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The map label for this gene is mutS

Identifier: 326423853

GI number: 326423853

Start: 1560503

End: 1563064

Strand: Reverse

Name: mutS

Synonym: NA

Alternate gene names: 326423853

Gene position: 1563064-1560503 (Counterclockwise)

Preceding gene: 27364975

Following gene: 27364942

Centisome position: 47.63

GC content: 49.96

Gene sequence:

>2562_bases
GTGAAAGCTGAACAACAACATACCCCAATGATGCAGCAATACCTCAGATTGAAGGCAGAAAATCCAGATATTTTGCTGTT
TTATCGCATGGGCGACTTCTACGAACTTTTTTACGATGATGCAAAGAAGGCGTCGCAATTGCTGGATATTTCTCTCACCA
AGCGCGGCGCTTCGGCAGGAGAACCCATTCCGATGGCGGGTGTGCCATTTCATGCCGTTGAAGGGTATTTAGCCAAATTG
GTTCAGCTTGGGGAGTCGGTGGCGATCTGCGAACAAGTTGGCGATCCTGCCACCAGTAAAGGCCCAGTAGAGCGCAAAGT
CGTTCGTATTGTCACGCCGGGTACGGTAACGGATGAAGCTTTACTGTCTGAACGTTTGGATAACTTAATTGCCGCGATTT
ATCACCACAATGGTAAATTCGGCTACGCCACCTTGGATGTCACCTCTGGGCGTTTCCAATTGGTTGAACCCCAGTCAGAA
GAGGCAATGGCAGCTGAGCTACAACGCACCTCTCCGCGTGAGTTACTCTTCCCAGAAGATTTTGAGCCCGTTCATTTGAT
GACAGGTCGTAACGGCAACCGTCGTCGTCCAGTTTGGGAGTTCGAACTCGAAACGGCCAAACAACAGCTCAACCAGCAAT
TTGGCACCAAAGACTTGGTCGGTTTTGGCGTAGAAAATGCGGTTTTAGGATTGTGCGCCGCAGGTTGCTTGATCCAGTAT
GTCAAAGATACTCAACGTACAACACTTCCTCATATCCGCGCGCTTACTTATGATCGCCAAGATGACTCGGTTATCCTTGA
TGCCGCGACCAGACGCAATCTCGAACTGACTCAAAACCTTGCTGGCGGAAGTGACAACACGCTTGCTGCGGTTTTGGATC
GTTGTGCGACGCCGATGGGAAGCCGGATGCTGAAACGTTGGATCCATCAACCAATGCGCTGTATTACCACGCGAGAGCAT
CGCCTAGACGCCATCGCCGAACTGAAAGAACAAGCTCTATTTAGCGATATTCATCCCGTGGTGAAACAAATCGGCGATAT
TGAACGTATTTTGGCTCGCTTAGCACTCCGCTCTGCACGTCCACGCGATCTCGCGCGATTACGCCATGCGATGCAACAGC
TACCCGAATTGGCTCAGACGTTGTCTTCACTGGGCAATAGCCATCTCAAATCACTGGCCACGGCAGCCGCTCCAATGGAT
GATGTGTGTGAGTTGCTCGAACGTGCCATTAAAGAAAACCCGCCAGTAGTGATTCGCGATGGAGGTGTCATTGCCGAAGG
GTACAGCGCAGATTTGGATGAATGGCGCGATCTTGCAGACGGTGCCACGGGCTACTTGGAAAAACTCGAAGAGGAAGAGC
GTGATCGCCACGGTATCGATACGCTGAAAGTGGGATACAACAATGTCCACGGTTTCTACATCCAAGTAAGCCGCGGTCAA
AGCCATTTGGTTCCACCACACTATGTTCGCCGTCAAACGCTGAAAAACGCTGAACGTTACATCATTCCTGAACTGAAAGA
GCACGAAGACAAAGTTCTCAACTCAAAATCGAAAGCATTAGCCATTGAAAAGCAACTGTGGGAAGAGCTCTTTGATTTAT
TGCTACCTCACCTAGCCCGTTTGCAAGAGTTGGCAGCAGCGGTTGCACAATTGGATGTATTGCAAAATTTGGCGGAGCGT
GCTGATACGCTGGATTATTGCCGCCCAAATTTGACCAAAGATCCCGTCGTTCACATTACCGCGGGTCGTCACCCTGTGGT
AGAACAAGTCACTTCCGATCCCTTTATTGCCAACCCAATTGAACTGAACAGCCAACGTAAAATGTTGATCATCACCGGTC
CAAACATGGGGGGTAAGTCCACCTACATGCGCCAAACCGCATTGATTGCTTTAATGGCGCACATTGGTTCTTACGTTCCT
GCAGAATCGGCCACCATTGGCTCAATTGATCGCATCTTTACTCGAATTGGTGCATCGGATGATCTCGCGTCAGGTCGTTC
AACCTTCATGGTAGAAATGACAGAAACAGCCAATATCTTGCACAACGCGACAGCAAATAGCTTAGTTTTGATGGATGAAA
TTGGCCGTGGTACCAGTACCTATGATGGTCTTTCCCTAGCGTGGGCAAGCGCACACTGGCTTGCGACTCAGATTGGGGCA
ATGACGCTATTTGCGACGCATTACTTTGAACTGACAGAACTGCCAAATCAACTCCCTCACTTGGCCAACGTGCATCTTGA
TGCGGTTGAGCATGGCGACAGCATCGCCTTTATGCACGCCGTACAAGAGGGGGCGGCAAGCAAATCCTACGGTTTGGCGG
TGGCGGGGTTAGCGGGCGTTCCAAAAACGGTGATTAAAAACGCCCGTCAAAAATTGTCTCAACTTGAGCTACTCAGCGCA
GAGGGTTCGCAGCCGAAAGCAAGAACGGTGGATATCGCTAACCAATTAAGCCTCATTCCAGAGCCAAGTGAAGTAGAACA
AGCGTTGGCCAGCATCGATCCGGATGATCTGACCCCACGCCAAGCGTTAGAAGCCCTATATCGTTTAAAGAAAATGCTCT
AA

Upstream 100 bases:
NA

Downstream 100 bases:
NA

Product: DNA mismatch repair protein MutS

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 853; Mature: 853

Protein sequence:
NA

Sequences:

>Translated_853_residues
MKAEQQHTPMMQQYLRLKAENPDILLFYRMGDFYELFYDDAKKASQLLDISLTKRGASAGEPIPMAGVPFHAVEGYLAKL
VQLGESVAICEQVGDPATSKGPVERKVVRIVTPGTVTDEALLSERLDNLIAAIYHHNGKFGYATLDVTSGRFQLVEPQSE
EAMAAELQRTSPRELLFPEDFEPVHLMTGRNGNRRRPVWEFELETAKQQLNQQFGTKDLVGFGVENAVLGLCAAGCLIQY
VKDTQRTTLPHIRALTYDRQDDSVILDAATRRNLELTQNLAGGSDNTLAAVLDRCATPMGSRMLKRWIHQPMRCITTREH
RLDAIAELKEQALFSDIHPVVKQIGDIERILARLALRSARPRDLARLRHAMQQLPELAQTLSSLGNSHLKSLATAAAPMD
DVCELLERAIKENPPVVIRDGGVIAEGYSADLDEWRDLADGATGYLEKLEEEERDRHGIDTLKVGYNNVHGFYIQVSRGQ
SHLVPPHYVRRQTLKNAERYIIPELKEHEDKVLNSKSKALAIEKQLWEELFDLLLPHLARLQELAAAVAQLDVLQNLAER
ADTLDYCRPNLTKDPVVHITAGRHPVVEQVTSDPFIANPIELNSQRKMLIITGPNMGGKSTYMRQTALIALMAHIGSYVP
AESATIGSIDRIFTRIGASDDLASGRSTFMVEMTETANILHNATANSLVLMDEIGRGTSTYDGLSLAWASAHWLATQIGA
MTLFATHYFELTELPNQLPHLANVHLDAVEHGDSIAFMHAVQEGAASKSYGLAVAGLAGVPKTVIKNARQKLSQLELLSA
EGSQPKARTVDIANQLSLIPEPSEVEQALASIDPDDLTPRQALEALYRLKKML
>Mature_853_residues
MKAEQQHTPMMQQYLRLKAENPDILLFYRMGDFYELFYDDAKKASQLLDISLTKRGASAGEPIPMAGVPFHAVEGYLAKL
VQLGESVAICEQVGDPATSKGPVERKVVRIVTPGTVTDEALLSERLDNLIAAIYHHNGKFGYATLDVTSGRFQLVEPQSE
EAMAAELQRTSPRELLFPEDFEPVHLMTGRNGNRRRPVWEFELETAKQQLNQQFGTKDLVGFGVENAVLGLCAAGCLIQY
VKDTQRTTLPHIRALTYDRQDDSVILDAATRRNLELTQNLAGGSDNTLAAVLDRCATPMGSRMLKRWIHQPMRCITTREH
RLDAIAELKEQALFSDIHPVVKQIGDIERILARLALRSARPRDLARLRHAMQQLPELAQTLSSLGNSHLKSLATAAAPMD
DVCELLERAIKENPPVVIRDGGVIAEGYSADLDEWRDLADGATGYLEKLEEEERDRHGIDTLKVGYNNVHGFYIQVSRGQ
SHLVPPHYVRRQTLKNAERYIIPELKEHEDKVLNSKSKALAIEKQLWEELFDLLLPHLARLQELAAAVAQLDVLQNLAER
ADTLDYCRPNLTKDPVVHITAGRHPVVEQVTSDPFIANPIELNSQRKMLIITGPNMGGKSTYMRQTALIALMAHIGSYVP
AESATIGSIDRIFTRIGASDDLASGRSTFMVEMTETANILHNATANSLVLMDEIGRGTSTYDGLSLAWASAHWLATQIGA
MTLFATHYFELTELPNQLPHLANVHLDAVEHGDSIAFMHAVQEGAASKSYGLAVAGLAGVPKTVIKNARQKLSQLELLSA
EGSQPKARTVDIANQLSLIPEPSEVEQALASIDPDDLTPRQALEALYRLKKML

