Click here to switch to the map view.

The map label for this gene is ilvC [H]

Identifier: 33862586

GI number: 33862586

Start: 359518

End: 360513

Strand: Reverse

Name: ilvC [H]

Synonym: PMT0313

Alternate gene names: 33862586

Gene position: 360513-359518 (Counterclockwise)

Preceding gene: 33862587

Following gene: 33862585

Centisome position: 14.95

GC content: 55.62

Gene sequence:

>996_bases
ATGGCCCAGCTCTTCTACGACTCCGATGCCGATCTCGGCCTACTCAATGGCAAGACCGTCGCCATCATTGGCTATGGCTC
CCAGGGCCATGCCCATGCCCTCAACCTCAAGGACAGCGGCGTAGATGTGGTAGTGGGCCTATATGAAGGCAGCCGCTCCG
CCGAGAAAGCCCGCGCCGATGGACTGGAAGTGCTCAGCGTCGCTGAAGCCGCCGCCAAAGCGGACTGGATCATGGTGCTA
CTACCGGATGAATTCCAAAAAGATGTTTATGCAAAAGAGATCGCCTCTCATCTGAGTTCAGGCAAAGTGTTGAGCTTCGC
TCACGGCTTCAACATCCGCTTCGGGTTAATTCAGCCGCCAGCTGATGTCGACGTGGTGATGATTGCTCCCAAGGGGCCTG
GCCATACCGTGCGCTGGGAATACCAAAACGGGCAAGGAGTACCAGCCCTATTCGCAATTGAACAAGATGCCTCCGGTCAA
GCACGTGCACTGGCCATGGCCTACGCCAAGGGCATCGGCGGCACCCGAGCGGGCATCCTCGAAACCAACTTCAAGGAAGA
AACCGAAACCGACTTGTTCGGCGAACAAGCCGTGCTCTGTGGCGGGCTCTCAGAGCTCGTCAAAGCAGGCTTTGAAACCC
TTGTAGAAGCTGGCTACCAGCCTGAGCTGGCCTACTTCGAGTGCCTTCACGAGGTGAAGTTAATCGTTGATCTGATGGTG
AAGGGCGGCCTCACTGCCATGCGTGATTCAATCTCCAACACTGCCGAATACGGCGACTACGTGAGTGGGCCAAGACTGAT
CAACGCTGATACCAAAGCTGAGATGAAACGCATCCTCGCTGACATCCAAGACGGCACCTTCGCTAAAAACTTTGTCGCCG
AATGCGAATCAGGCAAACCTGAGATGAAGAAGATTCGCGATCGCGATGCCAACCATCCAATTGAGCAAGTCGGCAAAGGT
CTCCGCGCCATGTTCAGCTGGTTGAAAACAGCCTGA

Upstream 100 bases:

>100_bases
GATTGCACTGACAACCGAAAAAAGGACTATTGGGCCTTCAGCCAAAGCCATGGGGCCCTTGCCTAAGCTCTGACCTTGCC
CTGAACGCAATCCAGCCAGG

Downstream 100 bases:

>100_bases
CCCTTGCCATTCTGCTAGTCATCACTGCAGCAGGTCTCGACCTGCTGATCGGTGATCCGCGCTGGTGTCCACATCCCGTT
GAGTTGATGGGATCTGTGAT

Product: ketol-acid reductoisomerase

Products: NA

Alternate protein names: Acetohydroxy-acid isomeroreductase; Alpha-keto-beta-hydroxylacil reductoisomerase [H]

Number of amino acids: Translated: 331; Mature: 330

Protein sequence:

>331_residues
MAQLFYDSDADLGLLNGKTVAIIGYGSQGHAHALNLKDSGVDVVVGLYEGSRSAEKARADGLEVLSVAEAAAKADWIMVL
LPDEFQKDVYAKEIASHLSSGKVLSFAHGFNIRFGLIQPPADVDVVMIAPKGPGHTVRWEYQNGQGVPALFAIEQDASGQ
ARALAMAYAKGIGGTRAGILETNFKEETETDLFGEQAVLCGGLSELVKAGFETLVEAGYQPELAYFECLHEVKLIVDLMV
KGGLTAMRDSISNTAEYGDYVSGPRLINADTKAEMKRILADIQDGTFAKNFVAECESGKPEMKKIRDRDANHPIEQVGKG
LRAMFSWLKTA

Sequences:

>Translated_331_residues
MAQLFYDSDADLGLLNGKTVAIIGYGSQGHAHALNLKDSGVDVVVGLYEGSRSAEKARADGLEVLSVAEAAAKADWIMVL
LPDEFQKDVYAKEIASHLSSGKVLSFAHGFNIRFGLIQPPADVDVVMIAPKGPGHTVRWEYQNGQGVPALFAIEQDASGQ
ARALAMAYAKGIGGTRAGILETNFKEETETDLFGEQAVLCGGLSELVKAGFETLVEAGYQPELAYFECLHEVKLIVDLMV
KGGLTAMRDSISNTAEYGDYVSGPRLINADTKAEMKRILADIQDGTFAKNFVAECESGKPEMKKIRDRDANHPIEQVGKG
LRAMFSWLKTA
>Mature_330_residues
AQLFYDSDADLGLLNGKTVAIIGYGSQGHAHALNLKDSGVDVVVGLYEGSRSAEKARADGLEVLSVAEAAAKADWIMVLL
PDEFQKDVYAKEIASHLSSGKVLSFAHGFNIRFGLIQPPADVDVVMIAPKGPGHTVRWEYQNGQGVPALFAIEQDASGQA
RALAMAYAKGIGGTRAGILETNFKEETETDLFGEQAVLCGGLSELVKAGFETLVEAGYQPELAYFECLHEVKLIVDLMVK
GGLTAMRDSISNTAEYGDYVSGPRLINADTKAEMKRILADIQDGTFAKNFVAECESGKPEMKKIRDRDANHPIEQVGKGL
RAMFSWLKTA

Specific function: Valine and isoleucine biosynthesis; second step. [C]

COG id: COG0059

COG function: function code EH; Ketol-acid reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ketol-acid reductoisomerase family [H]

Homologues:

Organism=Escherichia coli, GI1790210, Length=290, Percent_Identity=37.5862068965517, Blast_Score=155, Evalue=4e-39,
Organism=Saccharomyces cerevisiae, GI6323387, Length=324, Percent_Identity=32.4074074074074, Blast_Score=142, Evalue=8e-35,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1420 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR013023
- InterPro:   IPR000506
- InterPro:   IPR013328
- InterPro:   IPR013116 [H]

Pfam domain/function: PF01450 IlvC; PF07991 IlvN [H]

EC number: =1.1.1.86 [H]

Molecular weight: Translated: 35677; Mature: 35546

Theoretical pI: Translated: 4.83; Mature: 4.83

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAQLFYDSDADLGLLNGKTVAIIGYGSQGHAHALNLKDSGVDVVVGLYEGSRSAEKARAD
CCEEEECCCCCEEEECCCEEEEEEECCCCCEEEEECCCCCCEEEEEEECCCCCHHHHHHC
GLEVLSVAEAAAKADWIMVLLPDEFQKDVYAKEIASHLSSGKVLSFAHGFNIRFGLIQPP
CHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHHHCCCCEEEEECCCEEEEEEECCC
ADVDVVMIAPKGPGHTVRWEYQNGQGVPALFAIEQDASGQARALAMAYAKGIGGTRAGIL
CCCEEEEEECCCCCCCEEEEECCCCCCCEEEEEECCCCCHHHHHHHHHHHCCCCCCCCEE
ETNFKEETETDLFGEQAVLCGGLSELVKAGFETLVEAGYQPELAYFECLHEVKLIVDLMV
ECCCCCHHHHHHCCCHHHHHCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
KGGLTAMRDSISNTAEYGDYVSGPRLINADTKAEMKRILADIQDGTFAKNFVAECESGKP
HCCHHHHHHHHHHHHHHCCCCCCCEEECCCHHHHHHHHHHHCCCCCHHHHHHHHHCCCCH
EMKKIRDRDANHPIEQVGKGLRAMFSWLKTA
HHHHHHCCCCCCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
AQLFYDSDADLGLLNGKTVAIIGYGSQGHAHALNLKDSGVDVVVGLYEGSRSAEKARAD
CEEEECCCCCEEEECCCEEEEEEECCCCCEEEEECCCCCCEEEEEEECCCCCHHHHHHC
GLEVLSVAEAAAKADWIMVLLPDEFQKDVYAKEIASHLSSGKVLSFAHGFNIRFGLIQPP
CHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHHHCCCCEEEEECCCEEEEEEECCC
ADVDVVMIAPKGPGHTVRWEYQNGQGVPALFAIEQDASGQARALAMAYAKGIGGTRAGIL
CCCEEEEEECCCCCCCEEEEECCCCCCCEEEEEECCCCCHHHHHHHHHHHCCCCCCCCEE
ETNFKEETETDLFGEQAVLCGGLSELVKAGFETLVEAGYQPELAYFECLHEVKLIVDLMV
ECCCCCHHHHHHCCCHHHHHCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
KGGLTAMRDSISNTAEYGDYVSGPRLINADTKAEMKRILADIQDGTFAKNFVAECESGKP
HCCHHHHHHHHHHHHHHCCCCCCCEEECCCHHHHHHHHHHHCCCCCHHHHHHHHHCCCCH
EMKKIRDRDANHPIEQVGKGLRAMFSWLKTA
HHHHHHCCCCCCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA