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The map label for this gene is glmM

Identifier: 32267278

GI number: 32267278

Start: 1702066

End: 1703427

Strand: Direct

Name: glmM

Synonym: HH1779

Alternate gene names: 32267278

Gene position: 1702066-1703427 (Clockwise)

Preceding gene: 32267274

Following gene: 32267279

Centisome position: 94.6

GC content: 39.79

Gene sequence:

>1362_bases
ATGAAGACAAAAGATACAAAGGCAAAACTATTTGGCACTGATGGTGTCCGAGGACGTGCGGGGGAAGTGATTACTCCCTC
AAGTGTGATAGCTTTAGGAACAAGTGCGGGGATACACTTTCGCCAACATTCATTGACAAATAAGATTCTCGTAGGCAAGG
ATACACGTCGTAGCGGTTATATGATAGAAAACGCTCTTGTTTCTGCTCTCACTTCTGTGGGCTATGATGTGATACAAATT
GGTCCTATGCCTACTCCCGCCGTTGCTTTTTTGACAGAGGATATGCGATGCGATGCGGGAATTATGATAAGCGCAAGCCA
TAATCCCTATGATGATAATGGTATAAAATTCTTTAATCATTATGGTTATAAACTTGCTCAAGAAGAAGAAGAAAGTATAG
AATCTTATTATTACAATCCCACCTCGCTCCAAAGCGCACTCAAAAGTGGGCTAGAAATCGGTAGTTCAAAGCGTATTGAT
GATGTGGTGGGACGTTATATTGTGCATATTAAAAATTCTTTTCCAAAGAATCTAACTTTACGAGGATTGCGTATAGTGTG
TGATTGTGCTAATGGTGCGGCATATCGTGTTGCTCCTATTGTGTTGAGCGAATTAGGAGCTGATGTGATAGCTATTAATG
ATGAGCCTAATGGATACAATATCAACAAGCAGTGCGGAGCTATGCACCCTGAAGGCTTGGCTCAAGAAGTGATGACATAT
CGTGCTGATGTGGGCTTTGCTCTTGATGGCGATGCGGATAGATTAGTGGTGGTGGATAATAAAGGAAATATTGTCAATGG
TGATAAACTCATCGGTGCACTTGCTTTGTATCAAAAGCAAATTGGCAAACTTGAAAATAATGCTATTGTGGCAACTTTGA
TGAGTAATCTTGCACTTGAAGAGTTCCTTAAGTCTCATCAAATAGGGCTTCATCGTTGCAATGTTGGAGATAAATATGTA
TGGGATAAAATGCGTGAGCATAAGCTTAATTTTGGAGGGGAGAGCAGCGGACATATTATTTTTAGTGATTATGCAAAAAC
TGGCGATGGCTTGGTGAGTGCATTGCAAGTTTTAGCACTTTTAATCCAAAGTGGGAAAAGTTCTCAAGATGCGCTTAATC
CCTTTGAGATTTATCCGAGCGAGCTTGTGAATCTTAAAGTTTCTCAAAAAAAGCCACTTGAAAAAATTAATGGATTGCAA
GAAAAATTAGATTCTATAAGTGCATCTGGGAATCGCTACCTTGTGCGCTACTCTGGCACAGAAAATAAACTTAGAATCTT
GGTGGAAGGTAAAGATTACAAGCTTGTGAGTGAGCAAGTTAAAATGCTTGTTGATTTATGCCAAAAGCAGCTCAATGTGT
AA

Upstream 100 bases:

>100_bases
TATGATTTGCCATTTTTATTAGTCCTTTTTTTAAAAAATTAGGGCAAGATTCTGCCAAAAGTTTGATTAAATGCAGTTTA
AAAGTCTGTAAGGGGATTGA

Downstream 100 bases:

>100_bases
ATAACAAATAAAATGAGACAATATGACTTTTGCATTTAGGCATTTAAAGCAGATTACAGCAAAACAACTAAGCATTTTTA
TCGTGCTTTTTATCCTAAGT

Product: phosphoglucosamine mutase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 453; Mature: 453

Protein sequence:

>453_residues
MKTKDTKAKLFGTDGVRGRAGEVITPSSVIALGTSAGIHFRQHSLTNKILVGKDTRRSGYMIENALVSALTSVGYDVIQI
GPMPTPAVAFLTEDMRCDAGIMISASHNPYDDNGIKFFNHYGYKLAQEEEESIESYYYNPTSLQSALKSGLEIGSSKRID
DVVGRYIVHIKNSFPKNLTLRGLRIVCDCANGAAYRVAPIVLSELGADVIAINDEPNGYNINKQCGAMHPEGLAQEVMTY
RADVGFALDGDADRLVVVDNKGNIVNGDKLIGALALYQKQIGKLENNAIVATLMSNLALEEFLKSHQIGLHRCNVGDKYV
WDKMREHKLNFGGESSGHIIFSDYAKTGDGLVSALQVLALLIQSGKSSQDALNPFEIYPSELVNLKVSQKKPLEKINGLQ
EKLDSISASGNRYLVRYSGTENKLRILVEGKDYKLVSEQVKMLVDLCQKQLNV

Sequences:

>Translated_453_residues
MKTKDTKAKLFGTDGVRGRAGEVITPSSVIALGTSAGIHFRQHSLTNKILVGKDTRRSGYMIENALVSALTSVGYDVIQI
GPMPTPAVAFLTEDMRCDAGIMISASHNPYDDNGIKFFNHYGYKLAQEEEESIESYYYNPTSLQSALKSGLEIGSSKRID
DVVGRYIVHIKNSFPKNLTLRGLRIVCDCANGAAYRVAPIVLSELGADVIAINDEPNGYNINKQCGAMHPEGLAQEVMTY
RADVGFALDGDADRLVVVDNKGNIVNGDKLIGALALYQKQIGKLENNAIVATLMSNLALEEFLKSHQIGLHRCNVGDKYV
WDKMREHKLNFGGESSGHIIFSDYAKTGDGLVSALQVLALLIQSGKSSQDALNPFEIYPSELVNLKVSQKKPLEKINGLQ
EKLDSISASGNRYLVRYSGTENKLRILVEGKDYKLVSEQVKMLVDLCQKQLNV
>Mature_453_residues
MKTKDTKAKLFGTDGVRGRAGEVITPSSVIALGTSAGIHFRQHSLTNKILVGKDTRRSGYMIENALVSALTSVGYDVIQI
GPMPTPAVAFLTEDMRCDAGIMISASHNPYDDNGIKFFNHYGYKLAQEEEESIESYYYNPTSLQSALKSGLEIGSSKRID
DVVGRYIVHIKNSFPKNLTLRGLRIVCDCANGAAYRVAPIVLSELGADVIAINDEPNGYNINKQCGAMHPEGLAQEVMTY
RADVGFALDGDADRLVVVDNKGNIVNGDKLIGALALYQKQIGKLENNAIVATLMSNLALEEFLKSHQIGLHRCNVGDKYV
WDKMREHKLNFGGESSGHIIFSDYAKTGDGLVSALQVLALLIQSGKSSQDALNPFEIYPSELVNLKVSQKKPLEKINGLQ
EKLDSISASGNRYLVRYSGTENKLRILVEGKDYKLVSEQVKMLVDLCQKQLNV

Specific function: Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate

COG id: COG1109

COG function: function code G; Phosphomannomutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the phosphohexose mutase family

Homologues:

Organism=Escherichia coli, GI1789566, Length=442, Percent_Identity=45.2488687782805, Blast_Score=349, Evalue=3e-97,
Organism=Escherichia coli, GI1788361, Length=479, Percent_Identity=24.6346555323591, Blast_Score=112, Evalue=6e-26,
Organism=Drosophila melanogaster, GI17864244, Length=334, Percent_Identity=25.1497005988024, Blast_Score=65, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GLMM_HELHP (Q7VF98)

Other databases:

- EMBL:   AE017125
- RefSeq:   NP_861310.1
- ProteinModelPortal:   Q7VF98
- SMR:   Q7VF98
- GeneID:   1492326
- GenomeReviews:   AE017125_GR
- KEGG:   hhe:HH1779
- NMPDR:   fig|235279.1.peg.1779
- HOGENOM:   HBG644964
- OMA:   VHDRYIE
- ProtClustDB:   PRK14324
- BioCyc:   HHEP235279:HH_1779-MONOMER
- BRENDA:   5.4.2.10
- HAMAP:   MF_01554_B
- InterPro:   IPR005844
- InterPro:   IPR016055
- InterPro:   IPR005845
- InterPro:   IPR005846
- InterPro:   IPR005843
- InterPro:   IPR016066
- InterPro:   IPR005841
- InterPro:   IPR006352
- Gene3D:   G3DSA:3.40.120.10
- PRINTS:   PR00509
- TIGRFAMs:   TIGR01455

Pfam domain/function: PF02878 PGM_PMM_I; PF02879 PGM_PMM_II; PF02880 PGM_PMM_III; PF00408 PGM_PMM_IV; SSF53738 A-D-PHexomutase_a/b/a-I/II/III

EC number: =5.4.2.10

Molecular weight: Translated: 49640; Mature: 49640

Theoretical pI: Translated: 7.29; Mature: 7.29

Prosite motif: PS00710 PGM_PMM

Important sites: ACT_SITE 106-106

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTKDTKAKLFGTDGVRGRAGEVITPSSVIALGTSAGIHFRQHSLTNKILVGKDTRRSGY
CCCCCCCEEEEECCCCCCCCCCEECCCCEEEECCCCCCEEEHHCCCCEEEECCCCCCCCC
MIENALVSALTSVGYDVIQIGPMPTPAVAFLTEDMRCDAGIMISASHNPYDDNGIKFFNH
HHHHHHHHHHHHCCCCEEEECCCCCCHHHHEECCCCCCCCEEEECCCCCCCCCCEEEHHH
YGYKLAQEEEESIESYYYNPTSLQSALKSGLEIGSSKRIDDVVGRYIVHIKNSFPKNLTL
CCCCHHCHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHEEECCCCCCCCEE
RGLRIVCDCANGAAYRVAPIVLSELGADVIAINDEPNGYNINKQCGAMHPEGLAQEVMTY
EEEEEEEECCCCCCCHHHHHHHHHCCCCEEEECCCCCCCCCCHHCCCCCCHHHHHHHHHH
RADVGFALDGDADRLVVVDNKGNIVNGDKLIGALALYQKQIGKLENNAIVATLMSNLALE
HHCCCEEECCCCCEEEEECCCCCEECHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHH
EFLKSHQIGLHRCNVGDKYVWDKMREHKLNFGGESSGHIIFSDYAKTGDGLVSALQVLAL
HHHHHHCCCEEECCCCCHHHHHHHHHHCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHH
LIQSGKSSQDALNPFEIYPSELVNLKVSQKKPLEKINGLQEKLDSISASGNRYLVRYSGT
HHHCCCCCCCCCCCHHCCCHHHEEEEECCCCCHHHHHHHHHHHHHHCCCCCEEEEEEECC
ENKLRILVEGKDYKLVSEQVKMLVDLCQKQLNV
CCEEEEEEECCCCHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKTKDTKAKLFGTDGVRGRAGEVITPSSVIALGTSAGIHFRQHSLTNKILVGKDTRRSGY
CCCCCCCEEEEECCCCCCCCCCEECCCCEEEECCCCCCEEEHHCCCCEEEECCCCCCCCC
MIENALVSALTSVGYDVIQIGPMPTPAVAFLTEDMRCDAGIMISASHNPYDDNGIKFFNH
HHHHHHHHHHHHCCCCEEEECCCCCCHHHHEECCCCCCCCEEEECCCCCCCCCCEEEHHH
YGYKLAQEEEESIESYYYNPTSLQSALKSGLEIGSSKRIDDVVGRYIVHIKNSFPKNLTL
CCCCHHCHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHEEECCCCCCCCEE
RGLRIVCDCANGAAYRVAPIVLSELGADVIAINDEPNGYNINKQCGAMHPEGLAQEVMTY
EEEEEEEECCCCCCCHHHHHHHHHCCCCEEEECCCCCCCCCCHHCCCCCCHHHHHHHHHH
RADVGFALDGDADRLVVVDNKGNIVNGDKLIGALALYQKQIGKLENNAIVATLMSNLALE
HHCCCEEECCCCCEEEEECCCCCEECHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHH
EFLKSHQIGLHRCNVGDKYVWDKMREHKLNFGGESSGHIIFSDYAKTGDGLVSALQVLAL
HHHHHHCCCEEECCCCCHHHHHHHHHHCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHH
LIQSGKSSQDALNPFEIYPSELVNLKVSQKKPLEKINGLQEKLDSISASGNRYLVRYSGT
HHHCCCCCCCCCCCHHCCCHHHEEEEECCCCCHHHHHHHHHHHHHHCCCCCEEEEEEECC
ENKLRILVEGKDYKLVSEQVKMLVDLCQKQLNV
CCEEEEEEECCCCHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12810954