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The map label for this gene is parC [H]

Identifier: 33862278

GI number: 33862278

Start: 6115

End: 8604

Strand: Reverse

Name: parC [H]

Synonym: PMT0005

Alternate gene names: 33862278

Gene position: 8604-6115 (Counterclockwise)

Preceding gene: 33862279

Following gene: NA

Centisome position: 0.36

GC content: 47.83

Gene sequence:

>2490_bases
ATGGCCGAGGAGCGCCTTCAACCAATCGCATTGCATCAAGAGATGCAACGCTCCTATCTCGAATACGCGATGAGCGTAAT
CGTAGGAAGAGCATTGCCCGATGCCCGAGATGGCCTCAAGCCAGTTCAGCGGCGCATCCTATTTGCAATGCACGAGCTAG
GCCTGACGCCAGATCGTCCCTATAGAAAATGCGCCCGTGTTGTTGGAGATGTCCTAGGGAAATATCACCCTCATGGCGAT
CAAGCCGTTTACGACGCACTCGTTCGACTCGTTCAGAACTTTTCAAGCCGTTTCCCAGTATTGGATGGACACGGCAACTT
CGGCTCCGTTGATGACGATCCGCCTGCGGCCATGCGTTACACAGAAACGCGTCTGGCTTCAATCGCCCATATGGCGTTGT
TGGATGAAATCGGAGAGGAAACCGTTGATTTTACTGCGAATTTTGATGGCTCCCAACAGGAACCCTCAGTACTGCCAGCC
CAACTTCCCTTCCTGCTACTAAATGGTTGTTCGGGAATCGCCGTAGGTATGGCGACCAGCATTCCACCCCACAACCTTGG
CGAAGTGGTCGATGGATTGATTGCCCTGATACGCAAACCCGATCTCAGTGACGACAAATTACTTGGTCTAATTCCTGGCC
CAGACTTTCCAACTGGTGGAGAGATCCTGCTGGGCACTGGCATCCATGAAACCTACCTCAAAGGACGCGGCAGCATCCCA
ATGCGTGGCGTGGCCCATGTCGAAGAAATACAACCTGGTAAGGGTCGGCACCGCCGAAGTGCTGTTGTCGTCACTGAATT
GCCCTATCAACTCAGCAAAGCTGGTTGGATCGAAAAACTGGCAGATCTTGTTAACAATGGAAAAATCGGTGGCATTGCCG
ATATTCGCGACGAAAGCGATAGAGAAGGAATGAGGATAGTGGTGGAACTGCGCCGAGATGCCAACCCAGAGAATGTTCTC
GGCGATCTGCATCGACGCACCTCATTACAAAGCAATTTCGGTGCAATTCTTCTGGCTCTTGTTAACGGCCAGCCCCAACA
ACTTTCACTGAGAAAATTGTTACAAACTTTTCTCGAATACCGAGAACTCACAGTTATCCGAAGAACCAACCACGCCCTAG
AAAAAACAAAAGCTCGCCTGGAAGTGGTGGAAGGATTAATCACAGCATTGAACGCACTACAAGCTGTCATTGCAATGATC
CAAGAGGCTGCCGATGCTGCTGCTGCAAGAGCCCGTCTGATGGTGCAATTAGATCTAAATGAAAAACAAGCCGACGCTGT
TCTGGCAATGCCACTAAGACGACTTACGAGTCTGGAACAAAGCAGTTTGAGGCAAGAAGCCAAAGAACTACAAGAAAAAC
AAGAACAACTTCAATTCCTTCTCGAAAATCGAGAAAGCATGCTGGAAGTACTCATTCAAGAACTTCGACAGCTCAAAAAA
CGCTTTAACAACCCCCGGCGAACTCGCCTTGTGGAGGGTGGCGATGATCTGGTCGCTGAGCGAGCGGCAAACCAAAGACC
GAATGCGGAAGTTCAACGACAACAAGCACTATCCGCCCTGCCAAGTGATGGACGAATACTCATCCAACAAGACAGCCAGG
TCAAGGTAATGAGCCCTCAAATCCTCGGTCGACTTCACCTCAACGAAGCCTGCAAACTCAGCGATGGACCTTCGCCAGCC
AGATTGATCTTGCCAATTGAACCAGCCCCACGTCTACTTGCGGTGACAAACAATGGTCGAGTAGCTCTAGTCCGCTGGGA
ATTTGCAGGGCAACAACCCGGGTCGCTGGAACGCTTCCTACCAGGAGGATTAGAAAAAGAAACATTGATCAATATATTCC
CCTTGCCCGTAGATCAAAACCTAAGCCTAGGCCTACTTAGCAGCGATGGACGCTTCAAGCGATTACCCATAGAAGAAGTG
ATGGAACTTTCCGGAAGAGCAGCAACCATTGTTAAATTGAAAGATGGTGTTATCTTAAAATCAGCATTCATTTGCAAAGC
AAATGATGATGTTATTCTAGCAAGTAATATAGGAAGAGTAATCAGAATTAATGTTAATAACGACAGCATGCCATTGATGG
GAAAATTAGCTCAGGGGCCTATGACAATGCGACTATTACCAGAAGAAATGGTCGTTGGAGCAGTATCTTGTCCACCAAAC
TGTGAAAGCACTGTATTACTTGCAACACGCCTAGGTAAATTCGCAAAAATATTGGTCTCTTCGATAAGAATCTGCCAGAG
AGGAGATTTAGGGGAAATTGGATTAACAATAAAAGATTCAAGCCGAGATCAAGATCGAGTCGTTGACATCTGTAATGGCA
ATAGGTTGGTCGGCCTAGTCAGTAGCCAAGGTCGCCATGGCCGTATTGAAGCTGGAAAGCTGGAACTGACCATACCGATC
AAACCGAGTCTAAATATTGTGGAATTAAAAGACAACGAAGAAATTCAAAAACTGGTGCCACTAATCACCACTAATAATAC
TTTAGATTAA

Upstream 100 bases:

>100_bases
CCAATGCTGATACAAACCAATAGGCACTGATCAACAATGCGGGTATCCGCTAAGTAGATCTGTAGGCTGAGCGCTTTAAG
CCCTCTAATCCCATATCTGG

Downstream 100 bases:

>100_bases
ACATTTAACACTTAAGGCCTTGATAGTCACCTTTATCAAGACAATTGTGTGCGTTCTATCCAATCGAGATATTCAGAAGT
AACTGTCCCTGTAATATACT

Product: DNA gyrase/topoisomerase IV, subunit A

Products: NA

Alternate protein names: Topoisomerase IV subunit A [H]

Number of amino acids: Translated: 829; Mature: 828

Protein sequence:

>829_residues
MAEERLQPIALHQEMQRSYLEYAMSVIVGRALPDARDGLKPVQRRILFAMHELGLTPDRPYRKCARVVGDVLGKYHPHGD
QAVYDALVRLVQNFSSRFPVLDGHGNFGSVDDDPPAAMRYTETRLASIAHMALLDEIGEETVDFTANFDGSQQEPSVLPA
QLPFLLLNGCSGIAVGMATSIPPHNLGEVVDGLIALIRKPDLSDDKLLGLIPGPDFPTGGEILLGTGIHETYLKGRGSIP
MRGVAHVEEIQPGKGRHRRSAVVVTELPYQLSKAGWIEKLADLVNNGKIGGIADIRDESDREGMRIVVELRRDANPENVL
GDLHRRTSLQSNFGAILLALVNGQPQQLSLRKLLQTFLEYRELTVIRRTNHALEKTKARLEVVEGLITALNALQAVIAMI
QEAADAAAARARLMVQLDLNEKQADAVLAMPLRRLTSLEQSSLRQEAKELQEKQEQLQFLLENRESMLEVLIQELRQLKK
RFNNPRRTRLVEGGDDLVAERAANQRPNAEVQRQQALSALPSDGRILIQQDSQVKVMSPQILGRLHLNEACKLSDGPSPA
RLILPIEPAPRLLAVTNNGRVALVRWEFAGQQPGSLERFLPGGLEKETLINIFPLPVDQNLSLGLLSSDGRFKRLPIEEV
MELSGRAATIVKLKDGVILKSAFICKANDDVILASNIGRVIRINVNNDSMPLMGKLAQGPMTMRLLPEEMVVGAVSCPPN
CESTVLLATRLGKFAKILVSSIRICQRGDLGEIGLTIKDSSRDQDRVVDICNGNRLVGLVSSQGRHGRIEAGKLELTIPI
KPSLNIVELKDNEEIQKLVPLITTNNTLD

Sequences:

>Translated_829_residues
MAEERLQPIALHQEMQRSYLEYAMSVIVGRALPDARDGLKPVQRRILFAMHELGLTPDRPYRKCARVVGDVLGKYHPHGD
QAVYDALVRLVQNFSSRFPVLDGHGNFGSVDDDPPAAMRYTETRLASIAHMALLDEIGEETVDFTANFDGSQQEPSVLPA
QLPFLLLNGCSGIAVGMATSIPPHNLGEVVDGLIALIRKPDLSDDKLLGLIPGPDFPTGGEILLGTGIHETYLKGRGSIP
MRGVAHVEEIQPGKGRHRRSAVVVTELPYQLSKAGWIEKLADLVNNGKIGGIADIRDESDREGMRIVVELRRDANPENVL
GDLHRRTSLQSNFGAILLALVNGQPQQLSLRKLLQTFLEYRELTVIRRTNHALEKTKARLEVVEGLITALNALQAVIAMI
QEAADAAAARARLMVQLDLNEKQADAVLAMPLRRLTSLEQSSLRQEAKELQEKQEQLQFLLENRESMLEVLIQELRQLKK
RFNNPRRTRLVEGGDDLVAERAANQRPNAEVQRQQALSALPSDGRILIQQDSQVKVMSPQILGRLHLNEACKLSDGPSPA
RLILPIEPAPRLLAVTNNGRVALVRWEFAGQQPGSLERFLPGGLEKETLINIFPLPVDQNLSLGLLSSDGRFKRLPIEEV
MELSGRAATIVKLKDGVILKSAFICKANDDVILASNIGRVIRINVNNDSMPLMGKLAQGPMTMRLLPEEMVVGAVSCPPN
CESTVLLATRLGKFAKILVSSIRICQRGDLGEIGLTIKDSSRDQDRVVDICNGNRLVGLVSSQGRHGRIEAGKLELTIPI
KPSLNIVELKDNEEIQKLVPLITTNNTLD
>Mature_828_residues
AEERLQPIALHQEMQRSYLEYAMSVIVGRALPDARDGLKPVQRRILFAMHELGLTPDRPYRKCARVVGDVLGKYHPHGDQ
AVYDALVRLVQNFSSRFPVLDGHGNFGSVDDDPPAAMRYTETRLASIAHMALLDEIGEETVDFTANFDGSQQEPSVLPAQ
LPFLLLNGCSGIAVGMATSIPPHNLGEVVDGLIALIRKPDLSDDKLLGLIPGPDFPTGGEILLGTGIHETYLKGRGSIPM
RGVAHVEEIQPGKGRHRRSAVVVTELPYQLSKAGWIEKLADLVNNGKIGGIADIRDESDREGMRIVVELRRDANPENVLG
DLHRRTSLQSNFGAILLALVNGQPQQLSLRKLLQTFLEYRELTVIRRTNHALEKTKARLEVVEGLITALNALQAVIAMIQ
EAADAAAARARLMVQLDLNEKQADAVLAMPLRRLTSLEQSSLRQEAKELQEKQEQLQFLLENRESMLEVLIQELRQLKKR
FNNPRRTRLVEGGDDLVAERAANQRPNAEVQRQQALSALPSDGRILIQQDSQVKVMSPQILGRLHLNEACKLSDGPSPAR
LILPIEPAPRLLAVTNNGRVALVRWEFAGQQPGSLERFLPGGLEKETLINIFPLPVDQNLSLGLLSSDGRFKRLPIEEVM
ELSGRAATIVKLKDGVILKSAFICKANDDVILASNIGRVIRINVNNDSMPLMGKLAQGPMTMRLLPEEMVVGAVSCPPNC
ESTVLLATRLGKFAKILVSSIRICQRGDLGEIGLTIKDSSRDQDRVVDICNGNRLVGLVSSQGRHGRIEAGKLELTIPIK
PSLNIVELKDNEEIQKLVPLITTNNTLD

Specific function: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule [H]

COG id: COG0188

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]

Homologues:

Organism=Homo sapiens, GI19913408, Length=344, Percent_Identity=25.2906976744186, Blast_Score=78, Evalue=3e-14,
Organism=Homo sapiens, GI19913406, Length=351, Percent_Identity=24.5014245014245, Blast_Score=75, Evalue=3e-13,
Organism=Escherichia coli, GI1788562, Length=795, Percent_Identity=36.3522012578616, Blast_Score=461, Evalue=1e-131,
Organism=Escherichia coli, GI1789396, Length=489, Percent_Identity=43.558282208589, Blast_Score=373, Evalue=1e-104,
Organism=Caenorhabditis elegans, GI212645845, Length=509, Percent_Identity=24.3614931237721, Blast_Score=91, Evalue=3e-18,
Organism=Saccharomyces cerevisiae, GI6324241, Length=184, Percent_Identity=30.9782608695652, Blast_Score=71, Evalue=6e-13,
Organism=Drosophila melanogaster, GI17136538, Length=174, Percent_Identity=28.735632183908, Blast_Score=67, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020899
- InterPro:   IPR006691
- InterPro:   IPR002205
- InterPro:   IPR013758
- InterPro:   IPR013760 [H]

Pfam domain/function: PF03989 DNA_gyraseA_C; PF00521 DNA_topoisoIV [H]

EC number: 5.99.1.3

Molecular weight: Translated: 91308; Mature: 91177

Theoretical pI: Translated: 7.03; Mature: 7.03

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEERLQPIALHQEMQRSYLEYAMSVIVGRALPDARDGLKPVQRRILFAMHELGLTPDRP
CCCHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCHHHHHHHHHHHHHHHCCCCCCH
YRKCARVVGDVLGKYHPHGDQAVYDALVRLVQNFSSRFPVLDGHGNFGSVDDDPPAAMRY
HHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCEEECCCCCCCCCCCCCCHHHH
TETRLASIAHMALLDEIGEETVDFTANFDGSQQEPSVLPAQLPFLLLNGCSGIAVGMATS
HHHHHHHHHHHHHHHHHCCHHEEEEECCCCCCCCCCCCCHHCCHHHHCCCCCEEEHHCCC
IPPHNLGEVVDGLIALIRKPDLSDDKLLGLIPGPDFPTGGEILLGTGIHETYLKGRGSIP
CCCCCHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCEEEECCCHHHHHCCCCCCC
MRGVAHVEEIQPGKGRHRRSAVVVTELPYQLSKAGWIEKLADLVNNGKIGGIADIRDESD
CCCCHHHHHCCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHCCCCCCCEECCCCCCC
REGMRIVVELRRDANPENVLGDLHRRTSLQSNFGAILLALVNGQPQQLSLRKLLQTFLEY
CCCCEEEEEEHHCCCHHHHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHHHH
RELTVIRRTNHALEKTKARLEVVEGLITALNALQAVIAMIQEAADAAAARARLMVQLDLN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEEECC
EKQADAVLAMPLRRLTSLEQSSLRQEAKELQEKQEQLQFLLENRESMLEVLIQELRQLKK
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RFNNPRRTRLVEGGDDLVAERAANQRPNAEVQRQQALSALPSDGRILIQQDSQVKVMSPQ
HHCCCCCEEEECCCHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCEEEEECCCCEEEECHH
ILGRLHLNEACKLSDGPSPARLILPIEPAPRLLAVTNNGRVALVRWEFAGQQPGSLERFL
HHHHHCCCCCCCCCCCCCCCEEEEECCCCCCEEEEECCCEEEEEEEEECCCCCCCHHHHC
PGGLEKETLINIFPLPVDQNLSLGLLSSDGRFKRLPIEEVMELSGRAATIVKLKDGVILK
CCCCCCCCEEEEECCCCCCCCCEEEECCCCCEEECCHHHHHHCCCCEEEEEEECCCEEEE
SAFICKANDDVILASNIGRVIRINVNNDSMPLMGKLAQGPMTMRLLPEEMVVGAVSCPPN
EEEEEECCCCEEEEECCCEEEEEEECCCCCCHHHHHCCCCEEEEECCHHHHEEEECCCCC
CESTVLLATRLGKFAKILVSSIRICQRGDLGEIGLTIKDSSRDQDRVVDICNGNRLVGLV
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCEEEEECCCEEEEEE
SSQGRHGRIEAGKLELTIPIKPSLNIVELKDNEEIQKLVPLITTNNTLD
CCCCCCCCEECCEEEEEEECCCCCEEEEECCCHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
AEERLQPIALHQEMQRSYLEYAMSVIVGRALPDARDGLKPVQRRILFAMHELGLTPDRP
CCHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCHHHHHHHHHHHHHHHCCCCCCH
YRKCARVVGDVLGKYHPHGDQAVYDALVRLVQNFSSRFPVLDGHGNFGSVDDDPPAAMRY
HHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCEEECCCCCCCCCCCCCCHHHH
TETRLASIAHMALLDEIGEETVDFTANFDGSQQEPSVLPAQLPFLLLNGCSGIAVGMATS
HHHHHHHHHHHHHHHHHCCHHEEEEECCCCCCCCCCCCCHHCCHHHHCCCCCEEEHHCCC
IPPHNLGEVVDGLIALIRKPDLSDDKLLGLIPGPDFPTGGEILLGTGIHETYLKGRGSIP
CCCCCHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCEEEECCCHHHHHCCCCCCC
MRGVAHVEEIQPGKGRHRRSAVVVTELPYQLSKAGWIEKLADLVNNGKIGGIADIRDESD
CCCCHHHHHCCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHCCCCCCCEECCCCCCC
REGMRIVVELRRDANPENVLGDLHRRTSLQSNFGAILLALVNGQPQQLSLRKLLQTFLEY
CCCCEEEEEEHHCCCHHHHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHHHH
RELTVIRRTNHALEKTKARLEVVEGLITALNALQAVIAMIQEAADAAAARARLMVQLDLN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEEECC
EKQADAVLAMPLRRLTSLEQSSLRQEAKELQEKQEQLQFLLENRESMLEVLIQELRQLKK
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RFNNPRRTRLVEGGDDLVAERAANQRPNAEVQRQQALSALPSDGRILIQQDSQVKVMSPQ
HHCCCCCEEEECCCHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCEEEEECCCCEEEECHH
ILGRLHLNEACKLSDGPSPARLILPIEPAPRLLAVTNNGRVALVRWEFAGQQPGSLERFL
HHHHHCCCCCCCCCCCCCCCEEEEECCCCCCEEEEECCCEEEEEEEEECCCCCCCHHHHC
PGGLEKETLINIFPLPVDQNLSLGLLSSDGRFKRLPIEEVMELSGRAATIVKLKDGVILK
CCCCCCCCEEEEECCCCCCCCCEEEECCCCCEEECCHHHHHHCCCCEEEEEEECCCEEEE
SAFICKANDDVILASNIGRVIRINVNNDSMPLMGKLAQGPMTMRLLPEEMVVGAVSCPPN
EEEEEECCCCEEEEECCCEEEEEEECCCCCCHHHHHCCCCEEEEECCHHHHEEEECCCCC
CESTVLLATRLGKFAKILVSSIRICQRGDLGEIGLTIKDSSRDQDRVVDICNGNRLVGLV
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCEEEEECCCEEEEEE
SSQGRHGRIEAGKLELTIPIKPSLNIVELKDNEEIQKLVPLITTNNTLD
CCCCCCCCEECCEEEEEEECCCCCEEEEECCCHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Isomerization [C]

Inhibitor: CJ-12, 371; CJ-12, 372; Coumermycin; Doxorubicin; Sitafloxacin [C]

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]