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The map label for this gene is pdhA [H]

Identifier: 33862620

GI number: 33862620

Start: 395091

End: 396182

Strand: Reverse

Name: pdhA [H]

Synonym: PMT0347

Alternate gene names: 33862620

Gene position: 396182-395091 (Counterclockwise)

Preceding gene: 33862627

Following gene: 161350046

Centisome position: 16.43

GC content: 54.21

Gene sequence:

>1092_bases
ATGAGCCAGAAAACCTCCGTGAGCTCAGGCCAAACCACGGCAAACCCCCTGGCAGCCGGCCGCCATGGCGAGAGAATCTC
CACGCTAATCAGCTCCAAACGCGCCAAGGTTGATCGTCAGATCGGCCTAGAACTCTTCCGAGACATGACCCTTGGGCGAC
GCTTCGAGGACAAATGTGCCGAGATGTACTACCGGGGGAAAATGTTTGGCTTCGTTCACCTCTACAACGGCCAAGAAGCC
GTTAGCACAGGTGTAATTGGTGCAATGAAACGCCAGCACGATTGGTTTTGCAGTACCTATCGCGATCACGTTCATGCCCT
TAGCGCCGGTGTACCCGCCCGCGAAGTAATGAGTGAGCTCTTCGGCAAGGAAACCGGCTGTAGCAAAGGTCGTGGGGGCT
CCATGCACCTCTTTTCGCAAGAGCATCACCTCCTAGGAGGATTTGCCTTCATCGGCGAAGGGATTCCCATCGCCCTGGGG
GCAGCCTTCACCAGTCGCTATAAGCGGGATGCCCTGGGTGATGCCAGCAGCAATGCTGTAACAGCAGCTTTTTTTGGTGA
CGGTACCTGCAATAACGGCCAGTTCTTTGAGTGCCTCAACATGGCGCAGCTTTGGCAGCTGCCAATCCTGTTCGTTGTCG
AGAACAACAAATGGGCCATTGGCATGGCCCATGAGCGAGCCACCAGTGAGCCGGAAATATGGCAAAAAGCTGCTGCCTTC
GGGATGGCTGGCGAAGAGGTTGACGGCATGGATGTTCTCGCCGTAAGAGCTGCCACTCAGAGAGCAATAAAAAGAGCCAG
GGCTGGCGAAGGTCCCACCCTGCTGGAGTGTCTCACCTATCGATTCCGTGGCCATTCTCTTGCTGATCCAGATGAACTAC
GCGCCGAAGAGGAAAAACAATTCTGGGCTAAACGAGATCCCCTAAAGGCTCTTGAGAAGGATCTCACCTCTGAATCTTTG
GTGCGTGCTGAAGAACTACGCGCTATTGAAAAAGAGATCGATGCAGAAATAAATGACTGCGTGGAGTTTGCCCTTGCCGC
AGCCGAACCAAATCCCAACGAACTCACTCGCTACATCTGGGCTGAAGATTAA

Upstream 100 bases:

>100_bases
TGCGCAGCGATTGGCCTAAAACTCTAGACATTGGAAGGGATTTTGCCCATTCCTAATCAACGGACCATTACAGTCGTGAC
TCGAATGACGGTCGTCTGTC

Downstream 100 bases:

>100_bases
TAGCCCTCTTGAGCACTAAGTACTGGAAGCAAGCAAAGCCAACAAGATAAGGGAGACAGTTTCAAATCTCGTTGGGCACC
CTACGCGTGAGGTTACGCAG

Product: pyruvate dehydrogenase E1 alpha subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 363; Mature: 362

Protein sequence:

>363_residues
MSQKTSVSSGQTTANPLAAGRHGERISTLISSKRAKVDRQIGLELFRDMTLGRRFEDKCAEMYYRGKMFGFVHLYNGQEA
VSTGVIGAMKRQHDWFCSTYRDHVHALSAGVPAREVMSELFGKETGCSKGRGGSMHLFSQEHHLLGGFAFIGEGIPIALG
AAFTSRYKRDALGDASSNAVTAAFFGDGTCNNGQFFECLNMAQLWQLPILFVVENNKWAIGMAHERATSEPEIWQKAAAF
GMAGEEVDGMDVLAVRAATQRAIKRARAGEGPTLLECLTYRFRGHSLADPDELRAEEEKQFWAKRDPLKALEKDLTSESL
VRAEELRAIEKEIDAEINDCVEFALAAAEPNPNELTRYIWAED

Sequences:

>Translated_363_residues
MSQKTSVSSGQTTANPLAAGRHGERISTLISSKRAKVDRQIGLELFRDMTLGRRFEDKCAEMYYRGKMFGFVHLYNGQEA
VSTGVIGAMKRQHDWFCSTYRDHVHALSAGVPAREVMSELFGKETGCSKGRGGSMHLFSQEHHLLGGFAFIGEGIPIALG
AAFTSRYKRDALGDASSNAVTAAFFGDGTCNNGQFFECLNMAQLWQLPILFVVENNKWAIGMAHERATSEPEIWQKAAAF
GMAGEEVDGMDVLAVRAATQRAIKRARAGEGPTLLECLTYRFRGHSLADPDELRAEEEKQFWAKRDPLKALEKDLTSESL
VRAEELRAIEKEIDAEINDCVEFALAAAEPNPNELTRYIWAED
>Mature_362_residues
SQKTSVSSGQTTANPLAAGRHGERISTLISSKRAKVDRQIGLELFRDMTLGRRFEDKCAEMYYRGKMFGFVHLYNGQEAV
STGVIGAMKRQHDWFCSTYRDHVHALSAGVPAREVMSELFGKETGCSKGRGGSMHLFSQEHHLLGGFAFIGEGIPIALGA
AFTSRYKRDALGDASSNAVTAAFFGDGTCNNGQFFECLNMAQLWQLPILFVVENNKWAIGMAHERATSEPEIWQKAAAFG
MAGEEVDGMDVLAVRAATQRAIKRARAGEGPTLLECLTYRFRGHSLADPDELRAEEEKQFWAKRDPLKALEKDLTSESLV
RAEELRAIEKEIDAEINDCVEFALAAAEPNPNELTRYIWAED

Specific function: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydroge

COG id: COG1071

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4885543, Length=329, Percent_Identity=36.7781155015198, Blast_Score=227, Evalue=2e-59,
Organism=Homo sapiens, GI4505685, Length=329, Percent_Identity=36.7781155015198, Blast_Score=206, Evalue=3e-53,
Organism=Homo sapiens, GI291084742, Length=329, Percent_Identity=36.7781155015198, Blast_Score=206, Evalue=4e-53,
Organism=Homo sapiens, GI291084744, Length=336, Percent_Identity=36.0119047619048, Blast_Score=199, Evalue=5e-51,
Organism=Homo sapiens, GI291084757, Length=329, Percent_Identity=34.0425531914894, Blast_Score=172, Evalue=6e-43,
Organism=Homo sapiens, GI11386135, Length=344, Percent_Identity=27.3255813953488, Blast_Score=113, Evalue=3e-25,
Organism=Homo sapiens, GI258645172, Length=344, Percent_Identity=27.3255813953488, Blast_Score=109, Evalue=4e-24,
Organism=Caenorhabditis elegans, GI17536047, Length=326, Percent_Identity=36.5030674846626, Blast_Score=214, Evalue=6e-56,
Organism=Caenorhabditis elegans, GI32564172, Length=326, Percent_Identity=36.5030674846626, Blast_Score=214, Evalue=7e-56,
Organism=Caenorhabditis elegans, GI86563355, Length=317, Percent_Identity=26.4984227129338, Blast_Score=110, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI86563357, Length=317, Percent_Identity=26.4984227129338, Blast_Score=110, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6321026, Length=310, Percent_Identity=35.8064516129032, Blast_Score=202, Evalue=5e-53,
Organism=Drosophila melanogaster, GI24639748, Length=331, Percent_Identity=37.1601208459215, Blast_Score=214, Evalue=1e-55,
Organism=Drosophila melanogaster, GI24639740, Length=331, Percent_Identity=35.0453172205438, Blast_Score=207, Evalue=6e-54,
Organism=Drosophila melanogaster, GI24639744, Length=331, Percent_Identity=35.0453172205438, Blast_Score=207, Evalue=6e-54,
Organism=Drosophila melanogaster, GI28571106, Length=331, Percent_Identity=35.0453172205438, Blast_Score=207, Evalue=6e-54,
Organism=Drosophila melanogaster, GI24639746, Length=313, Percent_Identity=36.1022364217252, Blast_Score=203, Evalue=1e-52,
Organism=Drosophila melanogaster, GI21355903, Length=338, Percent_Identity=22.4852071005917, Blast_Score=82, Evalue=5e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001017
- InterPro:   IPR017597 [H]

Pfam domain/function: PF00676 E1_dh [H]

EC number: =1.2.4.1 [H]

Molecular weight: Translated: 40211; Mature: 40080

Theoretical pI: Translated: 6.02; Mature: 6.02

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQKTSVSSGQTTANPLAAGRHGERISTLISSKRAKVDRQIGLELFRDMTLGRRFEDKCA
CCCCCCCCCCCCCCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
EMYYRGKMFGFVHLYNGQEAVSTGVIGAMKRQHDWFCSTYRDHVHALSAGVPAREVMSEL
HHHHHCCEEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
FGKETGCSKGRGGSMHLFSQEHHLLGGFAFIGEGIPIALGAAFTSRYKRDALGDASSNAV
HCCCCCCCCCCCCCEEEECCCCHHHHHHHHHCCCCCEEHHHHHHHHHHHHHCCCCCCCCE
TAAFFGDGTCNNGQFFECLNMAQLWQLPILFVVENNKWAIGMAHERATSEPEIWQKAAAF
EEEEECCCCCCCCHHHHHHHHHHHHCCCEEEEEECCEEEEEECHHCCCCCHHHHHHHHHH
GMAGEEVDGMDVLAVRAATQRAIKRARAGEGPTLLECLTYRFRGHSLADPDELRAEEEKQ
CCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHH
FWAKRDPLKALEKDLTSESLVRAEELRAIEKEIDAEINDCVEFALAAAEPNPNELTRYIW
HHHCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCHHHHEEEEE
AED
CCC
>Mature Secondary Structure 
SQKTSVSSGQTTANPLAAGRHGERISTLISSKRAKVDRQIGLELFRDMTLGRRFEDKCA
CCCCCCCCCCCCCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
EMYYRGKMFGFVHLYNGQEAVSTGVIGAMKRQHDWFCSTYRDHVHALSAGVPAREVMSEL
HHHHHCCEEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
FGKETGCSKGRGGSMHLFSQEHHLLGGFAFIGEGIPIALGAAFTSRYKRDALGDASSNAV
HCCCCCCCCCCCCCEEEECCCCHHHHHHHHHCCCCCEEHHHHHHHHHHHHHCCCCCCCCE
TAAFFGDGTCNNGQFFECLNMAQLWQLPILFVVENNKWAIGMAHERATSEPEIWQKAAAF
EEEEECCCCCCCCHHHHHHHHHHHHCCCEEEEEECCEEEEEECHHCCCCCHHHHHHHHHH
GMAGEEVDGMDVLAVRAATQRAIKRARAGEGPTLLECLTYRFRGHSLADPDELRAEEEKQ
CCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHH
FWAKRDPLKALEKDLTSESLVRAEELRAIEKEIDAEINDCVEFALAAAEPNPNELTRYIW
HHHCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCHHHHEEEEE
AED
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10796014; 11481430 [H]