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The map label for this gene is thiP [H]

Identifier: 326423752

GI number: 326423752

Start: 719067

End: 720674

Strand: Reverse

Name: thiP [H]

Synonym: NA

Alternate gene names: 326423752

Gene position: 720674-719067 (Counterclockwise)

Preceding gene: 326423753

Following gene: 27364157

Centisome position: 21.96

GC content: 52.24

Gene sequence:

>1608_bases
TTGAATTCGGTTCCTAAATTGGGCATTGGGGTCGCGATGATCATCGCGACCTTTGTTGTTTCTGCTCTCTCGGCGCTCTT
GTTGGCGACGCCGACGCTGAATCTCACGGCGGTATGGCAAGATCCTTATTACCGGCATGTTACGCAATTTAGTTTTCTTC
AAGCGACGCTGTCGATGCTGCTGAGTGTCGGTTTGGCGCTTCCTGTCGCACACGCCTTGTCTCGGCGACTTTTTGTTGGC
CGCTCGCTATTGCTCAAATTGTTTGCGTCAACTTTAGTGCTGCCAGTATTGGTAGGCGTGTTTGGCTTGTTGGCCATTTA
TGGGAACAGTGGTTGGTTGGCAAGTGTATTGGCGAGCTTTGACGCCAAATTGCCCTTTTCGATCTACGGATTGAGCGGCA
TTTTGCTCGCGCACGTGTTTTTCAATTTGCCGTATGCAGCGCGATTGCTGCTGCAAACCTTAGAGTCGATTCCGGCAGAG
CAGCACAAATTGGCGGCTCATCTTGGTATGAACAGCTGGCAGAAGTTTCGTTGGGTCGAATGGCCGCGATTGCGCCAGCA
ACTGCCACATGTGTGTGGCTTGGTGTTCATGCTTTGCTTCACCAGCTTTGCCACGGTCATGGCCCTCGGTGGCGGCCCAA
AATCGACCACCATCGAGCTGGCTATCTACCAAGCGATAAAATTTGATTTTGACTTACAAGCTGGAGCGCTACTGGCGATC
TGGCAAATGCTATTGTGTAGCTTGCTGGTGTTGGCGCTGCAGCGATTGACTAAACCGCTGCCTGTCTCGGTTGGCAGCCA
TACCCGCTTCGTTCAGTTAACCCCAGCTTCTAAGCGTCATTTTATGTGGGATTATGCGTGGATAGCACTGGCGACGCTGC
TGGTGGTTCCGCCGCTACTGTTTGTGGTGGCCAGCGGGATAAACAGCAAGCTCCCCGACGTGATCAGTGATGGCCGATTT
TGGTCCGCTCTGGGGGCCTCGTTACGTGTAGCGTTTGGCGCCGCCACGTTAGCCGTGGGCGCGGCGATTGCTATTTTGCT
CACCAGTCGTGCATGGCGGTTGCGTGGTCTGCGATACCCTGCAGACGGCATTGAGATGGTGGGCACCATCATCTTGGTGA
CGCCAGGTTTGGTGGTGAGTACGGGGCTGTTTTTATTGCTGCGCAGTTTTGCAGATGTGTTCAGTTTGTCGCTGTTGATC
GTCATCATCGTCAACAGTTTGATGGCATTACCGTACGCCATCAAAACGCTCGCTCAGCCGATGTTGCATTGCGAGCAGCA
GTATCAATACTTGGCTGCTACATTGGGCTTAAGCGGGTGGAATCGTTTTAAAATCGTTGAGTGGCGAGCACTGCGTAAAC
CTTTCGCCAATGCGTTTGCGCTCTGTTTTATGTTTTCCATTGGCGATTTGAGCGCGATTGCCTTATTTGGTAGTCAAGAT
TTTCGTACCCTACCGCTCTATCTGTACCAGTTACTCGGCAGTTATCAAATGGAGGCAGCAGCTGTGGTGTCACTCACGTT
ATTGCTGCTGAGTGTCGGCTGTTTTGCCCTGAGTGAGTCCTTACTCAGCAGCAAATCGAATCAACATCAGGAGAAGGCGC
CATGCTAA

Upstream 100 bases:
NA

Downstream 100 bases:
NA

Product: thiamine/thiamine pyrophosphate ABC transporter permease

Products: ADP; phosphate; thiamine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 535; Mature: 535

Protein sequence:
NA

Sequences:

>Translated_535_residues
MNSVPKLGIGVAMIIATFVVSALSALLLATPTLNLTAVWQDPYYRHVTQFSFLQATLSMLLSVGLALPVAHALSRRLFVG
RSLLLKLFASTLVLPVLVGVFGLLAIYGNSGWLASVLASFDAKLPFSIYGLSGILLAHVFFNLPYAARLLLQTLESIPAE
QHKLAAHLGMNSWQKFRWVEWPRLRQQLPHVCGLVFMLCFTSFATVMALGGGPKSTTIELAIYQAIKFDFDLQAGALLAI
WQMLLCSLLVLALQRLTKPLPVSVGSHTRFVQLTPASKRHFMWDYAWIALATLLVVPPLLFVVASGINSKLPDVISDGRF
WSALGASLRVAFGAATLAVGAAIAILLTSRAWRLRGLRYPADGIEMVGTIILVTPGLVVSTGLFLLLRSFADVFSLSLLI
VIIVNSLMALPYAIKTLAQPMLHCEQQYQYLAATLGLSGWNRFKIVEWRALRKPFANAFALCFMFSIGDLSAIALFGSQD
FRTLPLYLYQLLGSYQMEAAAVVSLTLLLLSVGCFALSESLLSSKSNQHQEKAPC
>Mature_535_residues
MNSVPKLGIGVAMIIATFVVSALSALLLATPTLNLTAVWQDPYYRHVTQFSFLQATLSMLLSVGLALPVAHALSRRLFVG
RSLLLKLFASTLVLPVLVGVFGLLAIYGNSGWLASVLASFDAKLPFSIYGLSGILLAHVFFNLPYAARLLLQTLESIPAE
QHKLAAHLGMNSWQKFRWVEWPRLRQQLPHVCGLVFMLCFTSFATVMALGGGPKSTTIELAIYQAIKFDFDLQAGALLAI
WQMLLCSLLVLALQRLTKPLPVSVGSHTRFVQLTPASKRHFMWDYAWIALATLLVVPPLLFVVASGINSKLPDVISDGRF
WSALGASLRVAFGAATLAVGAAIAILLTSRAWRLRGLRYPADGIEMVGTIILVTPGLVVSTGLFLLLRSFADVFSLSLLI
VIIVNSLMALPYAIKTLAQPMLHCEQQYQYLAATLGLSGWNRFKIVEWRALRKPFANAFALCFMFSIGDLSAIALFGSQD
FRTLPLYLYQLLGSYQMEAAAVVSLTLLLLSVGCFALSESLLSSKSNQHQEKAPC

Specific function: Part of the ABC transporter complex thiBPQ involved in thiamine import. Probably responsible for the translocation of the substrate across the membrane [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 ABC transmembrane type-1 domains [H]

Homologues:

Organism=Escherichia coli, GI1786254, Length=477, Percent_Identity=50.9433962264151, Blast_Score=420, Evalue=1e-118,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000515
- InterPro:   IPR005947 [H]

Pfam domain/function: PF00528 BPD_transp_1 [H]

EC number: NA

Molecular weight: Translated: 58424; Mature: 58424

Theoretical pI: Translated: 10.00; Mature: 10.00

Prosite motif: PS50928 ABC_TM1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNSVPKLGIGVAMIIATFVVSALSALLLATPTLNLTAVWQDPYYRHVTQFSFLQATLSML
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHHHHH
LSVGLALPVAHALSRRLFVGRSLLLKLFASTLVLPVLVGVFGLLAIYGNSGWLASVLASF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
DAKLPFSIYGLSGILLAHVFFNLPYAARLLLQTLESIPAEQHKLAAHLGMNSWQKFRWVE
CCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCHHHHHHHHHCCCHHHHHCCCC
WPRLRQQLPHVCGLVFMLCFTSFATVMALGGGPKSTTIELAIYQAIKFDFDLQAGALLAI
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEHHHHHHHHCCCCCCCCHHHHH
WQMLLCSLLVLALQRLTKPLPVSVGSHTRFVQLTPASKRHFMWDYAWIALATLLVVPPLL
HHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHH
FVVASGINSKLPDVISDGRFWSALGASLRVAFGAATLAVGAAIAILLTSRAWRLRGLRYP
HHHHHCCCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
ADGIEMVGTIILVTPGLVVSTGLFLLLRSFADVFSLSLLIVIIVNSLMALPYAIKTLAQP
CCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MLHCEQQYQYLAATLGLSGWNRFKIVEWRALRKPFANAFALCFMFSIGDLSAIALFGSQD
HHHHHHHHHHHHHHHCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHCCHHHHHEECCCC
FRTLPLYLYQLLGSYQMEAAAVVSLTLLLLSVGCFALSESLLSSKSNQHQEKAPC
CCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure
MNSVPKLGIGVAMIIATFVVSALSALLLATPTLNLTAVWQDPYYRHVTQFSFLQATLSML
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHHHHH
LSVGLALPVAHALSRRLFVGRSLLLKLFASTLVLPVLVGVFGLLAIYGNSGWLASVLASF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
DAKLPFSIYGLSGILLAHVFFNLPYAARLLLQTLESIPAEQHKLAAHLGMNSWQKFRWVE
CCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCHHHHHHHHHCCCHHHHHCCCC
WPRLRQQLPHVCGLVFMLCFTSFATVMALGGGPKSTTIELAIYQAIKFDFDLQAGALLAI
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEHHHHHHHHCCCCCCCCHHHHH
WQMLLCSLLVLALQRLTKPLPVSVGSHTRFVQLTPASKRHFMWDYAWIALATLLVVPPLL
HHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHH
FVVASGINSKLPDVISDGRFWSALGASLRVAFGAATLAVGAAIAILLTSRAWRLRGLRYP
HHHHHCCCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
ADGIEMVGTIILVTPGLVVSTGLFLLLRSFADVFSLSLLIVIIVNSLMALPYAIKTLAQP
CCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MLHCEQQYQYLAATLGLSGWNRFKIVEWRALRKPFANAFALCFMFSIGDLSAIALFGSQD
HHHHHHHHHHHHHHHCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHCCHHHHHEECCCC
FRTLPLYLYQLLGSYQMEAAAVVSLTLLLLSVGCFALSESLLSSKSNQHQEKAPC
CCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; thiamine [Periplasm]; H2O [C]

Specific reaction: ATP + thiamine [Periplasm] + H2O = ADP + phosphate + thiamine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1630901; 9278503; 9535878 [H]