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The map label for this gene is purQ

Identifier: 33862812

GI number: 33862812

Start: 587194

End: 587847

Strand: Reverse

Name: purQ

Synonym: PMT0539

Alternate gene names: 33862812

Gene position: 587847-587194 (Counterclockwise)

Preceding gene: 33862813

Following gene: 33862811

Centisome position: 24.38

GC content: 51.53

Gene sequence:

>654_bases
ATGAGTATTGGTGTTGTTGTCTTCCCTGGCTCAAATTGTGATCGCGATGTGCGCTGGGCAGCGCAAGGATGCTTGAACAT
CCCAACGCGCTTTCTCTGGCATGAGACCCGTGATTTAAATGGTCTTGATGCTGTTGTGCTTCCAGGCGGGTTTAGTTATG
GCGACTACCTCCGTTGTGGTGCAATTGCCCGTTTTGCGCCGGTGCTTGAGTCGCTGGTGGAATTTGTTGCACGTGGCGGC
AGGGTGCTCGGCATCTGCAATGGCTTTCAGGTTCTGACTGAACTAGGTCTGCTCCCTGGAGCTCTAACCCGCAATCGAAG
CCTTCATTTCATCTGTGAGGATGCTTTGCTCACTGTGGAAAGCAACCGCACGCCTTGGCTAATGGGTCATCAACGAAAAG
ATTCTCTCACCCTGCCCATTGCCCATGGTGAGGGTCGATATCAGTGCAGTGACGAAACCCTTTGCCAGCTACAAGACGAT
GACGCTATCGCCTTGCGCTATGTCAATAATCCCAATGGTTCAGTGGCTGATATCGCTGGAATTACAAACAAGACTGGCAA
TGTACTTGGCTTAATGCCCCATCCTGAACGGGCTTGTGATCCTGTGATTGGTGGTGTGGATGGCAGAGGATTATTGCAAT
CACTGCTTGGCTGA

Upstream 100 bases:

>100_bases
CAGCTGGAACTGCTCAGTGATCGCCTGTTTGCCAATCCCGTGATTGAAGATTGGAGTCTTGAGCTTCAGCCGATTCCTAC
AACCACCGCTTAATGCAGCC

Downstream 100 bases:

>100_bases
TTCACGATGCGACGGCGCTCGCTGCTGATGGGGCTTCCGGCTGCCATAGCAGCAACCTTTGCTTGGCCAAAGCTAGGGCG
AACATTGACCCCAGCCTTTC

Product: phosphoribosylformylglycinamidine synthase I

Products: NA

Alternate protein names: Phosphoribosylformylglycinamidine synthase I; FGAM synthase I

Number of amino acids: Translated: 217; Mature: 216

Protein sequence:

>217_residues
MSIGVVVFPGSNCDRDVRWAAQGCLNIPTRFLWHETRDLNGLDAVVLPGGFSYGDYLRCGAIARFAPVLESLVEFVARGG
RVLGICNGFQVLTELGLLPGALTRNRSLHFICEDALLTVESNRTPWLMGHQRKDSLTLPIAHGEGRYQCSDETLCQLQDD
DAIALRYVNNPNGSVADIAGITNKTGNVLGLMPHPERACDPVIGGVDGRGLLQSLLG

Sequences:

>Translated_217_residues
MSIGVVVFPGSNCDRDVRWAAQGCLNIPTRFLWHETRDLNGLDAVVLPGGFSYGDYLRCGAIARFAPVLESLVEFVARGG
RVLGICNGFQVLTELGLLPGALTRNRSLHFICEDALLTVESNRTPWLMGHQRKDSLTLPIAHGEGRYQCSDETLCQLQDD
DAIALRYVNNPNGSVADIAGITNKTGNVLGLMPHPERACDPVIGGVDGRGLLQSLLG
>Mature_216_residues
SIGVVVFPGSNCDRDVRWAAQGCLNIPTRFLWHETRDLNGLDAVVLPGGFSYGDYLRCGAIARFAPVLESLVEFVARGGR
VLGICNGFQVLTELGLLPGALTRNRSLHFICEDALLTVESNRTPWLMGHQRKDSLTLPIAHGEGRYQCSDETLCQLQDDD
AIALRYVNNPNGSVADIAGITNKTGNVLGLMPHPERACDPVIGGVDGRGLLQSLLG

