Click here to switch to the map view.

The map label for this gene is hemH

Identifier: 32266495

GI number: 32266495

Start: 971883

End: 972818

Strand: Direct

Name: hemH

Synonym: HH0996

Alternate gene names: 32266495

Gene position: 971883-972818 (Clockwise)

Preceding gene: 32266488

Following gene: 32266496

Centisome position: 54.02

GC content: 35.9

Gene sequence:

>936_bases
ATGGGCTCTCCAAATAGCCTTTTTGAGGTAGAAAGTTTTTTAAAAAATATGTTTAATGACCCTCTAATTTTGGGGATAAA
AAATACCTTTGCACGTAAAATGCTGGCAAGTTTCATTACCCATAGTCGCGTTGAAGAAACTAAAAAAAATTATCAAGCCA
TTGGTGGCAAATCACCTCTCACAGCTCACACTTTAAATCTTACAAATAAACTCAATGAACTTGATTGTAAGCGATTTTAT
ACTTATGCAATGCGCTATACACCGCCATTTGCATATCAAGTATTAGAGGATATAAAAACACAAGGTATACAATCCGTAGT
GCTTTTTAGCCTTTATCCGCAATTTTCTTATTCTACTATTGCCTCCTCGCTTATTGATGCCAAAGCAGCTCTACAAAAAC
TTGCATTTACACCCACACTCTATGAAATATCCTCTTATCACACTCACCCAGATTACATAAGCTGTATTATAGAGCGCATT
AAAGAATCTTTAGGTGCAGATAATCCAAATGAATTTGTGCTTTTGCTCTCTGCTCACAGCCTCCCACAATCACGTATAGA
TGAGGGTGACCCTTATCAAAAACAATGTGAAGAAAACAAAGAAGTCATACAAAAGGCACTTGAGAGTGAAGGGATTGTCT
TTAAAAAGATTGCACTTGCCTATCAATCTAAAGTGGGTCGTATGAAATGGATTGGACCAAGCACAAAAGAGACTATTACC
AAATATAAAAAACATAAGATGATTATTTTCCCTCTCTCTTTCACACTTGATAATTCCGAAACAGAATACGAATTAAAGAT
ACTCTACGCCTCCCTTGCAAAAGAGCTAAATGTTCCTCAATATCGTGTTTGTAGCTGCTTTAATGATAATGAAAGATTCG
CTAAAAGTATTATGAACATACTTGAAGAACATCTTCGCGGCAAAGCAGAAGTGTAG

Upstream 100 bases:

>100_bases
AACTTTAATTAACTTTTGTAGTTTATTATCACTTAAAATCTTTAACCTCACTATTAAAAAAGGATTTTCCATCAAATCGC
AGGCTGTTGTTTTACTCAAT

Downstream 100 bases:

>100_bases
CCATAAGGTTAAGGAGTAAAACAAAATGAATAAACTATGGATGCTATGTGCGATTATTTATGCAATGATGATAAGTTTTG
GTTGTAATGATGATAATGAA

Product: ferrochelatase

Products: NA

Alternate protein names: Heme synthase; Protoheme ferro-lyase

Number of amino acids: Translated: 311; Mature: 310

Protein sequence:

>311_residues
MGSPNSLFEVESFLKNMFNDPLILGIKNTFARKMLASFITHSRVEETKKNYQAIGGKSPLTAHTLNLTNKLNELDCKRFY
TYAMRYTPPFAYQVLEDIKTQGIQSVVLFSLYPQFSYSTIASSLIDAKAALQKLAFTPTLYEISSYHTHPDYISCIIERI
KESLGADNPNEFVLLLSAHSLPQSRIDEGDPYQKQCEENKEVIQKALESEGIVFKKIALAYQSKVGRMKWIGPSTKETIT
KYKKHKMIIFPLSFTLDNSETEYELKILYASLAKELNVPQYRVCSCFNDNERFAKSIMNILEEHLRGKAEV

Sequences:

>Translated_311_residues
MGSPNSLFEVESFLKNMFNDPLILGIKNTFARKMLASFITHSRVEETKKNYQAIGGKSPLTAHTLNLTNKLNELDCKRFY
TYAMRYTPPFAYQVLEDIKTQGIQSVVLFSLYPQFSYSTIASSLIDAKAALQKLAFTPTLYEISSYHTHPDYISCIIERI
KESLGADNPNEFVLLLSAHSLPQSRIDEGDPYQKQCEENKEVIQKALESEGIVFKKIALAYQSKVGRMKWIGPSTKETIT
KYKKHKMIIFPLSFTLDNSETEYELKILYASLAKELNVPQYRVCSCFNDNERFAKSIMNILEEHLRGKAEV
>Mature_310_residues
GSPNSLFEVESFLKNMFNDPLILGIKNTFARKMLASFITHSRVEETKKNYQAIGGKSPLTAHTLNLTNKLNELDCKRFYT
YAMRYTPPFAYQVLEDIKTQGIQSVVLFSLYPQFSYSTIASSLIDAKAALQKLAFTPTLYEISSYHTHPDYISCIIERIK
ESLGADNPNEFVLLLSAHSLPQSRIDEGDPYQKQCEENKEVIQKALESEGIVFKKIALAYQSKVGRMKWIGPSTKETITK
YKKHKMIIFPLSFTLDNSETEYELKILYASLAKELNVPQYRVCSCFNDNERFAKSIMNILEEHLRGKAEV

Specific function: Catalyzes the ferrous insertion into protoporphyrin IX

COG id: COG0276

COG function: function code H; Protoheme ferro-lyase (ferrochelatase)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ferrochelatase family

Homologues:

Organism=Homo sapiens, GI60499021, Length=324, Percent_Identity=31.4814814814815, Blast_Score=142, Evalue=4e-34,
Organism=Homo sapiens, GI60499025, Length=324, Percent_Identity=31.4814814814815, Blast_Score=142, Evalue=4e-34,
Organism=Escherichia coli, GI1786681, Length=273, Percent_Identity=26.007326007326, Blast_Score=95, Evalue=7e-21,
Organism=Saccharomyces cerevisiae, GI6324750, Length=324, Percent_Identity=27.7777777777778, Blast_Score=107, Evalue=2e-24,
Organism=Drosophila melanogaster, GI17864156, Length=331, Percent_Identity=28.7009063444109, Blast_Score=132, Evalue=2e-31,
Organism=Drosophila melanogaster, GI24651774, Length=255, Percent_Identity=27.843137254902, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI45552018, Length=176, Percent_Identity=31.25, Blast_Score=93, Evalue=2e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HEMH_HELHP (Q7VHH1)

Other databases:

- EMBL:   AE017125
- RefSeq:   NP_860527.1
- ProteinModelPortal:   Q7VHH1
- SMR:   Q7VHH1
- GeneID:   1492685
- GenomeReviews:   AE017125_GR
- KEGG:   hhe:HH0996
- NMPDR:   fig|235279.1.peg.996
- HOGENOM:   HBG697135
- OMA:   HSLPMEI
- ProtClustDB:   PRK00035
- BioCyc:   HHEP235279:HH_0996-MONOMER
- BRENDA:   4.99.1.1
- GO:   GO:0005737
- HAMAP:   MF_00323
- InterPro:   IPR001015
- InterPro:   IPR019772
- PANTHER:   PTHR11108
- TIGRFAMs:   TIGR00109

Pfam domain/function: PF00762 Ferrochelatase

EC number: =4.99.1.1

Molecular weight: Translated: 35563; Mature: 35432

Theoretical pI: Translated: 8.41; Mature: 8.41

Prosite motif: PS00534 FERROCHELATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGSPNSLFEVESFLKNMFNDPLILGIKNTFARKMLASFITHSRVEETKKNYQAIGGKSPL
CCCCHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
TAHTLNLTNKLNELDCKRFYTYAMRYTPPFAYQVLEDIKTQGIQSVVLFSLYPQFSYSTI
EEEEEHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHH
ASSLIDAKAALQKLAFTPTLYEISSYHTHPDYISCIIERIKESLGADNPNEFVLLLSAHS
HHHHHHHHHHHHHHHCCCHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEEECCC
LPQSRIDEGDPYQKQCEENKEVIQKALESEGIVFKKIALAYQSKVGRMKWIGPSTKETIT
CCHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCEEECCCCHHHHHH
KYKKHKMIIFPLSFTLDNSETEYELKILYASLAKELNVPQYRVCSCFNDNERFAKSIMNI
HHHHCCEEEEEEEEEECCCCCCHHHHHHHHHHHHHCCCCCHHHHHHCCCHHHHHHHHHHH
LEEHLRGKAEV
HHHHHCCCCCC
>Mature Secondary Structure 
GSPNSLFEVESFLKNMFNDPLILGIKNTFARKMLASFITHSRVEETKKNYQAIGGKSPL
CCCHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
TAHTLNLTNKLNELDCKRFYTYAMRYTPPFAYQVLEDIKTQGIQSVVLFSLYPQFSYSTI
EEEEEHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHH
ASSLIDAKAALQKLAFTPTLYEISSYHTHPDYISCIIERIKESLGADNPNEFVLLLSAHS
HHHHHHHHHHHHHHHCCCHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEEECCC
LPQSRIDEGDPYQKQCEENKEVIQKALESEGIVFKKIALAYQSKVGRMKWIGPSTKETIT
CCHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCEEECCCCHHHHHH
KYKKHKMIIFPLSFTLDNSETEYELKILYASLAKELNVPQYRVCSCFNDNERFAKSIMNI
HHHHCCEEEEEEEEEECCCCCCHHHHHHHHHHHHHCCCCCHHHHHHCCCHHHHHHHHHHH
LEEHLRGKAEV
HHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12810954