| Definition | Helicobacter hepaticus ATCC 51449 chromosome, complete genome. |
|---|---|
| Accession | NC_004917 |
| Length | 1,799,146 |
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The map label for this gene is topA
Identifier: 32267297
GI number: 32267297
Start: 1718740
End: 1720989
Strand: Direct
Name: topA
Synonym: HH1798
Alternate gene names: 32267297
Gene position: 1718740-1720989 (Clockwise)
Preceding gene: 32267293
Following gene: 32267298
Centisome position: 95.53
GC content: 36.93
Gene sequence:
>2250_bases ATGAAAGATTTAATCATTGTAGAATCGCCCGCCAAAGCAAGGACGATTAAAAATTTTTTAGGGAGTAAATATGAGGTTAT AGCCTCTAAAGGTCATATCCGAGACTTGCCAAAATATACTTTTGGCATTGATATAAAGGATAAAACATTCCACCCACAAT ACACTATCAGTAAAGACCATATGGAGATTGTTGAGAAAATTAAGGTTGCTAGCAAAAAAGCAAAGGTAACTTATATTGCA ACAGATGAGGATAGAGAGGGGGAGGCTATCGGTTTTCATATTACTCAAGCTCTAAATCTCCCTTATGAAAAAATCCCACG CATTGTGTTTCACGAGATTACAAAAAATGCTATTACGCACTCATTGCAAAATCCGCGTCAAATTGATATGGCAAAGGTAA ATGCTCAACAAGCACGGCGGTTGCTTGATAGGATTGTTGGTTTTAAACTTTCCGAACTTATTTCTTCCAAGATTCAGCGT GGATTATCAGCAGGACGTGTGCAAAGTTCTGCGCTTAAGATTATTGTGGATAGGGAACGAGAGATACGCGCCTTTAAGCC GACAATTTATTTTTTAATTAATGCAGTTTTTAATATGAAACCTAAGAGTAAGCAAAAAAACCAAGATAATGGTCAAAATA ATATAGAAGCCGAACTCATCACTTATGACAAAAAGCTTGAAAAGCTCTCTTTGCAAAATTTTGAGGCGGTAGAGGCGATG TTGGAGCATATCCAAAAGCAGCAATTTTTTATTAAAGAAATTATCACAAAAAGTAAGAAAATATCAACACCTCCACCATT TATGACTTCTACATTACAACAAAGTGCCTCAAGTTTATTAGGATTTTCTCCCTCACGGACGATGAGTATTGCACAACGAC TTTATGAAGGTGTGGAAACGAATTTTGGAAGTATGGGGGTAATTACCTATATGAGGACAGATAGTCTTAATATTGCCAAA GAAGCGCAAAAAGCCGCAAGAGAAATGATTATAAAAACTTATGGCAAAGAATATGTTCCTGCTAAAACCAAAAATTACGC TACCAAATCCAAAGCTGCACAAGAAGCTCACGAAGCGATACGACCAACCAATCTTGATTTTACTCCAGAAATCGCAAAAT CTTATCTTAAGCCAGAAGAGCATAAGCTTTATGCACTTATTTATTATCGTTTTTTGGCTTCACAAAGTCAAGATGCGCTT TTTGAGATACAAAATATTATTTTTACACCTCATAATCAAACACATTTGATTGAATTTAAAGCAAGTGGGCGCAAACTTGT TTATGATGGATTCTATAAGATTATGGGAAATGATGACAAAGATAAGCTTTTGCCCGAATGCAAAGAGGGCGAAGATGTGT TATTAAATAATATAGAATCTGTTCAAAAATCCACCGAAGCTCCGTCGCGTTATTCTGAAGCAAGCATTATTAAAAGTATG GAATCACTTGGTATTGGTCGTCCCTCCACTTATGCACCAACTATTGCATTGCTTGTGGCACGAGAATATGTGAATATAGA AAAAAAGCAGCTTGTGCCGCAAGAAAGTGCATTTAAGGTGATAGAAATGTTGGAATCTTATTTTGATGAGATTGTAGATA CCCATTTTACCGCCGGATTAGAAGATAAGCTTGATGAAATCGCTCAAGCAAAAATGAATTGGGAATCTGTGCTGTGGGAG TTTTATCAGCCATTTATGCAAAAGATAGAATCTGGCAAAAAAGTGATTGTCTCACAAAAAGTTGCTATTCCTACAGGAGA GATGTGTCCAAAATGTGGGAAAGAGCTTGTGCAACGCAAGAGCAAATATGGTGAATTTATCGCGTGTAGCGGTTATCCCA AATGTAAATATATTAAACCTACACAACAAGATTCTCAATCGCAATCCCAAGAATATGGTGTATGTGAAAAATGTGGCGAA CCTATGATAAAAAAGTTTGGTCGTAATGGTGAATTTATCGCGTGTAGCGGTTATCCCAAATGTAAAAATACAAAATCTCT CACAGACAAAGCACAGGCTCATAGTGTTGAAGGTGTGGTTTGTCCAGAATGCGAAGGAGAGATTGTAAAAAGATTTAGCC GCAGGGGAGCGTTTTATGGCTGCAAGAACTATCCAAAATGCACTTTTATCTCAAAATTTGAGCCTATCAAAGAGAAATGT CCGCAATGTGGCGGAATAAGCGTAGAGCGTGAATATCGCAAAAAACAAGTGCGCGAATGTCTCAAATGCAAGCATAGAAT AGAAATATAA
Upstream 100 bases:
>100_bases TTTATGTTAAAAAACATAAAATGTGAAATTCTAATGAGAATCTGTGCTAAAATCCGTTTTTTATTTCTCATAGAAATTAG GCATTAGGGGAATTTAAGCT
Downstream 100 bases:
>100_bases AAATTATCAAATAATGTTACTTTTTCTCTAAAAAAATAGATAAACCTCAAAAAACCTTTTGCTTTTAAGCAAAATCGGGG GGGGGGGGGGGTAGAATAGC
Product: DNA topoisomerase I
Products: NA
Alternate protein names: DNA topoisomerase I; Omega-protein; Relaxing enzyme; Swivelase; Untwisting enzyme [H]
Number of amino acids: Translated: 749; Mature: 749
Protein sequence:
>749_residues MKDLIIVESPAKARTIKNFLGSKYEVIASKGHIRDLPKYTFGIDIKDKTFHPQYTISKDHMEIVEKIKVASKKAKVTYIA TDEDREGEAIGFHITQALNLPYEKIPRIVFHEITKNAITHSLQNPRQIDMAKVNAQQARRLLDRIVGFKLSELISSKIQR GLSAGRVQSSALKIIVDREREIRAFKPTIYFLINAVFNMKPKSKQKNQDNGQNNIEAELITYDKKLEKLSLQNFEAVEAM LEHIQKQQFFIKEIITKSKKISTPPPFMTSTLQQSASSLLGFSPSRTMSIAQRLYEGVETNFGSMGVITYMRTDSLNIAK EAQKAAREMIIKTYGKEYVPAKTKNYATKSKAAQEAHEAIRPTNLDFTPEIAKSYLKPEEHKLYALIYYRFLASQSQDAL FEIQNIIFTPHNQTHLIEFKASGRKLVYDGFYKIMGNDDKDKLLPECKEGEDVLLNNIESVQKSTEAPSRYSEASIIKSM ESLGIGRPSTYAPTIALLVAREYVNIEKKQLVPQESAFKVIEMLESYFDEIVDTHFTAGLEDKLDEIAQAKMNWESVLWE FYQPFMQKIESGKKVIVSQKVAIPTGEMCPKCGKELVQRKSKYGEFIACSGYPKCKYIKPTQQDSQSQSQEYGVCEKCGE PMIKKFGRNGEFIACSGYPKCKNTKSLTDKAQAHSVEGVVCPECEGEIVKRFSRRGAFYGCKNYPKCTFISKFEPIKEKC PQCGGISVEREYRKKQVRECLKCKHRIEI
Sequences:
>Translated_749_residues MKDLIIVESPAKARTIKNFLGSKYEVIASKGHIRDLPKYTFGIDIKDKTFHPQYTISKDHMEIVEKIKVASKKAKVTYIA TDEDREGEAIGFHITQALNLPYEKIPRIVFHEITKNAITHSLQNPRQIDMAKVNAQQARRLLDRIVGFKLSELISSKIQR GLSAGRVQSSALKIIVDREREIRAFKPTIYFLINAVFNMKPKSKQKNQDNGQNNIEAELITYDKKLEKLSLQNFEAVEAM LEHIQKQQFFIKEIITKSKKISTPPPFMTSTLQQSASSLLGFSPSRTMSIAQRLYEGVETNFGSMGVITYMRTDSLNIAK EAQKAAREMIIKTYGKEYVPAKTKNYATKSKAAQEAHEAIRPTNLDFTPEIAKSYLKPEEHKLYALIYYRFLASQSQDAL FEIQNIIFTPHNQTHLIEFKASGRKLVYDGFYKIMGNDDKDKLLPECKEGEDVLLNNIESVQKSTEAPSRYSEASIIKSM ESLGIGRPSTYAPTIALLVAREYVNIEKKQLVPQESAFKVIEMLESYFDEIVDTHFTAGLEDKLDEIAQAKMNWESVLWE FYQPFMQKIESGKKVIVSQKVAIPTGEMCPKCGKELVQRKSKYGEFIACSGYPKCKYIKPTQQDSQSQSQEYGVCEKCGE PMIKKFGRNGEFIACSGYPKCKNTKSLTDKAQAHSVEGVVCPECEGEIVKRFSRRGAFYGCKNYPKCTFISKFEPIKEKC PQCGGISVEREYRKKQVRECLKCKHRIEI >Mature_749_residues MKDLIIVESPAKARTIKNFLGSKYEVIASKGHIRDLPKYTFGIDIKDKTFHPQYTISKDHMEIVEKIKVASKKAKVTYIA TDEDREGEAIGFHITQALNLPYEKIPRIVFHEITKNAITHSLQNPRQIDMAKVNAQQARRLLDRIVGFKLSELISSKIQR GLSAGRVQSSALKIIVDREREIRAFKPTIYFLINAVFNMKPKSKQKNQDNGQNNIEAELITYDKKLEKLSLQNFEAVEAM LEHIQKQQFFIKEIITKSKKISTPPPFMTSTLQQSASSLLGFSPSRTMSIAQRLYEGVETNFGSMGVITYMRTDSLNIAK EAQKAAREMIIKTYGKEYVPAKTKNYATKSKAAQEAHEAIRPTNLDFTPEIAKSYLKPEEHKLYALIYYRFLASQSQDAL FEIQNIIFTPHNQTHLIEFKASGRKLVYDGFYKIMGNDDKDKLLPECKEGEDVLLNNIESVQKSTEAPSRYSEASIIKSM ESLGIGRPSTYAPTIALLVAREYVNIEKKQLVPQESAFKVIEMLESYFDEIVDTHFTAGLEDKLDEIAQAKMNWESVLWE FYQPFMQKIESGKKVIVSQKVAIPTGEMCPKCGKELVQRKSKYGEFIACSGYPKCKYIKPTQQDSQSQSQEYGVCEKCGE PMIKKFGRNGEFIACSGYPKCKNTKSLTDKAQAHSVEGVVCPECEGEIVKRFSRRGAFYGCKNYPKCTFISKFEPIKEKC PQCGGISVEREYRKKQVRECLKCKHRIEI
Specific function: The reaction catalyzed by topoisomerases leads to the conversion of one topological isomer of DNA to another [H]
COG id: COG0550
COG function: function code L; Topoisomerase IA
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Contains 1 Toprim domain [H]
Homologues:
Organism=Homo sapiens, GI10835218, Length=670, Percent_Identity=24.3283582089552, Blast_Score=145, Evalue=2e-34, Organism=Homo sapiens, GI4507635, Length=719, Percent_Identity=21.2795549374131, Blast_Score=111, Evalue=3e-24, Organism=Escherichia coli, GI1787529, Length=758, Percent_Identity=33.6411609498681, Blast_Score=402, Evalue=1e-113, Organism=Escherichia coli, GI48994931, Length=142, Percent_Identity=41.5492957746479, Blast_Score=110, Evalue=2e-25, Organism=Escherichia coli, GI1788061, Length=547, Percent_Identity=23.217550274223, Blast_Score=95, Evalue=2e-20, Organism=Caenorhabditis