Specific function: Unknown

COG id: COG0047

COG function: function code F; Phosphoribosylformylglycinamidine (FGAM) synthase, glutamine amidotransferase domain

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 glutamine amidotransferase type-1 domain

Homologues:

Organism=Escherichia coli, GI48994899, Length=183, Percent_Identity=33.879781420765, Blast_Score=78, Evalue=4e-16,
Organism=Saccharomyces cerevisiae, GI6321498, Length=182, Percent_Identity=31.3186813186813, Blast_Score=74, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24582111, Length=197, Percent_Identity=35.0253807106599, Blast_Score=88, Evalue=5e-18,
Organism=Drosophila melanogaster, GI24582109, Length=197, Percent_Identity=35.0253807106599, Blast_Score=88, Evalue=5e-18,
Organism=Drosophila melanogaster, GI17137292, Length=197, Percent_Identity=35.0253807106599, Blast_Score=88, Evalue=5e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PURQ_PROMM (Q7V834)

Other databases:

- EMBL:   BX548175
- RefSeq:   NP_894372.1
- ProteinModelPortal:   Q7V834
- SMR:   Q7V834
- STRING:   Q7V834
- GeneID:   1727701
- GenomeReviews:   BX548175_GR
- KEGG:   pmt:PMT0539
- NMPDR:   fig|74547.1.peg.539
- eggNOG:   COG0047
- HOGENOM:   HBG302712
- OMA:   HPENHVE
- ProtClustDB:   PRK03619
- BioCyc:   PMAR74547:PMT0539-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00421
- InterPro:   IPR017926
- InterPro:   IPR011698
- InterPro:   IPR010075
- PIRSF:   PIRSF001586
- TIGRFAMs:   TIGR01737

Pfam domain/function: PF07685 GATase_3

EC number: =6.3.5.3

Molecular weight: Translated: 23443; Mature: 23312

Theoretical pI: Translated: 5.60; Mature: 5.60

Prosite motif: PS51273 GATASE_TYPE_1

Important sites: ACT_SITE 86-86 ACT_SITE 194-194 ACT_SITE 196-196

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.7 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
3.7 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIGVVVFPGSNCDRDVRWAAQGCLNIPTRFLWHETRDLNGLDAVVLPGGFSYGDYLRCG
CCEEEEEECCCCCCCHHHHHHHHHHCCCHHHHHHHCCCCCCCCEEEECCCCCCCCHHHHH
AIARFAPVLESLVEFVARGGRVLGICNGFQVLTELGLLPGALTRNRSLHFICEDALLTVE
HHHHHHHHHHHHHHHHHCCCCEEEEECHHHHHHHHHCCCCCCCCCCCEEEEEECEEEEEE
SNRTPWLMGHQRKDSLTLPIAHGEGRYQCSDETLCQLQDDDAIALRYVNNPNGSVADIAG
CCCCCEEECCCCCCCEEEEEECCCCCEEECCCCEEEECCCCEEEEEEEECCCCCEEEECC
ITNKTGNVLGLMPHPERACDPVIGGVDGRGLLQSLLG
CCCCCCCEEEECCCCHHHCCCCCCCCCCHHHHHHHCC
>Mature Secondary Structure 
SIGVVVFPGSNCDRDVRWAAQGCLNIPTRFLWHETRDLNGLDAVVLPGGFSYGDYLRCG
CEEEEEECCCCCCCHHHHHHHHHHCCCHHHHHHHCCCCCCCCEEEECCCCCCCCHHHHH
AIARFAPVLESLVEFVARGGRVLGICNGFQVLTELGLLPGALTRNRSLHFICEDALLTVE
HHHHHHHHHHHHHHHHHCCCCEEEEECHHHHHHHHHCCCCCCCCCCCEEEEEECEEEEEE
SNRTPWLMGHQRKDSLTLPIAHGEGRYQCSDETLCQLQDDDAIALRYVNNPNGSVADIAG
CCCCCEEECCCCCCCEEEEEECCCCCEEECCCCEEEECCCCEEEEEEEECCCCCEEEECC
ITNKTGNVLGLMPHPERACDPVIGGVDGRGLLQSLLG
CCCCCCCEEEECCCCHHHCCCCCCCCCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12917642