Click here to switch to the map view.

The map label for this gene is cobW [H]

Identifier: 33862829

GI number: 33862829

Start: 610874

End: 611992

Strand: Reverse

Name: cobW [H]

Synonym: PMT0556

Alternate gene names: 33862829

Gene position: 611992-610874 (Counterclockwise)

Preceding gene: 33862830

Following gene: 33862825

Centisome position: 25.38

GC content: 50.58

Gene sequence:

>1119_bases
TTGATTTCAAAGCGTCTACCAGTCACTGTTTTGACTGGTTTCCTTGGAGCTGGAAAGACCACCTTGCTACGTCATCTGCT
CACTCATGGGGGGCAGCGTTTAGCGGTCATGGTCAATGAATTTGGCACGATTGGTCTTGATGGCGATTTAATCCGTAGCT
GTGGCTTTTGTCCGGAGGAGGAATTGGATGGTCGAGTCGTTGAACTCAATAACGGTTGTCTCTGCTGCACGGTGCAGGAA
GACTTTTTACCCACCATGGAGACCTTGCTGAAACAGGCGGATAAGTTGGATGGAATTATCGTTGAAACCAGTGGCCTTGC
TCTTCCTCGCCCCCTCTTAAAAGCGCTCGACTGGCCTGCCGTACGCACTCGAGTTTATGTGAATGGAGTGGTCACAATGG
TGGATGGTGAAGCCCTCGCAGCGGGTAGCCCCGTTGGTGATCCTGCCGGGTTAGAACGGCAGCGACAGGAGGATCCAAGC
CTTGATCATCTCAGTGCTGTTGAAGACTTGTTCACTGATCAGTTGGAAGCTGCTGATTTGGTGTTGATCAGTCGAGCGGA
TGTTGTCTCCAATGTCGACCTCCGCAAGCTCAAAAGCGAACTTGCTGAAAAGGTACGCCTTGGCACGTCAATGATGCCCA
TCAGTCATGGCCAAGTTGATCCAGCTGTGGTGCTAGGCCTCAGTACGACAGAGAATAGTGACCAACAAAAGAGCTTGCCT
AAACAATTTGGCGACGACCTAATCGACGATGCTTCCATTGATGTCGATCATCATGAAGATGATCATCATCATGACCACAA
CCATGTGGAGATGGTGAGTGGTGTGGTGCGCTTTGAAGGTTCTGTTGATCGGGCTACGGTTGAAGCACTTCTGCCTGAGT
TGGCAACACTTCATCAGGTTGTACGCCTAAAAGGTCGCTTATGGCTACCGGGCAAAGCTTTACCCCTTCAGCTGCAGATG
GTTGGCCCAAGGCTTAGCAGTTGGTTTGAGGCTGCTCCAAAGAACGCCTGGCATCCTGAGGAGGCGGGCGTTGATCTGGT
GGTGCTTAGTTTTGAAAAGCAAGCAGCTGAAGCGATTCGCTTTGATCTTGAAAGCTCCTTGATGTCAGATATTCTCTAA

Upstream 100 bases:

>100_bases
AGCTTTGCGCCAGAGCAGACGGCACCAATGCCGCTAGCGGGTCTCAAACTCTTGACAGCCTTGGCTGTCGTTCTTAATTC
CCAACCTGCATAAACCTGCC

Downstream 100 bases:

>100_bases
GGGAAGTCAACTGATTAAGCAGCTCAAGAGCTGAGCGGGTGGTTATGGTTTGGCTTCTCTATCTTTCGGCTCTTGCATCG
TGCCGTTCATCCAGTAGTCG

Product: cobalamin synthesis protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 372; Mature: 372

Protein sequence:

>372_residues
MISKRLPVTVLTGFLGAGKTTLLRHLLTHGGQRLAVMVNEFGTIGLDGDLIRSCGFCPEEELDGRVVELNNGCLCCTVQE
DFLPTMETLLKQADKLDGIIVETSGLALPRPLLKALDWPAVRTRVYVNGVVTMVDGEALAAGSPVGDPAGLERQRQEDPS
LDHLSAVEDLFTDQLEAADLVLISRADVVSNVDLRKLKSELAEKVRLGTSMMPISHGQVDPAVVLGLSTTENSDQQKSLP
KQFGDDLIDDASIDVDHHEDDHHHDHNHVEMVSGVVRFEGSVDRATVEALLPELATLHQVVRLKGRLWLPGKALPLQLQM
VGPRLSSWFEAAPKNAWHPEEAGVDLVVLSFEKQAAEAIRFDLESSLMSDIL

Sequences:

>Translated_372_residues
MISKRLPVTVLTGFLGAGKTTLLRHLLTHGGQRLAVMVNEFGTIGLDGDLIRSCGFCPEEELDGRVVELNNGCLCCTVQE
DFLPTMETLLKQADKLDGIIVETSGLALPRPLLKALDWPAVRTRVYVNGVVTMVDGEALAAGSPVGDPAGLERQRQEDPS
LDHLSAVEDLFTDQLEAADLVLISRADVVSNVDLRKLKSELAEKVRLGTSMMPISHGQVDPAVVLGLSTTENSDQQKSLP
KQFGDDLIDDASIDVDHHEDDHHHDHNHVEMVSGVVRFEGSVDRATVEALLPELATLHQVVRLKGRLWLPGKALPLQLQM
VGPRLSSWFEAAPKNAWHPEEAGVDLVVLSFEKQAAEAIRFDLESSLMSDIL
>Mature_372_residues
MISKRLPVTVLTGFLGAGKTTLLRHLLTHGGQRLAVMVNEFGTIGLDGDLIRSCGFCPEEELDGRVVELNNGCLCCTVQE
DFLPTMETLLKQADKLDGIIVETSGLALPRPLLKALDWPAVRTRVYVNGVVTMVDGEALAAGSPVGDPAGLERQRQEDPS
LDHLSAVEDLFTDQLEAADLVLISRADVVSNVDLRKLKSELAEKVRLGTSMMPISHGQVDPAVVLGLSTTENSDQQKSLP
KQFGDDLIDDASIDVDHHEDDHHHDHNHVEMVSGVVRFEGSVDRATVEALLPELATLHQVVRLKGRLWLPGKALPLQLQM
VGPRLSSWFEAAPKNAWHPEEAGVDLVVLSFEKQAAEAIRFDLESSLMSDIL

Specific function: Might be involved in cobalt reduction leading to cobalt(I) corrinoids [H]

COG id: COG0523

COG function: function code R; Putative GTPases (G3E family)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 cobW C-terminal domain [H]

Homologues:

Organism=Homo sapiens, GI33469141, Length=226, Percent_Identity=33.6283185840708, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI126722884, Length=226, Percent_Identity=33.6283185840708, Blast_Score=113, Evalue=3e-25,
Organism=Homo sapiens, GI146231952, Length=226, Percent_Identity=33.6283185840708, Blast_Score=112, Evalue=6e-25,
Organism=Homo sapiens, GI148727351, Length=226, Percent_Identity=33.1858407079646, Blast_Score=112, Evalue=8e-25,
Organism=Homo sapiens, GI223941779, Length=200, Percent_Identity=34.5, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI223941776, Length=230, Percent_Identity=31.7391304347826, Blast_Score=96, Evalue=4e-20,
Organism=Homo sapiens, GI119120938, Length=136, Percent_Identity=38.9705882352941, Blast_Score=96, Evalue=4e-20,
Organism=Escherichia coli, GI87082430, Length=331, Percent_Identity=28.7009063444109, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI1788499, Length=182, Percent_Identity=31.3186813186813, Blast_Score=87, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6324356, Length=225, Percent_Identity=29.7777777777778, Blast_Score=93, Evalue=6e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012824
- InterPro:   IPR003495
- InterPro:   IPR011629 [H]

Pfam domain/function: PF02492 cobW; PF07683 CobW_C [H]

EC number: NA

Molecular weight: Translated: 40582; Mature: 40582

Theoretical pI: Translated: 4.58; Mature: 4.58

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MISKRLPVTVLTGFLGAGKTTLLRHLLTHGGQRLAVMVNEFGTIGLDGDLIRSCGFCPEE
CCCCCCCHHHHHHHHCCCHHHHHHHHHHCCCCEEEEEEECCCCCCCCHHHHHHCCCCCCH
ELDGRVVELNNGCLCCTVQEDFLPTMETLLKQADKLDGIIVETSGLALPRPLLKALDWPA
HHCCEEEEECCCEEEEEECHHHHHHHHHHHHHHHHCCCEEEECCCCCCCHHHHHHCCCCH
VRTRVYVNGVVTMVDGEALAAGSPVGDPAGLERQRQEDPSLDHLSAVEDLFTDQLEAADL
HHEEEEEEEEEEEECCCEEECCCCCCCCCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHCE
VLISRADVVSNVDLRKLKSELAEKVRLGTSMMPISHGQVDPAVVLGLSTTENSDQQKSLP
EEEECCHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEECCCCCCHHHHHHH
KQFGDDLIDDASIDVDHHEDDHHHDHNHVEMVSGVVRFEGSVDRATVEALLPELATLHQV
HHHCHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHH
VRLKGRLWLPGKALPLQLQMVGPRLSSWFEAAPKNAWHPEEAGVDLVVLSFEKQAAEAIR
HHHCCCEECCCCCCCEEEEECCCHHHHHHHHCCCCCCCCCCCCCEEEEEECCHHHHHHHH
FDLESSLMSDIL
HHHHHHHHHHCC
>Mature Secondary Structure
MISKRLPVTVLTGFLGAGKTTLLRHLLTHGGQRLAVMVNEFGTIGLDGDLIRSCGFCPEE
CCCCCCCHHHHHHHHCCCHHHHHHHHHHCCCCEEEEEEECCCCCCCCHHHHHHCCCCCCH
ELDGRVVELNNGCLCCTVQEDFLPTMETLLKQADKLDGIIVETSGLALPRPLLKALDWPA
HHCCEEEEECCCEEEEEECHHHHHHHHHHHHHHHHCCCEEEECCCCCCCHHHHHHCCCCH
VRTRVYVNGVVTMVDGEALAAGSPVGDPAGLERQRQEDPSLDHLSAVEDLFTDQLEAADL
HHEEEEEEEEEEEECCCEEECCCCCCCCCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHCE
VLISRADVVSNVDLRKLKSELAEKVRLGTSMMPISHGQVDPAVVLGLSTTENSDQQKSLP
EEEECCHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEECCCCCCHHHHHHH
KQFGDDLIDDASIDVDHHEDDHHHDHNHVEMVSGVVRFEGSVDRATVEALLPELATLHQV
HHHCHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHH
VRLKGRLWLPGKALPLQLQMVGPRLSSWFEAAPKNAWHPEEAGVDLVVLSFEKQAAEAIR
HHHCCCEECCCCCCCEEEEECCCHHHHHHHHCCCCCCCCCCCCCEEEEEECCHHHHHHHH
FDLESSLMSDIL
HHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]