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The map label for this gene is pgl [H]

Identifier: 33862837

GI number: 33862837

Start: 617384

End: 618094

Strand: Reverse

Name: pgl [H]

Synonym: PMT0564

Alternate gene names: 33862837

Gene position: 618094-617384 (Counterclockwise)

Preceding gene: 33862838

Following gene: 33862835

Centisome position: 25.64

GC content: 55.84

Gene sequence:

>711_bases
ATGACGACCTACAAAGTTGAGCGAGCGAGCGACCCTGAGGATCTGGCACGTCGCGCCGCCCAGAAGCTCGCATCTCATAT
TGATCTGGTACTTGATCAGCGTGATCGCGTTCAGATCGCTCTCTCGGGAGGGAGCACTCCCGCTATTGCTTATAGGTTGC
TTGGTCAGGAGCGACTGCCCTGGGATCGTGTTGATGTTTTTCTGGGGGATGAGCGCTGGGTTGATGCCAGGGATGACGCC
AGTAACGCCCGCATGCTTCGTACGACACTTCTTGCTGAAGGCCCAGGATCGCAGGCTGCGTTTCATCCCGTGCCAACGGT
GGAGCTGCCAAACCCTGAGGCCAGTGCCGAGGCCTACGCGAAGCTCGTGCAGGAAACCTGTGCAGGTGATCCGCCGGTGT
TTGATCTAATGGTTTTAGGACTTGGTGAAGATGGCCATACAGCCTCTCTTTTTCCAGGAACGGATGCCCCCGCCGTTGTT
GATCGCTGGGCTACTGTCGGTAAAGGGAAAGGTTTAGAAAGAATCACTCTCACCGCACCGGTGCTCAGCTCTGCACGCGA
AGTGATCTTTCTTGTGAGTGGTGTAGGGAAGCAGGTTGCCCTGAAGCGCTTATTAGATTCTGCTGAATCAGCTGAACGCA
CGCCTGCCCGCTTGGTTCAACCTCGTTCACCGATTTTGGTCTTGGCAGATGAGGCCGCCTTACTCGGATAA

Upstream 100 bases:

>100_bases
TTGGTGCAGGCCATGCGCGATTGCTTCGGCTCACATACCTACCAGCGGGTTGACAAAGAAGGAACCTTCCATACTGAGTG
GCTGGACTGAGGAGATCGTG

Downstream 100 bases:

>100_bases
TGATGCACTCTTGAGAAGTGTTCTTGTTCATTATTGCTTGCATTATCTTCCAATATCTACAAATATAAATTCAGCATTAA
TTGCAGATCAATGACTTTAC

Product: 6-phosphogluconolactonase (DevB, Pgl)

Products: NA

Alternate protein names: 6PGL [H]

Number of amino acids: Translated: 236; Mature: 235

Protein sequence:

>236_residues
MTTYKVERASDPEDLARRAAQKLASHIDLVLDQRDRVQIALSGGSTPAIAYRLLGQERLPWDRVDVFLGDERWVDARDDA
SNARMLRTTLLAEGPGSQAAFHPVPTVELPNPEASAEAYAKLVQETCAGDPPVFDLMVLGLGEDGHTASLFPGTDAPAVV
DRWATVGKGKGLERITLTAPVLSSAREVIFLVSGVGKQVALKRLLDSAESAERTPARLVQPRSPILVLADEAALLG

Sequences:

>Translated_236_residues
MTTYKVERASDPEDLARRAAQKLASHIDLVLDQRDRVQIALSGGSTPAIAYRLLGQERLPWDRVDVFLGDERWVDARDDA
SNARMLRTTLLAEGPGSQAAFHPVPTVELPNPEASAEAYAKLVQETCAGDPPVFDLMVLGLGEDGHTASLFPGTDAPAVV
DRWATVGKGKGLERITLTAPVLSSAREVIFLVSGVGKQVALKRLLDSAESAERTPARLVQPRSPILVLADEAALLG
>Mature_235_residues
TTYKVERASDPEDLARRAAQKLASHIDLVLDQRDRVQIALSGGSTPAIAYRLLGQERLPWDRVDVFLGDERWVDARDDAS
NARMLRTTLLAEGPGSQAAFHPVPTVELPNPEASAEAYAKLVQETCAGDPPVFDLMVLGLGEDGHTASLFPGTDAPAVVD
RWATVGKGKGLERITLTAPVLSSAREVIFLVSGVGKQVALKRLLDSAESAERTPARLVQPRSPILVLADEAALLG

Specific function: Hydrolysis of 6-phosphogluconolactone to 6- phosphogluconate [H]

COG id: COG0363

COG function: function code G; 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily [H]

Homologues:

Organism=Homo sapiens, GI6912586, Length=231, Percent_Identity=38.5281385281385, Blast_Score=99, Evalue=4e-21,
Organism=Homo sapiens, GI52145310, Length=240, Percent_Identity=30.8333333333333, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI115533058, Length=245, Percent_Identity=30.2040816326531, Blast_Score=82, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI115533060, Length=245, Percent_Identity=30.2040816326531, Blast_Score=82, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6321687, Length=217, Percent_Identity=29.9539170506912, Blast_Score=85, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6321957, Length=212, Percent_Identity=29.2452830188679, Blast_Score=80, Evalue=4e-16,
Organism=Saccharomyces cerevisiae, GI6324362, Length=198, Percent_Identity=29.2929292929293, Blast_Score=74, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6319918, Length=188, Percent_Identity=29.2553191489362, Blast_Score=71, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24641119, Length=232, Percent_Identity=29.7413793103448, Blast_Score=75, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005900
- InterPro:   IPR006148 [H]

Pfam domain/function: PF01182 Glucosamine_iso [H]

EC number: =3.1.1.31 [H]

Molecular weight: Translated: 25324; Mature: 25193

Theoretical pI: Translated: 4.86; Mature: 4.86

Prosite motif: PS00041 HTH_ARAC_FAMILY_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTYKVERASDPEDLARRAAQKLASHIDLVLDQRDRVQIALSGGSTPAIAYRLLGQERLP
CCCEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHCCCCCC
WDRVDVFLGDERWVDARDDASNARMLRTTLLAEGPGSQAAFHPVPTVELPNPEASAEAYA
CCCEEEEECCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCEECCCCCHHHHHHH
KLVQETCAGDPPVFDLMVLGLGEDGHTASLFPGTDAPAVVDRWATVGKGKGLERITLTAP
HHHHHHHCCCCCEEEEEEEEECCCCCEEEECCCCCCCHHHHHHHHHCCCCCCEEEEEEHH
VLSSAREVIFLVSGVGKQVALKRLLDSAESAERTPARLVQPRSPILVLADEAALLG
HHHHHHHEEEEECCCCHHHHHHHHHHHHHHHHCCHHHHCCCCCCEEEEECCHHHCC
>Mature Secondary Structure 
TTYKVERASDPEDLARRAAQKLASHIDLVLDQRDRVQIALSGGSTPAIAYRLLGQERLP
CCEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHCCCCCC
WDRVDVFLGDERWVDARDDASNARMLRTTLLAEGPGSQAAFHPVPTVELPNPEASAEAYA
CCCEEEEECCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCEECCCCCHHHHHHH
KLVQETCAGDPPVFDLMVLGLGEDGHTASLFPGTDAPAVVDRWATVGKGKGLERITLTAP
HHHHHHHCCCCCEEEEEEEEECCCCCEEEECCCCCCCHHHHHHHHHCCCCCCEEEEEEHH
VLSSAREVIFLVSGVGKQVALKRLLDSAESAERTPARLVQPRSPILVLADEAALLG
HHHHHHHEEEEECCCCHHHHHHHHHHHHHHHHCCHHHHCCCCCCEEEEECCHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905231; 9298645 [H]