Specific function: This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA mismatch repair mutS family

Homologues:

Organism=Homo sapiens, GI284813531, Length=887, Percent_Identity=27.8466741826381, Blast_Score=298, Evalue=1e-80,
Organism=Homo sapiens, GI4557761, Length=571, Percent_Identity=33.4500875656743, Blast_Score=284, Evalue=3e-76,
Organism=Homo sapiens, GI36949366, Length=735, Percent_Identity=27.6190476190476, Blast_Score=258, Evalue=2e-68,
Organism=Homo sapiens, GI4504191, Length=598, Percent_Identity=31.7725752508361, Blast_Score=244, Evalue=2e-64,
Organism=Homo sapiens, GI26638666, Length=534, Percent_Identity=28.6516853932584, Blast_Score=190, Evalue=5e-48,
Organism=Homo sapiens, GI4505253, Length=534, Percent_Identity=28.6516853932584, Blast_Score=190, Evalue=5e-48,
Organism=Homo sapiens, GI26638664, Length=535, Percent_Identity=28.5981308411215, Blast_Score=185, Evalue=1e-46,
Organism=Homo sapiens, GI262231786, Length=508, Percent_Identity=28.5433070866142, Blast_Score=171, Evalue=2e-42,
Organism=Escherichia coli, GI1789089, Length=850, Percent_Identity=70.8235294117647, Blast_Score=1197, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17508445, Length=605, Percent_Identity=32.7272727272727, Blast_Score=245, Evalue=6e-65,
Organism=Caenorhabditis elegans, GI17508447, Length=917, Percent_Identity=26.1723009814613, Blast_Score=243, Evalue=3e-64,
Organism=Caenorhabditis elegans, GI17534743, Length=627, Percent_Identity=24.0829346092504, Blast_Score=172, Evalue=6e-43,
Organism=Caenorhabditis elegans, GI17539736, Length=540, Percent_Identity=25.5555555555556, Blast_Score=138, Evalue=1e-32,
Organism=Saccharomyces cerevisiae, GI6320302, Length=876, Percent_Identity=26.9406392694064, Blast_Score=280, Evalue=9e-76,
Organism=Saccharomyces cerevisiae, GI6324482, Length=571, Percent_Identity=31.6987740805604, Blast_Score=268, Evalue=3e-72,
Organism=Saccharomyces cerevisiae, GI6321912, Length=891, Percent_Identity=27.6094276094276, Blast_Score=258, Evalue=2e-69,
Organism=Saccharomyces cerevisiae, GI6319935, Length=850, Percent_Identity=26.1176470588235, Blast_Score=230, Evalue=6e-61,
Organism=Saccharomyces cerevisiae, GI6321109, Length=715, Percent_Identity=24.7552447552448, Blast_Score=174, Evalue=5e-44,
Organism=Saccharomyces cerevisiae, GI6320047, Length=568, Percent_Identity=23.7676056338028, Blast_Score=116, Evalue=1e-26,
Organism=Drosophila melanogaster, GI24584320, Length=534, Percent_Identity=31.8352059925094, Blast_Score=264, Evalue=2e-70,
Organism=Drosophila melanogaster, GI24664545, Length=584, Percent_Identity=29.4520547945205, Blast_Score=225, Evalue=1e-58,
Organism=Drosophila melanogaster, GI62471629, Length=418, Percent_Identity=28.9473684210526, Blast_Score=161, Evalue=2e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MUTS_VIBVU (Q8DC53)

