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The map label for this gene is cobL [H]

Identifier: 33862643

GI number: 33862643

Start: 415927

End: 417222

Strand: Reverse

Name: cobL [H]

Synonym: PMT0370

Alternate gene names: 33862643

Gene position: 417222-415927 (Counterclockwise)

Preceding gene: 33862649

Following gene: 33862639

Centisome position: 17.31

GC content: 59.18

Gene sequence:

>1296_bases
ATGCCCGCCTCAATCAGCTCCGCAGCGATCCACATCATCGGCACCGATGCCGCAGGCCTAGATCACCTTGCTACTCCATT
GCACGAGCTAGTGCTCTCAGCCCAAGGGCTGGCTGCACCAACTCGGTTATTGCAACAGCTGCCGAGCTGGTGGCAGCAGC
AGCAAACGGATCAGCCTTTGCCAGAACTGATGGCGAGCGATCAACCAGAGGCTCTGATTGCCTGGTTGCACCAGCGGCAG
GGCACAGCCATCGTGCTAGCCAGCGGCGATCCGCTCTGGTTCGGCATCGGCAGGCGGCTACTCGAGGCCTGTTCTGCTGA
TCAGCTGCACTTTCATCCAGCACCTTGTTCGCTGCAACTAGCCTTTGCCCGGCTTGGACGCCCTTGGCAGGATGCCGCCT
GGATCAGCCTGCATGGCCGTGACCCGGCCCCCTTAGCTCAAAAGCTGCAACAACGCCCCGCAGCTCTAGCTGTACTAACC
GATCCCAACCGCGGTGGAGCCGAAGAGGTGCGTACGATTTTGCGCGCTTCTGGCCTAGAAGCTGCCTATGCAGTGTGGCT
TTGCGAACAGCTCGGACACGCCAATGAACGGGTGCAACGGCTGACGCCACAGGATGCCTTGCCATCGGATCTTCATCCCC
TACACATGGTGGTGCTGCTTGCCGAACAAGCTGCTCCAGCAGGAGATCCAGCCAAGCTTCCATTGTTCGGTCTTGACGAT
GGCTTGTTCCTGCAACACGACGATCGCCCTGGCCTGATGAGCAAACGGGAGCTCCGTGTTCAGCTCCTCTCAGAGTTAGA
GCTACCAGAACAGGGCGTGCTCTGGGATTTAGGTGCCGGCGTCGGCAGCGTTGGCTTAGAAGCCCTACGCTTGCGCCCAC
AACTGCAATTGCTTGCTGTTGAAAAGCGTGGCGGCGGCGCAGCGCTGATTAAGGCAAATGCTGCCCGGCTTGCCGTTCAT
CCTGCTGCTGTGCTCGAAGTTGAGGCCCTCAGCCTGCTGAATGGAACTGATCTACCAGCAAAACTCAGCAACCCCGACCG
GGTGCTCCTAGGGGGTGGCGGCCGCCAGGGAGCTGCTCTACTCAAGGCCGTATTGCAAAAACTTCAACCACATGGAGTCG
TCGTGATTCCACTGGTAACCGTTGAGGCCATGGCAGAACTCAAGCCCTTACTTCAAGATTGCGGTTGCACCGTGAAAGTG
AGTCAACACCAAGCCTGGAGGGGCCTGCCGCTGGCAAACGGCACACGCATGGCGCCGATGAACCCGGTGATGATCCTCAA
AGGCACGATGCCTTAA

Upstream 100 bases:

>100_bases
GTTTTCTGCACCTTGCCCGCCACCTTGCCCGCCTCCATGTTGCTCACCATTCAAGGCAAAGACAAGTCAGCCATACAACC
TCTCAGCCGAGAATGACAAC

Downstream 100 bases:

>100_bases
GGCTGCCAATCAACAAGCTTCGGCAAAGGTTGAATCTGCACAACATCACCAACCTTGATGGATAGCCGTGCTGCCTCCCC
GGCCGCCAACTCCACCACTC

Product: precorrin-6y methylase

Products: NA

Alternate protein names: Precorrin-6 methyltransferase; Precorrin-6Y methylase [H]

Number of amino acids: Translated: 431; Mature: 430

Protein sequence:

>431_residues
MPASISSAAIHIIGTDAAGLDHLATPLHELVLSAQGLAAPTRLLQQLPSWWQQQQTDQPLPELMASDQPEALIAWLHQRQ
GTAIVLASGDPLWFGIGRRLLEACSADQLHFHPAPCSLQLAFARLGRPWQDAAWISLHGRDPAPLAQKLQQRPAALAVLT
DPNRGGAEEVRTILRASGLEAAYAVWLCEQLGHANERVQRLTPQDALPSDLHPLHMVVLLAEQAAPAGDPAKLPLFGLDD
GLFLQHDDRPGLMSKRELRVQLLSELELPEQGVLWDLGAGVGSVGLEALRLRPQLQLLAVEKRGGGAALIKANAARLAVH
PAAVLEVEALSLLNGTDLPAKLSNPDRVLLGGGGRQGAALLKAVLQKLQPHGVVVIPLVTVEAMAELKPLLQDCGCTVKV
SQHQAWRGLPLANGTRMAPMNPVMILKGTMP

Sequences:

>Translated_431_residues
MPASISSAAIHIIGTDAAGLDHLATPLHELVLSAQGLAAPTRLLQQLPSWWQQQQTDQPLPELMASDQPEALIAWLHQRQ
GTAIVLASGDPLWFGIGRRLLEACSADQLHFHPAPCSLQLAFARLGRPWQDAAWISLHGRDPAPLAQKLQQRPAALAVLT
DPNRGGAEEVRTILRASGLEAAYAVWLCEQLGHANERVQRLTPQDALPSDLHPLHMVVLLAEQAAPAGDPAKLPLFGLDD
GLFLQHDDRPGLMSKRELRVQLLSELELPEQGVLWDLGAGVGSVGLEALRLRPQLQLLAVEKRGGGAALIKANAARLAVH
PAAVLEVEALSLLNGTDLPAKLSNPDRVLLGGGGRQGAALLKAVLQKLQPHGVVVIPLVTVEAMAELKPLLQDCGCTVKV
SQHQAWRGLPLANGTRMAPMNPVMILKGTMP
>Mature_430_residues
PASISSAAIHIIGTDAAGLDHLATPLHELVLSAQGLAAPTRLLQQLPSWWQQQQTDQPLPELMASDQPEALIAWLHQRQG
TAIVLASGDPLWFGIGRRLLEACSADQLHFHPAPCSLQLAFARLGRPWQDAAWISLHGRDPAPLAQKLQQRPAALAVLTD
PNRGGAEEVRTILRASGLEAAYAVWLCEQLGHANERVQRLTPQDALPSDLHPLHMVVLLAEQAAPAGDPAKLPLFGLDDG
LFLQHDDRPGLMSKRELRVQLLSELELPEQGVLWDLGAGVGSVGLEALRLRPQLQLLAVEKRGGGAALIKANAARLAVHP
AAVLEVEALSLLNGTDLPAKLSNPDRVLLGGGGRQGAALLKAVLQKLQPHGVVVIPLVTVEAMAELKPLLQDCGCTVKVS
QHQAWRGLPLANGTRMAPMNPVMILKGTMP

Specific function: Catalyzes the methylation of both C-5 and C-15 in precorrin-6Y to form precorrin-8X [H]

COG id: COG2241

COG function: function code H; Precorrin-6B methylase 1

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the precorrin methyltransferase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000878
- InterPro:   IPR014777
- InterPro:   IPR012818
- InterPro:   IPR014008
- InterPro:   IPR006365 [H]

Pfam domain/function: PF00590 TP_methylase [H]

EC number: =2.1.1.132 [H]

Molecular weight: Translated: 46118; Mature: 45987

Theoretical pI: Translated: 6.75; Mature: 6.75

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPASISSAAIHIIGTDAAGLDHLATPLHELVLSAQGLAAPTRLLQQLPSWWQQQQTDQPL
CCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCH
PELMASDQPEALIAWLHQRQGTAIVLASGDPLWFGIGRRLLEACSADQLHFHPAPCSLQL
HHHHCCCCCHHHHHHHHHCCCCEEEEECCCCEEHHHHHHHHHHCCCCCEEECCCCCHHHH
AFARLGRPWQDAAWISLHGRDPAPLAQKLQQRPAALAVLTDPNRGGAEEVRTILRASGLE
HHHHCCCCCCCCEEEEEECCCCCHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHCCCH
AAYAVWLCEQLGHANERVQRLTPQDALPSDLHPLHMVVLLAEQAAPAGDPAKLPLFGLDD
HHHHHHHHHHHCCHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCEEEECCC
GLFLQHDDRPGLMSKRELRVQLLSELELPEQGVLWDLGAGVGSVGLEALRLRPQLQLLAV
CEEEEECCCCCCCHHHHHHHHHHHHCCCCCCCCEEECCCCCCHHHHHHHHCCCCEEEEEE
EKRGGGAALIKANAARLAVHPAAVLEVEALSLLNGTDLPAKLSNPDRVLLGGGGRQGAAL
EECCCCEEEEEECCEEEEECCHHHHHHHHHHHHCCCCCCCCCCCCCEEEECCCCCCHHHH
LKAVLQKLQPHGVVVIPLVTVEAMAELKPLLQDCGCTVKVSQHQAWRGLPLANGTRMAPM
HHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCCCCCCCCCC
NPVMILKGTMP
CCEEEEECCCC
>Mature Secondary Structure 
PASISSAAIHIIGTDAAGLDHLATPLHELVLSAQGLAAPTRLLQQLPSWWQQQQTDQPL
CCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCH
PELMASDQPEALIAWLHQRQGTAIVLASGDPLWFGIGRRLLEACSADQLHFHPAPCSLQL
HHHHCCCCCHHHHHHHHHCCCCEEEEECCCCEEHHHHHHHHHHCCCCCEEECCCCCHHHH
AFARLGRPWQDAAWISLHGRDPAPLAQKLQQRPAALAVLTDPNRGGAEEVRTILRASGLE
HHHHCCCCCCCCEEEEEECCCCCHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHCCCH
AAYAVWLCEQLGHANERVQRLTPQDALPSDLHPLHMVVLLAEQAAPAGDPAKLPLFGLDD
HHHHHHHHHHHCCHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCEEEECCC
GLFLQHDDRPGLMSKRELRVQLLSELELPEQGVLWDLGAGVGSVGLEALRLRPQLQLLAV
CEEEEECCCCCCCHHHHHHHHHHHHCCCCCCCCEEECCCCCCHHHHHHHHCCCCEEEEEE
EKRGGGAALIKANAARLAVHPAAVLEVEALSLLNGTDLPAKLSNPDRVLLGGGGRQGAAL
EECCCCEEEEEECCEEEEECCHHHHHHHHHHHHCCCCCCCCCCCCCEEEECCCCCCHHHH
LKAVLQKLQPHGVVVIPLVTVEAMAELKPLLQDCGCTVKVSQHQAWRGLPLANGTRMAPM
HHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCCCCCCCCCC
NPVMILKGTMP
CCEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2211521; 1732195 [H]