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The map label for this gene is mco [H]

Identifier: 326423786

GI number: 326423786

Start: 971788

End: 973173

Strand: Reverse

Name: mco [H]

Synonym: NA

Alternate gene names: 326423786

Gene position: 973173-971788 (Counterclockwise)

Preceding gene: 27364413

Following gene: 27364404

Centisome position: 29.65

GC content: 46.9

Gene sequence:

>1386_bases
ATGGATATTTCTCGCCGCCACTTTCTTCAAACTTCATTGGCGTTTTCCGCATTAACGCTTCTCCCTGCGTGTTCACTTTC
GCGTAGAACATCGCTTCATCATGGGCGGTTTGTCTATGAGATGACTGCAGAACCGGCTACTGCTGAGGTGGTGCCTGGTT
TTGCTACGGATGTGCTCGCCTTTAATGGTGCTATCCCTGCCCCTACGATTCGTTGTCGACAAGGAGAAGAAGTGATCATT
CACTTCACCAACAAACTCAACGAGCCAACGACAATCCATTGGCATGGTTTGCGTGTACCTATTGAGATGGATGGTGTTCC
CTTTTTGAGTCAAAAACCCGTTATGCCAGGGGAGAGCTTTACCTATCGCTTTACTCCACCTGACGCAGGGACATTTTGGT
ATCACCCGCATATGAACAGTGTCAAGCAGCTAGGTATGGGGCTAGTTGGGTTAATCATTGTTGATGAAGCAGAGCCAGTT
TCTTTTGATGAAGACCATGCTCTAATGCTTAAGCATTGGCATCTCAATGAGAAAGGTGAGTGGAAATCGTTATTGGTCCC
ACGCTTAAGTGCCCGCATGGGAACTCCTGGTGAGTGGGGAACTGTGAATGGCGTCCATGAGCCCATCTATCCGTTGAAAG
CGAATGCGATGACGAGGCTGAGAATCGCAAATGTGGACAATACCATCACTTATCCTATCGCTATTGAAGGTGTGGACGCA
TGGGTTATAGCAATAGATGGAAACCCAATAAAAACCCCTTATAAGCTCTCTGAACACAAGATTGGGCCTGGAATGAGGGT
TGATGTCGGGTTAATTGCTCCAGGTGTTGGAGAGCGTTTCTATGTGCGACAAATGAAAGGGAAGTTTCCGTTTCCTCTTT
GTGCATTCGAATCGGTTGAATCGGACCTATTAAACCAGAATATATTGCCAACATTGCCGCTCAACCCTATTGCGCCGTTA
GATTTAGATACGGCTGAACAAATTGATTTTGTCTTCGAGTGGGAAGGTGCTGTTACTCCGATGGATAAATCTGGCCAAGC
TCTGCCGACGTTTTGGTTGGTGAATAAACGCGCTTGGGAGGGGATGAGCCAAGATTCAATTCCAGCACCGTTAGCGACGT
TAGAACGAGGGCGGACCTACATATTTAATCTTAAGAACGTGACGCAATACCATCACCCCATTCATTTGCATGGGCACACA
TTTACCGTATTGGAATTAAATGGCCAGACGCTCGCAGAACCGTTTCATACGGATACTGTTTTGCTAGGTAAGAATGGCAG
TGCCAAAGCGGCGTTTGTTGCGGACAACCCCGGTCGCTGGATGTATCACTGCCACGTGATTGAACATATGAAAACCGGAT
TAATGGGATATATTGAAGTAAAGTGA

Upstream 100 bases:
NA

Downstream 100 bases:
NA

Product: Multicopper oxidase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 461; Mature: 461

Protein sequence:
NA

Sequences:

>Translated_461_residues
MDISRRHFLQTSLAFSALTLLPACSLSRRTSLHHGRFVYEMTAEPATAEVVPGFATDVLAFNGAIPAPTIRCRQGEEVII
HFTNKLNEPTTIHWHGLRVPIEMDGVPFLSQKPVMPGESFTYRFTPPDAGTFWYHPHMNSVKQLGMGLVGLIIVDEAEPV
SFDEDHALMLKHWHLNEKGEWKSLLVPRLSARMGTPGEWGTVNGVHEPIYPLKANAMTRLRIANVDNTITYPIAIEGVDA
WVIAIDGNPIKTPYKLSEHKIGPGMRVDVGLIAPGVGERFYVRQMKGKFPFPLCAFESVESDLLNQNILPTLPLNPIAPL
DLDTAEQIDFVFEWEGAVTPMDKSGQALPTFWLVNKRAWEGMSQDSIPAPLATLERGRTYIFNLKNVTQYHHPIHLHGHT
FTVLELNGQTLAEPFHTDTVLLGKNGSAKAAFVADNPGRWMYHCHVIEHMKTGLMGYIEVK
>Mature_461_residues
MDISRRHFLQTSLAFSALTLLPACSLSRRTSLHHGRFVYEMTAEPATAEVVPGFATDVLAFNGAIPAPTIRCRQGEEVII
HFTNKLNEPTTIHWHGLRVPIEMDGVPFLSQKPVMPGESFTYRFTPPDAGTFWYHPHMNSVKQLGMGLVGLIIVDEAEPV
SFDEDHALMLKHWHLNEKGEWKSLLVPRLSARMGTPGEWGTVNGVHEPIYPLKANAMTRLRIANVDNTITYPIAIEGVDA
WVIAIDGNPIKTPYKLSEHKIGPGMRVDVGLIAPGVGERFYVRQMKGKFPFPLCAFESVESDLLNQNILPTLPLNPIAPL
DLDTAEQIDFVFEWEGAVTPMDKSGQALPTFWLVNKRAWEGMSQDSIPAPLATLERGRTYIFNLKNVTQYHHPIHLHGHT
FTVLELNGQTLAEPFHTDTVLLGKNGSAKAAFVADNPGRWMYHCHVIEHMKTGLMGYIEVK

Specific function: May be involved in copper homeostasis and oxidative stress response [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multicopper oxidase family [H]

Homologues:

Organism=Escherichia coli, GI1786314, Length=540, Percent_Identity=25.3703703703704, Blast_Score=102, Evalue=7e-23,
Organism=Escherichia coli, GI1789394, Length=301, Percent_Identity=25.2491694352159, Blast_Score=70, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6321067, Length=485, Percent_Identity=25.979381443299, Blast_Score=114, Evalue=4e-26,
Organism=Saccharomyces cerevisiae, GI6323703, Length=196, Percent_Identity=32.6530612244898, Blast_Score=96, Evalue=1e-20,
Organism=Drosophila melanogaster, GI18859919, Length=503, Percent_Identity=25.0497017892644, Blast_Score=106, Evalue=3e-23,
Organism=Drosophila melanogaster, GI24650186, Length=130, Percent_Identity=36.9230769230769, Blast_Score=88, Evalue=1e-17,
Organism=Drosophila melanogaster, GI28574104, Length=133, Percent_Identity=33.8345864661654, Blast_Score=73, Evalue=3e-13,
Organism=Drosophila melanogaster, GI221330000, Length=254, Percent_Identity=28.3464566929134, Blast_Score=72, Evalue=7e-13,
Organism=Drosophila melanogaster, GI24585842, Length=254, Percent_Identity=28.3464566929134, Blast_Score=72, Evalue=1e-12,
Organism=Drosophila melanogaster, GI281360167, Length=254, Percent_Identity=28.3464566929134, Blast_Score=72, Evalue=1e-12,
Organism=Drosophila melanogaster, GI221329998, Length=254, Percent_Identity=28.3464566929134, Blast_Score=71, Evalue=1e-12,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011706
- InterPro:   IPR011707
- InterPro:   IPR002355
- InterPro:   IPR008972 [H]

Pfam domain/function: PF07731 Cu-oxidase_2; PF07732 Cu-oxidase_3 [H]

