Click here to switch to the map view.

The map label for this gene is msrA [H]

Identifier: 33862765

GI number: 33862765

Start: 542962

End: 543681

Strand: Reverse

Name: msrA [H]

Synonym: PMT0492

Alternate gene names: 33862765

Gene position: 543681-542962 (Counterclockwise)

Preceding gene: 33862766

Following gene: 33862762

Centisome position: 22.55

GC content: 47.78

Gene sequence:

>720_bases
ATGTTCCCATCGTGGTTAACCCCAAAGGCTTCAAAAGAGGCTGCAATTCCCTCAGGAACTCAGCAGCACGCCGTTCTAGG
TACAAGGCTGAATGACCCGCTAACCACAGATCAGGAAGATGCTCTGTTTGCTTGTGGCTGCTTTTGGGGAGCCGAAAAGG
GTTTCTGGAAATTGCCTGGAATCATCACCACGGCAGTGGGTTACGCCGGTGGTCATCAAGAGCAGCCGACCTATCAAGAG
GTCTGCTCAGGACGTAGCGGACACACTGAAATCGTACGGGTGGTGTGGAATAAATCCGTGATTGACTACAGCGACCTCCT
CAAATTGTTCTGGGAGTGCCATGACCCCACACAAGGAAATCGCCAGGGTAATGATCGAGGGAGTCAATATCGATCGGCGA
TTTACACCACAACGATTCAGCAGATTGAGCTTGCGCAGGCCAGTCGAGACAGCTTTCAGCAACTCTTAAGCAAGGCTGGT
TTTGGAGCAATTACAACTGAAATCAAAGCCGATCAACAATTCCATTATGCCGAGTCCTATCACCAGCAATACCTAGCAAA
ACCCGGAAGTAGACCATACTGCTCTGCAATGCCTACTCAGGTTGCTCTAAATGATTTTCCAGGTGCAAACTTTAAATTAC
CAGTAAGTGTCTGGCAAGAATATGATTGGTCAGTTAGTCATTGCGTTCTAAGATCTGGAAATGAAAAAATAAAGCTCTAG

Upstream 100 bases:

>100_bases
TTACCCCCCCCTCTTTTTGTGGTTCGTGACAGGGCTCCATAACCACCTGCATCTAAAACCAAAAGGAGTTGCCTATGGTT
AGTAATCTTGCCTGAATTTG

Downstream 100 bases:

>100_bases
AAACAGCACACTTAAAAGGTAGAATCTCAAACCAAGTCAATTCAAGGCATACAACCAAAGCTTCAACTATACGCAAAAGG
AGGCGTCGGGTTGGGCAAAC

Product: peptide methionine sulfoxide reductase

Products: NA

Alternate protein names: Protein-methionine-S-oxide reductase; Peptide-methionine (S)-S-oxide reductase; Peptide Met(O) reductase [H]

Number of amino acids: Translated: 239; Mature: 239

Protein sequence:

>239_residues
MFPSWLTPKASKEAAIPSGTQQHAVLGTRLNDPLTTDQEDALFACGCFWGAEKGFWKLPGIITTAVGYAGGHQEQPTYQE
VCSGRSGHTEIVRVVWNKSVIDYSDLLKLFWECHDPTQGNRQGNDRGSQYRSAIYTTTIQQIELAQASRDSFQQLLSKAG
FGAITTEIKADQQFHYAESYHQQYLAKPGSRPYCSAMPTQVALNDFPGANFKLPVSVWQEYDWSVSHCVLRSGNEKIKL

Sequences:

>Translated_239_residues
MFPSWLTPKASKEAAIPSGTQQHAVLGTRLNDPLTTDQEDALFACGCFWGAEKGFWKLPGIITTAVGYAGGHQEQPTYQE
VCSGRSGHTEIVRVVWNKSVIDYSDLLKLFWECHDPTQGNRQGNDRGSQYRSAIYTTTIQQIELAQASRDSFQQLLSKAG
FGAITTEIKADQQFHYAESYHQQYLAKPGSRPYCSAMPTQVALNDFPGANFKLPVSVWQEYDWSVSHCVLRSGNEKIKL
>Mature_239_residues
MFPSWLTPKASKEAAIPSGTQQHAVLGTRLNDPLTTDQEDALFACGCFWGAEKGFWKLPGIITTAVGYAGGHQEQPTYQE
VCSGRSGHTEIVRVVWNKSVIDYSDLLKLFWECHDPTQGNRQGNDRGSQYRSAIYTTTIQQIELAQASRDSFQQLLSKAG
FGAITTEIKADQQFHYAESYHQQYLAKPGSRPYCSAMPTQVALNDFPGANFKLPVSVWQEYDWSVSHCVLRSGNEKIKL

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine [H]

COG id: COG0225

COG function: function code O; Peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the msrA Met sulfoxide reductase family [H]

Homologues:

Organism=Homo sapiens, GI6912516, Length=199, Percent_Identity=49.2462311557789, Blast_Score=204, Evalue=5e-53,
Organism=Homo sapiens, GI208609995, Length=181, Percent_Identity=51.9337016574586, Blast_Score=202, Evalue=1e-52,
Organism=Homo sapiens, GI208609993, Length=103, Percent_Identity=57.2815533980583, Blast_Score=136, Evalue=1e-32,
Organism=Escherichia coli, GI1790665, Length=166, Percent_Identity=53.6144578313253, Blast_Score=179, Evalue=2e-46,
Organism=Caenorhabditis elegans, GI17533973, Length=166, Percent_Identity=36.144578313253, Blast_Score=96, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6320881, Length=166, Percent_Identity=34.9397590361446, Blast_Score=95, Evalue=8e-21,
Organism=Drosophila melanogaster, GI24664627, Length=144, Percent_Identity=37.5, Blast_Score=90, Evalue=1e-18,
Organism=Drosophila melanogaster, GI45553131, Length=139, Percent_Identity=37.410071942446, Blast_Score=85, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24664631, Length=144, Percent_Identity=36.8055555555556, Blast_Score=85, Evalue=4e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002569 [H]

Pfam domain/function: PF01625 PMSR [H]

EC number: =1.8.4.11 [H]

Molecular weight: Translated: 26688; Mature: 26688

Theoretical pI: Translated: 6.86; Mature: 6.86

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFPSWLTPKASKEAAIPSGTQQHAVLGTRLNDPLTTDQEDALFACGCFWGAEKGFWKLPG
CCCCCCCCCCCCCCCCCCCCCCHHEEECCCCCCCCCCCCCCEEEEEHHHCCCCCCEECCH
IITTAVGYAGGHQEQPTYQEVCSGRSGHTEIVRVVWNKSVIDYSDLLKLFWECHDPTQGN
HHHHHHHCCCCCCCCCCHHHHHCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCC
RQGNDRGSQYRSAIYTTTIQQIELAQASRDSFQQLLSKAGFGAITTEIKADQQFHYAESY
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHH
HQQYLAKPGSRPYCSAMPTQVALNDFPGANFKLPVSVWQEYDWSVSHCVLRSGNEKIKL
HHHHHHCCCCCCCCCCCCCCEEECCCCCCCEEEHHHHHHCCCCCHHHHHHHCCCCCCCC
>Mature Secondary Structure
MFPSWLTPKASKEAAIPSGTQQHAVLGTRLNDPLTTDQEDALFACGCFWGAEKGFWKLPG
CCCCCCCCCCCCCCCCCCCCCCHHEEECCCCCCCCCCCCCCEEEEEHHHCCCCCCEECCH
IITTAVGYAGGHQEQPTYQEVCSGRSGHTEIVRVVWNKSVIDYSDLLKLFWECHDPTQGN
HHHHHHHCCCCCCCCCCHHHHHCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCC
RQGNDRGSQYRSAIYTTTIQQIELAQASRDSFQQLLSKAGFGAITTEIKADQQFHYAESY
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHH
HQQYLAKPGSRPYCSAMPTQVALNDFPGANFKLPVSVWQEYDWSVSHCVLRSGNEKIKL
HHHHHHCCCCCCCCCCCCCCEEECCCCCCCEEEHHHHHHCCCCCHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA