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The map label for this gene is FPG

Identifier: 33862459

GI number: 33862459

Start: 215736

End: 216611

Strand: Reverse

Name: FPG

Synonym: PMT0186

Alternate gene names: 33862459

Gene position: 216611-215736 (Counterclockwise)

Preceding gene: 33862460

Following gene: 33862458

Centisome position: 8.98

GC content: 52.97

Gene sequence:

>876_bases
TTGCCGGAATTACCTGAAGTTGAGACGGTCCGCCGCGGATTGGCAGACCGTCTTGTTGATTTTCAGATCGGCCAGGTTGA
GGTTTGCCGAGAACGAGCCATAGCAAGCCCTGGCGGTTCTGCCCTATTTATCAAGATGCTCTGCGGCATGCACGTGGGCT
CATGGTTAAGACGCGGCAAGTACTTAATGGCGTCTTTACATCATGAAATTGCCCAGTCATCAGCTGATTCAGAACCTGAT
CCTGATGGTGGATGGTGGGGCGTTCACCTGCGCATGACAGGACAATTTCAATGGCATGAGGCCATCAGTTCACCCTGCCC
GCATACACGCGTACGCATCTGGAACAAAAAAAATGAGGAACTGCGCTTCGTTGACACGCGCAGCTTCGGACAAATGTGGT
GGGTTCCACCTGGCAACGCCCCGGAAACAATCATCACAGGACTGCAAAAACTTGGGCCAGAACCATTCAGCAGCGCCTTC
AATTCCTCATACCTAAGCAAACGCTTGAAGGGTTCGAAACGACCAATCAAGTCAGCACTTTTGGATCAATCCATCGTGGC
AGGGGCAGGAAACATCTATACCGATGAAAGCCTTTTTGCAGCCAGAATCCGTCCCCACACTCCATCAGGTCAATTAAAAA
AGGTCGAGCTTGAACGCTTATGCAACTGCCTCACGGAGGTCCTCAGAGTGAGCATCGGTGCTGGAGGAACAACCTTCAGC
GACTTCAGAGATCTTGAAGGCATTAACGGCAACTACGGTGGTCAAGCCTGGGTGTATCGCAGAGGAGGCCAAGCCTGCCG
GATATGCAGCACGCCCATCCGCCGTGAAAGCCTTTGCGGTCGTGGCACCCACTGGTGCCCCAATTGCCAACGATGA

Upstream 100 bases:

>100_bases
TTCGCTTCGAGAAAACGAACTACTTCGGCATGCAAGGTACCGATAACGGCAACCTCACCAACAGCTTTGCTGAATCAGAG
CTCGATCGCGCCTAAGGCGC

Downstream 100 bases:

>100_bases
ATCCTGGCAAAAATGTTCGATTCACAGCAACAGCGGCAAGCTCTAAGCGACACCATTCGCGATCTCCATCAACGTGGTTG
GTGTGATGGAACTGGCGGTA

Product: formamidopyrimidine-DNA glycosylase

Products: NA

Alternate protein names: Fapy-DNA glycosylase; DNA-(apurinic or apyrimidinic site) lyase mutM; AP lyase mutM

Number of amino acids: Translated: 291; Mature: 290

Protein sequence:

>291_residues
MPELPEVETVRRGLADRLVDFQIGQVEVCRERAIASPGGSALFIKMLCGMHVGSWLRRGKYLMASLHHEIAQSSADSEPD
PDGGWWGVHLRMTGQFQWHEAISSPCPHTRVRIWNKKNEELRFVDTRSFGQMWWVPPGNAPETIITGLQKLGPEPFSSAF
NSSYLSKRLKGSKRPIKSALLDQSIVAGAGNIYTDESLFAARIRPHTPSGQLKKVELERLCNCLTEVLRVSIGAGGTTFS
DFRDLEGINGNYGGQAWVYRRGGQACRICSTPIRRESLCGRGTHWCPNCQR

Sequences:

>Translated_291_residues
MPELPEVETVRRGLADRLVDFQIGQVEVCRERAIASPGGSALFIKMLCGMHVGSWLRRGKYLMASLHHEIAQSSADSEPD
PDGGWWGVHLRMTGQFQWHEAISSPCPHTRVRIWNKKNEELRFVDTRSFGQMWWVPPGNAPETIITGLQKLGPEPFSSAF
NSSYLSKRLKGSKRPIKSALLDQSIVAGAGNIYTDESLFAARIRPHTPSGQLKKVELERLCNCLTEVLRVSIGAGGTTFS
DFRDLEGINGNYGGQAWVYRRGGQACRICSTPIRRESLCGRGTHWCPNCQR
>Mature_290_residues
PELPEVETVRRGLADRLVDFQIGQVEVCRERAIASPGGSALFIKMLCGMHVGSWLRRGKYLMASLHHEIAQSSADSEPDP
DGGWWGVHLRMTGQFQWHEAISSPCPHTRVRIWNKKNEELRFVDTRSFGQMWWVPPGNAPETIITGLQKLGPEPFSSAFN
SSYLSKRLKGSKRPIKSALLDQSIVAGAGNIYTDESLFAARIRPHTPSGQLKKVELERLCNCLTEVLRVSIGAGGTTFSD
FRDLEGINGNYGGQAWVYRRGGQACRICSTPIRRESLCGRGTHWCPNCQR

Specific function: Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyr

COG id: COG0266

COG function: function code L; Formamidopyrimidine-DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FPG-type zinc finger

Homologues:

Organism=Escherichia coli, GI1790066, Length=291, Percent_Identity=36.0824742268041, Blast_Score=154, Evalue=4e-39,
Organism=Escherichia coli, GI1786932, Length=158, Percent_Identity=27.2151898734177, Blast_Score=63, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FPG_PROMM (Q7V8Y5)

Other databases:

- EMBL:   BX548175
- RefSeq:   NP_894019.1
- ProteinModelPortal:   Q7V8Y5
- SMR:   Q7V8Y5
- STRING:   Q7V8Y5
- GeneID:   1728332
- GenomeReviews:   BX548175_GR
- KEGG:   pmt:PMT0186
- NMPDR:   fig|74547.1.peg.186
- eggNOG:   COG0266
- HOGENOM:   HBG690070
- OMA:   RMTGQLL
- ProtClustDB:   PRK13945
- BioCyc:   PMAR74547:PMT0186-MONOMER
- HAMAP:   MF_00103
- InterPro:   IPR015886
- InterPro:   IPR015887
- InterPro:   IPR000191
- InterPro:   IPR012319
- InterPro:   IPR020629
- InterPro:   IPR010979
- InterPro:   IPR000214
- InterPro:   IPR010663
- SMART:   SM00898
- TIGRFAMs:   TIGR00577

Pfam domain/function: PF01149 Fapy_DNA_glyco; PF06831 H2TH; PF06827 zf-FPG_IleRS; SSF81624 Form_DNAglyc_cat; SSF46946 Ribosomal_H2TH

EC number: =3.2.2.23; =4.2.99.18

Molecular weight: Translated: 32467; Mature: 32336

Theoretical pI: Translated: 9.03; Mature: 9.03

Prosite motif: PS51068 FPG_CAT; PS01242 ZF_FPG_1; PS51066 ZF_FPG_2

Important sites: ACT_SITE 2-2 ACT_SITE 3-3 ACT_SITE 60-60 ACT_SITE 281-281 BINDING 108-108 BINDING 127-127

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.4 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
3.4 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPELPEVETVRRGLADRLVDFQIGQVEVCRERAIASPGGSALFIKMLCGMHVGSWLRRGK
CCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHH
YLMASLHHEIAQSSADSEPDPDGGWWGVHLRMTGQFQWHEAISSPCPHTRVRIWNKKNEE
HHHHHHHHHHHHHCCCCCCCCCCCEEEEEEEEECCCHHHHHHCCCCCCCEEEEECCCCCC
LRFVDTRSFGQMWWVPPGNAPETIITGLQKLGPEPFSSAFNSSYLSKRLKGSKRPIKSAL
EEEEECCCCCCEEEECCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCHHHHHH
LDQSIVAGAGNIYTDESLFAARIRPHTPSGQLKKVELERLCNCLTEVLRVSIGAGGTTFS
HHHHHHHCCCCCCCCCHHHEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHH
DFRDLEGINGNYGGQAWVYRRGGQACRICSTPIRRESLCGRGTHWCPNCQR
HHHHCCCCCCCCCCEEEEEECCCCEEEECCCCHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure 
PELPEVETVRRGLADRLVDFQIGQVEVCRERAIASPGGSALFIKMLCGMHVGSWLRRGK
CCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHH
YLMASLHHEIAQSSADSEPDPDGGWWGVHLRMTGQFQWHEAISSPCPHTRVRIWNKKNEE
HHHHHHHHHHHHHCCCCCCCCCCCEEEEEEEEECCCHHHHHHCCCCCCCEEEEECCCCCC
LRFVDTRSFGQMWWVPPGNAPETIITGLQKLGPEPFSSAFNSSYLSKRLKGSKRPIKSAL
EEEEECCCCCCEEEECCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCHHHHHH
LDQSIVAGAGNIYTDESLFAARIRPHTPSGQLKKVELERLCNCLTEVLRVSIGAGGTTFS
HHHHHHHCCCCCCCCCHHHEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHH
DFRDLEGINGNYGGQAWVYRRGGQACRICSTPIRRESLCGRGTHWCPNCQR
HHHHCCCCCCCCCCEEEEEECCCCEEEECCCCHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12917642