMINAGMVFSDRHAGGINYPRGG
CCCCHHHHHHHHCCCCHHHHEEEEEEEEEECCCCCCCCHHCCCEEEECCCCCCCCCCCCC
VGVIAQKLVKGMQRHGGEIRYKARVTRVVLKDNRAVGVQLANGEIIHARRVISNATRWDT
HHHHHHHHHHHHHHCCCCEEEEEEEEEEEEECCCEEEEEECCCCEEHHHHHHCCCCCCCC
FSGEGSKQALVDAEHTPAAEQTWRRRYVPSPSFLSLHLGVRNEAIPANSHCHHLLLESWD
CCCCCCCCEEEECCCCCCHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHH
EMESEQGVAFVSMPTLLDPSLAPEGHHIVHAFTPSSMQAWQDLSPATYNSKKQADADRLI
HHHHHCCEEEEECCCCCCCCCCCCCCEEEEEECCCHHHHHHCCCCCCCCCHHHCCHHHHH
RKLEKILPGLSQAIVHREVGTPRSHRRFLGRFQGSYGPIPSSRLPGLLTMPFNRTGLKGL
HHHHHHCCCHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCCCEEEECCCCCCCCCEE
YCVGDSCFPGQGLNAVAFSGFACSHLIGADLGINPWALPN
EEECCCCCCCCCCCCEEECCHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure
MEPIRIEKDATQPWDAVVIGSGIGGLVTASQLAVKGAKVLVLESYTIPGGSSGSFQREGY
CCCCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHCCCEEEEEEEEECCCCCCCCCCCCCE
TFDVGASMIFGFGEKGYTNLLTRALADVGEHCDTLPDPAQLAYHLPGGLELAVDRKYEQF
EEECCCHHEECCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHEEECCCCEEEEECHHHHHH
IADLTARFPHEAKGIRHFYDICWQVFNCLDAMPLLSIEDPTYLAKVFFKSPLACLGLARW
HHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCEECCCHHHHHHHHHHCCHHHHHHHHH
LPVNVGDVARRHIKDPELLRFIDIECFCWSVMPADLTPMINAGMVFSDRHAGGINYPRGG
CCCCHHHHHHHHCCCCHHHHEEEEEEEEEECCCCCCCCHHCCCEEEECCCCCCCCCCCCC
VGVIAQKLVKGMQRHGGEIRYKARVTRVVLKDNRAVGVQLANGEIIHARRVISNATRWDT
HHHHHHHHHHHHHHCCCCEEEEEEEEEEEEECCCEEEEEECCCCEEHHHHHHCCCCCCCC
FSGEGSKQALVDAEHTPAAEQTWRRRYVPSPSFLSLHLGVRNEAIPANSHCHHLLLESWD
CCCCCCCCEEEECCCCCCHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHH
EMESEQGVAFVSMPTLLDPSLAPEGHHIVHAFTPSSMQAWQDLSPATYNSKKQADADRLI
HHHHHCCEEEEECCCCCCCCCCCCCCEEEEEECCCHHHHHHCCCCCCCCCHHHCCHHHHH
RKLEKILPGLSQAIVHREVGTPRSHRRFLGRFQGSYGPIPSSRLPGLLTMPFNRTGLKGL
HHHHHHCCCHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCCCEEEECCCCCCCCCEE
YCVGDSCFPGQGLNAVAFSGFACSHLIGADLGINPWALPN
EEECCCCCCCCCCCCEEECCHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2263648 [H]