elegans, GI17555378, Length=529, Percent_Identity=25.3308128544423, Blast_Score=113, Evalue=4e-25, Organism=Saccharomyces cerevisiae, GI6323263, Length=509, Percent_Identity=23.5756385068762, Blast_Score=99, Evalue=3e-21, Organism=Drosophila melanogaster, GI24640096, Length=553, Percent_Identity=22.4231464737794, Blast_Score=94, Evalue=4e-19,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR003601 - InterPro: IPR013497 - InterPro: IPR013824 - InterPro: IPR013825 - InterPro: IPR000380 - InterPro: IPR003602 - InterPro: IPR013498 - InterPro: IPR005733 - InterPro: IPR006171 [H]
Pfam domain/function: PF01131 Topoisom_bac; PF01751 Toprim; PF01396 zf-C4_Topoisom [H]
EC number: =5.99.1.2 [H]
Molecular weight: Translated: 85362; Mature: 85362
Theoretical pI: Translated: 9.43; Mature: 9.43
Prosite motif: PS00396 TOPOISOMERASE_I_PROK
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
2.3 %Cys (Translated Protein) 2.3 %Met (Translated Protein) 4.5 %Cys+Met (Translated Protein) 2.3 %Cys (Mature Protein) 2.3 %Met (Mature Protein) 4.5 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MKDLIIVESPAKARTIKNFLGSKYEVIASKGHIRDLPKYTFGIDIKDKTFHPQYTISKDH CCCEEEEECCHHHHHHHHHHCCCEEEEECCCCCCCCCCCEEEEECCCCCCCCCEEECHHH MEIVEKIKVASKKAKVTYIATDEDREGEAIGFHITQALNLPYEKIPRIVFHEITKNAITH HHHHHHHHHHHCCCEEEEEECCCCCCCCEEEEEHHHHHCCCHHHHHHHHHHHHHHHHHHH SLQNPRQIDMAKVNAQQARRLLDRIVGFKLSELISSKIQRGLSAGRVQSSALKIIVDRER HHCCCCHHHHHHCCHHHHHHHHHHHHCHHHHHHHHHHHHHCHHHCCHHHHHHEEEECCCH EIRAFKPTIYFLINAVFNMKPKSKQKNQDNGQNNIEAELITYDKKLEKLSLQNFEAVEAM HHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEHHHHHHHHHHHCCHHHHHHH LEHIQKQQFFIKEIITKSKKISTPPPFMTSTLQQSASSLLGFSPSRTMSIAQRLYEGVET HHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHC NFGSMGVITYMRTDSLNIAKEAQKAAREMIIKTYGKEYVPAKTKNYATKSKAAQEAHEAI CCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHC RPTNLDFTPEIAKSYLKPEEHKLYALIYYRFLASQSQDALFEIQNIIFTPHNQTHLIEFK CCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHEECCCCCEEEEEEE ASGRKLVYDGFYKIMGNDDKDKLLPECKEGEDVLLNNIESVQKSTEAPSRYSEASIIKSM CCCCEEEEHHHHHHCCCCCHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHH ESLGIGRPSTYAPTIALLVAREYVNIEKKQLVPQESAFKVIEMLESYFDEIVDTHFTAGL HHHCCCCCCCHHHHHHHHHHHHHHCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCH EDKLDEIAQAKMNWESVLWEFYQPFMQKIESGKKVIVSQKVAIPTGEMCPKCGKELVQRK HHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCEEEEECEECCCCHHCCHHHHHHHHHHH SKYGEFIACSGYPKCKYIKPTQQDSQSQSQEYGVCEKCGEPMIKKFGRNGEFIACSGYPK HHCCCEEEECCCCCCCCCCCCCCCHHHHHHHCCCHHHHCCHHHHHHCCCCCEEEECCCCC CKNTKSLTDKAQAHSVEGVVCPECEGEIVKRFSRRGAFYGCKNYPKCTFISKFEPIKEKC CCCCHHHHHHHHHHCCCCEECCCCCHHHHHHHHHCCCCCCCCCCCCEEEHHCCCHHHHHC PQCGGISVEREYRKKQVRECLKCKHRIEI CCCCCCCHHHHHHHHHHHHHHHHHHCCCC >Mature Secondary Structure MKDLIIVESPAKARTIKNFLGSKYEVIASKGHIRDLPKYTFGIDIKDKTFHPQYTISKDH CCCEEEEECCHHHHHHHHHHCCCEEEEECCCCCCCCCCCEEEEECCCCCCCCCEEECHHH MEIVEKIKVASKKAKVTYIATDEDREGEAIGFHITQALNLPYEKIPRIVFHEITKNAITH HHHHHHHHHHHCCCEEEEEECCCCCCCCEEEEEHHHHHCCCHHHHHHHHHHHHHHHHHHH SLQNPRQIDMAKVNAQQARRLLDRIVGFKLSELISSKIQRGLSAGRVQSSALKIIVDRER HHCCCCHHHHHHCCHHHHHHHHHHHHCHHHHHHHHHHHHHCHHHCCHHHHHHEEEECCCH EIRAFKPTIYFLINAVFNMKPKSKQKNQDNGQNNIEAELITYDKKLEKLSLQNFEAVEAM HHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEHHHHHHHHHHHCCHHHHHHH LEHIQKQQFFIKEIITKSKKISTPPPFMTSTLQQSASSLLGFSPSRTMSIAQRLYEGVET HHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHC NFGSMGVITYMRTDSLNIAKEAQKAAREMIIKTYGKEYVPAKTKNYATKSKAAQEAHEAI CCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHC RPTNLDFTPEIAKSYLKPEEHKLYALIYYRFLASQSQDALFEIQNIIFTPHNQTHLIEFK CCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHEECCCCCEEEEEEE ASGRKLVYDGFYKIMGNDDKDKLLPECKEGEDVLLNNIESVQKSTEAPSRYSEASIIKSM CCCCEEEEHHHHHHCCCCCHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHH ESLGIGRPSTYAPTIALLVAREYVNIEKKQLVPQESAFKVIEMLESYFDEIVDTHFTAGL HHHCCCCCCCHHHHHHHHHHHHHHCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCH EDKLDEIAQAKMNWESVLWEFYQPFMQKIESGKKVIVSQKVAIPTGEMCPKCGKELVQRK HHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCEEEEECEECCCCHHCCHHHHHHHHHHH SKYGEFIACSGYPKCKYIKPTQQDSQSQSQEYGVCEKCGEPMIKKFGRNGEFIACSGYPK HHCCCEEEECCCCCCCCCCCCCCCHHHHHHHCCCHHHHCCHHHHHHCCCCCEEEECCCCC CKNTKSLTDKAQAHSVEGVVCPECEGEIVKRFSRRGAFYGCKNYPKCTFISKFEPIKEKC CCCCHHHHHHHHHHCCCCEECCCCCHHHHHHHHHCCCCCCCCCCCCEEEHHCCCHHHHHC PQCGGISVEREYRKKQVRECLKCKHRIEI CCCCCCCHHHHHHHHHHHHHHHHHHCCCC
PDB accession: NA
Resolution: NA
Structure class: Unstructured
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: 9923682 [H]