Other databases:

- EMBL:   AE016795
- RefSeq:   NP_760485.1
- ProteinModelPortal:   Q8DC53
- SMR:   Q8DC53
- GeneID:   1178501
- GenomeReviews:   AE016795_GR
- KEGG:   vvu:VV1_1589
- HOGENOM:   HBG735169
- OMA:   DFFECFF
- ProtClustDB:   PRK05399
- BioCyc:   VVUL216895:VV1_1589-MONOMER
- HAMAP:   MF_00096
- InterPro:   IPR005748
- InterPro:   IPR007695
- InterPro:   IPR000432
- InterPro:   IPR007861
- InterPro:   IPR007860
- InterPro:   IPR007696
- InterPro:   IPR016151
- Gene3D:   G3DSA:3.30.420.110
- Gene3D:   G3DSA:3.40.1170.10
- PANTHER:   PTHR11361
- SMART:   SM00534
- SMART:   SM00533
- TIGRFAMs:   TIGR01070

Pfam domain/function: PF01624 MutS_I; PF05188 MutS_II; PF05192 MutS_III; PF05190 MutS_IV; PF00488 MutS_V; SSF53150 DNA_mismatch_repair_MutS_connt; SSF55271 DNA_mismatch_repair_MutS_N; SSF48334 DNA_repair_MutS_domIII

EC number: NA

Molecular weight: Translated: 94484; Mature: 94484

Theoretical pI: Translated: 5.97; Mature: 5.97

Prosite motif: PS00486 DNA_MISMATCH_REPAIR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAEQQHTPMMQQYLRLKAENPDILLFYRMGDFYELFYDDAKKASQLLDISLTKRGASAG
CCCCCCCCHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCCC
EPIPMAGVPFHAVEGYLAKLVQLGESVAICEQVGDPATSKGPVERKVVRIVTPGTVTDEA
CCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHCCCCCCCCCCCCEEEEEEECCCCCCHHH
LLSERLDNLIAAIYHHNGKFGYATLDVTSGRFQLVEPQSEEAMAAELQRTSPRELLFPED
HHHHHHHHHHHHHHHCCCCEEEEEEEECCCEEEEECCCCHHHHHHHHHHCCCCCCCCCCC
FEPVHLMTGRNGNRRRPVWEFELETAKQQLNQQFGTKDLVGFGVENAVLGLCAAGCLIQY
CCCEEEEECCCCCCCCCEEEHHHHHHHHHHHHHCCCHHHHHCCHHHHHHHHHHHHHHHHH
VKDTQRTTLPHIRALTYDRQDDSVILDAATRRNLELTQNLAGGSDNTLAAVLDRCATPMG
HHHHHHHCCCHHHHEEECCCCCCEEEEHHHCCCHHHHHHCCCCCCCHHHHHHHHHCCCHH
SRMLKRWIHQPMRCITTREHRLDAIAELKEQALFSDIHPVVKQIGDIERILARLALRSAR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCC
PRDLARLRHAMQQLPELAQTLSSLGNSHLKSLATAAAPMDDVCELLERAIKENPPVVIRD
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCEEEEC
GGVIAEGYSADLDEWRDLADGATGYLEKLEEEERDRHGIDTLKVGYNNVHGFYIQVSRGQ
CCEEECCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHCCCCEEEECCCCCCEEEEEEECCC
SHLVPPHYVRRQTLKNAERYIIPELKEHEDKVLNSKSKALAIEKQLWEELFDLLLPHLAR
CCCCCHHHHHHHHHHCCHHEECCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHH
LQELAAAVAQLDVLQNLAERADTLDYCRPNLTKDPVVHITAGRHPVVEQVTSDPFIANPI
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCHHHHHHCCCCCCCCCE
ELNSQRKMLIITGPNMGGKSTYMRQTALIALMAHIGSYVPAESATIGSIDRIFTRIGASD
EECCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCC
DLASGRSTFMVEMTETANILHNATANSLVLMDEIGRGTSTYDGLSLAWASAHWLATQIGA
CCCCCCCEEEEEEHHHHHHHHCCCCCCEEEEHHCCCCCCCCCCCHHHHHHHHHHHHHHHH
MTLFATHYFELTELPNQLPHLANVHLDAVEHGDSIAFMHAVQEGAASKSYGLAVAGLAGV
HHHHHHHHHHHHHHHHHCCHHHCCCHHHHHCCCCHHHHHHHHHCCCCCCCCEEEECCCCC
PKTVIKNARQKLSQLELLSAEGSQPKARTVDIANQLSLIPEPSEVEQALASIDPDDLTPR
CHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCHH
QALEALYRLKKML
HHHHHHHHHHHCC
>Mature Secondary Structure
MKAEQQHTPMMQQYLRLKAENPDILLFYRMGDFYELFYDDAKKASQLLDISLTKRGASAG
CCCCCCCCHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCCC
EPIPMAGVPFHAVEGYLAKLVQLGESVAICEQVGDPATSKGPVERKVVRIVTPGTVTDEA
CCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHCCCCCCCCCCCCEEEEEEECCCCCCHHH
LLSERLDNLIAAIYHHNGKFGYATLDVTSGRFQLVEPQSEEAMAAELQRTSPRELLFPED
HHHHHHHHHHHHHHHCCCCEEEEEEEECCCEEEEECCCCHHHHHHHHHHCCCCCCCCCCC
FEPVHLMTGRNGNRRRPVWEFELETAKQQLNQQFGTKDLVGFGVENAVLGLCAAGCLIQY
CCCEEEEECCCCCCCCCEEEHHHHHHHHHHHHHCCCHHHHHCCHHHHHHHHHHHHHHHHH
VKDTQRTTLPHIRALTYDRQDDSVILDAATRRNLELTQNLAGGSDNTLAAVLDRCATPMG
HHHHHHHCCCHHHHEEECCCCCCEEEEHHHCCCHHHHHHCCCCCCCHHHHHHHHHCCCHH
SRMLKRWIHQPMRCITTREHRLDAIAELKEQALFSDIHPVVKQIGDIERILARLALRSAR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCC
PRDLARLRHAMQQLPELAQTLSSLGNSHLKSLATAAAPMDDVCELLERAIKENPPVVIRD
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCEEEEC
GGVIAEGYSADLDEWRDLADGATGYLEKLEEEERDRHGIDTLKVGYNNVHGFYIQVSRGQ
CCEEECCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHCCCCEEEECCCCCCEEEEEEECCC
SHLVPPHYVRRQTLKNAERYIIPELKEHEDKVLNSKSKALAIEKQLWEELFDLLLPHLAR
CCCCCHHHHHHHHHHCCHHEECCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHH
LQELAAAVAQLDVLQNLAERADTLDYCRPNLTKDPVVHITAGRHPVVEQVTSDPFIANPI
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCHHHHHHCCCCCCCCCE
ELNSQRKMLIITGPNMGGKSTYMRQTALIALMAHIGSYVPAESATIGSIDRIFTRIGASD
EECCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCC
DLASGRSTFMVEMTETANILHNATANSLVLMDEIGRGTSTYDGLSLAWASAHWLATQIGA
CCCCCCCEEEEEEHHHHHHHHCCCCCCEEEEHHCCCCCCCCCCCHHHHHHHHHHHHHHHH
MTLFATHYFELTELPNQLPHLANVHLDAVEHGDSIAFMHAVQEGAASKSYGLAVAGLAGV
HHHHHHHHHHHHHHHHHCCHHHCCCHHHHHCCCCHHHHHHHHHCCCCCCCCEEEECCCCC
PKTVIKNARQKLSQLELLSAEGSQPKARTVDIANQLSLIPEPSEVEQALASIDPDDLTPR
CHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCHH
QALEALYRLKKML
HHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA