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The map label for this gene is serS

Identifier: 32266989

GI number: 32266989

Start: 1426404

End: 1427672

Strand: Direct

Name: serS

Synonym: HH1490

Alternate gene names: 32266989

Gene position: 1426404-1427672 (Clockwise)

Preceding gene: 32266982

Following gene: 32266990

Centisome position: 79.28

GC content: 36.8

Gene sequence:

>1269_bases
ATGATTGATACAAAGGCATTGATAAATCAATTTGATGAAATAAAATCGCGACTTGCAATTAAAAAAGTAAGTGAAGAAAC
ATTGAGTGCTCTTAAAGATATGGCTCTTAAATATAAATCCTGCAAACAGGAGCTTGAAGAGTTACAAGCTTTTCAAAATA
AAACTTCAAAACTTTTTGGCGAATATAAAAGAGAGCAAAAAGATATTACAGCACTTAAAGTGGCGCTTGATGAGAATAAA
GTTAAGATGAGCACTTTAGAATCTACGCTAAAAGAGATAGAATCACATTTAGAAACACTTGCTTATGGGATACCGAATCT
ACCTGATGATGCCACGCCAGAGGGTGAGGATGAGAATGATAATGTTGAAATTAAAAAAGTGCTCTCTCCTCCACATTTTG
ATTTTGTTCCTAAAGAGCATTGGGAACTTGGTATTGCAAATGGTTGGATTGATTTTGAAGCAGGAGTAAAACTTGCTAAA
AGTCGTTTTAGTGTGTTGCGTGGAATGGGAGCAAAACTCAATCGCGCACTTATTAATTTTATGTTAGATTATAATGAAAA
AGCAGGTTTTGAATCTATTGTAACACCCGTAATTGTTAATGCACGAGCACTTTTTGGCACAGGACAGCTTCCAAAGTTTG
AAGAAGATATGTTTAAAGTAGATTCTCATTTTTGTGATGAACAAAGTGAGCACGATTTGTATCTTATCTCTACTTCAGAA
ATTACGCTTACTAATCTCTATCAAGATAGTATTATTCCAAGTGAGGAACTACCTATTATGCTCACAGCTCAAACACCTTG
TTTTCGTAAAGAAGCGGGAAGTGCAGGGCGAGATACGCGGGGTATGATACGCCAACATCAGTTTGATAAAGTTGAGCTTG
TGGCTATTACTCACCCAACCCAAAGTGCAGCAATGCAGGAGAAAATGGTGCAAACAGCAAGCGAGATTTTAAGTGAGCTT
AAGCTTCCACATCGTTTAATGCAGTTATGTGGTGGTGATTTGGGCTTTAGTGCAAGTAATACCATTGATATTGAAGTGTG
GCTTCCGGGACAAAATTGTTATCGTGAGATTAGCTCTATATCAAATACGCGTGATTTTCAAGCTCGTAGAGCGAAGATTC
GTTACAAAGAAAATGGTAAAAATGCCCTTGTGCATACACTTAATGGTTCATCTTTGGCAGTAGGACGCACACTTATTGCA
ATTATGGAAAATTATCAGCAAGTAGATGGGAGTGTAATGATTCCTGAAGTGCTACAAAAGTATCTATAA

Upstream 100 bases:

>100_bases
AACTTAGTAATTTTACAAGTTTCTTGCTTGCCCTTTTAGGAATAAAAAATGCTTTTTTGGGTTAAAATTAGAGTTTATTT
AGAGATAAAGTGGAGCAGTA

Downstream 100 bases:

>100_bases
AAGTGAGATATTATGGCAGAAGAACAAGAAAATAATGTTGGTGATAACTTAGAAATCCCAGATTCACAAGGTAAAGATGG
TGCAAATGAGGGAGATTCTC

Product: seryl-tRNA synthetase

Products: NA

Alternate protein names: Serine--tRNA ligase; SerRS; Seryl-tRNA(Ser/Sec) synthetase

Number of amino acids: Translated: 422; Mature: 422

Protein sequence:

>422_residues
MIDTKALINQFDEIKSRLAIKKVSEETLSALKDMALKYKSCKQELEELQAFQNKTSKLFGEYKREQKDITALKVALDENK
VKMSTLESTLKEIESHLETLAYGIPNLPDDATPEGEDENDNVEIKKVLSPPHFDFVPKEHWELGIANGWIDFEAGVKLAK
SRFSVLRGMGAKLNRALINFMLDYNEKAGFESIVTPVIVNARALFGTGQLPKFEEDMFKVDSHFCDEQSEHDLYLISTSE
ITLTNLYQDSIIPSEELPIMLTAQTPCFRKEAGSAGRDTRGMIRQHQFDKVELVAITHPTQSAAMQEKMVQTASEILSEL
KLPHRLMQLCGGDLGFSASNTIDIEVWLPGQNCYREISSISNTRDFQARRAKIRYKENGKNALVHTLNGSSLAVGRTLIA
IMENYQQVDGSVMIPEVLQKYL

Sequences:

>Translated_422_residues
MIDTKALINQFDEIKSRLAIKKVSEETLSALKDMALKYKSCKQELEELQAFQNKTSKLFGEYKREQKDITALKVALDENK
VKMSTLESTLKEIESHLETLAYGIPNLPDDATPEGEDENDNVEIKKVLSPPHFDFVPKEHWELGIANGWIDFEAGVKLAK
SRFSVLRGMGAKLNRALINFMLDYNEKAGFESIVTPVIVNARALFGTGQLPKFEEDMFKVDSHFCDEQSEHDLYLISTSE
ITLTNLYQDSIIPSEELPIMLTAQTPCFRKEAGSAGRDTRGMIRQHQFDKVELVAITHPTQSAAMQEKMVQTASEILSEL
KLPHRLMQLCGGDLGFSASNTIDIEVWLPGQNCYREISSISNTRDFQARRAKIRYKENGKNALVHTLNGSSLAVGRTLIA
IMENYQQVDGSVMIPEVLQKYL
>Mature_422_residues
MIDTKALINQFDEIKSRLAIKKVSEETLSALKDMALKYKSCKQELEELQAFQNKTSKLFGEYKREQKDITALKVALDENK
VKMSTLESTLKEIESHLETLAYGIPNLPDDATPEGEDENDNVEIKKVLSPPHFDFVPKEHWELGIANGWIDFEAGVKLAK
SRFSVLRGMGAKLNRALINFMLDYNEKAGFESIVTPVIVNARALFGTGQLPKFEEDMFKVDSHFCDEQSEHDLYLISTSE
ITLTNLYQDSIIPSEELPIMLTAQTPCFRKEAGSAGRDTRGMIRQHQFDKVELVAITHPTQSAAMQEKMVQTASEILSEL
KLPHRLMQLCGGDLGFSASNTIDIEVWLPGQNCYREISSISNTRDFQARRAKIRYKENGKNALVHTLNGSSLAVGRTLIA
IMENYQQVDGSVMIPEVLQKYL

Specific function: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)

COG id: COG0172

COG function: function code J; Seryl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily

Homologues:

Organism=Homo sapiens, GI16306548, Length=425, Percent_Identity=31.2941176470588, Blast_Score=195, Evalue=8e-50,
Organism=Homo sapiens, GI8923421, Length=366, Percent_Identity=31.1475409836066, Blast_Score=181, Evalue=1e-45,
Organism=Homo sapiens, GI225579074, Length=334, Percent_Identity=32.6347305389222, Blast_Score=180, Evalue=2e-45,
Organism=Escherichia coli, GI1787120, Length=428, Percent_Identity=46.4953271028037, Blast_Score=375, Evalue=1e-105,
Organism=Caenorhabditis elegans, GI17539260, Length=292, Percent_Identity=32.8767123287671, Blast_Score=176, Evalue=3e-44,
Organism=Caenorhabditis elegans, GI17542084, Length=345, Percent_Identity=27.2463768115942, Blast_Score=135, Evalue=3e-32,
Organism=Saccharomyces cerevisiae, GI6320226, Length=425, Percent_Identity=31.2941176470588, Blast_Score=194, Evalue=2e-50,
Organism=Saccharomyces cerevisiae, GI6321799, Length=429, Percent_Identity=27.039627039627, Blast_Score=172, Evalue=6e-44,
Organism=Drosophila melanogaster, GI24581334, Length=463, Percent_Identity=28.2937365010799, Blast_Score=175, Evalue=5e-44,
Organism=Drosophila melanogaster, GI17737985, Length=360, Percent_Identity=29.7222222222222, Blast_Score=143, Evalue=2e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SYS_HELHP (Q7VG34)

Other databases:

- EMBL:   AE017125
- RefSeq:   NP_861021.1
- ProteinModelPortal:   Q7VG34
- SMR:   Q7VG34
- GeneID:   1492037
- GenomeReviews:   AE017125_GR
- KEGG:   hhe:HH1490
- NMPDR:   fig|235279.1.peg.1490
- HOGENOM:   HBG629391
- OMA:   PDGETDE
- ProtClustDB:   PRK05431
- BioCyc:   HHEP235279:HH_1490-MONOMER
- BRENDA:   6.1.1.11
- GO:   GO:0005737
- HAMAP:   MF_00176
- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR002317
- InterPro:   IPR015866
- InterPro:   IPR010978
- Gene3D:   G3DSA:1.10.287.40
- PANTHER:   PTHR11778
- PIRSF:   PIRSF001529
- PRINTS:   PR00981
- TIGRFAMs:   TIGR00414

Pfam domain/function: PF02403 Seryl_tRNA_N; PF00587 tRNA-synt_2b; SSF46589 tRNA_binding_arm

EC number: =6.1.1.11

Molecular weight: Translated: 47589; Mature: 47589

Theoretical pI: Translated: 5.26; Mature: 5.26

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: BINDING 292-292 BINDING 390-390

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIDTKALINQFDEIKSRLAIKKVSEETLSALKDMALKYKSCKQELEELQAFQNKTSKLFG
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EYKREQKDITALKVALDENKVKMSTLESTLKEIESHLETLAYGIPNLPDDATPEGEDEND
HHHHHHHHHHHEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
NVEIKKVLSPPHFDFVPKEHWELGIANGWIDFEAGVKLAKSRFSVLRGMGAKLNRALINF
CEEEEEECCCCCCCCCCCHHCEEECCCCEEEHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
MLDYNEKAGFESIVTPVIVNARALFGTGQLPKFEEDMFKVDSHFCDEQSEHDLYLISTSE
HHHCCCCCCHHHHHHHHHHCCHHEECCCCCCCHHHHHHHHHHHHCCCCCCCCEEEEEECC
ITLTNLYQDSIIPSEELPIMLTAQTPCFRKEAGSAGRDTRGMIRQHQFDKVELVAITHPT
EEEEHHHHHCCCCCCCCCEEEECCCCCHHHHCCCCCCCHHHHHHHCCCCCEEEEEEECCC
QSAAMQEKMVQTASEILSELKLPHRLMQLCGGDLGFSASNTIDIEVWLPGQNCYREISSI
HHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCCCCCCEEEEEEEECCHHHHHHHHHH
SNTRDFQARRAKIRYKENGKNALVHTLNGSSLAVGRTLIAIMENYQQVDGSVMIPEVLQK
CCCHHHHHHHHHEEEECCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHCCCEEHHHHHHH
YL
HC
>Mature Secondary Structure
MIDTKALINQFDEIKSRLAIKKVSEETLSALKDMALKYKSCKQELEELQAFQNKTSKLFG
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EYKREQKDITALKVALDENKVKMSTLESTLKEIESHLETLAYGIPNLPDDATPEGEDEND
HHHHHHHHHHHEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
NVEIKKVLSPPHFDFVPKEHWELGIANGWIDFEAGVKLAKSRFSVLRGMGAKLNRALINF
CEEEEEECCCCCCCCCCCHHCEEECCCCEEEHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
MLDYNEKAGFESIVTPVIVNARALFGTGQLPKFEEDMFKVDSHFCDEQSEHDLYLISTSE
HHHCCCCCCHHHHHHHHHHCCHHEECCCCCCCHHHHHHHHHHHHCCCCCCCCEEEEEECC
ITLTNLYQDSIIPSEELPIMLTAQTPCFRKEAGSAGRDTRGMIRQHQFDKVELVAITHPT
EEEEHHHHHCCCCCCCCCEEEECCCCCHHHHCCCCCCCHHHHHHHCCCCCEEEEEEECCC
QSAAMQEKMVQTASEILSELKLPHRLMQLCGGDLGFSASNTIDIEVWLPGQNCYREISSI
HHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCCCCCCEEEEEEEECCHHHHHHHHHH
SNTRDFQARRAKIRYKENGKNALVHTLNGSSLAVGRTLIAIMENYQQVDGSVMIPEVLQK
CCCHHHHHHHHHEEEECCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHCCCEEHHHHHHH
YL
HC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12810954