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The map label for this gene is gltP [H]

Identifier: 33863181

GI number: 33863181

Start: 990347

End: 992560

Strand: Direct

Name: gltP [H]

Synonym: PMT0909

Alternate gene names: 33863181

Gene position: 990347-992560 (Clockwise)

Preceding gene: 33863180

Following gene: 33863184

Centisome position: 41.08

GC content: 47.92

Gene sequence:

>2214_bases
ATGGTTGCCGGACTGCGATGGCTTCTCTGGCCACTGAGCCGCTTTCTGCGTCAGAGCCTATCGATGCAGATCCTTGAAGG
TTTGCTGGCAGGGGTCATTGCTGGGTTGATGCTTCCCGTAGCCCTGGTGAGCCTGCTTGCACCAATAGGGGAAGGCTTCC
TTCGCCTGTTCCAGATGCCAGTTGTGCCGTTTTTGAGCATTTCGCTCGTGGCTGGAGTGGGACGCCTTGAACTTGCTCAA
GCAAGTCGGCTACTCGGCCGAGCAGCGATTGTGCTGATGGGGTTCTGGGTGGTCGTGCTCGGGGCAGTGCTTTTGATTCC
CCTTGGCTTTCCAGATTGGCGGGAAGCATCGTTCTTCCGGCCAAGCCTCTTAGAGGCTGCTAAGCCGATGAACCTCATCG
AACTGTTTATTCCAGTCAATCCATTCGCAGCATTTGCAGACACACAAATTCCAGCAGTGGTGCTGTTTTCCATTGCGCTC
GGCATCGCTCTGATTTCAGTTCCAAAAAGGCAGGGCTTGATCGAGGTGTTGGATCGGGTTCAATCAGCGCTGTTGAAGAT
CTCTGCATACATCGCAAGGTATACACCACTTGGAGTGTTTGCGATCCTCGCAAGCACGACGTCTCAAGTTTCACCATCAG
AGCTCCCTCGACTCGCCATCTACATTGTTTTGCAGGGCGGAATTGCAGTTGTCCTTACATTTCTCTTCCTTCCCTACCTC
GTTCAAGCAGTCATCCCTATCAAGGCCGGGGAACTGATCAAGTCTTTCCGTACACCGCTTTTGATTGCGTTCTCAACAGC
AAATTTACTGGTGGTCCTTCCATTACTAATCAATCAAGGCAAACAGCTCTTGATTGAGGGAATGGCAAGGCAACGTTCCC
TTGGCTTAGAAGATCGTGAAAGCCGTAAAAAGTTAGCTCAGTCGATCGAATTACCGGTTGAGGTGCTGACTCCTCTTGCG
CTGGTCTTCCCTGATATGGGCCGAGTGTTGTCGCTTGCTTTCGTCCCTTTTGCAGGTTGGCTTACAGGCAATCCGTTAAC
AGTCGAACAAATGCCCAGCTTCCTCATCACAGGTCTGGCAAGCACCTTCCTTGAAGGCGTGCTTGCGATGACATTCCTGC
TGAGCAAGATGGGCCTGCCTACAGACATGGTGAATCTCTACATTGCCCTTGATCAGTTGGCTGTAGCACGTCTTGGCACA
CTGCTTGCATGCATGAGTGTGATCAGCCTTGTACTTGTTGGGACATGGATCAGCCTTGAGGGATTTCGATACAGATTATC
GAAACTCTTACCAGTTGCTATCTCAATGCTAATCATACCAATATTCATCAGTGTGAATCGGTTTATTCTCAATCAAATTC
CGCAACCAAGCAATCCATACCGAAGTCAACTCGAGACTCAAGGCTTTGTTCTGGCCAAAGAGAAAGCAGAGCTAATCAAG
GAACCAAAGCCACTCGAAGGAGCCGGTATCTGGCCATCAATGCAGGCTAGAGGAGCAATCCGTTATTGCATCCATAAGCA
GGATTATCCAATGGCTTATCGCAATGCAAAACAAGAGTTAGTTGGTGCTGATGTTGAAACTGGGCTCTTATTTGCAGAAG
ATATGGGTATGAAAGCAAGTTTTATTCAAATCGATCACTTGGGTAATCAAAATAAGGTTAGACCAAATGGACTCGAGGCA
CTGAAGAATGAATTATGTGACCTAAAGCTATCCAGTGATATCATTGTACCTCAGGAGTCTGCTGAGGTGTTGTACACTTC
AACCAATCAAAGCTACGGCATAGGATTGCTGTTAAAGGGGAGTCGATTCAGTAGTAAATATAGATGGAAAGAGATCAAGG
CTATAAAAGGTTTTCGAGTTGGCCTCGAAGCTCATTCCCCGTACAGTATCAATTGGGTGCAACGATTGCTTCCGCACGCT
ATCTTGAATACATCGAAAGTAACGGCCGAGCTACTCAAGGAACTCAAAAATGATAATCTTGATGCAGTAATCATTTCGGC
CCAGAAAGGTGCTGCTTGGAATGTACTCGAACCAAGCCTCACATTACTCGTACCAAAACCTACAAAAAGCTTGCCGACCG
CAAGACAAGTTCCTGAAGATGCGATTGAGCTTTCGAGGGTTTGGAATCACTGGCTAAAGCTGCAGGGGTTTGACGGAACT
AAAAATAAAGTTTATCAACACTGGGTTGAAGGGATTGCAGATGAGGGAAAATAA

Upstream 100 bases:

>100_bases
CTTGAGTGACAGGTCCTCAACTCTGTGCTTGCCTTTAATGGCTAATCGTGAGGAATCGTTTTTCTGACGTTAAACGCCCT
CCGGGACATGGAGTTGCGAG

Downstream 100 bases:

>100_bases
TGACGCCAACAATATCAACCGAGTAATAGACAAGATTTGACAGTTTCCTAATCATTTTAAGATTGATATTCTGGAAATAT
GTATGTCAATGATGGTGCTA

Product: DAACS family glutamate/aspartate/dicarboxylate symporter

Products: L-aspartate [Cytoplasm]; Proton [Cytoplasm]; L-glutamate [Cytoplasm] [C]

Alternate protein names: Glutamate-aspartate carrier protein [H]

Number of amino acids: Translated: 737; Mature: 737

Protein sequence:

>737_residues
MVAGLRWLLWPLSRFLRQSLSMQILEGLLAGVIAGLMLPVALVSLLAPIGEGFLRLFQMPVVPFLSISLVAGVGRLELAQ
ASRLLGRAAIVLMGFWVVVLGAVLLIPLGFPDWREASFFRPSLLEAAKPMNLIELFIPVNPFAAFADTQIPAVVLFSIAL
GIALISVPKRQGLIEVLDRVQSALLKISAYIARYTPLGVFAILASTTSQVSPSELPRLAIYIVLQGGIAVVLTFLFLPYL
VQAVIPIKAGELIKSFRTPLLIAFSTANLLVVLPLLINQGKQLLIEGMARQRSLGLEDRESRKKLAQSIELPVEVLTPLA
LVFPDMGRVLSLAFVPFAGWLTGNPLTVEQMPSFLITGLASTFLEGVLAMTFLLSKMGLPTDMVNLYIALDQLAVARLGT
LLACMSVISLVLVGTWISLEGFRYRLSKLLPVAISMLIIPIFISVNRFILNQIPQPSNPYRSQLETQGFVLAKEKAELIK
EPKPLEGAGIWPSMQARGAIRYCIHKQDYPMAYRNAKQELVGADVETGLLFAEDMGMKASFIQIDHLGNQNKVRPNGLEA
LKNELCDLKLSSDIIVPQESAEVLYTSTNQSYGIGLLLKGSRFSSKYRWKEIKAIKGFRVGLEAHSPYSINWVQRLLPHA
ILNTSKVTAELLKELKNDNLDAVIISAQKGAAWNVLEPSLTLLVPKPTKSLPTARQVPEDAIELSRVWNHWLKLQGFDGT
KNKVYQHWVEGIADEGK

Sequences:

>Translated_737_residues
MVAGLRWLLWPLSRFLRQSLSMQILEGLLAGVIAGLMLPVALVSLLAPIGEGFLRLFQMPVVPFLSISLVAGVGRLELAQ
ASRLLGRAAIVLMGFWVVVLGAVLLIPLGFPDWREASFFRPSLLEAAKPMNLIELFIPVNPFAAFADTQIPAVVLFSIAL
GIALISVPKRQGLIEVLDRVQSALLKISAYIARYTPLGVFAILASTTSQVSPSELPRLAIYIVLQGGIAVVLTFLFLPYL
VQAVIPIKAGELIKSFRTPLLIAFSTANLLVVLPLLINQGKQLLIEGMARQRSLGLEDRESRKKLAQSIELPVEVLTPLA
LVFPDMGRVLSLAFVPFAGWLTGNPLTVEQMPSFLITGLASTFLEGVLAMTFLLSKMGLPTDMVNLYIALDQLAVARLGT
LLACMSVISLVLVGTWISLEGFRYRLSKLLPVAISMLIIPIFISVNRFILNQIPQPSNPYRSQLETQGFVLAKEKAELIK
EPKPLEGAGIWPSMQARGAIRYCIHKQDYPMAYRNAKQELVGADVETGLLFAEDMGMKASFIQIDHLGNQNKVRPNGLEA
LKNELCDLKLSSDIIVPQESAEVLYTSTNQSYGIGLLLKGSRFSSKYRWKEIKAIKGFRVGLEAHSPYSINWVQRLLPHA
ILNTSKVTAELLKELKNDNLDAVIISAQKGAAWNVLEPSLTLLVPKPTKSLPTARQVPEDAIELSRVWNHWLKLQGFDGT
KNKVYQHWVEGIADEGK
>Mature_737_residues
MVAGLRWLLWPLSRFLRQSLSMQILEGLLAGVIAGLMLPVALVSLLAPIGEGFLRLFQMPVVPFLSISLVAGVGRLELAQ
ASRLLGRAAIVLMGFWVVVLGAVLLIPLGFPDWREASFFRPSLLEAAKPMNLIELFIPVNPFAAFADTQIPAVVLFSIAL
GIALISVPKRQGLIEVLDRVQSALLKISAYIARYTPLGVFAILASTTSQVSPSELPRLAIYIVLQGGIAVVLTFLFLPYL
VQAVIPIKAGELIKSFRTPLLIAFSTANLLVVLPLLINQGKQLLIEGMARQRSLGLEDRESRKKLAQSIELPVEVLTPLA
LVFPDMGRVLSLAFVPFAGWLTGNPLTVEQMPSFLITGLASTFLEGVLAMTFLLSKMGLPTDMVNLYIALDQLAVARLGT
LLACMSVISLVLVGTWISLEGFRYRLSKLLPVAISMLIIPIFISVNRFILNQIPQPSNPYRSQLETQGFVLAKEKAELIK
EPKPLEGAGIWPSMQARGAIRYCIHKQDYPMAYRNAKQELVGADVETGLLFAEDMGMKASFIQIDHLGNQNKVRPNGLEA
LKNELCDLKLSSDIIVPQESAEVLYTSTNQSYGIGLLLKGSRFSSKYRWKEIKAIKGFRVGLEAHSPYSINWVQRLLPHA
ILNTSKVTAELLKELKNDNLDAVIISAQKGAAWNVLEPSLTLLVPKPTKSLPTARQVPEDAIELSRVWNHWLKLQGFDGT
KNKVYQHWVEGIADEGK

Specific function: This carrier protein is part of the Na(+)-independent, binding-protein-independent glutamate-aspartate transport system [H]

COG id: COG1301

COG function: function code C; Na+/H+-dicarboxylate symporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family [H]

Homologues:

Organism=Escherichia coli, GI1790514, Length=302, Percent_Identity=28.1456953642384, Blast_Score=76, Evalue=7e-15,
Organism=Escherichia coli, GI1789947, Length=288, Percent_Identity=25, Blast_Score=63, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001991
- InterPro:   IPR018107 [H]

Pfam domain/function: PF00375 SDF [H]

EC number: NA

Molecular weight: Translated: 81068; Mature: 81068

Theoretical pI: Translated: 9.86; Mature: 9.86

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVAGLRWLLWPLSRFLRQSLSMQILEGLLAGVIAGLMLPVALVSLLAPIGEGFLRLFQMP
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
VVPFLSISLVAGVGRLELAQASRLLGRAAIVLMGFWVVVLGAVLLIPLGFPDWREASFFR
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
PSLLEAAKPMNLIELFIPVNPFAAFADTQIPAVVLFSIALGIALISVPKRQGLIEVLDRV
HHHHHHCCCCCEEEEEECCCCHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
QSALLKISAYIARYTPLGVFAILASTTSQVSPSELPRLAIYIVLQGGIAVVLTFLFLPYL
HHHHHHHHHHHHHHCHHHHHHHHHHCCCCCCHHHCCCEEEEEEECCCHHHHHHHHHHHHH
VQAVIPIKAGELIKSFRTPLLIAFSTANLLVVLPLLINQGKQLLIEGMARQRSLGLEDRE
HHHHHCCCHHHHHHHHCCCEEEEEEHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCHH
SRKKLAQSIELPVEVLTPLALVFPDMGRVLSLAFVPFAGWLTGNPLTVEQMPSFLITGLA
HHHHHHHHHCCCHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCEEHHHHHHHHHHHHH
STFLEGVLAMTFLLSKMGLPTDMVNLYIALDQLAVARLGTLLACMSVISLVLVGTWISLE
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GFRYRLSKLLPVAISMLIIPIFISVNRFILNQIPQPSNPYRSQLETQGFVLAKEKAELIK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCCCEEEHHHHHHHC
EPKPLEGAGIWPSMQARGAIRYCIHKQDYPMAYRNAKQELVGADVETGLLFAEDMGMKAS
CCCCCCCCCCCCCHHHCCHHHHHCCCCCCCHHHHHHHHHHHCCCCHHCEEEECCCCCCEE
FIQIDHLGNQNKVRPNGLEALKNELCDLKLSSDIIVPQESAEVLYTSTNQSYGIGLLLKG
EEEEECCCCCCCCCCCHHHHHHHHHCCCCCCCCEECCCCCCCEEEEECCCCCCEEEEEEC
SRFSSKYRWKEIKAIKGFRVGLEAHSPYSINWVQRLLPHAILNTSKVTAELLKELKNDNL
CCCCCCHHHHHHHHHHCCEEEECCCCCCCHHHHHHHHHHHHHCHHHHHHHHHHHHCCCCC
DAVIISAQKGAAWNVLEPSLTLLVPKPTKSLPTARQVPEDAIELSRVWNHWLKLQGFDGT
CEEEEEECCCCCCCEECCCEEEEECCCCCCCCCHHCCCHHHHHHHHHHHHHHEECCCCCC
KNKVYQHWVEGIADEGK
HHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MVAGLRWLLWPLSRFLRQSLSMQILEGLLAGVIAGLMLPVALVSLLAPIGEGFLRLFQMP
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
VVPFLSISLVAGVGRLELAQASRLLGRAAIVLMGFWVVVLGAVLLIPLGFPDWREASFFR
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
PSLLEAAKPMNLIELFIPVNPFAAFADTQIPAVVLFSIALGIALISVPKRQGLIEVLDRV
HHHHHHCCCCCEEEEEECCCCHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
QSALLKISAYIARYTPLGVFAILASTTSQVSPSELPRLAIYIVLQGGIAVVLTFLFLPYL
HHHHHHHHHHHHHHCHHHHHHHHHHCCCCCCHHHCCCEEEEEEECCCHHHHHHHHHHHHH
VQAVIPIKAGELIKSFRTPLLIAFSTANLLVVLPLLINQGKQLLIEGMARQRSLGLEDRE
HHHHHCCCHHHHHHHHCCCEEEEEEHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCHH
SRKKLAQSIELPVEVLTPLALVFPDMGRVLSLAFVPFAGWLTGNPLTVEQMPSFLITGLA
HHHHHHHHHCCCHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCEEHHHHHHHHHHHHH
STFLEGVLAMTFLLSKMGLPTDMVNLYIALDQLAVARLGTLLACMSVISLVLVGTWISLE
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GFRYRLSKLLPVAISMLIIPIFISVNRFILNQIPQPSNPYRSQLETQGFVLAKEKAELIK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCCCEEEHHHHHHHC
EPKPLEGAGIWPSMQARGAIRYCIHKQDYPMAYRNAKQELVGADVETGLLFAEDMGMKAS
CCCCCCCCCCCCCHHHCCHHHHHCCCCCCCHHHHHHHHHHHCCCCHHCEEEECCCCCCEE
FIQIDHLGNQNKVRPNGLEALKNELCDLKLSSDIIVPQESAEVLYTSTNQSYGIGLLLKG
EEEEECCCCCCCCCCCHHHHHHHHHCCCCCCCCEECCCCCCCEEEEECCCCCCEEEEEEC
SRFSSKYRWKEIKAIKGFRVGLEAHSPYSINWVQRLLPHAILNTSKVTAELLKELKNDNL
CCCCCCHHHHHHHHHHCCEEEECCCCCCCHHHHHHHHHHHHHCHHHHHHHHHHHHCCCCC
DAVIISAQKGAAWNVLEPSLTLLVPKPTKSLPTARQVPEDAIELSRVWNHWLKLQGFDGT
CEEEEEECCCCCCCEECCCEEEEECCCCCCCCCHHCCCHHHHHHHHHHHHHHEECCCCCC
KNKVYQHWVEGIADEGK
HHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-aspartate [Periplasm]; Proton [Periplasm]; L-glutamate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-aspartate [Periplasm] = Proton [Cytoplasm] + L-aspartate [Cytoplasm] Proton [Periplasm] + L-glutamate [Periplasm] = Proton [Cytoplasm] + L-glutamate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1971622; 1551855; 8265357; 9278503 [H]