EC number: NA

Molecular weight: Translated: 51516; Mature: 51516

Theoretical pI: Translated: 6.66; Mature: 6.66

Prosite motif: PS00079 MULTICOPPER_OXIDASE1 ; PS00080 MULTICOPPER_OXIDASE2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDISRRHFLQTSLAFSALTLLPACSLSRRTSLHHGRFVYEMTAEPATAEVVPGFATDVLA
CCCCHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCEEEEEEECCCCCEEECCCCHHHHHE
FNGAIPAPTIRCRQGEEVIIHFTNKLNEPTTIHWHGLRVPIEMDGVPFLSQKPVMPGESF
ECCCCCCCEEEECCCCEEEEEEECCCCCCCEEEEEEEEEEEEECCCCCCCCCCCCCCCCE
TYRFTPPDAGTFWYHPHMNSVKQLGMGLVGLIIVDEAEPVSFDEDHALMLKHWHLNEKGE
EEEECCCCCCEEEECCCHHHHHHHCCCEEEEEEEECCCCCCCCCCCEEEEEEEECCCCCC
WKSLLVPRLSARMGTPGEWGTVNGVHEPIYPLKANAMTRLRIANVDNTITYPIAIEGVDA
HHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEECCCCEEEEEEECCCCEEEEEEEEECCEE
WVIAIDGNPIKTPYKLSEHKIGPGMRVDVGLIAPGVGERFYVRQMKGKFPFPLCAFESVE
EEEEECCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCEEEHHHHCCCCCCCCHHHHHHH
SDLLNQNILPTLPLNPIAPLDLDTAEQIDFVFEWEGAVTPMDKSGQALPTFWLVNKRAWE
HHHHCCCCCCCCCCCCCCCCCCCCHHHEEEEEEECCCCCCCCCCCCCCCEEEEEEHHHHC
GMSQDSIPAPLATLERGRTYIFNLKNVTQYHHPIHLHGHTFTVLELNGQTLAEPFHTDTV
CCCCCCCCCCHHHHHCCCEEEEEECCHHHHCCCEEECCCEEEEEEECCCEECCCCCCCEE
LLGKNGSAKAAFVADNPGRWMYHCHVIEHMKTGLMGYIEVK
EEECCCCCEEEEEECCCCCEEEEEEEHHHHHCCCEEEEEEC
>Mature Secondary Structure
MDISRRHFLQTSLAFSALTLLPACSLSRRTSLHHGRFVYEMTAEPATAEVVPGFATDVLA
CCCCHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCEEEEEEECCCCCEEECCCCHHHHHE
FNGAIPAPTIRCRQGEEVIIHFTNKLNEPTTIHWHGLRVPIEMDGVPFLSQKPVMPGESF
ECCCCCCCEEEECCCCEEEEEEECCCCCCCEEEEEEEEEEEEECCCCCCCCCCCCCCCCE
TYRFTPPDAGTFWYHPHMNSVKQLGMGLVGLIIVDEAEPVSFDEDHALMLKHWHLNEKGE
EEEECCCCCCEEEECCCHHHHHHHCCCEEEEEEEECCCCCCCCCCCEEEEEEEECCCCCC
WKSLLVPRLSARMGTPGEWGTVNGVHEPIYPLKANAMTRLRIANVDNTITYPIAIEGVDA
HHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEECCCCEEEEEEECCCCEEEEEEEEECCEE
WVIAIDGNPIKTPYKLSEHKIGPGMRVDVGLIAPGVGERFYVRQMKGKFPFPLCAFESVE
EEEEECCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCEEEHHHHCCCCCCCCHHHHHHH
SDLLNQNILPTLPLNPIAPLDLDTAEQIDFVFEWEGAVTPMDKSGQALPTFWLVNKRAWE
HHHHCCCCCCCCCCCCCCCCCCCCHHHEEEEEEECCCCCCCCCCCCCCCEEEEEEHHHHC
GMSQDSIPAPLATLERGRTYIFNLKNVTQYHHPIHLHGHTFTVLELNGQTLAEPFHTDTV
CCCCCCCCCCHHHHHCCCEEEEEECCHHHHCCCEEECCCEEEEEEECCCEECCCCCCCEE
LLGKNGSAKAAFVADNPGRWMYHCHVIEHMKTGLMGYIEVK
EEECCCCCEEEEEECCCCCEEEEEEEHHHHHCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA